SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4wer'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SA1_B_PODB700_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 4wer DIACYLGLYCEROL
KINASE CATALYTIC
DOMAIN PROTEIN
(Enterococcus
faecalis) 		6 / 12 VAL A 135
LEU A 103
ALA A  98
LEU A  97
ASN A 134
MET A 133
 None
 1.47A 1sa1A-4werA:
undetectable
1sa1B-4werA:
undetectable		 1sa1A-4werA:
21.79
1sa1B-4werA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SA1_D_PODD701_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 4wer DIACYLGLYCEROL
KINASE CATALYTIC
DOMAIN PROTEIN
(Enterococcus
faecalis) 		6 / 12 VAL A 135
LEU A 103
ALA A  98
LEU A  97
ASN A 134
MET A 133
 None
 1.47A 1sa1C-4werA:
undetectable
1sa1D-4werA:
undetectable		 1sa1C-4werA:
21.79
1sa1D-4werA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UKB_A_BEZA1300_0
(2-HYDROXY-6-OXO-7-ME
THYLOCTA-2,4-DIENOAT
E HYDROLASE)		 4wer DIACYLGLYCEROL
KINASE CATALYTIC
DOMAIN PROTEIN
(Enterococcus
faecalis) 		5 / 11 GLY A  44
ALA A  46
ALA A  50
PHE A  86
VAL A  63
 None
 1.15A 1ukbA-4werA:
2.9		 1ukbA-4werA:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8G_B_017B401_1
(POL POLYPROTEIN)		 4wer DIACYLGLYCEROL
KINASE CATALYTIC
DOMAIN PROTEIN
(Enterococcus
faecalis) 		5 / 12 ALA A  46
VAL A  63
GLY A  76
VAL A   5
ILE A   7
 None
 0.98A 2f8gA-4werA:
undetectable		 2f8gA-4werA:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FT9_A_CHDA130_0
(FATTY ACID-BINDING
PROTEIN 2, LIVER)		 4wer DIACYLGLYCEROL
KINASE CATALYTIC
DOMAIN PROTEIN
(Enterococcus
faecalis) 		5 / 12 ASN A 128
ILE A 281
ILE A 259
VAL A 271
LEU A 218
 None
 1.15A 2ft9A-4werA:
undetectable		 2ft9A-4werA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_G_ASDG1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 4wer DIACYLGLYCEROL
KINASE CATALYTIC
DOMAIN PROTEIN
(Enterococcus
faecalis) 		4 / 7 LEU A  31
ALA A   4
LEU A   6
PHE A  89
 None
 0.98A 2vcvG-4werA:
undetectable		 2vcvG-4werA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYX_A_ROCA201_1
(HIV-1 PROTEASE)		 4wer DIACYLGLYCEROL
KINASE CATALYTIC
DOMAIN PROTEIN
(Enterococcus
faecalis) 		5 / 12 LEU A 279
GLY A 276
ASP A 130
VAL A 135
ILE A 281
 None
 1.06A 3cyxA-4werA:
undetectable		 3cyxA-4werA:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKV_A_478A200_2
(PROTEASE)		 4wer DIACYLGLYCEROL
KINASE CATALYTIC
DOMAIN PROTEIN
(Enterococcus
faecalis) 		5 / 9 ALA A  46
VAL A  63
GLY A  76
VAL A   5
ILE A   7
 None
 1.01A 3ekvB-4werA:
undetectable		 3ekvB-4werA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB153_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4wer DIACYLGLYCEROL
KINASE CATALYTIC
DOMAIN PROTEIN
(Enterococcus
faecalis) 		4 / 7 ILE A  74
PHE A  62
PHE A  89
GLY A  68
 None
None
None
AMP  A 401 (-3.4A)
 1.01A 3em0B-4werA:
