SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4whx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I9G_A_SAMA301_1
(HYPOTHETICAL PROTEIN
RV2118C)		 4whx BRANCHED-CHAIN-AMINO
-ACID TRANSAMINASE
(Burkholderia
pseudomallei) 		3 / 3 GLU A  39
HIS A  59
ASP A 219
 LLP  A 161 ( 3.9A)
LLP  A 161 ( 4.9A)
None
 0.76A 1i9gA-4whxA:
undetectable		 1i9gA-4whxA:
24.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_K_AG2K7002_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 4whx BRANCHED-CHAIN-AMINO
-ACID TRANSAMINASE
(Burkholderia
pseudomallei) 		4 / 7 GLU A 199
LEU A 132
ASP A 182
GLY A 180
 None
 0.85A 1mt1H-4whxA:
undetectable
1mt1K-4whxA:
undetectable		 1mt1H-4whxA:
18.39
1mt1K-4whxA:
12.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_H_AG2H7012_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 4whx BRANCHED-CHAIN-AMINO
-ACID TRANSAMINASE
(Burkholderia
pseudomallei) 		4 / 6 GLU A 199
LEU A 132
ASP A 182
GLY A 180
 None
 0.91A 1n13H-4whxA:
undetectable
1n13K-4whxA:
undetectable		 1n13H-4whxA:
18.39
1n13K-4whxA:
12.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TD7_A_NFLA2001_1
(PHOSPHOLIPASE A2
ISOFORM 3)		 4whx BRANCHED-CHAIN-AMINO
-ACID TRANSAMINASE
(Burkholderia
pseudomallei) 		5 / 9 LEU A 132
ILE A 265
PHE A 201
GLY A 198
TYR A 131
 None
None
None
ALA  A 401 (-4.0A)
EDO  A 402 (-3.7A)
 1.37A 1td7A-4whxA:
undetectable		 1td7A-4whxA:
12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1H_A_GBNA502_1
(BRANCHED CHAIN
AMINOTRANSFERASE)		 4whx BRANCHED-CHAIN-AMINO
-ACID TRANSAMINASE
(Burkholderia
pseudomallei) 		5 / 8 TYR A  98
ARG A 100
GLY A 257
THR A 258
ALA A 259
 ALA  A 401 (-4.3A)
ALA  A 401 ( 4.6A)
LLP  A 161 ( 3.4A)
LLP  A 161 (-3.6A)
ALA  A 401 (-3.4A)
 0.50A 2a1hA-4whxA:
30.5
2a1hB-4whxA:
30.3		 2a1hA-4whxA:
28.19
2a1hB-4whxA:
28.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2COI_A_GBNA420_1
(BRANCHED CHAIN
AMINOTRANSFERASE 1,
CYTOSOLIC)		 4whx BRANCHED-CHAIN-AMINO
-ACID TRANSAMINASE
(Burkholderia
pseudomallei) 		6 / 10 TYR A  98
ARG A 100
TYR A 131
GLY A 257
THR A 258
ALA A 259
 ALA  A 401 (-4.3A)
ALA  A 401 ( 4.6A)
EDO  A 402 (-3.7A)
LLP  A 161 ( 3.4A)
LLP  A 161 (-3.6A)
ALA  A 401 (-3.4A)
 0.54A 2coiA-4whxA:
31.2
2coiB-4whxA:
31.5		 2coiA-4whxA:
26.49
2coiB-4whxA:
26.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2COI_B_GBNB420_1
(BRANCHED CHAIN
AMINOTRANSFERASE 1,
CYTOSOLIC)		 4whx BRANCHED-CHAIN-AMINO
-ACID TRANSAMINASE
(Burkholderia
pseudomallei) 		6 / 10 TYR A  98
ARG A 100
TYR A 131
GLY A 257
THR A 258
ALA A 259
 ALA  A 401 (-4.3A)
ALA  A 401 ( 4.6A)
EDO  A 402 (-3.7A)
LLP  A 161 ( 3.4A)
LLP  A 161 (-3.6A)
ALA  A 401 (-3.4A)
 0.52A 2coiA-4whxA:
31.2
2coiB-4whxA:
31.5		 2coiA-4whxA:
26.49
2coiB-4whxA:
26.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2COI_B_GBNB420_1
(BRANCHED CHAIN
AMINOTRANSFERASE 1,
CYTOSOLIC)		 4whx BRANCHED-CHAIN-AMINO
