SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4wgk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ4_A_CAMA502_0
(CYTOCHROME P450-CAM)		 4wgk NEUTRAL CERAMIDASE
(Homo
sapiens) 		4 / 6 PHE A 341
VAL A 283
VAL A 287
ASP A 293
 None
 0.98A 1dz4A-4wgkA:
undetectable		 1dz4A-4wgkA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J36_A_LPRA801_1
(ANGIOTENSIN
CONVERTING ENZYME)		 4wgk NEUTRAL CERAMIDASE
(Homo
sapiens) 		5 / 12 GLN A 471
HIS A 303
HIS A 194
GLU A 540
TYR A 579
 None
ZN  A 801 ( 3.2A)
ZN  A 801 ( 3.3A)
ZN  A 801 ( 2.0A)
ZN  A 801 ( 4.3A)
 1.18A 1j36A-4wgkA:
undetectable		 1j36A-4wgkA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J36_B_LPRB802_1
(ANGIOTENSIN
CONVERTING ENZYME)		 4wgk NEUTRAL CERAMIDASE
(Homo
sapiens) 		5 / 12 GLN A 471
HIS A 303
HIS A 194
GLU A 540
TYR A 579
 None
ZN  A 801 ( 3.2A)
ZN  A 801 ( 3.3A)
ZN  A 801 ( 2.0A)
ZN  A 801 ( 4.3A)
 1.17A 1j36B-4wgkA:
undetectable		 1j36B-4wgkA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1O86_A_LPRA702_1
(ANGIOTENSIN
CONVERTING ENZYME)		 4wgk NEUTRAL CERAMIDASE
(Homo
sapiens) 		5 / 12 GLN A 471
HIS A 303
HIS A 194
GLU A 540
TYR A 579
 None
ZN  A 801 ( 3.2A)
ZN  A 801 ( 3.3A)
ZN  A 801 ( 2.0A)
ZN  A 801 ( 4.3A)
 1.14A 1o86A-4wgkA:
undetectable		 1o86A-4wgkA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJO_A_CUA701_0
(PHENYLETHYLAMINE
OXIDASE)		 4wgk NEUTRAL CERAMIDASE
(Homo
sapiens) 		3 / 3 HIS A 194
HIS A 196
HIS A 303
 ZN  A 801 ( 3.3A)
PO4  A 810 (-4.0A)
ZN  A 801 ( 3.2A)
 0.69A 1rjoA-4wgkA:
undetectable		 1rjoA-4wgkA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_A_CUA517_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I)		 4wgk NEUTRAL CERAMIDASE
(Homo
sapiens) 		3 / 3 HIS A 303
HIS A 194
HIS A 196
 ZN  A 801 ( 3.2A)
ZN  A 801 ( 3.3A)
PO4  A 810 (-4.0A)
 0.73A 1v54A-4wgkA:
undetectable		 1v54A-4wgkA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_N_CUN517_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I)		 4wgk NEUTRAL CERAMIDASE
(Homo
sapiens) 		3 / 3 HIS A 303
HIS A 194
HIS A 196
 ZN  A 801 ( 3.2A)
ZN  A 801 ( 3.3A)
PO4  A 810 (-4.0A)
 0.75A 1v54N-4wgkA:
undetectable		 1v54N-4wgkA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_A_CUA517_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I)		 4wgk NEUTRAL CERAMIDASE
(Homo
sapiens) 		3 / 3 HIS A 303
HIS A 194
HIS A 196
 ZN  A 801 ( 3.2A)
ZN  A 801 ( 3.3A)
PO4  A 810 (-4.0A)
 0.73A 1v55A-4wgkA:
undetectable		 1v55A-4wgkA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_N_CUN517_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I)		 4wgk NEUTRAL CERAMIDASE
(Homo
sapiens) 		3 / 3 HIS A 303
HIS A 194
HIS A 196
 ZN  A 801 ( 3.2A)
ZN  A 801 ( 3.3A)
PO4  A 810 (-4.0A)
 0.74A 1v55N-4wgkA:
undetectable		 1v55N-4wgkA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VQ1_B_SAMB301_0
(N5-GLUTAMINE
METHYLTRANSFERASE,
HEMK)		 4wgk NEUTRAL CERAMIDASE
(Homo
sapiens) 		6 / 12 PHE A 215
THR A 219
ILE A 642
GLY A 214
SER A 212
ILE A 118
 None
 1.26A 1vq1B-4wgkA:
undetectable		 1vq1B-4wgkA:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W2Z_A_CUA701_0
(AMINE OXIDASE,
COPPER CONTAINING)		 4wgk NEUTRAL CERAMIDASE
(Homo
sapiens) 		3 / 3 HIS A 194
HIS A 196
HIS A 303
 ZN  A 801 ( 3.3A)
PO4  A 810 (-4.0A)
ZN  A 801 ( 3.2A)
 0.73A 1w2zA-4wgkA:
undetectable		 1w2zA-4wgkA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W2Z_B_CUB701_0
(AMINE OXIDASE,
COPPER CONTAINING)		 4wgk NEUTRAL CERAMIDASE
(Homo
sapiens) 		3 / 3 HIS A 194
HIS A 196
HIS A 303
 ZN  A 801 ( 3.3A)
PO4  A 810 (-4.0A)
ZN  A 801 ( 3.2A)
 0.69A 1w2zB-4wgkA:
undetectable		 1w2zB-4wgkA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W2Z_C_CUC701_0
(AMINE OXIDASE,
COPPER CONTAINING)		 4wgk NEUTRAL CERAMIDASE
(Homo
sapiens) 		3 / 3 HIS A 194
HIS A 196
HIS A 303
 ZN  A 801 ( 3.3A)
PO4  A 810 (-4.0A)
ZN  A 801 ( 3.2A)
 0.68A 1w2zC-4wgkA:
undetectable		 1w2zC-4wgkA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W2Z_D_CUD701_0
(AMINE OXIDASE,
COPPER CONTAINING)		 4wgk NEUTRAL CERAMIDASE
(Homo
sapiens) 		3 / 3 HIS A 194
HIS A 196
HIS A 303
 ZN  A 801 ( 3.3A)
PO4  A 810 (-4.0A)
ZN  A 801 ( 3.2A)
 0.67A 1w2zD-4wgkA:
undetectable		 1w2zD-4wgkA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YRD_A_CAMA420_0
(CYTOCHROME P450-CAM)		 4wgk NEUTRAL CERAMIDASE
(Homo
sapiens) 		4 / 7 PHE A 341
VAL A 283
VAL A 287
ASP A 293
 None
 1.02A 1yrdA-4wgkA:
