SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4web'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_A_DVAA6_0
(GRAMICIDIN A)		 4web HEPATITIS C VIRUS
ENVELOPE
GLYCOPROTEIN 2
(Hepacivirus
C) 		3 / 3 ALA E 501
VAL E 504
TRP E 556
 None
 1.01A 1c4dA-4webE:
undetectable
1c4dB-4webE:
undetectable		 1c4dA-4webE:
6.05
1c4dB-4webE:
6.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_C_DVAC6_0
(GRAMICIDIN A)		 4web HEPATITIS C VIRUS
ENVELOPE
GLYCOPROTEIN 2
(Hepacivirus
C) 		3 / 3 ALA E 501
VAL E 504
TRP E 556
 None
 0.90A 1c4dC-4webE:
undetectable
1c4dD-4webE:
undetectable		 1c4dC-4webE:
6.05
1c4dD-4webE:
6.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_D_DVAD6_0
(GRAMICIDIN A)		 4web HEPATITIS C VIRUS
ENVELOPE
GLYCOPROTEIN 2
(Hepacivirus
C) 		3 / 3 TRP E 556
ALA E 501
VAL E 504
 None
 0.77A 1c4dC-4webE:
undetectable
1c4dD-4webE:
undetectable		 1c4dC-4webE:
6.05
1c4dD-4webE:
6.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F78_B_BEZB1004_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 4web HEPATITIS C VIRUS
ENVELOPE
GLYCOPROTEIN 2
MOUSE FAB HEAVY
CHAIN
(Hepacivirus
C;
Mus
musculus) 		4 / 7 ARG E 643
LEU E 644
PHE H  27
THR H  32
 None
 1.08A 2f78B-4webE:
undetectable		 2f78B-4webE:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9C_C_ACTC1120_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 4web MOUSE FAB HEAVY
CHAIN
(Mus
musculus) 		3 / 3 LYS H 213
TYR H 127
PRO H 128
 None
 1.46A 2j9cC-4webH:
undetectable		 2j9cC-4webH:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUE_A_SAMA303_0
(CATECHOL
O-METHYLTRANSFERASE)		 4web MOUSE FAB HEAVY
CHAIN
(Mus
musculus) 		5 / 12 TYR H  95
ILE H  70
ILE H  48
ASN H  38
HIS H  35
 None
 1.46A 4xueA-4webH:
undetectable		 4xueA-4webH:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EYP_B_LOCB502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 4web MOUSE FAB HEAVY
CHAIN
(Mus
musculus) 		3 / 3 SER H 208
ALA H 203
VAL H 202
 None
 0.58A 5eypA-4webH:
undetectable		 5eypA-4webH:
22.16