SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4wik'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK1_A_T44A3004_1
(SERUM ALBUMIN)		 4wik SPLICING FACTOR,
PROLINE- AND
GLUTAMINE-RICH
(Homo
sapiens) 		4 / 6 PHE A 394
PHE A 436
LEU A 387
VAL A 375
 None
 1.03A 1hk1A-4wikA:
undetectable		 1hk1A-4wikA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_B_SUEB1201_3
(NS3 PROTEASE, NS4A
PROTEIN)		 4wik SPLICING FACTOR,
PROLINE- AND
GLUTAMINE-RICH
(Homo
sapiens) 		4 / 5 SER A 379
ARG A 443
PRO A 444
VAL A 445
 None
 1.37A 3sufC-4wikA:
undetectable		 3sufC-4wikA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_F_9PLF1_1
(CYTOCHROME P450 2A13)		 4wik SPLICING FACTOR,
PROLINE- AND
GLUTAMINE-RICH
(Homo
sapiens) 		4 / 8 PHE A 394
PHE A 418
PHE A 436
PHE A 391
 None
 0.95A 3t3sF-4wikA:
undetectable		 3t3sF-4wikA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R87_I_SPMI202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 4wik SPLICING FACTOR,
PROLINE- AND
GLUTAMINE-RICH
(Homo
sapiens) 		4 / 7 ASN A 384
GLU A 388
GLU A 389
GLU A 385
 None
 1.28A 4r87I-4wikA:
undetectable		 4r87I-4wikA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R87_J_SPMJ202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 4wik SPLICING FACTOR,
PROLINE- AND
GLUTAMINE-RICH
(Homo
sapiens) 		4 / 7 GLU A 475
TYR A 470
GLU A 473
ARG A 474
 None
 1.38A 4r87J-4wikA:
undetectable
4r87L-4wikA:
undetectable		 4r87J-4wikA:
20.34
4r87L-4wikA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZPH_A_PRLA501_0
(ARYL HYDROCARBON
RECEPTOR NUCLEAR
TRANSLOCATOR
ENDOTHELIAL PAS
DOMAIN-CONTAINING
PROTEIN 1)		 4wik SPLICING FACTOR,
PROLINE- AND
GLUTAMINE-RICH
(Homo
sapiens) 		4 / 7 ARG A 443
VAL A 445
LEU A 378
SER A 379
 None
 1.09A 4zphA-4wikA:
undetectable
4zphB-4wikA:
undetectable		 4zphA-4wikA:
20.16
4zphB-4wikA:
20.27