SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4weo'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GRM_A_DVAA6_0
(GRAMICIDIN A)		 4weo PUTATIVE
ACETOIN(DIACETYL)
REDUCTASE
(Burkholderia
cenocepacia) 		3 / 3 ALA A 116
VAL A 111
TRP A 108
 None
 0.88A 1grmA-4weoA:
undetectable		 1grmA-4weoA:
12.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GRM_B_DVAB6_0
(GRAMICIDIN A)		 4weo PUTATIVE
ACETOIN(DIACETYL)
REDUCTASE
(Burkholderia
cenocepacia) 		3 / 3 ALA A 116
VAL A 111
TRP A 108
 None
 0.88A 1grmB-4weoA:
undetectable		 1grmB-4weoA:
12.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HTT_C_HISC450_0
(HISTIDYL-TRNA
SYNTHETASE)		 4weo PUTATIVE
ACETOIN(DIACETYL)
REDUCTASE
(Burkholderia
cenocepacia) 		5 / 12 GLU A  50
LEU A  25
GLY A  20
GLY A  18
ALA A  16
 None
 1.03A 1httC-4weoA:
3.0		 1httC-4weoA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HTT_C_HISC450_0
(HISTIDYL-TRNA
SYNTHETASE)		 4weo PUTATIVE
ACETOIN(DIACETYL)
REDUCTASE
(Burkholderia
cenocepacia) 		5 / 12 GLU A  50
THR A  47
GLY A  20
GLY A  15
ALA A  24
 None
 1.12A 1httC-4weoA:
3.0		 1httC-4weoA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HTT_D_HISD450_0
(HISTIDYL-TRNA
SYNTHETASE)		 4weo PUTATIVE
ACETOIN(DIACETYL)
REDUCTASE
(Burkholderia
cenocepacia) 		5 / 12 GLU A  50
THR A  47
GLY A  20
GLY A  15
ALA A  24
 None
 1.12A 1httD-4weoA:
3.0		 1httD-4weoA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG4_A_SAMA500_0
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)		 4weo PUTATIVE
ACETOIN(DIACETYL)
REDUCTASE
(Burkholderia
cenocepacia) 		5 / 12 VAL A  75
GLY A 122
GLY A  93
THR A  13
VAL A  63
 None
 1.12A 1jg4A-4weoA:
4.5		 1jg4A-4weoA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JO4_A_DVAA6_0
(GRAMICIDIN C)		 4weo PUTATIVE
ACETOIN(DIACETYL)
REDUCTASE
(Burkholderia
cenocepacia) 		3 / 3 ALA A 116
VAL A 111
TRP A 108
 None
 0.89A 1jo4A-4weoA:
undetectable		 1jo4A-4weoA:
7.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JO4_B_DVAB6_0
(GRAMICIDIN C)		 4weo PUTATIVE
ACETOIN(DIACETYL)
REDUCTASE
(Burkholderia
cenocepacia) 		3 / 3 ALA A 116
VAL A 111
TRP A 108
 None
 0.89A 1jo4B-4weoA:
undetectable		 1jo4B-4weoA:
7.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NRM_A_DVAA6_0
(GRAMICIDIN A)		 4weo PUTATIVE
ACETOIN(DIACETYL)
REDUCTASE
(Burkholderia
cenocepacia) 		3 / 3 ALA A 116
VAL A 111
TRP A 108
 None
 0.82A 1nrmA-4weoA:
undetectable		 1nrmA-4weoA:
12.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NRM_B_DVAB6_0
(GRAMICIDIN A)		 4weo PUTATIVE
ACETOIN(DIACETYL)
REDUCTASE
(Burkholderia
cenocepacia) 		3 / 3 ALA A 116
VAL A 111
TRP A 108
 None
 0.82A 1nrmB-4weoA:
undetectable		 1nrmB-4weoA:
12.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UAY_A_ADNA1001_1
(TYPE II
3-HYDROXYACYL-COA
DEHYDROGENASE)		 4weo PUTATIVE
ACETOIN(DIACETYL)
REDUCTASE
(Burkholderia
cenocepacia) 		9 / 11 GLY A  14
ALA A  16