undetectable		 1yrdA-4wgkA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_A_LPRA705_1
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		 4wgk NEUTRAL CERAMIDASE
(Homo
sapiens) 		5 / 12 GLN A 471
HIS A 303
HIS A 194
GLU A 540
TYR A 579
 None
ZN  A 801 ( 3.2A)
ZN  A 801 ( 3.3A)
ZN  A 801 ( 2.0A)
ZN  A 801 ( 4.3A)
 1.11A 2c6nA-4wgkA:
undetectable		 2c6nA-4wgkA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_B_LPRB705_1
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		 4wgk NEUTRAL CERAMIDASE
(Homo
sapiens) 		5 / 12 GLN A 471
HIS A 303
HIS A 194
GLU A 540
TYR A 579
 None
ZN  A 801 ( 3.2A)
ZN  A 801 ( 3.3A)
ZN  A 801 ( 2.0A)
ZN  A 801 ( 4.3A)
 1.21A 2c6nB-4wgkA:
undetectable		 2c6nB-4wgkA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_C_ZMRC3478_1
(NEURAMINIDASE)		 4wgk NEUTRAL CERAMIDASE
(Homo
sapiens) 		4 / 8 ASP A 352
SER A 258
SER A 261
GLN A 587
 None
 1.07A 2cmlC-4wgkA:
undetectable		 2cmlC-4wgkA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4wgk NEUTRAL CERAMIDASE
(Homo
sapiens) 		3 / 3 HIS A 303
HIS A 194
HIS A 196
 ZN  A 801 ( 3.2A)
ZN  A 801 ( 3.3A)
PO4  A 810 (-4.0A)
 0.73A 2dyrA-4wgkA:
undetectable		 2dyrA-4wgkA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4wgk NEUTRAL CERAMIDASE
(Homo
sapiens) 		3 / 3 HIS A 303
HIS A 194
HIS A 196
 ZN  A 801 ( 3.2A)
ZN  A 801 ( 3.3A)
PO4  A 810 (-4.0A)
 0.75A 2dyrN-4wgkA:
undetectable		 2dyrN-4wgkA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_A_CUA601_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4wgk NEUTRAL CERAMIDASE
(Homo
sapiens) 		3 / 3 HIS A 303
HIS A 194
HIS A 196
 ZN  A 801 ( 3.2A)
ZN  A 801 ( 3.3A)
PO4  A 810 (-4.0A)
 0.73A 2dysA-4wgkA:
undetectable		 2dysA-4wgkA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_N_CUN601_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4wgk NEUTRAL CERAMIDASE
(Homo
sapiens) 		3 / 3 HIS A 303
HIS A 194
HIS A 196
 ZN  A 801 ( 3.2A)
ZN  A 801 ( 3.3A)
PO4  A 810 (-4.0A)
 0.73A 2dysN-4wgkA:
undetectable		 2dysN-4wgkA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4wgk NEUTRAL CERAMIDASE
(Homo
sapiens) 		3 / 3 HIS A 303
HIS A 194
HIS A 196
 ZN  A 801 ( 3.2A)
ZN  A 801 ( 3.3A)
PO4  A 810 (-4.0A)
 0.71A 2eijA-4wgkA:
undetectable		 2eijA-4wgkA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4wgk NEUTRAL CERAMIDASE
(Homo
sapiens) 		3 / 3 HIS A 303
HIS A 194
HIS A 196
 ZN  A 801 ( 3.2A)
ZN  A 801 ( 3.3A)
PO4  A 810 (-4.0A)
 0.73A 2eijN-4wgkA:
undetectable		 2eijN-4wgkA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4wgk NEUTRAL CERAMIDASE
(Homo
sapiens) 		3 / 3 HIS A 303
HIS A 194
HIS A 196
 ZN  A 801 ( 3.2A)
ZN  A 801 ( 3.3A)
PO4  A 810 (-4.0A)
 0.69A 2eikA-4wgkA:
undetectable		 2eikA-4wgkA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4wgk NEUTRAL CERAMIDASE
(Homo
sapiens) 		3 / 3 HIS A 303
HIS A 194
HIS A 196
 ZN  A 801 ( 3.2A)
ZN  A 801 ( 3.3A)
PO4  A 810 (-4.0A)
 0.73A 2eikN-4wgkA:
undetectable		 2eikN-4wgkA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4wgk NEUTRAL CERAMIDASE
(Homo
sapiens) 		3 / 3 HIS A 303
HIS A 194
HIS A 196
 ZN  A 801 ( 3.2A)
ZN  A 801 ( 3.3A)
PO4  A 810 (-4.0A)
 0.72A 2eilA-4wgkA:
undetectable		 2eilA-4wgkA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4wgk NEUTRAL CERAMIDASE
(Homo
sapiens) 		3 / 3 HIS A 303
HIS A 194
HIS A 196
 ZN  A 801 ( 3.2A)
ZN  A 801 ( 3.3A)
PO4  A 810 (-4.0A)
 0.74A 2eilN-4wgkA:
undetectable		 2eilN-4wgkA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4wgk NEUTRAL CERAMIDASE
(Homo
sapiens) 		3 / 3 HIS A 303
HIS A 194
HIS A 196
 ZN  A 801 ( 3.2A)
ZN  A 801 ( 3.3A)
PO4  A 810 (-4.0A)
 0.70A 2eimN-4wgkA:
undetectable		 2eimN-4wgkA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4wgk NEUTRAL CERAMIDASE
(Homo
sapiens) 		3 / 3 HIS A 303
HIS A 194
HIS A 196
 ZN  A 801 ( 3.2A)
ZN  A 801 ( 3.3A)
PO4  A 810 (-4.0A)
 0.70A 2einA-4wgkA:
undetectable		 2einA-4wgkA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4wgk NEUTRAL CERAMIDASE
(Homo
sapiens) 		3 / 3 HIS A 303
HIS A 194
HIS A 196
 ZN  A 801 ( 3.2A)
ZN  A 801 ( 3.3A)
PO4  A 810 (-4.0A)
 0.69A 2einN-4wgkA:
undetectable		 2einN-4wgkA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FEU_B_CAMB1421_0
(CYTOCHROME P450-CAM)		 4wgk NEUTRAL CERAMIDASE
(Homo
sapiens) 		4 / 7 PHE A 341
VAL A 283
VAL A 287
ASP A 293
 None
 0.99A 2feuB-4wgkA:
undetectable		 2feuB-4wgkA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OQE_A_CUA801_0
(PEROXISOMAL COPPER
AMINE OXIDASE)		 4wgk NEUTRAL CERAMIDASE
