SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4wis'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DMI_A_BHSA1610_1
(NITRIC OXIDE
SYNTHASE)
4wis LIPID SCRAMBLASE
([Nectria]
haematococca)
4 / 8 ARG A 549
ALA A 544
TRP A 159
PHE A 181
None
1.03A 1dmiA-4wisA:
undetectable
1dmiB-4wisA:
undetectable
1dmiA-4wisA:
18.79
1dmiB-4wisA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_C_DVAC8_0
(GRAMICIDIN A)
4wis LIPID SCRAMBLASE
([Nectria]
haematococca)
3 / 4 VAL A 230
TRP A 235
TRP A 227
None
1.08A 1gmkC-4wisA:
undetectable
1gmkD-4wisA:
undetectable
1gmkC-4wisA:
2.36
1gmkD-4wisA:
2.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_A_117A2_1
(HMG-COA REDUCTASE)
4wis LIPID SCRAMBLASE
([Nectria]
haematococca)
4 / 8 SER A 184
VAL A 500
SER A 501
ASP A 367
None
1.05A 1hwkA-4wisA:
3.2
1hwkA-4wisA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_C_117C4_1
(HMG-COA REDUCTASE)
4wis LIPID SCRAMBLASE
([Nectria]
haematococca)
4 / 8 SER A 184
VAL A 500
SER A 501
ASP A 367
None
1.06A 1hwkC-4wisA:
3.1
1hwkC-4wisA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_D_117D3_2
(HMG-COA REDUCTASE)
4wis LIPID SCRAMBLASE
([Nectria]
haematococca)
4 / 8 SER A 184
VAL A 500
SER A 501
ASP A 367
None
1.05A 1hwkD-4wisA:
2.6
1hwkD-4wisA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JFF_B_TA1B601_1
(TUBULIN BETA CHAIN)
4wis LIPID SCRAMBLASE
([Nectria]
haematococca)
5 / 12 VAL A 500
ASP A 499
LEU A 565
SER A 184
THR A 563
None
1.05A 1jffB-4wisA:
undetectable
1jffB-4wisA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_B_AG2B7011_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)
4wis LIPID SCRAMBLASE
([Nectria]
haematococca)
4 / 5 GLU A 352
ARG A 505
LEU A 370
LEU A 377
None
1.21A 1n13B-4wisA:
undetectable
1n13C-4wisA:
undetectable
1n13B-4wisA:
8.73
1n13C-4wisA:
5.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TKQ_A_DVAA6_0
(MINI-GRAMICIDIN A)
4wis LIPID SCRAMBLASE
([Nectria]
haematococca)
3 / 3 ALA A 444
VAL A 442
TRP A 521
None
0.99A 1tkqA-4wisA:
undetectable
1tkqA-4wisA:
2.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HXF_B_TA1B601_1
(TUBULIN BETA CHAIN)
4wis LIPID SCRAMBLASE
([Nectria]
haematococca)
5 / 12 VAL A 500
ASP A 499
LEU A 565
SER A 184
THR A 563
None
1.05A 2hxfB-4wisA:
undetectable
2hxfB-4wisA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HXH_B_TA1B601_1
(TUBULIN BETA CHAIN)
4wis LIPID SCRAMBLASE
([Nectria]
haematococca)
5 / 12 VAL A 500
ASP A 499
LEU A 565
SER A 184
THR A 563
None
1.05A 2hxhB-4wisA:
undetectable
2hxhB-4wisA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1294_1
(FICOLIN-2)
4wis LIPID SCRAMBLASE
([Nectria]
haematococca)
5 / 9 VAL A 453
SER A 538
LEU A 192
ASP A 503
GLU A 506
None
CA  A 802 ( 4.9A)
None
CA  A 801 (-3.3A)
CA  A 801 ( 3.1A)
1.11A 2j2pB-4wisA:
undetectable
2j2pC-4wisA:
undetectable
2j2pB-4wisA:
14.70
2j2pC-4wisA:
14.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_E_SC2E1290_1
(FICOLIN-2)
4wis LIPID SCRAMBLASE
([Nectria]
haematococca)
5 / 9 VAL A 453
SER A 538
LEU A 192
ASP A 503
GLU A 506
None
CA  A 802 ( 4.9A)
None
CA  A 801 (-3.3A)
CA  A 801 ( 3.1A)
1.06A 2j2pD-4wisA:
undetectable
2j2pE-4wisA:
undetectable
2j2pD-4wisA:
14.70
2j2pE-4wisA:
14.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P4N_B_TA1B601_1
(TUBULIN BETA CHAIN)
4wis LIPID SCRAMBLASE
([Nectria]
haematococca)
5 / 12 VAL A 500
ASP A 499
LEU A 565
SER A 184
THR A 563
None
1.05A 2p4nB-4wisA:
undetectable
2p4nB-4wisA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WBE_B_TA1B1439_1
(TUBULIN BETA-2B
CHAIN)
4wis LIPID SCRAMBLASE
([Nectria]
haematococca)
5 / 12 VAL A 500
ASP A 499
LEU A 565
SER A 184
THR A 563
None
1.05A 2wbeB-4wisA:
undetectable
2wbeB-4wisA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_B_SVRB501_2
(PHOSPHOLIPASE A2)
4wis LIPID SCRAMBLASE
([Nectria]
haematococca)
5 / 11 VAL A 337
LEU A 336
