SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4wgg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DMA_A_NCAA700_0
(EXOTOXIN A)		 4wgg DOUBLE BOND
REDUCTASE
(Zingiber
officinale) 		4 / 7 GLY A 254
TYR A 234
LEU A 286
GLU A 236
 None
 0.82A 1dmaA-4wggA:
undetectable		 1dmaA-4wggA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FO4_B_SALB4005_1
(XANTHINE
DEHYDROGENASE)		 4wgg DOUBLE BOND
REDUCTASE
(Zingiber
officinale) 		4 / 7 SER A 167
PHE A 165
VAL A 238
ALA A 245
 None
None
NAP  A 400 ( 4.5A)
None
 1.09A 1fo4B-4wggA:
undetectable		 1fo4B-4wggA:
14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICV_A_NIOA704_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 4wgg DOUBLE BOND
REDUCTASE
(Zingiber
officinale) 		4 / 4 SER A 167
PHE A 235
GLU A 236
GLY A 260
 None
None
None
NAP  A 400 (-3.5A)
 1.34A 1icvA-4wggA:
undetectable
1icvB-4wggA:
undetectable		 1icvA-4wggA:
21.10
1icvB-4wggA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_C_SAMC2293_0
(GLYCINE
N-METHYLTRANSFERASE)		 4wgg DOUBLE BOND
REDUCTASE
(Zingiber
officinale) 		5 / 12 ILE A 127
GLY A 108
VAL A  89
GLY A 142
LEU A 290
 None
None
None
None
CIY  A 401 ( 4.0A)
 0.90A 1kiaC-4wggA:
7.5		 1kiaC-4wggA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_B_SAMB1293_0
(GLYCINE
N-METHYLTRANSFERASE)		 4wgg DOUBLE BOND
REDUCTASE
(Zingiber
officinale) 		5 / 12 ILE A 127
GLY A 108
VAL A  89
GLY A 142
LEU A 290
 None
None
None
None
CIY  A 401 ( 4.0A)
 0.92A 1nbhB-4wggA:
6.8		 1nbhB-4wggA:
22.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W98_B_P1ZB1356_1
(PROSTAGLANDIN
REDUCTASE 2)		 4wgg DOUBLE BOND
REDUCTASE
(Zingiber
officinale) 		4 / 8 TYR A  61
TYR A 265
LEU A 290
VAL A 291
 CIY  A 401 (-4.4A)
CIY  A 401 ( 4.0A)
CIY  A 401 ( 4.0A)
CIY  A 401 ( 3.3A)
 0.63A 2w98B-4wggA:
44.5		 2w98B-4wggA:
34.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2WEK_B_DIFB1376_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 4wgg DOUBLE BOND
REDUCTASE
(Zingiber
officinale) 		4 / 7 TYR A 213
VAL A 238
GLY A 240
MET A 242
 NAP  A 400 (-4.5A)
NAP  A 400 ( 4.5A)
None
None
 0.50A 2wekB-4wggA:
36.9		 2wekB-4wggA:
30.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2WEK_B_DIFB1376_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 4wgg DOUBLE BOND
REDUCTASE
(Zingiber
officinale) 		4 / 7 VAL A 238
GLY A 240
MET A 242
SER A 263
 NAP  A 400 ( 4.5A)
None
None
NAP  A 400 (-4.8A)
 0.41A 2wekB-4wggA:
36.9		 2wekB-4wggA:
30.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q5S_A_ACHA1289_0
(MULTIDRUG-EFFLUX
TRANSPORTER 1
REGULATOR)		 4wgg DOUBLE BOND
REDUCTASE
(Zingiber
officinale) 		4 / 6 VAL A 246
ASN A 275
TYR A 234
GLU A 236
 None
 1.04A 3q5sA-4wggA:
undetectable		 3q5sA-4wggA:
24.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_H_ZPCH1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4wgg DOUBLE BOND
REDUCTASE
(Zingiber
officinale) 		4 / 7 GLU A 236
ILE A 256
HIS A 248
PHE A 165
 None
 1.01A 4a97H-4wggA:
undetectable		 4a97H-4wggA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_F_ACTF701_0
(RNA (33-MER)
RNA POLYMERASE
3D-POL)		 4wgg DOUBLE BOND
REDUCTASE
(Zingiber
officinale) 		4 / 4 PHE A 289
HIS A 294
GLY A 151
ILE A 155
 NAP  A 400 (-4.7A)
None
None
None
 1.28A 4k50E-4wggA:
undetectable		 4k50E-4wggA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_M_ACTM503_0
(RNA POLYMERASE
3D-POL)		 4wgg DOUBLE BOND
REDUCTASE
(Zingiber
officinale) 		4 / 4 PHE A 289
HIS A 294
GLY A 151
ILE A 155
 NAP  A 400 (-4.7A)
None
None
None
 1.26A 4k50M-4wggA:
undetectable		 4k50M-4wggA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_C_FK5C201_0
(PEPTIDYLPROLYL
ISOMERASE)		 4wgg DOUBLE BOND
REDUCTASE
(Zingiber
officinale) 		4 / 4 ASP A  29
ILE A  84
PRO A  83
LEU A  16
 None
 1.47A 6mkeB-4wggA:
undetectable		 6mkeB-4wggA:
11.78