(Homo
sapiens) 		3 / 3 HIS A 194
HIS A 196
HIS A 303
 ZN  A 801 ( 3.3A)
PO4  A 810 (-4.0A)
ZN  A 801 ( 3.2A)
 0.67A 2oqeA-4wgkA:
undetectable		 2oqeA-4wgkA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OQE_B_CUB801_0
(PEROXISOMAL COPPER
AMINE OXIDASE)		 4wgk NEUTRAL CERAMIDASE
(Homo
sapiens) 		3 / 3 HIS A 194
HIS A 196
HIS A 303
 ZN  A 801 ( 3.3A)
PO4  A 810 (-4.0A)
ZN  A 801 ( 3.2A)
 0.66A 2oqeB-4wgkA:
undetectable		 2oqeB-4wgkA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OQE_C_CUC801_0
(PEROXISOMAL COPPER
AMINE OXIDASE)		 4wgk NEUTRAL CERAMIDASE
(Homo
sapiens) 		3 / 3 HIS A 194
HIS A 196
HIS A 303
 ZN  A 801 ( 3.3A)
PO4  A 810 (-4.0A)
ZN  A 801 ( 3.2A)
 0.68A 2oqeC-4wgkA:
undetectable		 2oqeC-4wgkA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OQE_D_CUD801_0
(PEROXISOMAL COPPER
AMINE OXIDASE)		 4wgk NEUTRAL CERAMIDASE
(Homo
sapiens) 		3 / 3 HIS A 194
HIS A 196
HIS A 303
 ZN  A 801 ( 3.3A)
PO4  A 810 (-4.0A)
ZN  A 801 ( 3.2A)
 0.66A 2oqeD-4wgkA:
undetectable		 2oqeD-4wgkA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OQE_F_CUF801_0
(PEROXISOMAL COPPER
AMINE OXIDASE)		 4wgk NEUTRAL CERAMIDASE
(Homo
sapiens) 		3 / 3 HIS A 194
HIS A 196
HIS A 303
 ZN  A 801 ( 3.3A)
PO4  A 810 (-4.0A)
ZN  A 801 ( 3.2A)
 0.68A 2oqeF-4wgkA:
undetectable		 2oqeF-4wgkA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q63_A_1UNA1001_2
(PROTEASE RETROPEPSIN)		 4wgk NEUTRAL CERAMIDASE
(Homo
sapiens) 		3 / 3 ARG A 136
ASN A 119
THR A 219
 None
 0.61A 2q63A-4wgkA:
undetectable		 2q63A-4wgkA:
9.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QBL_A_CAMA517_0
(CYTOCHROME P450-CAM)		 4wgk NEUTRAL CERAMIDASE
(Homo
sapiens) 		4 / 7 PHE A 341
VAL A 283
VAL A 287
ASP A 293
 None
 0.96A 2qblA-4wgkA:
undetectable		 2qblA-4wgkA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCD_A_RAPA138_1
(OUTER MEMBRANE
PROTEIN MIP)		 4wgk NEUTRAL CERAMIDASE
(Homo
sapiens) 		5 / 11 TYR A 591
PHE A 456
ILE A 597
PRO A 450
VAL A 575
 PO4  A 810 (-4.4A)
None
None
None
None
 1.28A 2vcdA-4wgkA:
undetectable		 2vcdA-4wgkA:
12.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDV_E_SAME1287_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 4wgk NEUTRAL CERAMIDASE
(Homo
sapiens) 		5 / 12 GLY A 388
GLY A 390
ILE A 357
ALA A 386
PHE A 394
 None
 1.27A 2vdvE-4wgkA:
undetectable		 2vdvE-4wgkA:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDV_F_SAMF1287_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 4wgk NEUTRAL CERAMIDASE
(Homo
sapiens) 		5 / 11 GLY A 388
GLY A 390
ILE A 357
ALA A 386
PHE A 394
 None
 1.27A 2vdvF-4wgkA:
undetectable		 2vdvF-4wgkA:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDY_B_HCYB1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 4wgk NEUTRAL CERAMIDASE
(Homo
sapiens) 		5 / 12 VAL A 314
GLN A 218
ILE A 118
SER A 216
HIS A 222
 None
 1.40A 2vdyB-4wgkA:
undetectable		 2vdyB-4wgkA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W0Q_A_CUA801_0
(COPPER AMINE OXIDASE)		 4wgk NEUTRAL CERAMIDASE
(Homo
sapiens) 		3 / 3 HIS A 194
HIS A 196
HIS A 303
 ZN  A 801 ( 3.3A)
PO4  A 810 (-4.0A)
ZN  A 801 ( 3.2A)
 0.69A 2w0qA-4wgkA:
undetectable		 2w0qA-4wgkA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W0Q_B_CUB801_0
(COPPER AMINE OXIDASE)		 4wgk NEUTRAL CERAMIDASE
(Homo
sapiens) 		3 / 3 HIS A 194
HIS A 196
HIS A 303
 ZN  A 801 ( 3.3A)
PO4  A 810 (-4.0A)
ZN  A 801 ( 3.2A)
 0.67A 2w0qB-4wgkA:
undetectable		 2w0qB-4wgkA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X8Z_A_X8ZA1615_1
(ANGIOTENSIN
CONVERTING ENZYME)		 4wgk NEUTRAL CERAMIDASE
(Homo
sapiens) 		5 / 11 GLN A 471
HIS A 303
HIS A 194
GLU A 540
TYR A 579
 None
ZN  A 801 ( 3.2A)
ZN  A 801 ( 3.3A)
ZN  A 801 ( 2.0A)
ZN  A 801 ( 4.3A)
 1.10A 2x8zA-4wgkA:
undetectable		 2x8zA-4wgkA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X91_A_LPRA1615_1
(ANGIOTENSIN
CONVERTING ENZYME)		 4wgk NEUTRAL CERAMIDASE
(Homo
sapiens) 		5 / 12 GLN A 471
HIS A 303
HIS A 194
GLU A 540
TYR A 579
 None
ZN  A 801 ( 3.2A)
ZN  A 801 ( 3.3A)
ZN  A 801 ( 2.0A)
ZN  A 801 ( 4.3A)
 1.09A 2x91A-4wgkA:
undetectable		 2x91A-4wgkA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZMB_A_PXBA692_1
(LACTOTRANSFERRIN)		 4wgk NEUTRAL CERAMIDASE
(Homo
sapiens) 		3 / 3 PRO A 501
GLU A 585
TYR A 586
 None
 0.67A 2zmbA-4wgkA:
undetectable		 2zmbA-4wgkA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4wgk NEUTRAL CERAMIDASE
(Homo
sapiens) 		3 / 3 HIS A 303
HIS A 194
HIS A 196