GLY A 339
ILE A 343
SER A 344
None
1.24A 3bjwB-4wisA:
undetectable
3bjwB-4wisA:
10.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF502_3
(PHOSPHOLIPASE A2)
4wis LIPID SCRAMBLASE
([Nectria]
haematococca)
5 / 12 VAL A 337
LEU A 336
GLY A 339
ILE A 343
SER A 344
None
1.27A 3bjwF-4wisA:
undetectable
3bjwF-4wisA:
10.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCO_B_TA1B601_1
(BOVINE BETA TUBULIN)
4wis LIPID SCRAMBLASE
([Nectria]
haematococca)
5 / 12 VAL A 500
ASP A 499
LEU A 565
SER A 184
THR A 563
None
1.05A 3dcoB-4wisA:
undetectable
3dcoB-4wisA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EDL_B_TA1B601_1
(BETA TUBULIN)
4wis LIPID SCRAMBLASE
([Nectria]
haematococca)
5 / 12 VAL A 500
ASP A 499
LEU A 565
SER A 184
THR A 563
None
1.05A 3edlB-4wisA:
undetectable
3edlB-4wisA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_A_MTXA605_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)
4wis LIPID SCRAMBLASE
([Nectria]
haematococca)
5 / 12 ALA A 444
ILE A 306
ARG A 432
TYR A 513
THR A 443
None
1.14A 3hj3A-4wisA:
undetectable
3hj3A-4wisA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IZ0_B_TA1B820_1
(BETA TUBULIN, CHAIN
B FROM PDB 1JFF)
4wis LIPID SCRAMBLASE
([Nectria]
haematococca)
5 / 12 VAL A 500
ASP A 499
LEU A 565
SER A 184
THR A 563
None
1.03A 3iz0B-4wisA:
undetectable
3iz0B-4wisA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6P_B_TA1B502_1
(TUBULIN BETA CHAIN)
4wis LIPID SCRAMBLASE
([Nectria]
haematococca)
5 / 12 VAL A 500
ASP A 499
LEU A 565
SER A 184
THR A 563
None
1.06A 3j6pB-4wisA:
undetectable
3j6pB-4wisA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_2
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)
4wis LIPID SCRAMBLASE
([Nectria]
haematococca)
3 / 3 SER A 547
SER A 546
HIS A 153
None
0.81A 3mzeA-4wisA:
undetectable
3mzeA-4wisA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OCT_A_1N1A663_2
(TYROSINE-PROTEIN
KINASE BTK)
4wis LIPID SCRAMBLASE
([Nectria]
haematococca)
4 / 5 PHE A 388
ILE A 579
ASN A 317
PHE A 391
None
1.29A 3octA-4wisA:
undetectable
3octA-4wisA:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX7_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)
4wis LIPID SCRAMBLASE
([Nectria]
haematococca)
4 / 8 SER A 573
ILE A 574
TRP A 570
PHE A 567
None
1.23A 4cx7A-4wisA:
undetectable
4cx7B-4wisA:
undetectable
4cx7A-4wisA:
18.29
4cx7B-4wisA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX7_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)
4wis LIPID SCRAMBLASE
([Nectria]
haematococca)
4 / 8 SER A 573
MET A 516
ILE A 574
PHE A 567
None
1.28A 4cx7A-4wisA:
undetectable
4cx7B-4wisA:
undetectable
4cx7A-4wisA:
18.29
4cx7B-4wisA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX7_C_H4BC600_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)
4wis LIPID SCRAMBLASE
([Nectria]
haematococca)
4 / 8 SER A 573
ILE A 574
TRP A 570
PHE A 567
None
1.25A 4cx7C-4wisA:
undetectable
4cx7D-4wisA:
0.0
4cx7C-4wisA:
18.29
4cx7D-4wisA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_A_CQAA302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)
4wis LIPID SCRAMBLASE
([Nectria]
haematococca)
4 / 7 GLU A 496
GLU A 497
TYR A 498
GLY A 502
None
0.88A 4fgzA-4wisA:
undetectable
4fgzA-4wisA:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7U_D_YTZD802_1
(SEPIAPTERIN
REDUCTASE)
4wis LIPID SCRAMBLASE
([Nectria]
haematococca)
4 / 8 LEU A 529
PHE A 196
TYR A 195
GLN A 445
None
1.16A 4j7uD-4wisA:
undetectable
4j7uD-4wisA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_A_MTXA604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)
4wis LIPID SCRAMBLASE
([Nectria]
haematococca)
5 / 12 ALA A 444
ILE A 306
ARG A 432
TYR A 513
THR A 443
None
1.14A 4q0dA-4wisA:
undetectable
4q0dA-4wisA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_B_MTXB604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)
