SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4wed'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SDT_B_MK1B902_2
(PROTEASE RETROPEPSIN)		 4wed ABC TRANSPORTER,
PERIPLASMIC
SOLUTE-BINDING
PROTEIN
(Sinorhizobium
meliloti) 		5 / 12 ASP A 269
VAL A 266
ILE A 497
GLY A 245
ILE A 248
 None
 0.81A 1sdtB-4wedA:
undetectable		 1sdtB-4wedA:
11.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SDV_B_MK1B902_2
(PROTEASE RETROPEPSIN)		 4wed ABC TRANSPORTER,
PERIPLASMIC
SOLUTE-BINDING
PROTEIN
(Sinorhizobium
meliloti) 		5 / 11 ASP A 269
VAL A 266
ILE A 497
GLY A 245
ILE A 248
 None
 0.83A 1sdvB-4wedA:
undetectable		 1sdvB-4wedA:
11.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TDR_B_MTXB170_1
(TELLUROMETHIONYL
DIHYDROFOLATE
REDUCTASE)		 4wed ABC TRANSPORTER,
PERIPLASMIC
SOLUTE-BINDING
PROTEIN
(Sinorhizobium
meliloti) 		5 / 10 ALA A 328
LEU A 433
ILE A 488
LEU A 449
TYR A 493
 None
 1.37A 1tdrB-4wedA:
undetectable		 1tdrB-4wedA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H79_A_T3A1_1
(THRA PROTEIN)		 4wed ABC TRANSPORTER,
PERIPLASMIC
SOLUTE-BINDING
PROTEIN
(Sinorhizobium
meliloti) 		5 / 12 ILE A 225
ILE A  42
ALA A 249
MET A 516
LEU A 220
 None
 0.88A 2h79A-4wedA:
undetectable		 2h79A-4wedA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XCT_G_CPFG1020_1
(DNA GYRASE SUBUNIT
B, DNA GYRASE
SUBUNIT A)		 4wed ABC TRANSPORTER,
PERIPLASMIC
SOLUTE-BINDING
PROTEIN
(Sinorhizobium
meliloti) 		3 / 3 ARG A 219
GLY A  36
SER A 501
 None
 0.62A 2xctB-4wedA:
4.4		 2xctB-4wedA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_C_CHDC271_0
(CYTOCHROME C OXIDASE
SUBUNIT 3)		 4wed ABC TRANSPORTER,
PERIPLASMIC
SOLUTE-BINDING
PROTEIN
(Sinorhizobium
meliloti) 		4 / 7 LEU A  63
GLN A  61
PHE A 204
LEU A 220
 None
 1.01A 3ag2C-4wedA:
undetectable		 3ag2C-4wedA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HVC_B_HFGB1602_0
(BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE)		 4wed ABC TRANSPORTER,
PERIPLASMIC
SOLUTE-BINDING
PROTEIN
(Sinorhizobium
meliloti) 		5 / 12 PHE A 246
GLU A 513
PRO A 250
GLU A 255
GLY A 256
 None
 1.28A 4hvcB-4wedA:
undetectable		 4hvcB-4wedA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KUK_A_RBFA201_2
(BLUE-LIGHT
PHOTORECEPTOR)		 4wed ABC TRANSPORTER,
PERIPLASMIC
SOLUTE-BINDING
PROTEIN
(Sinorhizobium
meliloti) 		5 / 9 VAL A 384
ILE A 385
LEU A 396
ILE A 305
GLY A 418
 None
 1.01A 4kukA-4wedA:
undetectable		 4kukA-4wedA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM4_B_8PRB603_1
(TRANSPORTER)		 4wed ABC TRANSPORTER,
PERIPLASMIC
SOLUTE-BINDING
PROTEIN
(Sinorhizobium
meliloti) 		5 / 12 ASP A 269
ALA A 499
VAL A 266
SER A 496
GLY A 244
 None
 1.26A 4mm4B-4wedA:
undetectable		 4mm4B-4wedA:
24.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLF_A_HFGA802_0
(PROLINE--TRNA LIGASE)		 4wed ABC TRANSPORTER,
PERIPLASMIC
SOLUTE-BINDING
PROTEIN
(Sinorhizobium
meliloti) 		5 / 12 PHE A 246
GLU A 513
PRO A 250
GLU A 255
GLY A 256
 None
 1.34A 4olfA-4wedA:
undetectable		 4olfA-4wedA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BPH_C_ACTC403_0
(D-ALANINE--D-ALANINE
LIGASE)		 4wed ABC TRANSPORTER,
PERIPLASMIC
SOLUTE-BINDING
PROTEIN
(Sinorhizobium
meliloti) 		4 / 4 TYR A 479
GLY A 431
SER A 432
LEU A 433
 None
 1.28A 5bphC-4wedA:
undetectable		 5bphC-4wedA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_W_BEZW801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 4wed ABC TRANSPORTER,
PERIPLASMIC
SOLUTE-BINDING
PROTEIN
(Sinorhizobium
meliloti) 		5 / 5 PHE A 419
ILE A 385
GLY A 418
ILE A 381
LEU A 417
 None
 1.44A 5dzkB-4wedA:
undetectable
5dzkI-4wedA:
undetectable
5dzkW-4wedA:
undetectable		 5dzkB-4wedA:
19.31
5dzkI-4wedA:
17.39
5dzkW-4wedA:
0.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EML_A_SAMA701_0
(PROTEIN ARGININE
N-METHYLTRANSFERASE
5)		 4wed ABC TRANSPORTER,
PERIPLASMIC
SOLUTE-BINDING
PROTEIN
(Sinorhizobium
meliloti) 		5 / 12 LEU A 482
LEU A 275
ASN A 319
LEU A 449
CYH A 437
 None
 1.42A 5emlA-4wedA:
undetectable		 5emlA-4wedA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_K_IPHK101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 4wed ABC TRANSPORTER,
PERIPLASMIC
SOLUTE-BINDING
PROTEIN
(Sinorhizobium
meliloti) 		4 / 6 VAL A 142
CYH A 115
HIS A 147
LEU A  98
 None
 1.13A 5hrqH-4wedA:
undetectable
5hrqK-4wedA:
undetectable
5hrqL-4wedA:
undetectable		 5hrqH-4wedA:
4.75
5hrqK-4wedA:
3.53
5hrqL-4wedA:
4.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T7B_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 4wed ABC TRANSPORTER,
PERIPLASMIC
SOLUTE-BINDING
PROTEIN
(Sinorhizobium
meliloti) 		4 / 6 PHE A 152
PRO A 155
VAL A 156
THR A 467
 None
 1.13A 5t7bA-4wedA:
undetectable		 5t7bA-4wedA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_H_CVIH301_1
(REGULATORY PROTEIN
TETR)		 4wed ABC TRANSPORTER,
PERIPLASMIC
SOLUTE-BINDING
PROTEIN
(Sinorhizobium
meliloti) 		4 / 8 GLN A  61
GLY A  47
ILE A  42
ASP A 198
 None
 0.80A 5vlmH-4wedA:
undetectable		 5vlmH-4wedA:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBP_A_DAHA123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 4wed ABC TRANSPORTER,
PERIPLASMIC
SOLUTE-BINDING
PROTEIN
(Sinorhizobium
meliloti) 		5 / 9 LEU A 157
GLY A  90
ILE A  87
PHE A 430
ILE A 471
 None
 1.33A 6ebpA-4wedA:
undetectable		 6ebpA-4wedA:
9.68