SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4whb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_A_ADNA601_2
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 4whb PHENYLUREA HYDROLASE
B
(Mycolicibacteriu
m
brisbanense) 		4 / 5 THR E 230
THR E 142
HIS E 114
HIS E 180
 None
 1.41A 1d4fA-4whbE:
undetectable		 1d4fA-4whbE:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_D_ADND604_2
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 4whb PHENYLUREA HYDROLASE
B
(Mycolicibacteriu
m
brisbanense) 		4 / 5 THR E 230
THR E 142
HIS E 114
HIS E 180
 None
 1.35A 1d4fD-4whbE:
undetectable		 1d4fD-4whbE:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_D_SAMD3293_0
(GLYCINE
N-METHYLTRANSFERASE)		 4whb PHENYLUREA HYDROLASE
B
(Mycolicibacteriu
m
brisbanense) 		5 / 12 GLY E  64
VAL E  66
ASP E 112
ALA E 398
LEU E 415
 None
 1.34A 1kiaD-4whbE:
undetectable		 1kiaD-4whbE:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MSK_A_SAMA1301_0
(COBALAMIN-DEPENDENT
METHIONINE SYNTHASE)		 4whb PHENYLUREA HYDROLASE
B
(Mycolicibacteriu
m
brisbanense) 		5 / 10 ASP E 211
ALA E 319
TYR E 325
PRO E 324
ALA E 326
 None
 1.49A 1mskA-4whbE:
undetectable		 1mskA-4whbE:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NRM_A_DVAA6_0
(GRAMICIDIN A)		 4whb PHENYLUREA HYDROLASE
B
(Mycolicibacteriu
m
brisbanense) 		3 / 3 ALA E 404
VAL E 397
TRP E 296
 None
 0.93A 1nrmA-4whbE:
undetectable		 1nrmA-4whbE:
4.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NRM_B_DVAB6_0
(GRAMICIDIN A)		 4whb PHENYLUREA HYDROLASE
B
(Mycolicibacteriu
m
brisbanense) 		3 / 3 ALA E 404
VAL E 397
TRP E 296
 None
 0.93A 1nrmB-4whbE:
undetectable		 1nrmB-4whbE:
4.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG1_A_SPMA999_1
(TYROSYL-DNA
PHOSPHODIESTERASE 1)		 4whb PHENYLUREA HYDROLASE
B
(Mycolicibacteriu
m
brisbanense) 		3 / 3 TRP E  56
VAL E 426
PRO E 425
 None
 0.95A 1rg1A-4whbE:
undetectable		 1rg1A-4whbE:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RH0_A_SPMA999_1
(TYROSYL-DNA
PHOSPHODIESTERASE 1)		 4whb PHENYLUREA HYDROLASE
B
(Mycolicibacteriu
m
brisbanense) 		3 / 3 TRP E  56
VAL E 426
PRO E 425
 None
 0.95A 1rh0A-4whbE:
undetectable		 1rh0A-4whbE:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNI_A_MTKA501_1
(CYTOCHROME P450 2C8)		 4whb PHENYLUREA HYDROLASE
B
(Mycolicibacteriu
m
brisbanense) 		5 / 12 SER E 210
SER E 254
THR E 252
SER E 263
ASN E 342
 None
 1.22A 2nniA-4whbE:
undetectable		 2nniA-4whbE:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNI_A_MTKA501_1
(CYTOCHROME P450 2C8)		 4whb PHENYLUREA HYDROLASE
B
(Mycolicibacteriu
m
brisbanense) 		5 / 12 THR E 301
SER E 378
ASN E  65
ALA E 392
VAL E 107
 None
 1.27A 2nniA-4whbE:
undetectable		 2nniA-4whbE:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3M_B_FOLB1188_0
(DIHYDROFOLATE
REDUCTASE)		 4whb PHENYLUREA HYDROLASE
B
(Mycolicibacteriu
m
brisbanense) 		5 / 12 ALA E 321
LEU E 310
GLN E 377
ASN E 370
TYR E 276
 None
 1.32A 2w3mB-4whbE:
undetectable		 2w3mB-4whbE:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_A_SALA1302_1
(LYSR-TYPE REGULATORY
PROTEIN)		 4whb PHENYLUREA HYDROLASE
B
(Mycolicibacteriu
m
brisbanense) 		5 / 11 THR E 113
ILE E 143
PHE E 154
HIS E 212
HIS E 273
 None
 1.24A 2y7kA-4whbE:
undetectable		 2y7kA-4whbE:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_B_SALB1304_1
