SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4wdr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_B_CIAB2003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 4wdr HALOALKANE
DEHALOGENASE
(Sphingobium
japonicum) 		5 / 12 ALA A 285
ILE A 286
ILE A 266
VAL A 268
ALA A 243
 None
 1.03A 1uduB-4wdrA:
undetectable		 1uduB-4wdrA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VPO_H_TESH1010_1
(ANTI-TESTOSTERONE
(HEAVY CHAIN)
ANTI-TESTOSTERONE
(LIGHT CHAIN))		 4wdr HALOALKANE
DEHALOGENASE
(Sphingobium
japonicum) 		5 / 12 TYR A  82
ALA A 133
LEU A 248
VAL A 220
PRO A 212
 None
 0.90A 1vpoH-4wdrA:
undetectable
1vpoL-4wdrA:
undetectable		 1vpoH-4wdrA:
22.52
1vpoL-4wdrA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VPT_A_SAMA400_1
(VP39)		 4wdr HALOALKANE
DEHALOGENASE
(Sphingobium
japonicum) 		3 / 3 ASP A 116
ARG A  86
ASP A 226
 None
 0.88A 1vptA-4wdrA:
undetectable		 1vptA-4wdrA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y00_B_Y00B601_2
(BETA-1 ADRENERGIC
RECEPTOR)		 4wdr HALOALKANE
DEHALOGENASE
(Sphingobium
japonicum) 		3 / 3 VAL A 163
ASN A  38
TRP A 109
 None
CL  A 301 (-4.2A)
CL  A 301 (-4.7A)
 1.03A 2y00B-4wdrA:
undetectable		 2y00B-4wdrA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGN_A_PCFA1179_1
(WNT INHIBITORY
FACTOR 1)		 4wdr HALOALKANE
DEHALOGENASE
(Sphingobium
japonicum) 		4 / 5 ILE A 236
PHE A 115
PRO A 261
PHE A 240
 None
 1.26A 2ygnA-4wdrA:
undetectable		 2ygnA-4wdrA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_C_CHDC151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4wdr HALOALKANE
DEHALOGENASE
(Sphingobium
japonicum) 		5 / 10 ILE A  48
ILE A 282
VAL A 268
GLY A 270
LEU A  44
 None
 1.24A 3elzC-4wdrA:
undetectable		 3elzC-4wdrA:
15.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FBW_A_BEZA501_0
(HALOALKANE
DEHALOGENASE)		 4wdr HALOALKANE
DEHALOGENASE
(Sphingobium
japonicum) 		7 / 9 ASN A  38
ASP A 108
TRP A 109
PHE A 151
PHE A 169
LEU A 211
HIS A 272
 CL  A 301 (-4.2A)
CL  A 301 ( 4.6A)
CL  A 301 (-4.7A)
None
CL  A 301 ( 4.8A)
None
None
 0.42A 3fbwA-4wdrA:
44.4		 3fbwA-4wdrA:
48.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R4X_A_PZAA598_0
(LACTOPEROXIDASE)		 4wdr HALOALKANE
DEHALOGENASE
(Sphingobium
japonicum) 		4 / 5 PHE A  34
GLU A  26
PHE A   8
PRO A  50
 None
 1.32A 3r4xA-4wdrA:
undetectable		 3r4xA-4wdrA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZV_A_SAMA1474_1
(WBDD)		 4wdr HALOALKANE
DEHALOGENASE
(Sphingobium
japonicum) 		4 / 6 GLN A 172
ASP A 147
GLN A 146
GLU A 132
 None
 1.32A 4azvA-4wdrA:
2.0		 4azvA-4wdrA:
18.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4F5Z_A_BEZA302_0
(HALOALKANE
DEHALOGENASE)		 4wdr HALOALKANE
DEHALOGENASE
(Sphingobium
japonicum) 		7 / 8 ASN A  38
ASP A 108
TRP A 109
PHE A 169
VAL A 173
LEU A 211
HIS A 272
 CL  A 301 (-4.2A)
CL  A 301 ( 4.6A)
CL  A 301 (-4.7A)
CL  A 301 ( 4.8A)
None
None
None
 0.30A 4f5zA-4wdrA:
44.5		 4f5zA-4wdrA:
48.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4F5Z_A_BEZA302_0
(HALOALKANE
DEHALOGENASE)		 4wdr HALOALKANE
DEHALOGENASE
(Sphingobium
japonicum) 		4 / 8 ASP A 108
TRP A 109
PHE A 151
HIS A 272
 CL  A 301 ( 4.6A)
CL  A 301 (-4.7A)
None
None
 1.17A 4f5zA-4wdrA:
44.5		 4f5zA-4wdrA:
48.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_O_BEZO801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 4wdr HALOALKANE
DEHALOGENASE
(Sphingobium
japonicum) 		4 / 6 PHE A 194
PRO A 203
MET A  66
LEU A 205
 None
 1.45A 5dzka-4wdrA:
undetectable
5dzko-4wdrA:
undetectable		 5dzka-4wdrA:
24.57
5dzko-4wdrA:
1.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I8F_A_ML1A210_1
(PHENOLIC OXIDATIVE
COUPLING PROTEIN)		 4wdr HALOALKANE
DEHALOGENASE
(Sphingobium
japonicum) 		5 / 12 GLN A 275
HIS A 272
LEU A 248
TYR A 227
GLY A 110
 None
 1.31A 5i8fA-4wdrA:
undetectable		 5i8fA-4wdrA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_A_ERMA2001_2
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)		 4wdr HALOALKANE
DEHALOGENASE
(Sphingobium
japonicum) 		4 / 7 LEU A 248
VAL A 173
GLN A 146
GLU A 145
 None
 1.03A 5tudA-4wdrA:
undetectable		 5tudA-4wdrA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VW5_A_NCAA403_0
(FERREDOXIN--NADP
REDUCTASE)		 4wdr HALOALKANE
DEHALOGENASE
(Sphingobium
japonicum) 		4 / 8 GLY A  37
GLY A 110
LEU A 113
ALA A 112
 None
 0.74A 5vw5A-4wdrA:
undetectable		 5vw5A-4wdrA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YSI_A_NCAA1001_0
(UBIQUITINATING/DEUBI
QUITINATING ENZYME
SDEA)		 4wdr HALOALKANE
DEHALOGENASE
(Sphingobium
japonicum) 		5 / 6 ARG A 209
GLY A 159
SER A 206
THR A 204
VAL A 163
 None
 1.34A 5ysiA-4wdrA:
undetectable		 5ysiA-4wdrA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D8P_A_ACTA816_0
(UNCHARACTERIZED
PROTEIN)		 4wdr HALOALKANE
DEHALOGENASE
(Sphingobium
japonicum) 		3 / 3 ARG A 294
ARG A 101
ASP A  30
 None
 0.90A 6d8pA-4wdrA:
undetectable		 6d8pA-4wdrA:
17.44