ASP A  38
LEU A  39
ASP A  64
VAL A  65
ALA A  92
VAL A  94
VAL A 114
 None
 0.60A 1uayA-4weoA:
31.4		 1uayA-4weoA:
31.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UAY_B_ADNB1002_1
(TYPE II
3-HYDROXYACYL-COA
DEHYDROGENASE)		 4weo PUTATIVE
ACETOIN(DIACETYL)
REDUCTASE
(Burkholderia
cenocepacia) 		8 / 10 GLY A  14
ALA A  16
ASP A  38
ASP A  64
VAL A  65
ALA A  92
VAL A  94
VAL A 114
 None
 0.49A 1uayB-4weoA:
31.7		 1uayB-4weoA:
31.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UAY_B_ADNB1002_1
(TYPE II
3-HYDROXYACYL-COA
DEHYDROGENASE)		 4weo PUTATIVE
ACETOIN(DIACETYL)
REDUCTASE
(Burkholderia
cenocepacia) 		8 / 10 GLY A  14
ALA A  16
ASP A  38
LEU A  39
ASP A  64
VAL A  65
ALA A  92
VAL A 114
 None
 0.65A 1uayB-4weoA:
31.7		 1uayB-4weoA:
31.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DU8_A_BEZA352_0
(D-AMINO-ACID OXIDASE)		 4weo PUTATIVE
ACETOIN(DIACETYL)
REDUCTASE
(Burkholderia
cenocepacia) 		4 / 6 LEU A 153
TYR A 156
ILE A  95
GLY A 187
 None
 0.81A 2du8A-4weoA:
6.2		 2du8A-4weoA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DU8_B_BEZB1352_0
(D-AMINO-ACID OXIDASE)		 4weo PUTATIVE
ACETOIN(DIACETYL)
REDUCTASE
(Burkholderia
cenocepacia) 		4 / 6 LEU A 153
TYR A 156
ILE A  95
GLY A 187
 None
 0.79A 2du8B-4weoA:
6.4		 2du8B-4weoA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYU_A_SAMA201_0
(PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2)		 4weo PUTATIVE
ACETOIN(DIACETYL)
REDUCTASE
(Burkholderia
cenocepacia) 		5 / 12 GLY A  14
ALA A  16
LEU A  39
LEU A  40
VAL A  65
 None
 0.92A 2nyuA-4weoA:
9.1		 2nyuA-4weoA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYU_B_SAMB201_0
(PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2)		 4weo PUTATIVE
ACETOIN(DIACETYL)
REDUCTASE
(Burkholderia
cenocepacia) 		6 / 12 GLY A  14
ALA A  16
LEU A  39
LEU A  40
VAL A  65
THR A  66
 None
 0.95A 2nyuB-4weoA:
9.1		 2nyuB-4weoA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WA2_A_SAMA1248_0
(NON-STRUCTURAL
PROTEIN 5)		 4weo PUTATIVE
ACETOIN(DIACETYL)
REDUCTASE
(Burkholderia
cenocepacia) 		5 / 12 GLY A  22
LEU A  39
ASP A  64
VAL A  65
THR A  66
 None
 1.02A 2wa2A-4weoA:
6.3		 2wa2A-4weoA:
25.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WQ5_A_MIYA1120_1
(PHOSPHOLIPASE A2,
ACIDIC)		 4weo PUTATIVE
ACETOIN(DIACETYL)
REDUCTASE
(Burkholderia
cenocepacia) 		4 / 7 LEU A 170
ALA A 126
GLY A 122
PHE A 166
 None
 0.97A 2wq5A-4weoA:
undetectable		 2wq5A-4weoA:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGQ_A_AB1A200_2
(FIV PROTEASE)		 4weo PUTATIVE
ACETOIN(DIACETYL)
REDUCTASE
(Burkholderia
cenocepacia) 		5 / 12 GLY A  29
ALA A  30
GLY A 232
ILE A  23
LEU A   5
 None
 1.08A 3ogqB-4weoA:
undetectable		 3ogqB-4weoA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q87_B_SAMB300_0
(N6 ADENINE SPECIFIC
DNA METHYLASE)		 4weo PUTATIVE
ACETOIN(DIACETYL)
REDUCTASE
(Burkholderia
cenocepacia) 		5 / 12 GLY A  14