(LYSR-TYPE REGULATORY
PROTEIN)		 4whb PHENYLUREA HYDROLASE
B
(Mycolicibacteriu
m
brisbanense) 		5 / 10 THR E 113
ILE E 143
PHE E 154
HIS E 212
HIS E 273
 None
 1.27A 2y7kB-4whbE:
undetectable		 2y7kB-4whbE:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7P_A_SALA1000_1
(LYSR-TYPE REGULATORY
PROTEIN)		 4whb PHENYLUREA HYDROLASE
B
(Mycolicibacteriu
m
brisbanense) 		5 / 10 THR E 113
ILE E 143
PHE E 154
HIS E 212
HIS E 273
 None
 1.24A 2y7pA-4whbE:
undetectable		 2y7pA-4whbE:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM4_A_DR7A100_2
(PROTEASE)		 4whb PHENYLUREA HYDROLASE
B
(Mycolicibacteriu
m
brisbanense) 		5 / 9 ALA E 337
GLY E 298
LEU E 340
VAL E 264
ILE E 290
 None
 1.16A 3em4B-4whbE:
undetectable		 3em4B-4whbE:
13.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JUS_B_ECNB602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4whb PHENYLUREA HYDROLASE
B
(Mycolicibacteriu
m
brisbanense) 		5 / 9 THR E 142
PHE E 154
GLY E 145
ALA E 208
ILE E 272
 None
 1.11A 3jusB-4whbE:
undetectable		 3jusB-4whbE:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW5_A_TOPA208_1
(DIHYDROFOLATE
REDUCTASE)		 4whb PHENYLUREA HYDROLASE
B
(Mycolicibacteriu
m
brisbanense) 		5 / 11 ALA E 297
ASN E 331
LEU E 332
LEU E 260
VAL E 264
 None
 1.23A 3jw5A-4whbE:
undetectable		 3jw5A-4whbE:
14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_B_CGEB501_1
(CYTOCHROME P450 2B4)		 4whb PHENYLUREA HYDROLASE
B
(Mycolicibacteriu
m
brisbanense) 		4 / 8 ILE E   6
PHE E 439
VAL E 410
VAL E  25
 None
 0.92A 3me6B-4whbE:
undetectable		 3me6B-4whbE:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AN2_A_EUIA1382_2
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 4whb PHENYLUREA HYDROLASE
B
(Mycolicibacteriu
m
brisbanense) 		4 / 4 ASN E 331
SER E 254
LEU E 260
THR E 327
 None
 1.40A 4an2A-4whbE:
undetectable		 4an2A-4whbE:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KQ8_A_ASDA602_1
(CYTOCHROME P450 19A1)		 4whb PHENYLUREA HYDROLASE
B
(Mycolicibacteriu
m
brisbanense) 		5 / 10 ILE E 137
ALA E 139
ASP E 112
MET E 173
LEU E  69
 None
 1.42A 4kq8A-4whbE:
undetectable		 4kq8A-4whbE:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYK_B_IMNB300_1
(LACTOYLGLUTATHIONE
LYASE)		 4whb PHENYLUREA HYDROLASE
B
(Mycolicibacteriu
m
brisbanense) 		5 / 12 ALA E 317
PHE E 224
LEU E 278
GLY E  77
MET E  75
 None
 1.19A 4kykA-4whbE:
undetectable
4kykB-4whbE:
undetectable		 4kykA-4whbE:
16.20
4kykB-4whbE:
16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_A_SHHA404_2
(HISTONE DEACETYLASE
8)		 4whb PHENYLUREA HYDROLASE
B
(Mycolicibacteriu
m
brisbanense) 		3 / 3 PRO E 249
MET E 204
TYR E 401
 None
 1.01A 4qa0B-4whbE:
undetectable		 4qa0B-4whbE:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_B_SHHB404_1
(HISTONE DEACETYLASE
8)		 4whb PHENYLUREA HYDROLASE
B
(Mycolicibacteriu
m
brisbanense) 		3 / 3 PRO E 249
MET E 204
TYR E 401
 None
 1.07A 4qa0A-4whbE:
undetectable		 4qa0A-4whbE:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QN9_B_DXCB610_0
(N-ACYL-PHOSPHATIDYLE
THANOLAMINE-HYDROLYZ
ING PHOSPHOLIPASE D)		 4whb PHENYLUREA HYDROLASE
B
(Mycolicibacteriu
m
brisbanense) 		3 / 3 GLY E 148
PRO E 149
ALA E  71
 None
 0.55A 4qn9B-4whbE:
1.4		 4qn9B-4whbE:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVL_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4whb PHENYLUREA HYDROLASE
B
