SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4wfh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2PKK_A_2FAA501_2 (ADENOSINE KINASE)	4wfh	POTASSIUM CHANNEL SUBFAMILY K MEMBER 4 (Homo sapiens)	4 / 4	ALA A 228 VAL A 210 PHE A 217 THR A 235	None	1.42A	2pkkA-4wfhA: undetectable	2pkkA-4wfhA: 23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2YVL_A_SAMA601_0 (HYPOTHETICAL PROTEIN)	4wfh	POTASSIUM CHANNEL SUBFAMILY K MEMBER 4 (Homo sapiens)	5 / 12	ILE A 176 GLY A 169 SER A 170 VAL A 164 PHE A 272	None	1.01A	2yvlA-4wfhA: undetectable	2yvlA-4wfhA: 20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4G24_A_ACAA1004_1 (PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN AT2G32230, MITOCHONDRIAL)	4wfh	POTASSIUM CHANNEL SUBFAMILY K MEMBER 4 (Homo sapiens)	4 / 6	ALA A 256 LEU A 260 VAL A 261 GLU A 221	None	1.06A	4g24A-4wfhA: undetectable	4g24A-4wfhA: 20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4QWP_B_GCSB302_1 (CHITOSANASE)	4wfh	POTASSIUM CHANNEL SUBFAMILY K MEMBER 4 (Homo sapiens)	4 / 5	TYR A 132 ILE A 265 THR A 235 TYR A 257	None	1.20A	4qwpB-4wfhA: undetectable	4qwpB-4wfhA: 21.43

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["2PKK_A_2FAA501_2","ADENOSINE KINASE","4wfh","POTASSIUM CHANNEL SUBFAMILY K MEMBER 4","Homo sapiens",4,"ALA A 228;VAL A 210;PHE A 217;THR A 235","None","1.42A","2pkkA-4wfhA:undetectable","2pkkA-4wfhA:23.78"],["2YVL_A_SAMA601_0","HYPOTHETICAL PROTEIN","4wfh","POTASSIUM CHANNEL SUBFAMILY K MEMBER 4","Homo sapiens",5,"ILE A 176;GLY A 169;SER A 170;VAL A 164;PHE A 272","None","1.01A","2yvlA-4wfhA:undetectable","2yvlA-4wfhA:20.51"],["4G24_A_ACAA1004_1","PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN AT2G32230, MITOCHONDRIAL","4wfh","POTASSIUM CHANNEL SUBFAMILY K MEMBER 4","Homo sapiens",4,"ALA A 256;LEU A 260;VAL A 261;GLU A 221","None","1.06A","4g24A-4wfhA:undetectable","4g24A-4wfhA:20.61"],["4QWP_B_GCSB302_1","CHITOSANASE","4wfh","POTASSIUM CHANNEL SUBFAMILY K MEMBER 4","Homo sapiens",4,"TYR A 132;ILE A 265;THR A 235;TYR A 257","None","1.20A","4qwpB-4wfhA:undetectable","4qwpB-4wfhA:21.43"]]