SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4whn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5Q_B_CFFB1864_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 4whn APXC
(Actinobacillus
pleuropneumoniae) 		3 / 3 TRP A  60
HIS A 107
MET A 108
 None
 1.40A 1l5qB-4whnA:
undetectable		 1l5qB-4whnA:
13.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_B_THHB643_0
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 4whn APXC
(Actinobacillus
pleuropneumoniae) 		5 / 12 GLU A  41
ASN A  43
VAL A  14
GLY A   7
ILE A  40
 None
 1.24A 3k13B-4whnA:
undetectable		 3k13B-4whnA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V35_A_NTIA317_1
(ALDOSE REDUCTASE)		 4whn APXC
(Actinobacillus
pleuropneumoniae) 		4 / 8 HIS A  24
TRP A  18
PHE A  57
TRP A  83
 None
 1.34A 3v35A-4whnA:
undetectable		 3v35A-4whnA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BLV_A_SAMA1281_1
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 4whn APXC
(Actinobacillus
pleuropneumoniae) 		4 / 6 HIS A 152
SER A 157
GLU A  68
ASP A  87
 None
 1.22A 4blvA-4whnA:
undetectable		 4blvA-4whnA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA705_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 4whn APXC
(Actinobacillus
pleuropneumoniae) 		5 / 9 ALA A 144
PHE A 148
LEU A 116
ILE A 139
PHE A 134
 None
 1.42A 5i73A-4whnA:
undetectable		 5i73A-4whnA:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 4whn APXC
(Actinobacillus
pleuropneumoniae) 		4 / 6 PRO A  54
HIS A  24
ALA A  33
LEU A  37
 None
 1.06A 5igiA-4whnA:
undetectable		 5igiA-4whnA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_B_GLYB709_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 4whn APXC
(Actinobacillus
pleuropneumoniae) 		4 / 5 GLY A  86
ASN A  62
ARG A  88
ARG A  89
 None
 1.40A 6dwdB-4whnA:
undetectable
6dwdD-4whnA:
undetectable		 6dwdB-4whnA:
16.91
6dwdD-4whnA:
16.91