(Mycolicibacteriu
m
brisbanense) 		5 / 11 HIS E 273
THR E 113
GLY E 145
ALA E 208
THR E 230
 None
 1.41A 4qvlV-4whbE:
undetectable
4qvlb-4whbE:
undetectable		 4qvlV-4whbE:
21.85
4qvlb-4whbE:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVL_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4whb PHENYLUREA HYDROLASE
B
(Mycolicibacteriu
m
brisbanense) 		5 / 11 HIS E 273
THR E 113
GLY E 145
ALA E 208
THR E 230
 None
 1.42A 4qvlH-4whbE:
undetectable
4qvlN-4whbE:
undetectable		 4qvlH-4whbE:
21.85
4qvlN-4whbE:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVM_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4whb PHENYLUREA HYDROLASE
B
(Mycolicibacteriu
m
brisbanense) 		5 / 11 HIS E 273
THR E 113
GLY E 145
ALA E 208
THR E 230
 None
 1.41A 4qvmV-4whbE:
undetectable
4qvmb-4whbE:
undetectable		 4qvmV-4whbE:
21.85
4qvmb-4whbE:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVM_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4whb PHENYLUREA HYDROLASE
B
(Mycolicibacteriu
m
brisbanense) 		5 / 11 HIS E 273
THR E 113
GLY E 145
ALA E 208
THR E 230
 None
 1.42A 4qvmH-4whbE:
undetectable
4qvmN-4whbE:
undetectable		 4qvmH-4whbE:
21.85
4qvmN-4whbE:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVP_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4whb PHENYLUREA HYDROLASE
B
(Mycolicibacteriu
m
brisbanense) 		5 / 11 HIS E 273
THR E 113
GLY E 145
ALA E 208
THR E 230
 None
 1.43A 4qvpV-4whbE:
undetectable
4qvpb-4whbE:
undetectable		 4qvpV-4whbE:
21.85
4qvpb-4whbE:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVP_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4whb PHENYLUREA HYDROLASE
B
(Mycolicibacteriu
m
brisbanense) 		5 / 11 HIS E 273
THR E 113
GLY E 145
ALA E 208
THR E 230
 None
 1.43A 4qvpH-4whbE:
undetectable
4qvpN-4whbE:
undetectable		 4qvpH-4whbE:
21.85
4qvpN-4whbE:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVQ_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4whb PHENYLUREA HYDROLASE
B
(Mycolicibacteriu
m
brisbanense) 		5 / 11 HIS E 273
THR E 113
GLY E 145
ALA E 208
THR E 230
 None
 1.42A 4qvqV-4whbE:
undetectable
4qvqb-4whbE:
undetectable		 4qvqV-4whbE:
21.85
4qvqb-4whbE:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVQ_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4whb PHENYLUREA HYDROLASE
B
(Mycolicibacteriu
m
brisbanense) 		5 / 11 HIS E 273
THR E 113
GLY E 145
ALA E 208
THR E 230
 None
 1.43A 4qvqH-4whbE:
undetectable
4qvqN-4whbE:
undetectable		 4qvqH-4whbE:
21.85
4qvqN-4whbE:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVW_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4whb PHENYLUREA HYDROLASE
B
(Mycolicibacteriu
m
brisbanense) 		5 / 11 HIS E 273
THR E 113
GLY E 145
ALA E 208
THR E 230
 None
 1.42A 4qvwV-4whbE:
undetectable
4qvwb-4whbE:
undetectable		 4qvwV-4whbE:
21.85
4qvwb-4whbE:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVW_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4whb PHENYLUREA HYDROLASE
B
(Mycolicibacteriu
m
brisbanense) 		5 / 11 HIS E 273
THR E 113
GLY E 145
ALA E 208
THR E 230
 None
 1.42A 4qvwH-4whbE:
undetectable
4qvwN-4whbE:
undetectable		 4qvwH-4whbE:
21.85
4qvwN-4whbE:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4whb PHENYLUREA HYDROLASE
B
(Mycolicibacteriu
m
brisbanense) 		5 / 11 HIS E 273
THR E 113
GLY E 145
ALA E 208
THR E 230
 None
 1.40A 4qw0V-4whbE:
undetectable
4qw0b-4whbE:
undetectable		 4qw0V-4whbE:
21.85
4qw0b-4whbE:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4whb PHENYLUREA HYDROLASE
B
(Mycolicibacteriu
m
brisbanense) 		5 / 11 HIS E 273
THR E 113
GLY E 145
ALA E 208
THR E 230
 None
 1.40A 4qw0H-4whbE:
undetectable
4qw0N-4whbE:
undetectable		 4qw0H-4whbE:
21.85
4qw0N-4whbE:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW1_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4whb PHENYLUREA HYDROLASE
B
(Mycolicibacteriu
m
brisbanense) 		5 / 11 HIS E 273
THR E 113
GLY E 145
ALA E 208
THR E 230
 None
 1.42A 4qw1V-4whbE:
undetectable
4qw1b-4whbE:
undetectable		 4qw1V-4whbE:
21.85
4qw1b-4whbE:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW1_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4whb PHENYLUREA HYDROLASE
B
(Mycolicibacteriu
m
brisbanense) 		5 / 11 HIS E 273
THR E 113
GLY E 145
ALA E 208
THR E 230
 None
 1.42A 4qw1H-4whbE:
undetectable
4qw1N-4whbE:
undetectable		 4qw1H-4whbE:
21.85
4qw1N-4whbE:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW3_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4whb PHENYLUREA HYDROLASE
B
(Mycolicibacteriu
m
brisbanense) 		5 / 11 HIS E 273
THR E 113
GLY E 145
ALA E 208
THR E 230
 None
 1.41A 4qw3V-4whbE:
undetectable
4qw3b-4whbE:
undetectable		 4qw3V-4whbE:
21.85
4qw3b-4whbE:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW3_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4whb PHENYLUREA HYDROLASE
B
(Mycolicibacteriu
m
brisbanense) 		5 / 11 HIS E 273
THR E 113
GLY E 145
ALA E 208
THR E 230
 None
 1.42A 4qw3H-4whbE:
undetectable
4qw3N-4whbE:
undetectable		 4qw3H-4whbE:
21.85
4qw3N-4whbE:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWU_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4whb PHENYLUREA HYDROLASE
B
(Mycolicibacteriu
m
brisbanense) 		5 / 11 HIS E 273
THR E 113
GLY E 145
ALA E 208
THR E 230
 None
 1.45A 4qwuV-4whbE:
undetectable
4qwub-4whbE:
undetectable		 4qwuV-4whbE:
21.85
4qwub-4whbE:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWU_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4whb PHENYLUREA HYDROLASE
B
(Mycolicibacteriu
m
brisbanense) 		5 / 11 HIS E 273
THR E 113
GLY E 145
ALA E 208
THR E 230
 None
 1.45A 4qwuH-4whbE:
undetectable
4qwuN-4whbE:
undetectable		 4qwuH-4whbE:
21.85
4qwuN-4whbE:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYN_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 2)		 4whb PHENYLUREA HYDROLASE
B
(Mycolicibacteriu
m
brisbanense) 		5 / 12 ALA E 243
TYR E 401
VAL E 397
LEU E 251
TRP E 296
 None
 1.34A 4qynA-4whbE:
undetectable		 4qynA-4whbE:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5Q_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 4whb PHENYLUREA HYDROLASE
B
(Mycolicibacteriu
m
brisbanense) 		4 / 6 ARG E 136
ILE E 137
ILE E 407
ASP E 417
 None
 0.93A 4w5qA-4whbE:
undetectable		 4w5qA-4whbE:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4F_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 4whb PHENYLUREA HYDROLASE
B
(Mycolicibacteriu
m
brisbanense) 		4 / 4 VAL E 144
ALA E 208
PHE E 231
THR E 230
 None
 1.20A 4z4fA-4whbE:
undetectable		 4z4fA-4whbE:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4G_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 4whb PHENYLUREA HYDROLASE
B
(Mycolicibacteriu
m
brisbanense) 		4 / 7 ARG E 136