 ZN  A 801 ( 3.2A)
ZN  A 801 ( 3.3A)
PO4  A 810 (-4.0A)
 0.74A 3abkA-4wgkA:
undetectable		 3abkA-4wgkA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4wgk NEUTRAL CERAMIDASE
(Homo
sapiens) 		3 / 3 HIS A 303
HIS A 194
HIS A 196
 ZN  A 801 ( 3.2A)
ZN  A 801 ( 3.3A)
PO4  A 810 (-4.0A)
 0.72A 3abkN-4wgkA:
undetectable		 3abkN-4wgkA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4wgk NEUTRAL CERAMIDASE
(Homo
sapiens) 		3 / 3 HIS A 303
HIS A 194
HIS A 196
 ZN  A 801 ( 3.2A)
ZN  A 801 ( 3.3A)
PO4  A 810 (-4.0A)
 0.76A 3ablA-4wgkA:
undetectable		 3ablA-4wgkA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4wgk NEUTRAL CERAMIDASE
(Homo
sapiens) 		3 / 3 HIS A 303
HIS A 194
HIS A 196
 ZN  A 801 ( 3.2A)
ZN  A 801 ( 3.3A)
PO4  A 810 (-4.0A)
 0.77A 3ablN-4wgkA:
undetectable		 3ablN-4wgkA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG1_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4wgk NEUTRAL CERAMIDASE
(Homo
sapiens) 		3 / 3 HIS A 303
HIS A 194
HIS A 196
 ZN  A 801 ( 3.2A)
ZN  A 801 ( 3.3A)
PO4  A 810 (-4.0A)
 0.74A 3ag1A-4wgkA:
undetectable		 3ag1A-4wgkA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG1_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4wgk NEUTRAL CERAMIDASE
(Homo
sapiens) 		3 / 3 HIS A 303
HIS A 194
HIS A 196
 ZN  A 801 ( 3.2A)
ZN  A 801 ( 3.3A)
PO4  A 810 (-4.0A)
 0.75A 3ag1N-4wgkA:
undetectable		 3ag1N-4wgkA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4wgk NEUTRAL CERAMIDASE
(Homo
sapiens) 		3 / 3 HIS A 303
HIS A 194
HIS A 196
 ZN  A 801 ( 3.2A)
ZN  A 801 ( 3.3A)
PO4  A 810 (-4.0A)
 0.74A 3ag2A-4wgkA:
undetectable		 3ag2A-4wgkA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4wgk NEUTRAL CERAMIDASE
(Homo
sapiens) 		3 / 3 HIS A 303
HIS A 194
HIS A 196
 ZN  A 801 ( 3.2A)
ZN  A 801 ( 3.3A)
PO4  A 810 (-4.0A)
 0.72A 3ag2N-4wgkA:
undetectable		 3ag2N-4wgkA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4wgk NEUTRAL CERAMIDASE
(Homo
sapiens) 		3 / 3 HIS A 303
HIS A 194
HIS A 196
 ZN  A 801 ( 3.2A)
ZN  A 801 ( 3.3A)
PO4  A 810 (-4.0A)
 0.72A 3ag3A-4wgkA:
undetectable		 3ag3A-4wgkA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4wgk NEUTRAL CERAMIDASE
(Homo
sapiens) 		3 / 3 HIS A 303
HIS A 194
HIS A 196
 ZN  A 801 ( 3.2A)
ZN  A 801 ( 3.3A)
PO4  A 810 (-4.0A)
 0.74A 3ag3N-4wgkA:
undetectable		 3ag3N-4wgkA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4wgk NEUTRAL CERAMIDASE
(Homo
sapiens) 		3 / 3 HIS A 303
HIS A 194
HIS A 196
 ZN  A 801 ( 3.2A)
ZN  A 801 ( 3.3A)
PO4  A 810 (-4.0A)
 0.71A 3ag4A-4wgkA:
undetectable		 3ag4A-4wgkA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4wgk NEUTRAL CERAMIDASE
(Homo
sapiens) 		3 / 3 HIS A 303
HIS A 194
HIS A 196
 ZN  A 801 ( 3.2A)
ZN  A 801 ( 3.3A)
PO4  A 810 (-4.0A)
 0.71A 3ag4N-4wgkA:
undetectable		 3ag4N-4wgkA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4wgk NEUTRAL CERAMIDASE
(Homo
sapiens) 		3 / 3 HIS A 303
HIS A 194
HIS A 196
 ZN  A 801 ( 3.2A)
ZN  A 801 ( 3.3A)
PO4  A 810 (-4.0A)
 0.73A 3asnA-4wgkA:
undetectable		 3asnA-4wgkA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4wgk NEUTRAL CERAMIDASE
(Homo
sapiens) 		3 / 3 HIS A 303
HIS A 194
HIS A 196
 ZN  A 801 ( 3.2A)
ZN  A 801 ( 3.3A)
PO4  A 810 (-4.0A)
 0.76A 3asnN-4wgkA:
undetectable		 3asnN-4wgkA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4wgk NEUTRAL CERAMIDASE
(Homo
sapiens) 		3 / 3 HIS A 303
HIS A 194
HIS A 196
 ZN  A 801 ( 3.2A)
ZN  A 801 ( 3.3A)
PO4  A 810 (-4.0A)
 0.73A 3asoA-4wgkA:
undetectable		 3asoA-4wgkA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4wgk NEUTRAL CERAMIDASE
(Homo
sapiens) 		3 / 3 HIS A 303
HIS A 194
HIS A 196
 ZN  A 801 ( 3.2A)
ZN  A 801 ( 3.3A)
PO4  A 810 (-4.0A)
 0.73A 3asoN-4wgkA:
undetectable		 3asoN-4wgkA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCM_X_SAMX5452_0
(UNCHARACTERIZED
PROTEIN TM_1570)		 4wgk NEUTRAL CERAMIDASE
(Homo
sapiens) 		5 / 11 THR A 654
GLY A 656
GLY A 678
LEU A 766
SER A 767
 None
 0.89A 3dcmX-4wgkA:
undetectable		 3dcmX-4wgkA:
14.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DTU_C_CUC569_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4wgk NEUTRAL CERAMIDASE
(Homo
sapiens) 		3 / 3 HIS A 303
HIS A 194
HIS A 196
 ZN  A 801 ( 3.2A)
ZN  A 801 ( 3.3A)
PO4  A 810 (-4.0A)
 0.75A 3dtuC-4wgkA:
undetectable		 3dtuC-4wgkA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4wgk NEUTRAL CERAMIDASE
(Homo
sapiens) 		5 / 12 ILE A 527
ILE A 189
GLY A 571
PHE A 541