ILE A  23
ASP A  38
LEU A  39
ASP A  64
 None
 0.70A 3q87B-4weoA:
7.0		 3q87B-4weoA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EOH_A_TEPA402_1
(PYRIDOXAL KINASE)		 4weo PUTATIVE
ACETOIN(DIACETYL)
REDUCTASE
(Burkholderia
cenocepacia) 		4 / 5 GLY A  14
THR A  66
VAL A  63
ASP A  38
 None
 1.06A 4eohA-4weoA:
4.3		 4eohA-4weoA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGH_A_SAMA401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)		 4weo PUTATIVE
ACETOIN(DIACETYL)
REDUCTASE
(Burkholderia
cenocepacia) 		5 / 11 GLY A  14
GLY A  15
ASP A  38
LEU A  39
ASP A  64
 None
 0.71A 4pghA-4weoA:
5.8		 4pghA-4weoA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_A_032A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4weo PUTATIVE
ACETOIN(DIACETYL)
REDUCTASE
(Burkholderia
cenocepacia) 		4 / 5 ILE A  23
VAL A  89
PHE A 166
CYH A 185
 None
 1.23A 4rzvA-4weoA:
undetectable		 4rzvA-4weoA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XLD_A_BRLA502_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4weo PUTATIVE
ACETOIN(DIACETYL)
REDUCTASE
(Burkholderia
cenocepacia) 		5 / 12 PHE A 120
GLY A 122
CYH A 123
LEU A 174
PHE A 166
 None
 1.27A 4xldA-4weoA:
undetectable		 4xldA-4weoA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DPD_B_SAMB601_0
(PROTEIN LYSINE
METHYLTRANSFERASE 1)		 4weo PUTATIVE
ACETOIN(DIACETYL)
REDUCTASE
(Burkholderia
cenocepacia) 		5 / 12 GLY A  14
ASP A  38
LEU A  39
VAL A  94
VAL A 114
 None
 1.00A 5dpdB-4weoA:
6.3		 5dpdB-4weoA:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E3I_A_HISA502_0
(HISTIDINE--TRNA
LIGASE)		 4weo PUTATIVE
ACETOIN(DIACETYL)
REDUCTASE
(Burkholderia
cenocepacia) 		5 / 12 GLU A  50
LEU A  25
GLY A  20
GLY A  18
ALA A  16
 None
 0.99A 5e3iA-4weoA:
undetectable		 5e3iA-4weoA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JI0_A_9CRA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4weo PUTATIVE
ACETOIN(DIACETYL)
REDUCTASE
(Burkholderia
cenocepacia) 		5 / 11 ILE A  23
LEU A  36
LEU A  27
ALA A  28
VAL A 141
 None
 1.06A 5ji0A-4weoA:
undetectable		 5ji0A-4weoA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOC_A_SAMA401_0
(PAVINE
N-METHYLTRANSFERASE)		 4weo PUTATIVE
ACETOIN(DIACETYL)
REDUCTASE
(Burkholderia
cenocepacia) 		5 / 12 GLY A  15
ASP A  64
VAL A  65
THR A  66
VAL A 141
 None
 0.93A 5kocA-4weoA:
5.2		 5kocA-4weoA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YNI_A_SAMA401_0
(NSP16 PROTEIN)		 4weo PUTATIVE
ACETOIN(DIACETYL)
REDUCTASE
(Burkholderia
cenocepacia) 		5 / 12 GLY A  14
GLY A  22
ASP A  38
LEU A  39
ASP A  64
 None
 0.86A 5yniA-4weoA:
4.6		 5yniA-4weoA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YNM_A_SAMA401_0
(NSP16 PROTEIN)		 4weo PUTATIVE
ACETOIN(DIACETYL)
REDUCTASE
(Burkholderia
cenocepacia) 		5 / 12 GLY A  14
GLY A  22
ASP A  38
LEU A  39
ASP A  64
 None
 0.87A 5ynmA-4weoA:
4.6		 5ynmA-4weoA:
21.98