SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4win'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZN_B_SAMB402_0
(UNCHARACTERIZED
PROTEIN MJ0883)		 4win GMP SYNTHETASE
(Plasmodium
falciparum) 		5 / 12 TYR A  18
PHE A  19
GLY A  57
PRO A  59
ILE A  54
 NO3  A1002 (-4.8A)
NO3  A1001 (-4.3A)
NO3  A1002 (-3.9A)
NO3  A1002 ( 4.5A)
None
 1.29A 2zznB-4winA:
undetectable		 2zznB-4winA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_A_ROFA901_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 4win GMP SYNTHETASE
(Plasmodium
falciparum) 		3 / 3 ASP A  37
LEU A  12
GLN A  98
 None
 0.77A 3g4lA-4winA:
undetectable		 3g4lA-4winA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O1C_A_ADNA127_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 1)		 4win GMP SYNTHETASE
(Plasmodium
falciparum) 		5 / 10 ILE A  83
PHE A  78
ILE A  85
ILE A   9
LEU A  12
 None
 1.07A 3o1cA-4winA:
undetectable		 3o1cA-4winA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O1X_A_ADNA1450_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 1)		 4win GMP SYNTHETASE
(Plasmodium
falciparum) 		5 / 10 ILE A  83
PHE A  78
ILE A  85
ILE A   9
LEU A  12
 None
 1.06A 3o1xA-4winA:
undetectable		 3o1xA-4winA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QGZ_A_ADNA127_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 1)		 4win GMP SYNTHETASE
(Plasmodium
falciparum) 		5 / 10 ILE A  83
PHE A  78
ILE A  85
ILE A   9
LEU A  12
 None
 1.04A 3qgzA-4winA:
undetectable		 3qgzA-4winA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U15_A_0HKA2001_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,LYSOZYME,MUSCARIN
IC ACETYLCHOLINE
RECEPTOR M3)		 4win GMP SYNTHETASE
(Plasmodium
falciparum) 		3 / 3 ASN A 227
PHE A 156
TYR A 196
 None
 0.72A 4u15A-4winA:
undetectable		 4u15A-4winA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_A_SAMA301_0
(UNCHARACTERIZED
PROTEIN MJ0489)		 4win GMP SYNTHETASE
(Plasmodium
falciparum) 		5 / 12 GLY A 204
LEU A  55
ILE A 192
LEU A 183
GLY A  57
 None
None
None
None
NO3  A1002 (-3.9A)
 1.13A 5d4uA-4winA:
undetectable		 5d4uA-4winA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_B_SAMB301_0
(UNCHARACTERIZED
PROTEIN MJ0489)		 4win GMP SYNTHETASE
(Plasmodium
falciparum) 		5 / 12 GLY A 204
LEU A  55
ILE A 192
LEU A 183
GLY A  57
 None
None
None
None
NO3  A1002 (-3.9A)
 1.10A 5d4uB-4winA:
undetectable		 5d4uB-4winA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WBV_A_SAMA402_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
KMT5B)		 4win GMP SYNTHETASE
(Plasmodium
falciparum) 		5 / 12 GLY A 101
SER A  61
HIS A 170
CYH A 190
CYH A 193
 None
 1.42A 5wbvA-4winA:
undetectable		 5wbvA-4winA:
21.03