SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4wib'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FW1_A_STIA233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4wib MAGNESIUM
TRANSPORTER MGTE
(Thermus
thermophilus) 		5 / 10 GLY A 325
GLY A 328
THR A 330
ASN A 332
ILE A 397
 None
 1.27A 3fw1A-4wibA:
undetectable		 3fw1A-4wibA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JUS_B_ECNB602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4wib MAGNESIUM
TRANSPORTER MGTE
(Thermus
thermophilus) 		5 / 9 LEU A 364
GLY A 331
ALA A 401
THR A 434
ILE A 438
 None
 1.48A 3jusB-4wibA:
undetectable		 3jusB-4wibA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_B_CELB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4wib MAGNESIUM
TRANSPORTER MGTE
(Thermus
thermophilus) 		5 / 12 VAL A 362
LEU A 366
SER A 371
GLY A 331
SER A 334
 None
 1.23A 3kk6B-4wibA:
undetectable		 3kk6B-4wibA:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFN_A_ROCA402_1
(HIV-1 PROTEASE)		 4wib MAGNESIUM
TRANSPORTER MGTE
(Thermus
thermophilus) 		4 / 5 LEU A 374
PRO A 321
VAL A 322
ASP A 381
 None
 0.95A 3ufnA-4wibA:
undetectable
3ufnB-4wibA:
undetectable		 3ufnA-4wibA:
20.99
3ufnB-4wibA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DXU_A_ACAA711_1
(LACTOTRANSFERRIN)		 4wib MAGNESIUM
TRANSPORTER MGTE
(Thermus
thermophilus) 		4 / 6 GLY A 327
VAL A 398
GLY A 405
GLU A 359
 None
 0.88A 4dxuA-4wibA:
undetectable		 4dxuA-4wibA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VW4_A_NCAA403_0
(FERREDOXIN--NADP
REDUCTASE)		 4wib MAGNESIUM
TRANSPORTER MGTE
(Thermus
thermophilus) 		5 / 9 THR A 330
GLY A 327
ALA A 401
LEU A 370
SER A 371
 None
 1.26A 5vw4A-4wibA:
undetectable		 5vw4A-4wibA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DEB_B_MTXB302_1
(BIFUNCTIONAL PROTEIN
FOLD)		 4wib MAGNESIUM
TRANSPORTER MGTE
(Thermus
thermophilus) 		5 / 12 LEU A 324
PRO A 321
THR A 330
ILE A 397
VAL A 398
 None
 1.28A 6debB-4wibA:
undetectable		 6debB-4wibA:
17.34