ILE E 137
ILE E 407
ASP E 417
 None
 0.99A 4z4gA-4whbE:
undetectable		 4z4gA-4whbE:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4H_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 4whb PHENYLUREA HYDROLASE
B
(Mycolicibacteriu
m
brisbanense) 		4 / 4 VAL E 144
ALA E 208
PHE E 231
THR E 230
 None
 1.21A 4z4hA-4whbE:
undetectable		 4z4hA-4whbE:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE2_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4whb PHENYLUREA HYDROLASE
B
(Mycolicibacteriu
m
brisbanense) 		5 / 12 GLY E 141
TYR E  83
LEU E  84
GLY E  77
THR E 142
 None
 1.03A 4ze2A-4whbE:
undetectable		 4ze2A-4whbE:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AOX_C_ACTC1001_0
(ALU JO CONSENSUS RNA
SIGNAL RECOGNITION
PARTICLE 14 KDA
PROTEIN)		 4whb PHENYLUREA HYDROLASE
B
(Mycolicibacteriu
m
brisbanense) 		3 / 3 TYR E  61
THR E 108
THR E 394
 None
 0.71A 5aoxB-4whbE:
0.2		 5aoxB-4whbE:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AOX_F_ACTF1001_0
(ALU JO CONSENSUS RNA
SIGNAL RECOGNITION
PARTICLE 14 KDA
PROTEIN)		 4whb PHENYLUREA HYDROLASE
B
(Mycolicibacteriu
m
brisbanense) 		3 / 3 TYR E  61
THR E 108
THR E 394
 None
 0.65A 5aoxE-4whbE:
undetectable		 5aoxE-4whbE:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BXN_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4whb PHENYLUREA HYDROLASE
B
(Mycolicibacteriu
m
brisbanense) 		5 / 11 HIS E 273
THR E 113
GLY E 145
ALA E 208
THR E 230
 None
 1.42A 5bxnV-4whbE:
undetectable
5bxnb-4whbE:
undetectable		 5bxnV-4whbE:
21.85
5bxnb-4whbE:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BXN_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4whb PHENYLUREA HYDROLASE
B
(Mycolicibacteriu
m
brisbanense) 		5 / 11 HIS E 273
THR E 113
GLY E 145
ALA E 208
THR E 230
 None
 1.43A 5bxnH-4whbE:
undetectable
5bxnN-4whbE:
undetectable		 5bxnH-4whbE:
21.85
5bxnN-4whbE:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CZ7_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4whb PHENYLUREA HYDROLASE
B
(Mycolicibacteriu
m
brisbanense) 		5 / 11 HIS E 273
THR E 113
GLY E 145
ALA E 208
THR E 230
 None
 1.42A 5cz7H-4whbE:
undetectable
5cz7N-4whbE:
undetectable		 5cz7H-4whbE:
21.85
5cz7N-4whbE:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0X_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4whb PHENYLUREA HYDROLASE
B
(Mycolicibacteriu
m
brisbanense) 		5 / 11 HIS E 273
THR E 113
GLY E 145
ALA E 208
THR E 230
 None
 1.40A 5d0xV-4whbE:
undetectable
5d0xb-4whbE:
undetectable		 5d0xV-4whbE:
21.85
5d0xb-4whbE:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0X_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4whb PHENYLUREA HYDROLASE
B
(Mycolicibacteriu
m
brisbanense) 		5 / 11 HIS E 273
THR E 113
GLY E 145
ALA E 208
THR E 230
 None
 1.41A 5d0xH-4whbE:
undetectable
5d0xN-4whbE:
undetectable		 5d0xH-4whbE:
21.85
5d0xN-4whbE:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IH0_A_ERYA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 4whb PHENYLUREA HYDROLASE
B
(Mycolicibacteriu
m
brisbanense) 		4 / 6 ASP E 344
HIS E  67
ILE E 368
TYR E 401
 None
 1.06A 5ih0A-4whbE:
undetectable		 5ih0A-4whbE:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4whb PHENYLUREA HYDROLASE
B
(Mycolicibacteriu
m
brisbanense) 		5 / 12 HIS E 372
THR E 108
THR E 109
SER E 409
GLY E 408
 None
