SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4wfi'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA1_1
(CES1 PROTEIN)		 4wfi CUTINASE
(Saccharomonospor
a
viridis) 		5 / 12 PHE A 106
GLY A 178
GLY A 179
LEU A 183
HIS A 254
 None
 1.03A 1ya4A-4wfiA:
14.6		 1ya4A-4wfiA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_1
(CES1 PROTEIN)		 4wfi CUTINASE
(Saccharomonospor
a
viridis) 		5 / 12 PHE A 106
GLY A 178
GLY A 179
LEU A 183
HIS A 254
 None
 1.01A 1ya4C-4wfiA:
14.0		 1ya4C-4wfiA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_J_BEZJ5041_0
(CES1 PROTEIN)		 4wfi CUTINASE
(Saccharomonospor
a
viridis) 		4 / 4 GLY A 105
SER A 176
ILE A 224
HIS A 254
 None
 1.22A 1yajJ-4wfiA:
8.4		 1yajJ-4wfiA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FT9_A_CHDA130_0
(FATTY ACID-BINDING
PROTEIN 2, LIVER)		 4wfi CUTINASE
(Saccharomonospor
a
viridis) 		5 / 12 VAL A 227
ASN A 261
ILE A 264
ILE A 217
HIS A 175
 None
 1.09A 2ft9A-4wfiA:
undetectable		 2ft9A-4wfiA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZGW_A_ADNA1301_1
(BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 4wfi CUTINASE
(Saccharomonospor
a
viridis) 		4 / 7 ALA A 252
ASN A 261
PRO A 257
ALA A 256
 None
 1.13A 2zgwA-4wfiA:
undetectable		 2zgwA-4wfiA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZGW_B_ADNB1302_1
(BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 4wfi CUTINASE
(Saccharomonospor
a
viridis) 		4 / 6 ALA A 252
ASN A 261
PRO A 257
ALA A 256
 None
 1.15A 2zgwB-4wfiA:
undetectable		 2zgwB-4wfiA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_C_MTXC164_2
(DIHYDROFOLATE
REDUCTASE)		 4wfi CUTINASE
(Saccharomonospor
a
viridis) 		4 / 4 ILE A 126
ARG A 156
ILE A  86
THR A  96
 None
 1.10A 3ia4C-4wfiA:
undetectable		 3ia4C-4wfiA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BQF_A_QPSA951_1
(ALPHA-GLUCAN
PHOSPHORYLASE 2,
CYTOSOLIC)		 4wfi CUTINASE
(Saccharomonospor
a
viridis) 		4 / 6 GLY A 124
ARG A 169
GLU A  50
ARG A 281
 None
 1.14A 4bqfA-4wfiA:
3.0		 4bqfA-4wfiA:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_1
(ADENOSINE KINASE)		 4wfi CUTINASE
(Saccharomonospor
a
viridis) 		5 / 12 LEU A 238
GLY A 174
GLY A 179
THR A 214
GLY A 143
 None
 0.92A 4dc3B-4wfiA:
4.8		 4dc3B-4wfiA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_2
(ADENOSINE KINASE)		 4wfi CUTINASE
(Saccharomonospor
a
viridis) 		4 / 5 LEU A 150
ILE A 130
ALA A 148
PHE A  77
 None
 1.05A 4dc3B-4wfiA:
4.8		 4dc3B-4wfiA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FR0_A_SAMA401_0
(ARSENIC
METHYLTRANSFERASE)		 4wfi CUTINASE
(Saccharomonospor
a
viridis) 		5 / 12 GLY A  98
LEU A 272
ILE A 126
ASN A 168
LEU A 150
 None
 1.14A 4fr0A-4wfiA:
2.4		 4fr0A-4wfiA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GH8_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 4wfi CUTINASE
(Saccharomonospor
a
viridis) 		5 / 12 ILE A  60
MET A 247
ASP A 292
PRO A 257
ARG A 119
 None
 1.36A 4gh8B-4wfiA:
undetectable		 4gh8B-4wfiA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4USW_A_ACTA1470_0
(ADENYLATE CYCLASE
TYPE 10)		 4wfi CUTINASE
(Saccharomonospor
a
viridis) 		4 / 6 LEU A 153
VAL A 154
ARG A 156
PHE A  77
 None
 1.10A 4uswA-4wfiA:
undetectable		 4uswA-4wfiA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z7F_C_FOLC201_0
(FOLATE ECF
TRANSPORTER)		 4wfi CUTINASE
(Saccharomonospor
a
viridis) 		5 / 12 ARG A  73
SER A 114
PHE A  81
THR A 134
LEU A 146
 None
 1.13A 4z7fC-4wfiA:
undetectable		 4z7fC-4wfiA:
26.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6J_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 4wfi CUTINASE
(Saccharomonospor
a
viridis) 		3 / 3 MET A 247
ASP A 292
ARG A 119
 None
 0.93A 5z6jA-4wfiA:
undetectable		 5z6jA-4wfiA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6K_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 4wfi CUTINASE
(Saccharomonospor
a
viridis) 		3 / 3 MET A 247
ASP A 292
ARG A 119
 None
 0.88A 5z6kA-4wfiA:
undetectable		 5z6kA-4wfiA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CK2_C_IPHC101_0
(INSULIN A CHAIN
INSULIN B CHAIN)		 4wfi CUTINASE
(Saccharomonospor
a
viridis) 		4 / 4 ILE A 196
LEU A 146
HIS A 175
ALA A 103
 None
 0.88A 6ck2C-4wfiA:
undetectable
6ck2D-4wfiA:
undetectable		 6ck2C-4wfiA:
5.90
6ck2D-4wfiA:
9.63