SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4wen'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z2B_C_VLBC800_2
(TUBULIN ALPHA CHAIN)		 4wen K88 FIMBRIAL PROTEIN
AC
(Escherichia
coli) 		4 / 5 VAL A 257
ASN A 256
VAL A  29
ILE A  60
 None
 0.85A 1z2bC-4wenA:
undetectable		 1z2bC-4wenA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CEO_B_T44B1395_1
(THYROXINE-BINDING
GLOBULIN)		 4wen K88 FIMBRIAL PROTEIN
AC
(Escherichia
coli) 		5 / 10 ALA A 108
LEU A 112
LEU A 255
LEU A  95
ARG A  96
 None
 1.15A 2ceoB-4wenA:
undetectable		 2ceoB-4wenA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F7F_A_NIOA601_1
(NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE, PUTATIVE)		 4wen K88 FIMBRIAL PROTEIN
AC
(Escherichia
coli) 		4 / 6 SER A 142
GLY A 139
THR A 221
ARG A 137
 None
 1.07A 2f7fA-4wenA:
undetectable		 2f7fA-4wenA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A2Q_A_ACAA601_1
(6-AMINOHEXANOATE-CYC
LIC-DIMER HYDROLASE)		 4wen K88 FIMBRIAL PROTEIN
AC
(Escherichia
coli) 		4 / 7 GLY A 279
ALA A 253
VAL A 125
ILE A  52
 None
 0.77A 3a2qA-4wenA:
undetectable		 3a2qA-4wenA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOC_C_ERYC3402_0
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 4wen K88 FIMBRIAL PROTEIN
AC
(Escherichia
coli) 		5 / 12 SER A 224
MET A 215
PHE A 159
ILE A 158
ASP A 206
 None
 1.39A 3aocC-4wenA:
undetectable		 3aocC-4wenA:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_F_TOPF200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 4wen K88 FIMBRIAL PROTEIN
AC
(Escherichia
coli) 		5 / 10 VAL A  54
ALA A 253
ILE A 277
LEU A  33
PHE A  36
 None
 1.16A 3fl9F-4wenA:
undetectable		 3fl9F-4wenA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KKZ_A_SAMA301_0
(UNCHARACTERIZED
PROTEIN Q5LES9)		 4wen K88 FIMBRIAL PROTEIN
AC
ANTI-F4+ETEC
BACTERIA VHH
VARIABLE REGION
(Escherichia
coli;
Lama
glama) 		5 / 12 ARG A  64
GLY A 183
LEU B 904
LEU A 181
ALA B 833
 None
 1.09A 3kkzA-4wenA:
undetectable		 3kkzA-4wenA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V81_C_NVPC901_1
(HIV-1 REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 4wen K88 FIMBRIAL PROTEIN
AC
(Escherichia
coli) 		4 / 8 LEU A 229
VAL A 257
VAL A 275
TYR A 227
 None
 1.00A 3v81C-4wenA:
undetectable		 3v81C-4wenA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CLA_A_CLMA221_0
(TYPE III
CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4wen K88 FIMBRIAL PROTEIN
AC
(Escherichia
coli) 		5 / 11 ALA A 132
LEU A 163
SER A 184
VAL A 223
ILE A 190
 None
 1.17A 4claA-4wenA:
undetectable		 4claA-4wenA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_486A303_1
(ANCESTRAL STEROID
RECEPTOR 2)		 4wen K88 FIMBRIAL PROTEIN
AC
(Escherichia
coli) 		5 / 9 THR A  65
LEU A 185
ALA A 225
LEU A 147
THR A 179
 None
 1.42A 4ltwA-4wenA:
undetectable		 4ltwA-4wenA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EC8_C_SAMC4000_0
(GENOME POLYPROTEIN)		 4wen K88 FIMBRIAL PROTEIN
AC
ANTI-F4+ETEC
BACTERIA VHH
VARIABLE REGION
(Escherichia
coli;
Lama
glama) 		6 / 12 GLY B 901
GLY A  30
GLY A 183
GLU B 858
ASP A 276
VAL A 275
 None
 1.50A 5ec8C-4wenB:
undetectable		 5ec8C-4wenB:
14.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECM_D_LEUD602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 4wen ANTI-F4+ETEC
BACTERIA VHH
VARIABLE REGION
(Lama
glama) 		4 / 7 ALA B 891
THR B 890
VAL B 917
GLU B 888
 None
 0.75A 5ecmD-4wenB:
undetectable		 5ecmD-4wenB:
13.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECO_D_LEUD602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 4wen ANTI-F4+ETEC
BACTERIA VHH
VARIABLE REGION
(Lama
glama) 		4 / 7 ALA B 891
THR B 890
VAL B 917
GLU B 888
 None
 0.81A 5ecoD-4wenB:
1.3		 5ecoD-4wenB:
13.27