SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4wgx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_A_HLTA4001_1
(SERUM ALBUMIN)		 4wgx MOLINATE HYDROLASE
(Gulosibacter
molinativorax) 		4 / 5 ARG A  86
ALA A  85
ASP A 347
GLY A  80
 None
 0.98A 1e7bA-4wgxA:
undetectable		 1e7bA-4wgxA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4001_1
(SERUM ALBUMIN)		 4wgx MOLINATE HYDROLASE
(Gulosibacter
molinativorax) 		4 / 5 ARG A  86
ALA A  85
ASP A 347
GLY A  80
 None
 1.03A 1e7cA-4wgxA:
undetectable		 1e7cA-4wgxA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MMT_A_H4BA1426_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 4wgx MOLINATE HYDROLASE
(Gulosibacter
molinativorax) 		5 / 11 VAL A 212
LEU A 258
SER A 295
LEU A 268
THR A 213
 None
 1.34A 1mmtA-4wgxA:
undetectable		 1mmtA-4wgxA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T9W_A_NFNA6002_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 4wgx MOLINATE HYDROLASE
(Gulosibacter
molinativorax) 		4 / 7 GLN A 298
ALA A 343
ASN A  64
GLU A 296
 None
 1.32A 1t9wA-4wgxA:
undetectable		 1t9wA-4wgxA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_B_STRB2001_2
(MINERALOCORTICOID
RECEPTOR)		 4wgx MOLINATE HYDROLASE
(Gulosibacter
molinativorax) 		3 / 3 LEU A  59
LEU A 389
MET A 374
 None
 0.76A 1ya3B-4wgxA:
undetectable		 1ya3B-4wgxA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_F_SAMF301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4wgx MOLINATE HYDROLASE
(Gulosibacter
molinativorax) 		5 / 12 GLY A  61
GLY A 367
ASP A 369
ALA A 102
ALA A  99
 None
 1.07A 2bm9F-4wgxA:
undetectable		 2bm9F-4wgxA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J7X_A_ESTA1454_1
(ESTROGEN RECEPTOR
BETA)		 4wgx MOLINATE HYDROLASE
(Gulosibacter
molinativorax) 		5 / 12 LEU A 103
GLU A 133
ILE A  28
GLY A  31
LEU A 413
 None
 1.28A 2j7xA-4wgxA:
undetectable		 2j7xA-4wgxA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_B_9CRB501_1
(CYTOCHROME P450 2C8)		 4wgx MOLINATE HYDROLASE
(Gulosibacter
molinativorax) 		5 / 9 ARG A 242
GLY A 245
VAL A 238
ILE A 210
VAL A 212
 None
 1.31A 2nnhB-4wgxA:
undetectable		 2nnhB-4wgxA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_B_9CRB501_1
(CYTOCHROME P450 2C8)		 4wgx MOLINATE HYDROLASE
(Gulosibacter
molinativorax) 		5 / 9 GLY A 245
THR A 260
VAL A 238
ILE A 210
VAL A 212
 None
 1.16A 2nnhB-4wgxA:
undetectable		 2nnhB-4wgxA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_A_KLNA1500_1
(CYTOCHROME P450 3A4)		 4wgx MOLINATE HYDROLASE
(Gulosibacter
molinativorax) 		5 / 11 LEU A  70
ILE A 137
ALA A  99
GLU A 296
LEU A 366
 None
 1.42A 2v0mA-4wgxA:
undetectable		 2v0mA-4wgxA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_A_486A1000_1
(PROGESTERONE
RECEPTOR)		 4wgx MOLINATE HYDROLASE
(Gulosibacter
molinativorax) 		5 / 12 LEU A 389
LEU A  62
GLY A  61
LEU A 424
VAL A  26
 None
 1.43A 2w8yA-4wgxA:
undetectable		 2w8yA-4wgxA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_A_486A3_1
(GLUCOCORTICOID
RECEPTOR)		 4wgx MOLINATE HYDROLASE
(Gulosibacter
molinativorax) 		5 / 12 LEU A 255
GLY A 257
VAL A 212
MET A 269
ILE A 262
 None
 1.36A 3h52A-4wgxA:
undetectable		 3h52A-4wgxA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IX9_B_MTXB200_1
(DIHYDROFOLATE