-ACID TRANSAMINASE
(Burkholderia
pseudomallei) 		5 / 10 TYR A 166
TYR A 131
GLY A 257
THR A 258
ALA A 259
 LLP  A 161 ( 4.2A)
EDO  A 402 (-3.7A)
LLP  A 161 ( 3.4A)
LLP  A 161 (-3.6A)
ALA  A 401 (-3.4A)
 1.13A 2coiA-4whxA:
31.2
2coiB-4whxA:
31.5		 2coiA-4whxA:
26.49
2coiB-4whxA:
26.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2COJ_A_GBNA420_1
(BRANCHED CHAIN
AMINOTRANSFERASE 1,
CYTOSOLIC)		 4whx BRANCHED-CHAIN-AMINO
-ACID TRANSAMINASE
(Burkholderia
pseudomallei) 		7 / 11 PHE A  38
TYR A  98
ARG A 100
TYR A 131
GLY A 257
THR A 258
ALA A 259
 LLP  A 161 ( 4.4A)
ALA  A 401 (-4.3A)
ALA  A 401 ( 4.6A)
EDO  A 402 (-3.7A)
LLP  A 161 ( 3.4A)
LLP  A 161 (-3.6A)
ALA  A 401 (-3.4A)
 0.53A 2cojA-4whxA:
31.1
2cojB-4whxA:
31.4		 2cojA-4whxA:
26.49
2cojB-4whxA:
26.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2COJ_B_GBNB420_1
(BRANCHED CHAIN
AMINOTRANSFERASE 1,
CYTOSOLIC)		 4whx BRANCHED-CHAIN-AMINO
-ACID TRANSAMINASE
(Burkholderia
pseudomallei) 		5 / 9 TYR A  98
ARG A 100
GLY A 257
THR A 258
ALA A 259
 ALA  A 401 (-4.3A)
ALA  A 401 ( 4.6A)
LLP  A 161 ( 3.4A)
LLP  A 161 (-3.6A)
ALA  A 401 (-3.4A)
 0.43A 2cojA-4whxA:
31.1
2cojB-4whxA:
31.4		 2cojA-4whxA:
26.49
2cojB-4whxA:
26.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DPM_A_SAMA300_0
(PROTEIN
(ADENINE-SPECIFIC
METHYLTRANSFERASE
DPNII 1))		 4whx BRANCHED-CHAIN-AMINO
-ACID TRANSAMINASE
(Burkholderia
pseudomallei) 		5 / 12 GLY A 279
GLY A 274
GLY A 275
ALA A 277
ASP A 245
 None
 0.97A 2dpmA-4whxA:
undetectable		 2dpmA-4whxA:
22.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2EJ3_A_GBNA2414_1
(BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE)		 4whx BRANCHED-CHAIN-AMINO
-ACID TRANSAMINASE
(Burkholderia
pseudomallei) 		8 / 8 TYR A  98
ARG A 100
GLY A 198
GLU A 199
GLY A 257
THR A 258
ALA A 259
ALA A 260
 ALA  A 401 (-4.3A)
ALA  A 401 ( 4.6A)
ALA  A 401 (-4.0A)
None
LLP  A 161 ( 3.4A)
LLP  A 161 (-3.6A)
ALA  A 401 (-3.4A)
None
 0.26A 2ej3A-4whxA:
42.8		 2ej3A-4whxA:
51.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2EJ3_B_GBNB914_1
(BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE)		 4whx BRANCHED-CHAIN-AMINO
-ACID TRANSAMINASE
(Burkholderia
pseudomallei) 		10 / 10 PHE A  38
TYR A  98
ARG A 100
TYR A 166
GLY A 198
GLU A 199
GLY A 257
THR A 258
ALA A 259
ALA A 260
 LLP  A 161 ( 4.4A)
ALA  A 401 (-4.3A)
ALA  A 401 ( 4.6A)
LLP  A 161 ( 4.2A)
ALA  A 401 (-4.0A)
None
LLP  A 161 ( 3.4A)
LLP  A 161 (-3.6A)
ALA  A 401 (-3.4A)
None
 0.31A 2ej3B-4whxA:
42.5		 2ej3B-4whxA:
51.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OSH_A_OINA5811_1
(PHOSPHOLIPASE A2
ISOFORM 3)		 4whx BRANCHED-CHAIN-AMINO
-ACID TRANSAMINASE
(Burkholderia
pseudomallei) 		5 / 9 LEU A 132
ILE A 265
PHE A 201
GLY A 198
TYR A 131
 None
None
None
ALA  A 401 (-4.0A)
EDO  A 402 (-3.7A)
 1.26A 3oshA-4whxA:
undetectable		 3oshA-4whxA:
13.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OWX_B_XRAB233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4whx BRANCHED-CHAIN-AMINO
-ACID TRANSAMINASE
(Burkholderia
pseudomallei) 		5 / 11 VAL A 158
PHE A  38
GLY A 198
TYR A 131
GLU A 195
 None
LLP  A 161 ( 4.4A)
ALA  A 401 (-4.0A)
EDO  A 402 (-3.7A)
LLP  A 161 ( 3.1A)
 1.10A 3owxA-4whxA:
undetectable
3owxB-4whxA:
undetectable		 3owxA-4whxA:
23.10
3owxB-4whxA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3REQ_A_ADNA801_1
(METHYLMALONYL-COA
MUTASE)		 4whx BRANCHED-CHAIN-AMINO
-ACID TRANSAMINASE
(Burkholderia
pseudomallei) 		4 / 4 TYR A  98
TYR A 131
GLU A 199
GLY A 198
 ALA  A 401 (-4.3A)
EDO  A 402 (-3.7A)
None
ALA  A 401 (-4.0A)
 1.35A 3reqA-4whxA:
undetectable		 3reqA-4whxA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7N_A_ZMRA601_2
(NEURAMINIDASE)		 4whx BRANCHED-CHAIN-AMINO
-ACID TRANSAMINASE
(Burkholderia
pseudomallei) 		3 / 3 ARG A   6
ARG A  20
TRP A  19
 None
 1.03A 4b7nA-4whxA:
undetectable		 4b7nA-4whxA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_C_ZMRC1470_2
(NEURAMINIDASE)		 4whx BRANCHED-CHAIN-AMINO
-ACID TRANSAMINASE
(Burkholderia
pseudomallei) 		3 / 3 ARG A   6
ARG A  20
TRP A  19
 None
 0.99A 4cpzC-4whxA:
undetectable		 4cpzC-4whxA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_E_ZMRE1471_2
(NEURAMINIDASE)		 4whx BRANCHED-CHAIN-AMINO
-ACID TRANSAMINASE
(Burkholderia
pseudomallei) 		3 / 3 ARG A   6
ARG A  20
TRP A  19
 None
 0.98A 4cpzE-4whxA:
undetectable		 4cpzE-4whxA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_F_ZMRF1470_2
(NEURAMINIDASE)		 4whx BRANCHED-CHAIN-AMINO
-ACID TRANSAMINASE
(Burkholderia
pseudomallei) 		3 / 3 ARG A   6
ARG A  20
TRP A  19
 None
 0.99A 4cpzF-4whxA:
undetectable		 4cpzF-4whxA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_G_ZMRG1471_2
(NEURAMINIDASE)		 4whx BRANCHED-CHAIN-AMINO
-ACID TRANSAMINASE
(Burkholderia
pseudomallei) 		3 / 3 ARG A   6
ARG A  20
TRP A  19
 None
 0.97A 4cpzG-4whxA:
undetectable		 4cpzG-4whxA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_H_ZMRH1470_2
(NEURAMINIDASE)		 4whx BRANCHED-CHAIN-AMINO
-ACID TRANSAMINASE
(Burkholderia
pseudomallei) 		3 / 3 ARG A   6
ARG A  20
TRP A  19
 None
 0.94A 4cpzH-4whxA:
undetectable		 4cpzH-4whxA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_G_SAMG301_1
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 4whx BRANCHED-CHAIN-AMINO
-ACID TRANSAMINASE
(Burkholderia
pseudomallei) 		3 / 3 GLU A  39
HIS A  59
ASP A 219
 LLP  A 161 ( 3.9A)
LLP  A 161 ( 4.9A)
None
 0.67A 5c0oG-4whxA:
undetectable		 5c0oG-4whxA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V5Z_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4whx BRANCHED-CHAIN-AMINO
-ACID TRANSAMINASE
(Burkholderia
pseudomallei) 		5 / 12 TYR A  44
ILE A  53
PHE A 289
GLY A  40
PHE A 290
 None
None
None
ALA  A 401 ( 3.7A)
None
 1.33A 5v5zA-4whxA:
undetectable		 5v5zA-4whxA:
18.71