SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4who'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG3_A_ADNA500_1
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)		 4who PROTOCATECHUATE
3,4-DIOXYGENASE
ALPHA CHAIN
(Pseudomonas
putida) 		5 / 11 GLY A  60
GLY A  58
ILE A 189
ASP A 186
LEU A  62
 None
 1.12A 1jg3A-4whoA:
undetectable		 1jg3A-4whoA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG3_B_ADNB550_1
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)		 4who PROTOCATECHUATE
3,4-DIOXYGENASE
ALPHA CHAIN
(Pseudomonas
putida) 		5 / 11 GLY A  60
GLY A  58
ILE A 189
ASP A 186
LEU A  62
 None
 1.12A 1jg3B-4whoA:
undetectable		 1jg3B-4whoA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TQB_A_FOLA2001_0
(DIHYDROFOLATE
REDUCTASE)		 4who PROTOCATECHUATE
3,4-DIOXYGENASE
ALPHA CHAIN
(Pseudomonas
putida) 		5 / 11 ALA A 172
LEU A  51
THR A 141
LEU A  68
ILE A 187
 None
 1.03A 3tqbA-4whoA:
undetectable		 3tqbA-4whoA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N48_A_SAMA601_0
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 4who PROTOCATECHUATE
3,4-DIOXYGENASE
ALPHA CHAIN
(Pseudomonas
putida) 		5 / 12 GLY A 112
GLY A  77
ILE A  49
THR A 181
GLY A  46
 None
 1.02A 4n48A-4whoA:
undetectable		 4n48A-4whoA:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N48_B_SAMB601_0
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 4who PROTOCATECHUATE
3,4-DIOXYGENASE
ALPHA CHAIN
(Pseudomonas
putida) 		5 / 12 GLY A 112
GLY A  77
ILE A  49
THR A 181
GLY A  46
 None
 1.02A 4n48B-4whoA:
undetectable		 4n48B-4whoA:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RP8_C_ASCC501_0
(ASCORBATE-SPECIFIC
PERMEASE IIC
COMPONENT ULAA)		 4who PROTOCATECHUATE
3,4-DIOXYGENASE
ALPHA CHAIN
(Pseudomonas
putida) 		5 / 12 THR A 108
ILE A 126
GLN A  72
ALA A 172
ILE A  49
 None
 1.09A 4rp8C-4whoA:
undetectable		 4rp8C-4whoA:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RP9_A_ASCA501_0
(ASCORBATE-SPECIFIC
PERMEASE IIC
COMPONENT ULAA)		 4who PROTOCATECHUATE
3,4-DIOXYGENASE
ALPHA CHAIN
(Pseudomonas
putida) 		5 / 12 THR A 108
ILE A 126
GLN A  72
ALA A 172
ILE A  49
 None
 1.13A 4rp9A-4whoA:
undetectable		 4rp9A-4whoA:
17.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5DZK_1_BEZ1801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 4who PROTOCATECHUATE
3,4-DIOXYGENASE
ALPHA CHAIN
(Pseudomonas
putida) 		3 / 3 LEU A 160
PHE A 198
ILE A 161
 None
 0.71A 5dzk1-4whoA:
undetectable
5dzkF-4whoA:
undetectable
5dzkM-4whoA:
undetectable		 5dzk1-4whoA:
40.00
5dzkF-4whoA:
24.44
5dzkM-4whoA:
21.56