REDUCTASE)		 4wgx MOLINATE HYDROLASE
(Gulosibacter
molinativorax) 		5 / 12 ALA A 261
LEU A 258
LEU A 288
GLN A 292
LEU A 337
 None
 1.17A 3ix9B-4wgxA:
undetectable		 3ix9B-4wgxA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JAY_A_SAMA1102_1
(STRUCTURAL PROTEIN
VP3)		 4wgx MOLINATE HYDROLASE
(Gulosibacter
molinativorax) 		3 / 3 ARG A 183
ASP A 174
ASP A 153
 None
 0.78A 3jayA-4wgxA:
undetectable		 3jayA-4wgxA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB3_A_SAMA1102_1
(STRUCTURAL PROTEIN
VP3)		 4wgx MOLINATE HYDROLASE
(Gulosibacter
molinativorax) 		3 / 3 ARG A 183
ASP A 174
ASP A 153
 None
 0.81A 3jb3A-4wgxA:
undetectable		 3jb3A-4wgxA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MTE_A_SAMA220_0
(16S RRNA METHYLASE)		 4wgx MOLINATE HYDROLASE
(Gulosibacter
molinativorax) 		5 / 12 GLY A 105
GLY A 367
LEU A 448
THR A 432
LEU A 433
 None
 1.00A 3mteA-4wgxA:
undetectable		 3mteA-4wgxA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NVC_A_SALA370_1
(GENTISATE
1,2-DIOXYGENASE)		 4wgx MOLINATE HYDROLASE
(Gulosibacter
molinativorax) 		4 / 6 GLN A 298
HIS A 215
HIS A 251
ASP A 342
 None
MPD  A 502 (-3.3A)
MPD  A 502 ( 4.4A)
MPD  A 502 (-2.7A)
 1.12A 3nvcA-4wgxA:
undetectable		 3nvcA-4wgxA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_A_SAMA6735_0
(16S RRNA METHYLASE)		 4wgx MOLINATE HYDROLASE
(Gulosibacter
molinativorax) 		5 / 12 GLY A 105
GLY A 367
LEU A 448
THR A 432
LEU A 433
 None
 1.00A 3p2kA-4wgxA:
undetectable		 3p2kA-4wgxA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_B_SAMB6735_0
(16S RRNA METHYLASE)		 4wgx MOLINATE HYDROLASE
(Gulosibacter
molinativorax) 		5 / 12 GLY A 105
GLY A 367
LEU A 448
THR A 432
LEU A 433
 None
 1.04A 3p2kB-4wgxA:
undetectable		 3p2kB-4wgxA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S45_B_478B201_1
(PROTEASE)		 4wgx MOLINATE HYDROLASE
(Gulosibacter
molinativorax) 		5 / 9 ILE A 408
GLY A  37
ILE A  42
ILE A  28
ILE A  33
 None
 1.02A 3s45A-4wgxA:
undetectable		 3s45A-4wgxA:
12.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VRM_A_VD3A502_1
(VITAMIN D(3)
25-HYDROXYLASE)		 4wgx MOLINATE HYDROLASE
(Gulosibacter
molinativorax) 		5 / 12 PRO A 423
LEU A  62
LEU A 389
ALA A 393
ILE A  58
 None
 0.95A 3vrmA-4wgxA:
undetectable		 3vrmA-4wgxA:
23.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A99_C_MIYC392_1
(TETX2 PROTEIN)		 4wgx MOLINATE HYDROLASE
(Gulosibacter
molinativorax) 		5 / 12 GLU A 118
PHE A 177
VAL A  94
ILE A  95
GLU A  88
 None
 1.49A 4a99A-4wgxA:
undetectable
4a99C-4wgxA:
undetectable		 4a99A-4wgxA:
22.01
4a99C-4wgxA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E47_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 4wgx MOLINATE HYDROLASE
(Gulosibacter
molinativorax) 		5 / 11 ILE A   5
GLY A 414
GLU A 439
GLY A 106
HIS A 435
 None
 1.04A 4e47A-4wgxA:
undetectable		 4e47A-4wgxA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E47_B_SAMB800_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 4wgx MOLINATE HYDROLASE
(Gulosibacter
molinativorax) 		5 / 11 ILE A   5
GLY A 414
GLU A 439
GLY A 106
HIS A 435
 None
 1.03A 4e47B-4wgxA:
undetectable		 4e47B-4wgxA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E47_C_SAMC800_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 4wgx MOLINATE HYDROLASE