LEU A 549
 None
 1.11A 3em0B-4wgkA:
2.0		 3em0B-4wgkA:
13.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FWG_A_CAMA420_0
(CAMPHOR
5-MONOOXYGENASE)		 4wgk NEUTRAL CERAMIDASE
(Homo
sapiens) 		4 / 6 PHE A 341
VAL A 283
VAL A 287
ASP A 293
 None
 1.01A 3fwgA-4wgkA:
undetectable		 3fwgA-4wgkA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GCS_A_BAXA401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 4wgk NEUTRAL CERAMIDASE
(Homo
sapiens) 		5 / 12 VAL A 435
ALA A 605
LEU A 613
ILE A 189
ASP A 523
 None
 0.83A 3gcsA-4wgkA:
undetectable		 3gcsA-4wgkA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HII_A_CUA801_0
(AMILORIDE-SENSITIVE
AMINE OXIDASE)		 4wgk NEUTRAL CERAMIDASE
(Homo
sapiens) 		3 / 3 HIS A 194
HIS A 196
HIS A 303
 ZN  A 801 ( 3.3A)
PO4  A 810 (-4.0A)
ZN  A 801 ( 3.2A)
 0.69A 3hiiA-4wgkA:
2.4		 3hiiA-4wgkA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HII_B_CUB801_0
(AMILORIDE-SENSITIVE
AMINE OXIDASE)		 4wgk NEUTRAL CERAMIDASE
(Homo
sapiens) 		3 / 3 HIS A 194
HIS A 196
HIS A 303
 ZN  A 801 ( 3.3A)
PO4  A 810 (-4.0A)
ZN  A 801 ( 3.2A)
 0.70A 3hiiB-4wgkA:
2.2		 3hiiB-4wgkA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L63_A_CAMA440_0
(CAMPHOR
5-MONOOXYGENASE)		 4wgk NEUTRAL CERAMIDASE
(Homo
sapiens) 		4 / 7 PHE A 341
VAL A 283
VAL A 287
ASP A 293
 None
 0.98A 3l63A-4wgkA:
undetectable		 3l63A-4wgkA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_2
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		 4wgk NEUTRAL CERAMIDASE
(Homo
sapiens) 		3 / 3 SER A 348
SER A 570
HIS A 194
 None
None
ZN  A 801 ( 3.3A)
 0.83A 3mzeA-4wgkA:
undetectable		 3mzeA-4wgkA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PHN_A_ACTA108_0
(PROTEIN P-30)		 4wgk NEUTRAL CERAMIDASE
(Homo
sapiens) 		3 / 3 THR A 771
SER A 772
ARG A 747
 None
 0.82A 3phnA-4wgkA:
undetectable		 3phnA-4wgkA:
10.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R24_A_SAMA302_1
(2'-O-METHYL
TRANSFERASE)		 4wgk NEUTRAL CERAMIDASE
(Homo
sapiens) 		3 / 3 TYR A 412
ASP A 288
ASP A 293
 None
 0.63A 3r24A-4wgkA:
undetectable		 3r24A-4wgkA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UZZ_B_ASDB501_1
(3-OXO-5-BETA-STEROID
4-DEHYDROGENASE)		 4wgk NEUTRAL CERAMIDASE
(Homo
sapiens) 		4 / 8 TYR A 591
HIS A 196
TYR A 576
LEU A 350
 PO4  A 810 (-4.4A)
PO4  A 810 (-4.0A)
None
None
 1.29A 3uzzB-4wgkA:
undetectable		 3uzzB-4wgkA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VQR_A_ACTA1002_0
(PUTATIVE
OXIDOREDUCTASE)		 4wgk NEUTRAL CERAMIDASE
(Homo
sapiens) 		4 / 6 GLY A 320
TRP A 715
ASP A 159
THR A 193
 None
 1.04A 3vqrA-4wgkA:
undetectable		 3vqrA-4wgkA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRL_E_CAME503_0
(CAMPHOR
5-MONOOXYGENASE)		 4wgk NEUTRAL CERAMIDASE
(Homo
sapiens) 		4 / 7 PHE A 341
VAL A 283
VAL A 287
ASP A 293
 None
 1.00A 3wrlE-4wgkA:
undetectable		 3wrlE-4wgkA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRM_F_CAMF503_0
(CAMPHOR
5-MONOOXYGENASE)		 4wgk NEUTRAL CERAMIDASE
(Homo
sapiens) 		4 / 7 PHE A 341
VAL A 283
VAL A 287
ASP A 293
 None
 1.02A 3wrmF-4wgkA:
undetectable		 3wrmF-4wgkA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1476_0
(MJ0495-LIKE PROTEIN)		 4wgk NEUTRAL CERAMIDASE
(Homo
sapiens) 		4 / 5 ILE A 527
ALA A 424
HIS A 427
ARG A 184
 None
 1.25A 4ac9B-4wgkA:
undetectable
4ac9C-4wgkA:
undetectable		 4ac9B-4wgkA:
23.55
4ac9C-4wgkA:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1476_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 4wgk NEUTRAL CERAMIDASE
(Homo
sapiens) 		4 / 5 ILE A 527
ALA A 424
HIS A 427
ARG A 184
 None
 1.23A 4acaB-4wgkA:
undetectable
4acaC-4wgkA:
undetectable		 4acaB-4wgkA:
23.55
4acaC-4wgkA:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C2P_A_X8ZA709_1
(ANGIOTENSIN-CONVERTI
NG ENZYME)		 4wgk NEUTRAL CERAMIDASE
(Homo
sapiens) 		5 / 11 GLN A 471
HIS A 303
HIS A 194
GLU A 540
TYR A 579
 None
ZN  A 801 ( 3.2A)
ZN  A 801 ( 3.3A)
ZN  A 801 ( 2.0A)
ZN  A 801 ( 4.3A)
 1.21A 4c2pA-4wgkA:
undetectable		 4c2pA-4wgkA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G19_A_ACTA304_0
(GLUTATHIONE
TRANSFERASE GTE1)		 4wgk NEUTRAL CERAMIDASE
(Homo
sapiens) 		4 / 5 ALA A 415
ILE A 243
LEU A 284
LYS A 285
 None
 1.20A 4g19A-4wgkA:
undetectable		 4g19A-4wgkA:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G3R_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 4wgk NEUTRAL CERAMIDASE
(Homo
sapiens) 		4 / 6 PHE A 341
VAL A 283
VAL A 287
ASP A 293
