SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4we6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMC_A_SAMA105_0
(MET REPRESSOR)		 4we6 HEMAGGLUTININ HA1
CHAIN
(Influenza
A
virus) 		5 / 10 ALA A  73
PHE A  47
GLY A  76
GLU A  49
ARG A 229
 None
 1.33A 1cmcA-4we6A:
undetectable
1cmcB-4we6A:
undetectable		 1cmcA-4we6A:
18.68
1cmcB-4we6A:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMC_B_SAMB105_0
(MET REPRESSOR)		 4we6 HEMAGGLUTININ HA1
CHAIN
(Influenza
A
virus) 		5 / 10 GLU A  49
ARG A 229
ALA A  73
PHE A  47
GLY A  76
 None
 1.36A 1cmcA-4we6A:
undetectable
1cmcB-4we6A:
undetectable		 1cmcA-4we6A:
18.68
1cmcB-4we6A:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DB1_A_VDXA428_1
(VITAMIN D NUCLEAR
RECEPTOR)		 4we6 HEMAGGLUTININ HA1
CHAIN
(Influenza
A
virus) 		5 / 12 LEU A  68
LEU A  71
VAL A  72
SER A  75
LEU A 111
 None
 1.34A 1db1A-4we6A:
undetectable		 1db1A-4we6A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_B_CCSB47_0
(GLUTATHIONE
S-TRANSFERASE)		 4we6 HEMAGGLUTININ HA1
CHAIN
(Influenza
A
virus) 		4 / 7 LEU A 154
THR A 115
LEU A 211
GLY A 209
 None
GOL  A 303 ( 4.6A)
None
None
 0.81A 1gtiB-4we6A:
undetectable		 1gtiB-4we6A:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_A_SAMA200_0
(METHIONINE REPRESSOR)		 4we6 HEMAGGLUTININ HA1
CHAIN
(Influenza
A
virus) 		5 / 11 GLU A  49
ARG A 229
ALA A  73
PHE A  47
GLY A  76
 None
 1.35A 1mjqA-4we6A:
undetectable
1mjqB-4we6A:
undetectable		 1mjqA-4we6A:
18.68
1mjqB-4we6A:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_C_SAMC199_0
(METHIONINE REPRESSOR)		 4we6 HEMAGGLUTININ HA1
CHAIN
(Influenza
A
virus) 		5 / 10 GLU A  49
ARG A 229
ALA A  73
PHE A  47
GLY A  76
 None
 1.39A 1mjqC-4we6A:
undetectable
1mjqD-4we6A:
undetectable		 1mjqC-4we6A:
18.68
1mjqD-4we6A:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_I_BEZI518_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 4we6 HEMAGGLUTININ HA1
CHAIN
(Influenza
A
virus) 		4 / 7 ILE A 205
PRO A 214
PHE A  85
ASN A  86
 None
None
None
NAG  A 301 (-1.8A)
 0.86A 1oniG-4we6A:
undetectable
1oniI-4we6A:
undetectable		 1oniG-4we6A:
18.35
1oniI-4we6A:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_A_RIMA199_1
(MATRIX PROTEIN 2)		 4we6 HEMAGGLUTININ HA1
CHAIN
(Influenza
A
virus) 		4 / 6 LEU A  68
LEU A  71
ILE A  27
ARG A  69
 None
 1.02A 2rlfA-4we6A:
undetectable
2rlfB-4we6A:
undetectable		 2rlfA-4we6A:
10.37
2rlfB-4we6A:
10.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_C_RIMC399_1
(MATRIX PROTEIN 2)		 4we6 HEMAGGLUTININ HA1
CHAIN
(Influenza
A
virus) 		4 / 6 LEU A  68
LEU A  71
ILE A  27
ARG A  69
 None
 1.00A 2rlfC-4we6A:
undetectable
2rlfD-4we6A:
undetectable		 2rlfC-4we6A:
10.37
2rlfD-4we6A:
10.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_B_SAMB302_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 4we6 HEMAGGLUTININ HA1
CHAIN
(Influenza
A
virus) 		4 / 5 SER A 169
ASP A  64
ASP A  61
ILE A 192
 None
 1.13A 3uj7B-4we6A:
undetectable		 3uj7B-4we6A:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQ4_A_SALA601_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 4we6 HEMAGGLUTININ HA1
CHAIN
(Influenza
A
virus) 		4 / 7 LEU A 154
TYR A 155
ILE A 212
GLY A  94
 None
None
None
GOL  A 303 (-3.4A)
 0.85A 4eq4A-4we6A:
undetectable		 4eq4A-4we6A:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQL_A_SALA602_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 4we6 HEMAGGLUTININ HA1
CHAIN
(Influenza
A
virus) 		4 / 7 LEU A 154
TYR A 155
ILE A 212
GLY A  94
 None
None
None
GOL  A 303 (-3.4A)
 0.86A 4eqlA-4we6A:
undetectable		 4eqlA-4we6A:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQL_B_SALB602_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 4we6 HEMAGGLUTININ HA1
CHAIN
(Influenza
A
virus) 		4 / 7 LEU A 154
TYR A 155
ILE A 212
GLY A  94
 None
None
None
GOL  A 303 (-3.4A)
 0.86A 4eqlB-4we6A:
undetectable		 4eqlB-4we6A:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L39_A_SALA602_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 4we6 HEMAGGLUTININ HA1
CHAIN
(Influenza
A
virus) 		4 / 6 LEU A 154
TYR A 155
ILE A 212
GLY A  94
 None
None
None
GOL  A 303 (-3.4A)
 0.85A 4l39A-4we6A:
undetectable		 4l39A-4we6A:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L39_B_SALB601_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 4we6 HEMAGGLUTININ HA1
CHAIN
(Influenza
A
virus) 		4 / 7 LEU A 154
TYR A 155
ILE A 212
GLY A  94
 None
None
None
GOL  A 303 (-3.4A)
 0.86A 4l39B-4we6A:
undetectable		 4l39B-4we6A:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4S0V_A_SUVA2001_2
(HUMAN OREXIN
RECEPTOR TYPE 2
FUSION PROTEIN TO P.
ABYSII GLYCOGEN
SYNTHASE)		 4we6 HEMAGGLUTININ HA1
CHAIN
(Influenza
A
virus) 		4 / 5 ILE A 177
PRO A 145
TYR A 193
VAL A 173
 None
 0.90A 4s0vA-4we6A:
undetectable		 4s0vA-4we6A:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_C_6ZPC902_1
(GLUTAMATE RECEPTOR 2)		 4we6 HEMAGGLUTININ HA1
CHAIN
(Influenza
A
virus) 		4 / 7 SER A  55
ASP A  33
PRO A  34
PHE A 108
 None
 1.25A 5l1fC-4we6A:
undetectable		 5l1fC-4we6A:
17.14