(Gulosibacter
molinativorax) 		5 / 11 ILE A   5
GLY A 414
GLU A 439
GLY A 106
HIS A 435
 None
 1.03A 4e47C-4wgxA:
undetectable		 4e47C-4wgxA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J26_A_ESTA600_1
(ESTROGEN RECEPTOR
BETA)		 4wgx MOLINATE HYDROLASE
(Gulosibacter
molinativorax) 		5 / 12 LEU A 103
GLU A 133
ILE A  28
GLY A  31
LEU A 413
 None
 1.26A 4j26A-4wgxA:
undetectable		 4j26A-4wgxA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JDS_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 4wgx MOLINATE HYDROLASE
(Gulosibacter
molinativorax) 		5 / 11 ILE A   5
GLY A 414
GLU A 439
GLY A 106
HIS A 435
 None
 1.09A 4jdsA-4wgxA:
undetectable		 4jdsA-4wgxA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JDS_B_SAMB401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 4wgx MOLINATE HYDROLASE
(Gulosibacter
molinativorax) 		5 / 11 ILE A   5
GLY A 414
GLU A 439
GLY A 106
HIS A 435
 None
 1.07A 4jdsB-4wgxA:
undetectable		 4jdsB-4wgxA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JDS_C_SAMC401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 4wgx MOLINATE HYDROLASE
(Gulosibacter
molinativorax) 		5 / 11 ILE A   5
GLY A 414
GLU A 439
GLY A 106
HIS A 435
 None
 1.05A 4jdsC-4wgxA:
undetectable		 4jdsC-4wgxA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JLG_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 4wgx MOLINATE HYDROLASE
(Gulosibacter
molinativorax) 		5 / 12 ILE A   5
GLY A 414
GLU A 439
GLY A 106
HIS A 435
 None
 1.08A 4jlgA-4wgxA:
undetectable		 4jlgA-4wgxA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_I_HCYI900_2
(GLUCOCORTICOID
RECEPTOR)		 4wgx MOLINATE HYDROLASE
(Gulosibacter
molinativorax) 		3 / 3 MET A 173
MET A 155
TYR A  83
 None
 1.14A 4p6xI-4wgxA:
undetectable		 4p6xI-4wgxA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCI_A_SAMA2409_0
(RNA-DIRECTED RNA
POLYMERASE L)		 4wgx MOLINATE HYDROLASE
(Gulosibacter
molinativorax) 		5 / 12 THR A 341
GLY A 391
GLY A  65
ASN A  66
LEU A 389
 None
None
None
MPD  A 502 ( 4.7A)
None
 0.98A 4uciA-4wgxA:
undetectable		 4uciA-4wgxA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCI_B_SAMB2409_0
(RNA-DIRECTED RNA
POLYMERASE L)		 4wgx MOLINATE HYDROLASE
(Gulosibacter
molinativorax) 		5 / 12 THR A 341
GLY A 391
GLY A  65
ASN A  66
LEU A 389
 None
None
None
MPD  A 502 ( 4.7A)
None
 0.98A 4uciB-4wgxA:
undetectable		 4uciB-4wgxA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5I_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 4wgx MOLINATE HYDROLASE
(Gulosibacter
molinativorax) 		3 / 3 ASP A 312
ARG A  78
ARG A 156
 None
None
MPD  A 501 ( 4.2A)
 0.94A 4x5iA-4wgxA:
undetectable		 4x5iA-4wgxA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XEY_A_1N1A601_2
(TYROSINE-PROTEIN
KINASE ABL1)		 4wgx MOLINATE HYDROLASE
(Gulosibacter
molinativorax) 		3 / 3 MET A 155
ASP A 174
PHE A 177
 None
 0.95A 4xeyA-4wgxA:
undetectable		 4xeyA-4wgxA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XEY_B_1N1B601_2
(TYROSINE-PROTEIN
KINASE ABL1)		 4wgx MOLINATE HYDROLASE
(Gulosibacter
molinativorax) 		3 / 3 MET A 155
ASP A 174
PHE A 177
 None
 0.99A 4xeyB-4wgxA:
undetectable		 4xeyB-4wgxA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUC_A_SAMA303_0