 None
 1.05A 4g3rA-4wgkA:
undetectable		 4g3rA-4wgkA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G3R_B_CAMB502_0
(CAMPHOR
5-MONOOXYGENASE)		 4wgk NEUTRAL CERAMIDASE
(Homo
sapiens) 		4 / 6 PHE A 341
VAL A 283
VAL A 287
ASP A 293
 None
 1.01A 4g3rB-4wgkA:
undetectable		 4g3rB-4wgkA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GC9_A_SAMA401_1
(DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL)		 4wgk NEUTRAL CERAMIDASE
(Homo
sapiens) 		3 / 3 GLU A 592
ASP A 352
ASP A 462
 None
 0.78A 4gc9A-4wgkA:
undetectable		 4gc9A-4wgkA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HTF_A_ACTA303_0
(S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 4wgk NEUTRAL CERAMIDASE
(Homo
sapiens) 		3 / 3 TYR A 591
HIS A 303
ARG A 257
 PO4  A 810 (-4.4A)
ZN  A 801 ( 3.2A)
ZN  A 801 ( 4.5A)
 1.01A 4htfA-4wgkA:
undetectable		 4htfA-4wgkA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I13_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 4wgk NEUTRAL CERAMIDASE
(Homo
sapiens) 		3 / 3 ASP A 317
ARG A 257
THR A 397
 None
ZN  A 801 ( 4.5A)
None
 0.71A 4i13A-4wgkA:
undetectable		 4i13A-4wgkA:
13.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8F_B_BRLB501_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4wgk NEUTRAL CERAMIDASE
(Homo
sapiens) 		4 / 6 ILE A 534
ILE A 231
ILE A 297
LEU A 529
 None
 0.72A 4o8fB-4wgkA:
undetectable		 4o8fB-4wgkA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P3R_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 4wgk NEUTRAL CERAMIDASE
(Homo
sapiens) 		3 / 3 ASP A 317
ARG A 257
THR A 397
 None
ZN  A 801 ( 4.5A)
None
 0.71A 4p3rA-4wgkA:
undetectable		 4p3rA-4wgkA:
13.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PAH_A_LNRA600_1
(PHENYLALANINE
HYDROXYLASE)		 4wgk NEUTRAL CERAMIDASE
(Homo
sapiens) 		4 / 6 HIS A 303
HIS A 194
TYR A 576
GLU A 540
 ZN  A 801 ( 3.2A)
ZN  A 801 ( 3.3A)
None
ZN  A 801 ( 2.0A)
 0.94A 4pahA-4wgkA:
undetectable		 4pahA-4wgkA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZO1_X_T3X500_1
(THYROID HORMONE
RECEPTOR BETA)		 4wgk NEUTRAL CERAMIDASE
(Homo
sapiens) 		5 / 12 ILE A 133
ALA A 713
ARG A 140
LEU A 137
PHE A 693
 None
 1.42A 4zo1X-4wgkA:
undetectable		 4zo1X-4wgkA:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AYF_A_C7HA402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 4wgk NEUTRAL CERAMIDASE
(Homo
sapiens) 		4 / 5 TYR A 579
GLY A 122
TYR A 591
GLY A 465
 ZN  A 801 ( 4.3A)
PO4  A 810 (-4.4A)
PO4  A 810 (-4.4A)
None
 1.06A 5ayfA-4wgkA:
undetectable		 5ayfA-4wgkA:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4wgk NEUTRAL CERAMIDASE
(Homo
sapiens) 		3 / 3 HIS A 303
HIS A 194
HIS A 196
 ZN  A 801 ( 3.2A)
ZN  A 801 ( 3.3A)
PO4  A 810 (-4.0A)
 0.75A 5b1aA-4wgkA:
undetectable		 5b1aA-4wgkA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4wgk NEUTRAL CERAMIDASE
(Homo
sapiens) 		3 / 3 HIS A 303
HIS A 194
HIS A 196
 ZN  A 801 ( 3.2A)
ZN  A 801 ( 3.3A)
PO4  A 810 (-4.0A)
 0.76A 5b1aN-4wgkA:
undetectable		 5b1aN-4wgkA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4wgk NEUTRAL CERAMIDASE
(Homo
sapiens) 		3 / 3 HIS A 303
HIS A 194
HIS A 196
 ZN  A 801 ( 3.2A)
ZN  A 801 ( 3.3A)
PO4  A 810 (-4.0A)
 0.71A 5b1bA-4wgkA:
undetectable		 5b1bA-4wgkA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4wgk NEUTRAL CERAMIDASE
(Homo
sapiens) 		3 / 3 HIS A 303
HIS A 194
HIS A 196
 ZN  A 801 ( 3.2A)
ZN  A 801 ( 3.3A)
PO4  A 810 (-4.0A)
 0.73A 5b1bN-4wgkA:
undetectable		 5b1bN-4wgkA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4wgk NEUTRAL CERAMIDASE
(Homo
sapiens) 		3 / 3 HIS A 303
HIS A 194
HIS A 196
 ZN  A 801 ( 3.2A)
ZN  A 801 ( 3.3A)
PO4  A 810 (-4.0A)
 0.72A 5b3sA-4wgkA:
undetectable		 5b3sA-4wgkA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4wgk NEUTRAL CERAMIDASE
(Homo
sapiens) 		3 / 3 HIS A 303
HIS A 194
HIS A 196
 ZN  A 801 ( 3.2A)
ZN  A 801 ( 3.3A)
PO4  A 810 (-4.0A)
 0.74A 5b3sN-4wgkA:
undetectable		 5b3sN-4wgkA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BXN_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 4wgk NEUTRAL CERAMIDASE
(Homo
sapiens) 		5 / 11 SER A 164
GLN A 204
ALA A 200
GLY A 201
THR A 219
 None
 1.10A 5bxnH-4wgkA:
undetectable
5bxnI-4wgkA:
undetectable		 5bxnH-4wgkA:
16.18
5bxnI-4wgkA:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CP3_A_YTZA301_1
(LIGHT CHAIN OF
ANTIGEN-BINDING
FRAGMENT OF
MONOCLONAL ANTIBODY
OF 4C7
HEAVY CHAIN OF
ANTIGEN-BINDING
FRAGMENT OF
