SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4wfs'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_NCAA493_0
(CHORISMATE SYNTHASE)		 4wfs TRNA-DIHYDROURIDINE(
20) SYNTHASE
[NAD(P)+]-LIKE
(Homo
sapiens) 		5 / 11 ILE A 140
MET A  88
ILE A 110
ALA A 100
ALA A  96
 None
 1.08A 2qhfA-4wfsA:
undetectable		 2qhfA-4wfsA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPC_A_SAMA1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 4wfs TRNA-DIHYDROURIDINE(
20) SYNTHASE
[NAD(P)+]-LIKE
(Homo
sapiens) 		5 / 11 ILE A 203
THR A 165
VAL A 169
ILE A 172
ILE A 156
 None
 1.14A 3kpcA-4wfsA:
undetectable		 3kpcA-4wfsA:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGP_A_017A200_1
(FIV PROTEASE)		 4wfs TRNA-DIHYDROURIDINE(
20) SYNTHASE
[NAD(P)+]-LIKE
(Homo
sapiens) 		5 / 9 GLY A  35
ALA A  36
ASP A  37
ILE A  38
LEU A  16
 None
 0.99A 3ogpA-4wfsA:
undetectable		 3ogpA-4wfsA:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGP_B_017B200_2
(FIV PROTEASE)		 4wfs TRNA-DIHYDROURIDINE(
20) SYNTHASE
[NAD(P)+]-LIKE
(Homo
sapiens) 		5 / 9 GLY A  35
ALA A  36
ASP A  37
ILE A  38
LEU A  16
 None
 0.97A 3ogpB-4wfsA:
undetectable		 3ogpB-4wfsA:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KUK_A_RBFA201_2
(BLUE-LIGHT
PHOTORECEPTOR)		 4wfs TRNA-DIHYDROURIDINE(
20) SYNTHASE
[NAD(P)+]-LIKE
(Homo
sapiens) 		5 / 9 VAL A 182
ILE A 156
ARG A 157
LEU A 131
ILE A 180
 None
None
SO4  A 403 (-4.2A)
None
None
 0.96A 4kukA-4wfsA:
undetectable		 4kukA-4wfsA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4A_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 4wfs TRNA-DIHYDROURIDINE(
20) SYNTHASE
[NAD(P)+]-LIKE
(Homo
sapiens) 		4 / 8 THR A  90
THR A 148
VAL A 152
VAL A 103
 None
 0.95A 4l4aA-4wfsA:
undetectable		 4l4aA-4wfsA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QC6_B_KANB201_2
(BIFUNCTIONAL AAC/APH)		 4wfs TRNA-DIHYDROURIDINE(
20) SYNTHASE
[NAD(P)+]-LIKE
(Homo
sapiens) 		3 / 3 LEU A  30
ASP A  33
TYR A  34
 None
 0.62A 4qc6B-4wfsA:
undetectable		 4qc6B-4wfsA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BS8_H_MFXH101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 4wfs TRNA-DIHYDROURIDINE(
20) SYNTHASE
[NAD(P)+]-LIKE
(Homo
sapiens) 		4 / 7 ALA A 181
ARG A  28
THR A  76
GLU A  80
 None
 0.93A 5bs8A-4wfsA:
undetectable
5bs8B-4wfsA:
undetectable
5bs8C-4wfsA:
undetectable		 5bs8A-4wfsA:
21.24
5bs8B-4wfsA:
23.14
5bs8C-4wfsA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTD_E_GFNE101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 4wfs TRNA-DIHYDROURIDINE(
20) SYNTHASE
[NAD(P)+]-LIKE
(Homo
sapiens) 		4 / 7 ALA A 181
ARG A  28
THR A  76
GLU A  80
 None
 0.93A 5btdA-4wfsA:
undetectable
5btdB-4wfsA:
undetectable
5btdC-4wfsA:
undetectable		 5btdA-4wfsA:
21.24
5btdB-4wfsA:
23.14
5btdC-4wfsA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTD_G_GFNG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 4wfs TRNA-DIHYDROURIDINE(
20) SYNTHASE
[NAD(P)+]-LIKE
(Homo
sapiens) 		4 / 7 ALA A 181
ARG A  28
THR A  76
GLU A  80
 None
 0.96A 5btdA-4wfsA:
undetectable
5btdC-4wfsA:
undetectable
5btdD-4wfsA:
undetectable		 5btdA-4wfsA:
21.24
5btdC-4wfsA:
21.24
5btdD-4wfsA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTG_E_LFXE101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 4wfs TRNA-DIHYDROURIDINE(
20) SYNTHASE
[NAD(P)+]-LIKE
(Homo
sapiens) 		4 / 6 ALA A 181
ARG A  28
THR A  76
GLU A  80
 None
 0.97A 5btgA-4wfsA:
undetectable
5btgB-4wfsA:
undetectable
5btgC-4wfsA:
undetectable		 5btgA-4wfsA:
21.24
5btgB-4wfsA:
23.14
5btgC-4wfsA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH8_A_ACTA302_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 4wfs TRNA-DIHYDROURIDINE(
20) SYNTHASE
[NAD(P)+]-LIKE
(Homo
sapiens) 		3 / 3 CYH A 154
MET A 114
ASN A 113
 None
None
FMN  A 401 (-3.6A)
 1.34A 5qh8A-4wfsA:
undetectable		 5qh8A-4wfsA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 4wfs TRNA-DIHYDROURIDINE(
20) SYNTHASE
[NAD(P)+]-LIKE
(Homo
sapiens) 		3 / 3 TYR A 270
LEU A  25
ASP A  64
 None
 0.81A 5zv2B-4wfsA:
undetectable		 5zv2B-4wfsA:
13.18