(CATECHOL
O-METHYLTRANSFERASE)		 4wgx MOLINATE HYDROLASE
(Gulosibacter
molinativorax) 		5 / 12 VAL A  94
GLY A 344
ILE A  73
GLN A 298
HIS A  68
 None
None
MPD  A 502 (-4.4A)
None
MPD  A 502 (-3.7A)
 1.41A 4xucA-4wgxA:
undetectable		 4xucA-4wgxA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUD_A_SAMA303_0
(CATECHOL
O-METHYLTRANSFERASE)		 4wgx MOLINATE HYDROLASE
(Gulosibacter
molinativorax) 		5 / 12 VAL A  94
GLY A 344
ILE A  73
GLN A 298
HIS A  68
 None
None
MPD  A 502 (-4.4A)
None
MPD  A 502 (-3.7A)
 1.39A 4xudA-4wgxA:
undetectable		 4xudA-4wgxA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AYF_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 4wgx MOLINATE HYDROLASE
(Gulosibacter
molinativorax) 		5 / 11 ILE A   5
GLY A 414
GLU A 439
GLY A 106
HIS A 435
 None
 1.00A 5ayfA-4wgxA:
undetectable		 5ayfA-4wgxA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FCT_B_C2FB402_0
(THYMIDYLATE SYNTHASE)		 4wgx MOLINATE HYDROLASE
(Gulosibacter
molinativorax) 		5 / 12 VAL A  67
LEU A  59
LEU A 339
MET A 374
ALA A 387
 None
 1.42A 5fctB-4wgxA:
undetectable		 5fctB-4wgxA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OV9_A_CVIA608_0
(ACETYLCHOLINESTERASE)		 4wgx MOLINATE HYDROLASE
(Gulosibacter
molinativorax) 		4 / 7 ASP A 369
THR A 365
LEU A 366
THR A 341
 None
 0.87A 5ov9A-4wgxA:
2.5		 5ov9A-4wgxA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OV9_B_CVIB602_0
(ACETYLCHOLINESTERASE)		 4wgx MOLINATE HYDROLASE
(Gulosibacter
molinativorax) 		4 / 8 ASP A 369
THR A 365
LEU A 366
THR A 341
 None
 0.88A 5ov9B-4wgxA:
2.2		 5ov9B-4wgxA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYF_B_TA1B502_1
(TUBULIN BETA CHAIN)		 4wgx MOLINATE HYDROLASE
(Gulosibacter
molinativorax) 		5 / 12 ASP A 171
LEU A 219
ASP A 153
ALA A 161
ARG A 167
 None
 1.19A 5syfB-4wgxA:
undetectable		 5syfB-4wgxA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_H_CVIH301_1
(REGULATORY PROTEIN
TETR)		 4wgx MOLINATE HYDROLASE
(Gulosibacter
molinativorax) 		4 / 8 GLY A  65
ILE A 270
ASP A 342
ASP A 112
 None
None
MPD  A 502 (-2.7A)
None
 0.88A 5vlmH-4wgxA:
undetectable		 5vlmH-4wgxA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6J_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 4wgx MOLINATE HYDROLASE
(Gulosibacter
molinativorax) 		3 / 3 MET A 274
ASP A 342
ARG A 156
 None
MPD  A 502 (-2.7A)
MPD  A 501 ( 4.2A)
 1.02A 5z6jA-4wgxA:
undetectable		 5z6jA-4wgxA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B2W_A_AG2A401_1
(PUTATIVE
PEPTIDYL-ARGININE
DEIMINASE FAMILY
PROTEIN)		 4wgx MOLINATE HYDROLASE
(Gulosibacter
molinativorax) 		5 / 10 ASP A  71
ASP A 342
ASP A 112
THR A 113
ASN A 115
 None
MPD  A 502 (-2.7A)
None
MPD  A 502 ( 4.4A)
None
 1.44A 6b2wA-4wgxA:
0.0		 6b2wA-4wgxA:
10.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXN_B_SAMB901_0
(DIPHTHAMIDE
BIOSYNTHESIS ENZYME
DPH2)		 4wgx MOLINATE HYDROLASE
(Gulosibacter
molinativorax) 		5 / 12 LEU A 117
GLY A 141
VAL A 238
CYH A 208
ILE A 210
 None
 1.46A 6bxnB-4wgxA:
undetectable		 6bxnB-4wgxA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA825_0
(GEPHYRIN)		 4wgx MOLINATE HYDROLASE
(Gulosibacter
molinativorax) 		3 / 3 LYS A  56
VAL A 418
ASP A 420
 None
 0.65A 6fgdA-4wgxA:
undetectable		 6fgdA-4wgxA:
22.13