MONOCLONAL ANTIBODY
OF 4C7)		 4wgk NEUTRAL CERAMIDASE
(Homo
sapiens) 		5 / 11 ASN A 680
TRP A 721
HIS A 722
ASN A 730
GLY A 727
 None
None
NAG  A 803 (-3.8A)
NAG  A 803 (-1.9A)
None
 1.37A 5cp3A-4wgkA:
0.5
5cp3H-4wgkA:
6.7		 5cp3A-4wgkA:
15.67
5cp3H-4wgkA:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHZ_B_REAB602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)		 4wgk NEUTRAL CERAMIDASE
(Homo
sapiens) 		5 / 9 ILE A 597
GLY A 509
TRP A 517
LEU A 506
LEU A 488
 None
 1.33A 5fhzB-4wgkA:
undetectable		 5fhzB-4wgkA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_A_CUA601_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4wgk NEUTRAL CERAMIDASE
(Homo
sapiens) 		3 / 3 HIS A 303
HIS A 194
HIS A 196
 ZN  A 801 ( 3.2A)
ZN  A 801 ( 3.3A)
PO4  A 810 (-4.0A)
 0.74A 5iy5A-4wgkA:
undetectable		 5iy5A-4wgkA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_N_CUN602_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4wgk NEUTRAL CERAMIDASE
(Homo
sapiens) 		3 / 3 HIS A 303
HIS A 194
HIS A 196
 ZN  A 801 ( 3.2A)
ZN  A 801 ( 3.3A)
PO4  A 810 (-4.0A)
 0.74A 5iy5N-4wgkA:
undetectable		 5iy5N-4wgkA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5F_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 4wgk NEUTRAL CERAMIDASE
(Homo
sapiens) 		5 / 12 SER A 164
GLN A 204
ALA A 200
GLY A 201
THR A 219
 None
 0.99A 5l5fH-4wgkA:
undetectable
5l5fI-4wgkA:
undetectable		 5l5fH-4wgkA:
16.18
5l5fI-4wgkA:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5F_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 4wgk NEUTRAL CERAMIDASE
(Homo
sapiens) 		5 / 12 SER A 164
GLN A 204
ALA A 200
GLY A 201
THR A 219
 None
 0.98A 5l5fV-4wgkA:
undetectable
5l5fW-4wgkA:
undetectable		 5l5fV-4wgkA:
16.18
5l5fW-4wgkA:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 4wgk NEUTRAL CERAMIDASE
(Homo
sapiens) 		5 / 12 SER A 164
GLN A 204
ALA A 200
GLY A 201
THR A 219
 None
 0.99A 5l5zH-4wgkA:
undetectable
5l5zI-4wgkA:
undetectable		 5l5zH-4wgkA:
16.18
5l5zI-4wgkA:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 4wgk NEUTRAL CERAMIDASE
(Homo
sapiens) 		5 / 12 SER A 164
GLN A 204
ALA A 200
GLY A 201
THR A 219
 None
 1.00A 5l5zV-4wgkA:
undetectable
5l5zW-4wgkA:
undetectable		 5l5zV-4wgkA:
16.18
5l5zW-4wgkA:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 4wgk NEUTRAL CERAMIDASE
(Homo
sapiens) 		5 / 12 SER A 164
GLN A 204
ALA A 200
GLY A 201
THR A 219
 None
 1.02A 5l66H-4wgkA:
undetectable
5l66I-4wgkA:
undetectable		 5l66H-4wgkA:
16.18
5l66I-4wgkA:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 4wgk NEUTRAL CERAMIDASE
(Homo
sapiens) 		5 / 12 SER A 164
GLN A 204
ALA A 200
GLY A 201
THR A 219
 None
 1.02A 5l66V-4wgkA:
undetectable
5l66W-4wgkA:
undetectable		 5l66V-4wgkA:
16.18
5l66W-4wgkA:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_E_Z80E401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 4wgk NEUTRAL CERAMIDASE
(Homo
sapiens) 		5 / 12 ILE A 534
VAL A 568
THR A 566
ASN A 564
ILE A 245
 None
 1.09A 5lg3E-4wgkA:
undetectable		 5lg3E-4wgkA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_J_Z80J401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 4wgk NEUTRAL CERAMIDASE
(Homo
sapiens) 		5 / 12 ILE A 534
VAL A 568
THR A 566
ASN A 564
ILE A 245
 None
 1.13A 5lg3J-4wgkA:
undetectable		 5lg3J-4wgkA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5PAH_A_LDPA600_1
(PHENYLALANINE
4-MONOOXYGENASE)		 4wgk NEUTRAL CERAMIDASE
(Homo
sapiens) 		4 / 4 HIS A 303
HIS A 194
TYR A 576
GLU A 540
 ZN  A 801 ( 3.2A)
ZN  A 801 ( 3.3A)
None
ZN  A 801 ( 2.0A)
 0.94A 5pahA-4wgkA:
undetectable		 5pahA-4wgkA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W97_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4wgk NEUTRAL CERAMIDASE
(Homo
sapiens) 		3 / 3 HIS A 303
HIS A 194
HIS A 196
 ZN  A 801 ( 3.2A)
ZN  A 801 ( 3.3A)
PO4  A 810 (-4.0A)
 0.71A 5w97a-4wgkA:
undetectable		 5w97a-4wgkA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WAU_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4wgk NEUTRAL CERAMIDASE
(Homo
sapiens) 		3 / 3 HIS A 303
HIS A 194
HIS A 196
 ZN  A 801 ( 3.2A)
ZN  A 801 ( 3.3A)
PO4  A 810 (-4.0A)
 0.74A 5waua-4wgkA:
undetectable		 5waua-4wgkA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X19_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4wgk NEUTRAL CERAMIDASE
(Homo
sapiens) 		3 / 3 HIS A 303
HIS A 194
HIS A 196
 ZN  A 801 ( 3.2A)
ZN  A 801 ( 3.3A)
PO4  A 810 (-4.0A)
 0.71A 5x19A-4wgkA:
undetectable		 5x19A-4wgkA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X19_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4wgk NEUTRAL CERAMIDASE
(Homo
sapiens) 		3 / 3 HIS A 303
HIS A 194
HIS A 196
 ZN  A 801 ( 3.2A)
ZN  A 801 ( 3.3A)
PO4  A 810 (-4.0A)
 0.70A 5x19N-4wgkA:
undetectable		 5x19N-4wgkA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4wgk NEUTRAL CERAMIDASE
(Homo
sapiens) 		3 / 3 HIS A 303
HIS A 194
HIS A 196
 ZN  A 801 ( 3.2A)
ZN  A 801 ( 3.3A)
PO4  A 810 (-4.0A)
 0.70A 5x1fA-4wgkA:
undetectable		 5x1fA-4wgkA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4wgk NEUTRAL CERAMIDASE
(Homo
sapiens) 		3 / 3 HIS A 303
HIS A 194
HIS A 196
 ZN  A 801 ( 3.2A)
ZN  A 801 ( 3.3A)
PO4  A 810 (-4.0A)
 0.73A 5xdxA-4wgkA:
undetectable		 5xdxA-4wgkA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4wgk NEUTRAL CERAMIDASE
(Homo
sapiens) 		3 / 3 HIS A 303
HIS A 194
HIS A 196
 ZN  A 801 ( 3.2A)
ZN  A 801 ( 3.3A)
PO4  A 810 (-4.0A)
 0.74A 5xdxN-4wgkA:
undetectable		 5xdxN-4wgkA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4wgk NEUTRAL CERAMIDASE
(Homo
sapiens) 		3 / 3 HIS A 303
HIS A 194
HIS A 196
 ZN  A 801 ( 3.2A)
ZN  A 801 ( 3.3A)
PO4  A 810 (-4.0A)
 0.76A 5z84A-4wgkA:
undetectable		 5z84A-4wgkA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z85_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4wgk NEUTRAL CERAMIDASE
(Homo
sapiens) 		3 / 3 HIS A 303
HIS A 194
HIS A 196
 ZN  A 801 ( 3.2A)
ZN  A 801 ( 3.3A)
PO4  A 810 (-4.0A)
 0.77A 5z85A-4wgkA:
undetectable		 5z85A-4wgkA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4wgk NEUTRAL CERAMIDASE
(Homo
sapiens) 		3 / 3 HIS A 303
HIS A 194
HIS A 196
 ZN  A 801 ( 3.2A)
ZN  A 801 ( 3.3A)
PO4  A 810 (-4.0A)
 0.74A 5zcoA-4wgkA:
undetectable		 5zcoA-4wgkA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_N_CUN604_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4wgk NEUTRAL CERAMIDASE
(Homo
sapiens) 		3 / 3 HIS A 303
HIS A 194
HIS A 196
 ZN  A 801 ( 3.2A)
ZN  A 801 ( 3.3A)
PO4  A 810 (-4.0A)
 0.74A 5zcoN-4wgkA:
undetectable		 5zcoN-4wgkA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4wgk NEUTRAL CERAMIDASE
(Homo
sapiens) 		3 / 3 HIS A 303
HIS A 194
HIS A 196
 ZN  A 801 ( 3.2A)
ZN  A 801 ( 3.3A)
PO4  A 810 (-4.0A)
 0.76A 5zcpA-4wgkA:
undetectable		 5zcpA-4wgkA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCQ_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4wgk NEUTRAL CERAMIDASE
(Homo
sapiens) 		3 / 3 HIS A 303
HIS A 194
HIS A 196
 ZN  A 801 ( 3.2A)
ZN  A 801 ( 3.3A)
PO4  A 810 (-4.0A)
 0.75A 5zcqA-4wgkA:
undetectable		 5zcqA-4wgkA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_G_EU7G101_0
(MATRIX PROTEIN 2)		 4wgk NEUTRAL CERAMIDASE
(Homo
sapiens) 		5 / 9 ALA A 344
ALA A 141
ALA A 109
SER A 230
GLY A 107
 None
 1.22A 6bklE-4wgkA:
undetectable
6bklF-4wgkA:
undetectable
6bklG-4wgkA:
undetectable
6bklH-4wgkA:
undetectable		 6bklE-4wgkA:
3.74
6bklF-4wgkA:
3.74
6bklG-4wgkA:
3.74
6bklH-4wgkA:
3.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C06_D_FI8D1404_0
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		 4wgk NEUTRAL CERAMIDASE
(Homo
sapiens) 		4 / 8 ILE A 255
THR A 543
GLU A 585
SER A 261
 None
 1.12A 6c06C-4wgkA:
undetectable		 6c06C-4wgkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_N_CUN602_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4wgk NEUTRAL CERAMIDASE
(Homo
sapiens) 		3 / 3 HIS A 303
HIS A 194
HIS A 196
 ZN  A 801 ( 3.2A)
ZN  A 801 ( 3.3A)
PO4  A 810 (-4.0A)
 0.73A 6nknN-4wgkA:
undetectable		 6nknN-4wgkA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMF_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4wgk NEUTRAL CERAMIDASE
(Homo
sapiens) 		3 / 3 HIS A 303
HIS A 194
HIS A 196
 ZN  A 801 ( 3.2A)
ZN  A 801 ( 3.3A)
PO4  A 810 (-4.0A)
 0.71A 6nmfN-4wgkA:
undetectable		 6nmfN-4wgkA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_N_CUN601_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4wgk NEUTRAL CERAMIDASE
(Homo
sapiens) 		3 / 3 HIS A 303
HIS A 194
HIS A 196
 ZN  A 801 ( 3.2A)
ZN  A 801 ( 3.3A)
PO4  A 810 (-4.0A)
 0.72A 6nmpN-4wgkA:
undetectable		 6nmpN-4wgkA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6PAH_A_DAHA600_1
(PHENYLALANINE
4-MONOOXYGENASE)		 4wgk NEUTRAL CERAMIDASE
(Homo
sapiens) 		4 / 6 HIS A 303
HIS A 194
TYR A 576
GLU A 540
 ZN  A 801 ( 3.2A)
ZN  A 801 ( 3.3A)
None
ZN  A 801 ( 2.0A)
 0.96A 6pahA-4wgkA:
undetectable		 6pahA-4wgkA:
17.94