4wis LIPID SCRAMBLASE
([Nectria]
haematococca)
5 / 12 ALA A 444
ILE A 306
ARG A 432
TYR A 513
THR A 443
None
1.14A 4q0dB-4wisA:
undetectable
4q0dB-4wisA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_E_MTXE604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)
4wis LIPID SCRAMBLASE
([Nectria]
haematococca)
5 / 12 ALA A 444
ILE A 306
ARG A 432
TYR A 513
THR A 443
None
1.14A 4q0dE-4wisA:
undetectable
4q0dE-4wisA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UDA_A_DEXA1985_1
(MINERALOCORTICOID
RECEPTOR)
4wis LIPID SCRAMBLASE
([Nectria]
haematococca)
5 / 12 LEU A 377
ASN A 378
SER A 501
MET A 348
LEU A 370
None
1.46A 4udaA-4wisA:
2.3
4udaA-4wisA:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQE_A_AG2A506_1
(HOMOSPERMIDINE
SYNTHASE)
4wis LIPID SCRAMBLASE
([Nectria]
haematococca)
4 / 6 ARG A 178
ARG A 117
ARG A  84
ASP A  87
None
1.20A 4xqeA-4wisA:
undetectable
4xqeA-4wisA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQE_B_AG2B505_1
(HOMOSPERMIDINE
SYNTHASE)
4wis LIPID SCRAMBLASE
([Nectria]
haematococca)
4 / 6 ARG A 178
ARG A 117
ARG A  84
ASP A  87
None
1.21A 4xqeB-4wisA:
undetectable
4xqeB-4wisA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_A_SORA1343_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)
4wis LIPID SCRAMBLASE
([Nectria]
haematococca)
4 / 6 ARG A 554
ASP A  87
HIS A  90
ILE A 254
None
1.35A 5a06A-4wisA:
undetectable
5a06A-4wisA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNW_B_TA1B902_1
(TUBULIN BETA-2B
CHAIN)
4wis LIPID SCRAMBLASE
([Nectria]
haematococca)
5 / 12 VAL A 500
ASP A 499
LEU A 565
SER A 184
THR A 563
None
0.98A 5hnwB-4wisA:
undetectable
5hnwB-4wisA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNY_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)
4wis LIPID SCRAMBLASE
([Nectria]
haematococca)
5 / 12 VAL A 500
ASP A 499
LEU A 565
SER A 184
THR A 563
None
1.00A 5hnyB-4wisA:
undetectable
5hnyB-4wisA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNZ_B_TA1B902_1
(TUBULIN BETA-2B
CHAIN)
4wis LIPID SCRAMBLASE
([Nectria]
haematococca)
5 / 12 VAL A 500
ASP A 499
LEU A 565
SER A 184
THR A 563
None
1.05A 5hnzB-4wisA:
undetectable
5hnzB-4wisA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND3_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)
4wis LIPID SCRAMBLASE
([Nectria]
haematococca)
5 / 12 VAL A 500
ASP A 499
LEU A 565
SER A 184
THR A 563
None
1.14A 5nd3B-4wisA:
undetectable
5nd3B-4wisA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OGC_B_TA1B601_1
(TUBULIN BETA CHAIN)
4wis LIPID SCRAMBLASE
([Nectria]
haematococca)
5 / 12 VAL A 500
ASP A 499
LEU A 565
SER A 184
THR A 563
None
1.03A 5ogcB-4wisA:
undetectable
5ogcB-4wisA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_B_SUEB1202_1
(NS3 PROTEASE)
4wis LIPID SCRAMBLASE
([Nectria]
haematococca)
5 / 9 VAL A  92
HIS A  90
ASP A  87
ARG A  93
VAL A 111
None
1.28A 6c2mB-4wisA:
undetectable
6c2mB-4wisA:
7.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_B_TA1B501_2
(TUBULIN BETA CHAIN)
4wis LIPID SCRAMBLASE
([Nectria]
haematococca)
4 / 5 LEU A  52
THR A 124
ARG A 115
ARG A  84
None
1.19A 6ew0B-4wisA:
undetectable
6ew0B-4wisA:
6.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_D_TA1D501_2
(TUBULIN BETA CHAIN)
4wis LIPID SCRAMBLASE
([Nectria]
haematococca)
4 / 5 LEU A  52
THR A 124
ARG A 115
ARG A  84
None
1.19A 6ew0D-4wisA:
undetectable
6ew0D-4wisA:
6.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_H_TA1H501_2
(TUBULIN BETA CHAIN)
4wis LIPID SCRAMBLASE
([Nectria]
haematococca)
4 / 5 LEU A  52
THR A 124
ARG A 115
ARG A  84
None
1.20A 6ew0H-4wisA:
undetectable
6ew0H-4wisA:
6.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_I_TA1I501_2
(TUBULIN BETA CHAIN)
4wis LIPID SCRAMBLASE
([Nectria]
haematococca)
4 / 5 LEU A  52
THR A 124
ARG A 115
ARG A  84
None
1.20A 6ew0I-4wisA:
undetectable
6ew0I-4wisA:
6.74