SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4wfc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1F86_B_T44B528_1
(TRANSTHYRETIN
THR119MET VARIANT)		 4wfc EXOSOME COMPLEX
EXONUCLEASE RRP6
EXOSOME COMPLEX
PROTEIN LRP1
(Saccharomyces
cerevisiae) 		4 / 4 LYS B  89
LEU A  96
ALA B  90
LEU A  99
 None
 1.41A 1f86B-4wfcB:
undetectable		 1f86B-4wfcB:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FSL_B_NIOB145_1
(LEGHEMOGLOBIN A)		 4wfc EXOSOME COMPLEX
EXONUCLEASE RRP6
EXOSOME COMPLEX
PROTEIN LRP1
(Saccharomyces
cerevisiae) 		4 / 8 PHE A  38
ILE B   7
LEU A  42
VAL A  28
 None
 0.86A 1fslB-4wfcA:
undetectable		 1fslB-4wfcA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K4Y_A_ACTA502_0
(RNA-DEPENDENT RNA
POLYMERASE)		 4wfc EXOSOME COMPLEX
EXONUCLEASE RRP6
EXOSOME COMPLEX
PROTEIN LRP1
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		4 / 5 LYS B  27
LEU B  28
GLU B  24
LEU A   9
 None
 1.11A 4k4yA-4wfcB:
undetectable		 4k4yA-4wfcB:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K4Y_E_ACTE503_0
(RNA-DEPENDENT RNA
POLYMERASE)		 4wfc EXOSOME COMPLEX
EXONUCLEASE RRP6
EXOSOME COMPLEX
PROTEIN LRP1
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		4 / 4 LYS B  27
LEU B  28
GLU B  24
LEU A   9
 None
 1.12A 4k4yE-4wfcB:
undetectable		 4k4yE-4wfcB:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K4Y_I_ACTI503_0
(RNA-DEPENDENT RNA
POLYMERASE)		 4wfc EXOSOME COMPLEX
EXONUCLEASE RRP6
EXOSOME COMPLEX
PROTEIN LRP1
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		4 / 5 LYS B  27
LEU B  28
GLU B  24
LEU A   9
 None
 1.14A 4k4yI-4wfcB:
undetectable		 4k4yI-4wfcB:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOP_B_C2FB3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 4wfc EXOSOME COMPLEX
EXONUCLEASE RRP6
EXOSOME COMPLEX
PROTEIN LRP1
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		5 / 12 GLY A  82
VAL B  70
LEU B  68
SER B  58
ILE B  76
 None
 1.18A 5vopB-4wfcA:
undetectable		 5vopB-4wfcA:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_F_TA1F502_1
(TUBULIN BETA CHAIN)		 4wfc EXOSOME COMPLEX
PROTEIN LRP1
(Saccharomyces
cerevisiae) 		5 / 12 LEU B  37
ALA B  54
SER B  58
LEU B  33
LEU B  28
 None
 1.18A 6ew0F-4wfcB:
undetectable		 6ew0F-4wfcB:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_G_TA1G501_1
(TUBULIN BETA CHAIN)		 4wfc EXOSOME COMPLEX
PROTEIN LRP1
(Saccharomyces
cerevisiae) 		5 / 12 LEU B  37
ALA B  54
SER B  58
LEU B  33
LEU B  28
 None
 1.18A 6ew0G-4wfcB:
undetectable		 6ew0G-4wfcB:
21.05