0.7		 3em0B-4werA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM3_B_478B200_2
(PROTEASE)		 4wer DIACYLGLYCEROL
KINASE CATALYTIC
DOMAIN PROTEIN
(Enterococcus
faecalis) 		5 / 10 ALA A  46
VAL A  63
GLY A  76
VAL A   5
ILE A   7
 None
 0.97A 3em3B-4werA:
undetectable		 3em3B-4werA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXV_B_478B200_2
(HIV-1 PROTEASE)		 4wer DIACYLGLYCEROL
KINASE CATALYTIC
DOMAIN PROTEIN
(Enterococcus
faecalis) 		5 / 10 ALA A  46
VAL A  63
GLY A  76
VAL A   5
ILE A   7
 None
 1.06A 3oxvB-4werA:
undetectable		 3oxvB-4werA:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXV_C_478C200_2
(HIV-1 PROTEASE)		 4wer DIACYLGLYCEROL
KINASE CATALYTIC
DOMAIN PROTEIN
(Enterococcus
faecalis) 		5 / 11 ALA A  46
VAL A  63
GLY A  76
VAL A   5
ILE A   7
 None
 0.99A 3oxvD-4werA:
undetectable		 3oxvD-4werA:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXW_D_017D200_2
(HIV-1 PROTEASE)		 4wer DIACYLGLYCEROL
KINASE CATALYTIC
DOMAIN PROTEIN
(Enterococcus
faecalis) 		5 / 10 ALA A  46
VAL A  63
GLY A  76
VAL A   5
ILE A   7
 None
 0.97A 3oxwD-4werA:
undetectable		 3oxwD-4werA:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXX_A_DR7A100_1
(HIV-1 PROTEASE)		 4wer DIACYLGLYCEROL
KINASE CATALYTIC
DOMAIN PROTEIN
(Enterococcus
faecalis) 		5 / 12 LEU A 279
GLY A 276
ASP A 130
VAL A 135
ILE A 281
 None
 1.03A 3oxxA-4werA:
undetectable		 3oxxA-4werA:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQC_A_017A101_1
(ASPARTYL PROTEASE)		 4wer DIACYLGLYCEROL
KINASE CATALYTIC
DOMAIN PROTEIN
(Enterococcus
faecalis) 		5 / 10 ALA A  46
VAL A  63
GLY A  76
VAL A   5
ILE A   7
 None
 0.99A 4dqcA-4werA:
undetectable		 4dqcA-4werA:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOU_A_C04A207_1
(UNCHARACTERIZED
PROTEIN)		 4wer DIACYLGLYCEROL
KINASE CATALYTIC
DOMAIN PROTEIN
(Enterococcus
faecalis) 		3 / 3 GLY A  43
GLU A  41
THR A  40
 AMP  A 401 ( 3.5A)
None
AMP  A 401 (-3.9A)
 0.59A 4kouA-4werA:
undetectable		 4kouA-4werA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HHJ_A_GLYA403_0
(RETRON-TYPE REVERSE
TRANSCRIPTASE)		 4wer DIACYLGLYCEROL
KINASE CATALYTIC
DOMAIN PROTEIN
(Enterococcus
faecalis) 		4 / 4 LEU A 218
LEU A 181
GLY A 257
GLU A 256
 None
 1.04A 5hhjA-4werA:
undetectable		 5hhjA-4werA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND4_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 4wer DIACYLGLYCEROL
KINASE CATALYTIC
DOMAIN PROTEIN
(Enterococcus
faecalis) 		5 / 12 ASP A  33
LEU A   6
ALA A   4
PHE A  62
LEU A 116
 None
 1.09A 5nd4B-4werA:
undetectable		 5nd4B-4werA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZJI_B_PQNB842_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 4wer DIACYLGLYCEROL
KINASE CATALYTIC
DOMAIN PROTEIN
(Enterococcus
faecalis) 		5 / 10 MET A 133
ILE A   7
ALA A  50
LEU A  77
ALA A  78
 None
 1.20A 5zjiB-4werA:
undetectable		 5zjiB-4werA:
14.96