 1.14A 5l5zV-4whbE:
undetectable
5l5zb-4whbE:
undetectable		 5l5zV-4whbE:
21.85
5l5zb-4whbE:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4whb PHENYLUREA HYDROLASE
B
(Mycolicibacteriu
m
brisbanense) 		5 / 12 HIS E 372
THR E 108
THR E 109
SER E 409
GLY E 408
 None
 1.14A 5l5zH-4whbE:
undetectable
5l5zN-4whbE:
undetectable		 5l5zH-4whbE:
21.85
5l5zN-4whbE:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4whb PHENYLUREA HYDROLASE
B
(Mycolicibacteriu
m
brisbanense) 		5 / 11 HIS E 273
THR E 113
GLY E 145
ALA E 208
THR E 230
 None
 1.40A 5l66V-4whbE:
undetectable
5l66b-4whbE:
undetectable		 5l66V-4whbE:
21.85
5l66b-4whbE:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4whb PHENYLUREA HYDROLASE
B
(Mycolicibacteriu
m
brisbanense) 		5 / 11 HIS E 273
THR E 113
GLY E 145
ALA E 208
THR E 230
 None
 1.40A 5l66H-4whbE:
undetectable
5l66N-4whbE:
undetectable		 5l66H-4whbE:
21.85
5l66N-4whbE:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SVL_A_ACTA411_0
(P2X PURINOCEPTOR 3)		 4whb PHENYLUREA HYDROLASE
B
(Mycolicibacteriu
m
brisbanense) 		4 / 5 GLN E 300
VAL E  66
ASP E 344
ASN E  63
 None
 1.31A 5svlA-4whbE:
undetectable		 5svlA-4whbE:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1801_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 4whb PHENYLUREA HYDROLASE
B
(Mycolicibacteriu
m
brisbanense) 		4 / 6 ILE E 207
ILE E 213
HIS E 273
PHE E 156
 None
 0.67A 5vkqA-4whbE:
undetectable
5vkqB-4whbE:
undetectable		 5vkqA-4whbE:
14.69
5vkqB-4whbE:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1807_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 4whb PHENYLUREA HYDROLASE
B
(Mycolicibacteriu
m
brisbanense) 		4 / 6 PHE E 156
ILE E 207
ILE E 213
HIS E 273
 None
 0.66A 5vkqA-4whbE:
undetectable
5vkqD-4whbE:
undetectable		 5vkqA-4whbE:
14.69
5vkqD-4whbE:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BM5_A_SAMA1301_0
(METHIONINE SYNTHASE)		 4whb PHENYLUREA HYDROLASE
B
(Mycolicibacteriu
m
brisbanense) 		5 / 11 ASP E 211
ALA E 319
PRO E 324
ALA E 326
TYR E 276
 None
 1.40A 6bm5A-4whbE:
undetectable		 6bm5A-4whbE:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CBD_A_TRPA903_0
(PROTEIN ARGONAUTE-2)		 4whb PHENYLUREA HYDROLASE
B
(Mycolicibacteriu
m
brisbanense) 		4 / 6 ARG E 136
ILE E 137
ILE E 407
ASP E 417
 None
 0.94A 6cbdA-4whbE:
undetectable		 6cbdA-4whbE:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CJK_C_ACTC301_0
(IMMUNOGLOBULIN FAB
LIGHT CHAIN)		 4whb PHENYLUREA HYDROLASE
B
(Mycolicibacteriu
m
brisbanense) 		4 / 4 VAL E  27
GLY E 442
ASP E  30
ASP E 417
 None
 1.45A 6cjkC-4whbE:
undetectable		 6cjkC-4whbE:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6I_A_8PRA509_1
(ENVELOPE
GLYCOPROTEIN,GP,GP1
ENVELOPE
GLYCOPROTEIN)		 4whb PHENYLUREA HYDROLASE
B
(Mycolicibacteriu
m
brisbanense) 		5 / 12 VAL E  66
LEU E  68
ALA E 345
GLY E 346
LEU E 341
 None
 0.89A 6f6iA-4whbE:
undetectable
6f6iB-4whbE:
undetectable		 6f6iA-4whbE:
12.13
6f6iB-4whbE:
11.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_S_PCFS603_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 8
CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL)		 4whb PHENYLUREA HYDROLASE
B
(Mycolicibacteriu
m
brisbanense) 		5 / 7 GLN E 280
GLY E 279
PHE E 224
VAL E 222
SER E 227
 None
 1.46A 6hu9S-4whbE:
undetectable
6hu9q-4whbE:
undetectable		 6hu9S-4whbE:
15.47
6hu9q-4whbE:
13.23