SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4wh0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EII_A_RTLA135_0
(CELLULAR
RETINOL-BINDING
PROTEIN II)		 4wh0 PUTATIVE HYDROLASE
(Pseudomonas
aeruginosa) 		5 / 12 ALA A  13
ILE A  82
THR A  57
LEU A  56
LEU A  43
 None
 1.34A 1eiiA-4wh0A:
undetectable		 1eiiA-4wh0A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_A_RALA600_1
(ESTROGEN RECEPTOR)		 4wh0 PUTATIVE HYDROLASE
(Pseudomonas
aeruginosa) 		5 / 12 THR A 123
ALA A 126
GLU A 129
ILE A  82
LEU A  16
 None
 1.05A 1errA-4wh0A:
undetectable		 1errA-4wh0A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_A_AG2A7005_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 4wh0 PUTATIVE HYDROLASE
(Pseudomonas
aeruginosa) 		4 / 6 LEU A  24
ASP A  19
ILE A  88
ARG A  84
 None
 1.08A 1mt1A-4wh0A:
undetectable
1mt1F-4wh0A:
undetectable		 1mt1A-4wh0A:
11.94
1mt1F-4wh0A:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_B_AG2B7001_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 4wh0 PUTATIVE HYDROLASE
(Pseudomonas
aeruginosa) 		4 / 6 ILE A  88
ARG A  84
LEU A  24
ASP A  19
 None
 1.05A 1mt1B-4wh0A:
undetectable
1mt1C-4wh0A:
undetectable		 1mt1B-4wh0A:
19.51
1mt1C-4wh0A:
11.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_A_RALA600_1
(ESTROGEN RECEPTOR)		 4wh0 PUTATIVE HYDROLASE
(Pseudomonas
aeruginosa) 		5 / 12 THR A 123
ALA A 126
GLU A 129
ILE A  82
LEU A  16
 None
 1.03A 2jfaA-4wh0A:
undetectable		 2jfaA-4wh0A:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_A_AG2A671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 4wh0 PUTATIVE HYDROLASE
(Pseudomonas
aeruginosa) 		4 / 7 ILE A  88
ARG A  84
LEU A  24
ASP A  19
 None
 1.05A 2qqcB-4wh0A:
undetectable
2qqcC-4wh0A:
undetectable		 2qqcB-4wh0A:
19.51
2qqcC-4wh0A:
11.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_A_AG2A672_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 4wh0 PUTATIVE HYDROLASE
(Pseudomonas
aeruginosa) 		4 / 7 LEU A  24
ASP A  19
ILE A  88
ARG A  84
 None
 1.06A 2qqcA-4wh0A:
undetectable
2qqcF-4wh0A:
undetectable		 2qqcA-4wh0A:
11.94
2qqcF-4wh0A:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_I_AG2I671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 4wh0 PUTATIVE HYDROLASE
(Pseudomonas
aeruginosa) 		4 / 7 LEU A  24
ASP A  19
ILE A  88
ARG A  84
 None
 1.07A 2qqcG-4wh0A:
undetectable
2qqcJ-4wh0A:
undetectable		 2qqcG-4wh0A:
11.94
2qqcJ-4wh0A:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_I_AG2I672_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 4wh0 PUTATIVE HYDROLASE
(Pseudomonas
aeruginosa) 		4 / 7 LEU A  24
ASP A  19
ILE A  88
ARG A  84
 None
 1.03A 2qqcI-4wh0A:
undetectable
2qqcL-4wh0A:
undetectable		 2qqcI-4wh0A:
11.94
2qqcL-4wh0A:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B235_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		 4wh0 PUTATIVE HYDROLASE
(Pseudomonas
aeruginosa) 		4 / 6 PHE A 166
GLY A 188
GLY A 189
ASN A  38
 None
 0.85A 2qr2A-4wh0A:
undetectable
2qr2B-4wh0A:
4.2		 2qr2A-4wh0A:
21.17
2qr2B-4wh0A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CR5_X_PNTX94_0
(PROTEIN S100-B)		 4wh0 PUTATIVE HYDROLASE
(Pseudomonas
aeruginosa) 		3 / 3 PHE A 166
CYH A 170
PHE A 183
 None
 1.02A 3cr5X-4wh0A:
undetectable		 3cr5X-4wh0A:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_B_GCSB302_1
(CHITOSANASE)		 4wh0 PUTATIVE HYDROLASE
(Pseudomonas
aeruginosa) 		4 / 5 ARG A 148
THR A 142
THR A 115
ASP A 116
 None
 1.40A 4oltB-4wh0A:
undetectable		 4oltB-4wh0A:
25.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_A_GCSA302_1
(CHITOSANASE)		 4wh0 PUTATIVE HYDROLASE
(Pseudomonas
aeruginosa) 		4 / 5 ARG A 148
THR A 142
THR A 115
ASP A 116
 None
 1.40A 4qwpA-4wh0A:
undetectable		 4qwpA-4wh0A:
25.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1N_G_DVAG9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 4wh0 PUTATIVE HYDROLASE
(Pseudomonas
aeruginosa) 		3 / 3 ALA A 193
ASN A 196
LEU A 197
 None
 0.24A 5i1nB-4wh0A:
undetectable		 5i1nB-4wh0A:
11.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1O_F_DVAF9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 4wh0 PUTATIVE HYDROLASE
(Pseudomonas
aeruginosa) 		3 / 3 ALA A 193
ASN A 196
LEU A 197
 None
 0.39A 5i1oC-4wh0A:
undetectable		 5i1oC-4wh0A:
11.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1P_F_DVAF9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 4wh0 PUTATIVE HYDROLASE
(Pseudomonas
aeruginosa) 		3 / 3 ALA A 193
ASN A 196
LEU A 197
 None
 0.35A 5i1pA-4wh0A:
undetectable		 5i1pA-4wh0A:
11.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LBT_A_6T0A303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4wh0 PUTATIVE HYDROLASE
(Pseudomonas
aeruginosa) 		5 / 10 PHE A 166
ILE A  46
GLY A 188
GLY A 189
ASN A  38
 None
 1.42A 5lbtA-4wh0A:
4.3
5lbtB-4wh0A:
4.4		 5lbtA-4wh0A:
20.29
5lbtB-4wh0A:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5Y_D_9CRD501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4wh0 PUTATIVE HYDROLASE
(Pseudomonas
aeruginosa) 		3 / 3 ASN A  38
VAL A 113
HIS A  20
 None
 0.82A 6a5yD-4wh0A:
undetectable		 6a5yD-4wh0A:
18.23