SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4weu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_A_8MOA501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		 4weu ANTI-F4+ETEC
BACTERIA VHH
VARIABLE REGION
(Lama
glama) 		6 / 11 PHE D 829
ASN D 874
GLY D 855
THR D 858
ILE D 870
LEU D 879
 None
 1.44A 1z11A-4weuD:
undetectable		 1z11A-4weuD:
13.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXT_B_MTXB2000_1
(ANTI-METHOTREXATE
CDR1-3 GRAFT VHH)		 4weu ANTI-F4+ETEC
BACTERIA VHH
VARIABLE REGION
(Lama
glama) 		7 / 12 VAL D 802
LEU D 804
ALA D 824
MET D 834
ARG D 872
ALA D 898
TYR D 910
 None
 0.61A 3qxtB-4weuD:
22.5		 3qxtB-4weuD:
72.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXV_A_MTXA2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 4weu ANTI-F4+ETEC
BACTERIA VHH
VARIABLE REGION
(Lama
glama) 		7 / 12 VAL D 802
ALA D 824
MET D 834
ARG D 872
ASN D 874
ALA D 898
TYR D 910
 None
 0.66A 3qxvA-4weuD:
22.1		 3qxvA-4weuD:
72.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXV_B_MTXB2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 4weu ANTI-F4+ETEC
BACTERIA VHH
VARIABLE REGION
(Lama
glama) 		6 / 12 VAL D 802
ALA D 824
MET D 834
ARG D 872
ALA D 898
TYR D 910
 None
 0.69A 3qxvB-4weuD:
22.1		 3qxvB-4weuD:
72.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXV_C_MTXC2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 4weu ANTI-F4+ETEC
BACTERIA VHH
VARIABLE REGION
(Lama
glama) 		6 / 11 VAL D 802
ALA D 824
MET D 834
ARG D 872
ASN D 874
ALA D 898
 None
 0.70A 3qxvC-4weuD:
22.4		 3qxvC-4weuD:
72.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXV_D_MTXD2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 4weu ANTI-F4+ETEC
BACTERIA VHH
VARIABLE REGION
(Lama
glama) 		6 / 12 VAL D 802
ALA D 824
MET D 834
ARG D 872
ALA D 898
TYR D 910
 None
 0.68A 3qxvD-4weuD:
22.3		 3qxvD-4weuD:
72.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXV_E_MTXE2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 4weu ANTI-F4+ETEC
BACTERIA VHH
VARIABLE REGION
(Lama
glama) 		5 / 12 ALA D 824
MET D 834
ARG D 872
ALA D 898
TYR D 910
 None
 0.66A 3qxvE-4weuD:
18.5		 3qxvE-4weuD:
72.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6CJK_B_ACTB302_0
(IMMUNOGLOBULIN FAB
HEAVY CHAIN)		 4weu ANTI-F4+ETEC
BACTERIA VHH
VARIABLE REGION
(Lama
glama) 		3 / 3 TYR D 860
GLY D 866
THR D 869
 None
 0.12A 6cjkB-4weuD:
20.0		 6cjkB-4weuD:
31.30