SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4wep'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M8E_B_H4BB903_1
(INDUCIBLE NITRIC
OXIDE SYNTHASE)		 4wep PUTATIVE
OSMOPROTECTANT
UPTAKE SYSTEM
SUBSTRATE-BINDING
PROTEIN OSMF
(Escherichia
coli) 		3 / 3 ARG A  68
ILE A 119
TRP A 120
 None
 1.23A 1m8eB-4wepA:
undetectable		 1m8eB-4wepA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R35_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 4wep PUTATIVE
OSMOPROTECTANT
UPTAKE SYSTEM
SUBSTRATE-BINDING
PROTEIN OSMF
(Escherichia
coli) 		4 / 5 SER A 113
ARG A  68
ILE A 119
TRP A 120
 None
 1.41A 1r35A-4wepA:
0.0		 1r35A-4wepA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R35_B_H4BB1902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 4wep PUTATIVE
OSMOPROTECTANT
UPTAKE SYSTEM
SUBSTRATE-BINDING
PROTEIN OSMF
(Escherichia
coli) 		4 / 5 SER A 113
ARG A  68
ILE A 119
TRP A 120
 None
 1.40A 1r35B-4wepA:
0.0		 1r35B-4wepA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W0G_A_MYTA1499_1
(CYTOCHROME P450 3A4)		 4wep PUTATIVE
OSMOPROTECTANT
UPTAKE SYSTEM
SUBSTRATE-BINDING
PROTEIN OSMF
(Escherichia
coli) 		4 / 6 ILE A 169
ALA A 164
THR A 202
ALA A 215
 None
 0.88A 1w0gA-4wepA:
undetectable		 1w0gA-4wepA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOH_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 4wep PUTATIVE
OSMOPROTECTANT
UPTAKE SYSTEM
SUBSTRATE-BINDING
PROTEIN OSMF
(Escherichia
coli) 		4 / 5 ASP A 272
GLY A 220
PRO A 245
ALA A 124
 None
 0.95A 2aohA-4wepA:
undetectable		 2aohA-4wepA:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O5Y_H_STRH249_1
(CHIMERIC ANTIBODY
FAB 1E9-DB3)		 4wep PUTATIVE
OSMOPROTECTANT
UPTAKE SYSTEM
SUBSTRATE-BINDING
PROTEIN OSMF
(Escherichia
coli) 		4 / 7 ASN A 128
GLY A 220
THR A 131
TRP A 130
 None
 1.19A 2o5yH-4wepA:
undetectable
2o5yL-4wepA:
undetectable		 2o5yH-4wepA:
24.21
2o5yL-4wepA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E68_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 4wep PUTATIVE
OSMOPROTECTANT
UPTAKE SYSTEM
SUBSTRATE-BINDING
PROTEIN OSMF
(Escherichia
coli) 		3 / 3 ARG A  68
ILE A 119
TRP A 120
 None
 1.16A 3e68A-4wepA:
undetectable		 3e68A-4wepA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HRD_B_NIOB5661_1
(NICOTINATE
DEHYDROGENASE LARGE
MOLYBDOPTERIN
SUBUNIT
NICOTINATE
DEHYDROGENASE MEDIUM
MOLYBDOPTERIN
SUBUNIT)		 4wep PUTATIVE
OSMOPROTECTANT
UPTAKE SYSTEM
SUBSTRATE-BINDING
PROTEIN OSMF
(Escherichia
coli) 		4 / 8 ILE A  43
THR A 275
LEU A 279
ALA A 126
 None
 0.67A 3hrdA-4wepA:
undetectable
3hrdB-4wepA:
undetectable		 3hrdA-4wepA:
21.28
3hrdB-4wepA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_E_9PLE1_1
(CYTOCHROME P450 2A13)		 4wep PUTATIVE
OSMOPROTECTANT
UPTAKE SYSTEM
SUBSTRATE-BINDING
PROTEIN OSMF
(Escherichia
coli) 		4 / 8 PHE A 160
ALA A 206
ALA A 133
THR A 131
 None
 1.13A 3t3sE-4wepA:
undetectable		 3t3sE-4wepA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V8V_B_SAMB801_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE L)		 4wep PUTATIVE
OSMOPROTECTANT
UPTAKE SYSTEM
SUBSTRATE-BINDING
PROTEIN OSMF
(Escherichia
coli) 		5 / 11 GLY A  30
ASP A  77
VAL A  47
PRO A 247
LEU A 264
 None
 1.08A 3v8vB-4wepA:
undetectable		 3v8vB-4wepA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB513_1
(HEMOLYTIC LECTIN
CEL-III)		 4wep PUTATIVE
OSMOPROTECTANT
UPTAKE SYSTEM
SUBSTRATE-BINDING
PROTEIN OSMF
(Escherichia
coli) 		4 / 6 THR A  35
ASN A 280
ASP A 222
ILE A 203
 None
 1.43A 3w9tB-4wepA:
undetectable		 3w9tB-4wepA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A81_A_DXCA1161_0
(MAJOR POLLEN
ALLERGEN BET V 1-A)		 4wep PUTATIVE
OSMOPROTECTANT
UPTAKE SYSTEM
SUBSTRATE-BINDING
PROTEIN OSMF
(Escherichia
coli) 		5 / 12 GLY A 197
ASP A 198
ILE A 203
VAL A 225
ASP A 222
 None
 1.21A 4a81A-4wepA:
undetectable		 4a81A-4wepA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_B_SVRB207_2
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 4wep PUTATIVE
OSMOPROTECTANT
UPTAKE SYSTEM
SUBSTRATE-BINDING
PROTEIN OSMF
(Escherichia
coli) 		4 / 7 ASN A 100
LYS A  99
TYR A 243
PHE A 268
 None
 1.04A 4yv5B-4wepA:
undetectable		 4yv5B-4wepA:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQF_A_CZEA613_1
(SERUM ALBUMIN)		 4wep PUTATIVE
OSMOPROTECTANT
UPTAKE SYSTEM
SUBSTRATE-BINDING
PROTEIN OSMF
(Escherichia
coli) 		5 / 9 ALA A 294
LEU A  45
GLY A  41
LEU A 298
GLU A  49
 None
 1.18A 5dqfA-4wepA:
undetectable		 5dqfA-4wepA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IL1_A_SAMA601_0
(METTL3)		 4wep PUTATIVE
OSMOPROTECTANT
UPTAKE SYSTEM
SUBSTRATE-BINDING
PROTEIN OSMF
(Escherichia
coli) 		5 / 12 ILE A  43
PRO A 247
LEU A 264
GLU A  36
GLY A  41
 None
 1.18A 5il1A-4wepA:
undetectable		 5il1A-4wepA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IMS_A_ACTA708_0
(ACETOLACTATE
SYNTHASE CATALYTIC
SUBUNIT,
MITOCHONDRIAL)		 4wep PUTATIVE
OSMOPROTECTANT
UPTAKE SYSTEM
SUBSTRATE-BINDING
PROTEIN OSMF
(Escherichia
coli) 		3 / 3 GLY A 157
GLY A 158
GLN A 190
 None
 0.47A 5imsA-4wepA:
undetectable		 5imsA-4wepA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JQ7_B_T0RB705_2
(ENVELOPE
GLYCOPROTEIN 2)		 4wep PUTATIVE
OSMOPROTECTANT
UPTAKE SYSTEM
SUBSTRATE-BINDING
PROTEIN OSMF
(Escherichia
coli) 		4 / 7 LEU A 154
TYR A 153
ASP A 137
LEU A 186
 None
 1.01A 5jq7B-4wepA:
undetectable		 5jq7B-4wepA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L6E_A_SAMA601_0
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 4wep PUTATIVE
OSMOPROTECTANT
UPTAKE SYSTEM
SUBSTRATE-BINDING
PROTEIN OSMF
(Escherichia
coli) 		5 / 12 ILE A  43
PRO A 247
LEU A 264
GLU A  36
GLY A  41
 None
 1.17A 5l6eA-4wepA:
undetectable		 5l6eA-4wepA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_G_SAMG501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 4wep PUTATIVE
OSMOPROTECTANT
UPTAKE SYSTEM
SUBSTRATE-BINDING
PROTEIN OSMF
(Escherichia
coli) 		5 / 11 LEU A 192
GLY A 212
SER A 193
LEU A 194
ALA A 205
 None
 1.03A 5o96G-4wepA:
undetectable		 5o96G-4wepA:
20.43