SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4wiw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D1G_A_MTXA171_1
(DIHYDROFOLATE
REDUCTASE)		 4wiw GLYCOSIDE HYDROLASE
FAMILY 18
(Desulfitobacteri
um
hafniense) 		5 / 12 ALA A 452
ARG A 381
ILE A 457
ILE A 443
THR A 450
 None
 1.01A 1d1gA-4wiwA:
undetectable		 1d1gA-4wiwA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D1G_B_MTXB171_1
(DIHYDROFOLATE
REDUCTASE)		 4wiw GLYCOSIDE HYDROLASE
FAMILY 18
(Desulfitobacteri
um
hafniense) 		5 / 12 ALA A 452
ARG A 381
ILE A 457
ILE A 443
THR A 450
 None
 1.16A 1d1gB-4wiwA:
undetectable		 1d1gB-4wiwA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E9L_A_GCSA800_1
(YM1 SECRETORY
PROTEIN)		 4wiw GLYCOSIDE HYDROLASE
FAMILY 18
(Desulfitobacteri
um
hafniense) 		5 / 9 TYR A 348
ASP A 458
MET A 530
TYR A 532
ASP A 533
 None
CA  A 704 ( 4.4A)
CA  A 704 ( 4.4A)
None
None
 0.95A 1e9lA-4wiwA:
30.9		 1e9lA-4wiwA:
25.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EJ0_A_SAMA301_1
(FTSJ)		 4wiw GLYCOSIDE HYDROLASE
FAMILY 18
(Desulfitobacteri
um
hafniense) 		3 / 3 ASP A 464
ASP A 478
ASP A 467
 None
 0.69A 1ej0A-4wiwA:
undetectable		 1ej0A-4wiwA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_D_DVAD8_0
(GRAMICIDIN A)		 4wiw GLYCOSIDE HYDROLASE
FAMILY 18
(Desulfitobacteri
um
hafniense) 		3 / 3 TRP A 666
VAL A 671
TRP A 670
 None
 1.43A 1gmkC-4wiwA:
undetectable
1gmkD-4wiwA:
undetectable		 1gmkC-4wiwA:
5.05
1gmkD-4wiwA:
5.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_D_IMND476_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)		 4wiw GLYCOSIDE HYDROLASE
FAMILY 18
(Desulfitobacteri
um
hafniense) 		5 / 12 THR A 531
ILE A 557
ILE A 550
VAL A 529
LEU A 660
 None
 1.17A 1z9hD-4wiwA:
undetectable		 1z9hD-4wiwA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3A_A_TEPA1433_1
(CHITINASE)		 4wiw GLYCOSIDE HYDROLASE
FAMILY 18
(Desulfitobacteri
um
hafniense) 		7 / 11 TYR A 348
GLU A 460
MET A 530
TYR A 532
ASP A 533
TYR A 574
TRP A 666
 None
CA  A 704 (-2.8A)
CA  A 704 ( 4.4A)
None
None
None
None
 0.61A 2a3aA-4wiwA:
29.4		 2a3aA-4wiwA:
25.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3A_B_TEPB2433_1
(CHITINASE)		 4wiw GLYCOSIDE HYDROLASE
FAMILY 18
(Desulfitobacteri
um
hafniense) 		6 / 9 GLU A 460
MET A 530
TYR A 532
ASP A 533
TYR A 574
TRP A 666
 CA  A 704 (-2.8A)
CA  A 704 ( 4.4A)
None
None
None
None
 0.60A 2a3aB-4wiwA:
29.5		 2a3aB-4wiwA:
25.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3B_B_CFFB2435_1
(CHITINASE)		 4wiw GLYCOSIDE HYDROLASE
FAMILY 18
(Desulfitobacteri
um
hafniense) 		5 / 10 MET A 530
TYR A 532
ASP A 533
TYR A 574
TRP A 666
 CA  A 704 ( 4.4A)
None
None
None
None
 0.42A 2a3bB-4wiwA:
29.4		 2a3bB-4wiwA:
25.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3C_B_PNXB2433_1
(CHITINASE)		 4wiw GLYCOSIDE HYDROLASE
FAMILY 18
(Desulfitobacteri
um
hafniense) 		5 / 12 MET A 530
TYR A 532
ASP A 533
TYR A 574
TRP A 666
 CA  A 704 ( 4.4A)
None
None
None
None
 0.42A 2a3cB-4wiwA:
29.5		 2a3cB-4wiwA:
25.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UY4_A_AZMA1311_1
(ENDOCHITINASE)		 4wiw GLYCOSIDE HYDROLASE
FAMILY 18
(Desulfitobacteri
um
hafniense) 		5 / 9 TYR A 348
ASP A 458
GLU A 460
TYR A 532
TRP A 666
 None
CA  A 704 ( 4.4A)
CA  A 704 (-2.8A)
None
None
 0.69A 2uy4A-4wiwA:
16.6		 2uy4A-4wiwA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XTK_A_AZMA1339_1
(CLASS III CHITINASE
CHIA1)		 4wiw GLYCOSIDE HYDROLASE
FAMILY 18
(Desulfitobacteri
um
hafniense) 		5 / 11 TYR A 348
ASP A 458
GLU A 460
TYR A 532
TRP A 666
 None
CA  A 704 ( 4.4A)
CA  A 704 (-2.8A)
None
None
 0.95A 2xtkA-4wiwA:
17.7		 2xtkA-4wiwA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XTK_B_AZMB1339_1
(CLASS III CHITINASE
CHIA1)		 4wiw GLYCOSIDE HYDROLASE
FAMILY 18
(Desulfitobacteri
um
hafniense) 		5 / 10 TYR A 348
ASP A 458
GLU A 460
TYR A 532
TRP A 666
 None
CA  A 704 ( 4.4A)
CA  A 704 (-2.8A)
None
None
 0.83A 2xtkB-4wiwA:
17.6		 2xtkB-4wiwA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DOU_A_SAMA1_1
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 4wiw GLYCOSIDE HYDROLASE
FAMILY 18
(Desulfitobacteri
um
hafniense) 		3 / 3 ASP A 464
ASP A 478
ASP A 467
 None
 0.66A 3douA-4wiwA:
undetectable		 3douA-4wiwA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G6M_A_CFFA1_1
(CHITINASE)		 4wiw GLYCOSIDE HYDROLASE
FAMILY 18
(Desulfitobacteri
um
hafniense) 		7 / 11 TYR A 348
GLU A 460
MET A 530
TYR A 532
ASP A 533
TYR A 574
TRP A 666
 None
CA  A 704 (-2.8A)
CA  A 704 ( 4.4A)
None
None
None
None
 0.73A 3g6mA-4wiwA:
29.7		 3g6mA-4wiwA:
26.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSF_H_PZIH800_0
(GLUTAMATE RECEPTOR 2)		 4wiw GLYCOSIDE HYDROLASE
FAMILY 18
(Desulfitobacteri
um
hafniense) 		4 / 8 TYR A 517
SER A 506
LEU A 512
ASP A 513
 None
None
None
CA  A 701 ( 4.5A)
 0.88A 3lsfH-4wiwA:
undetectable		 3lsfH-4wiwA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WQV_A_GCSA501_1
(CHITINASE)		 4wiw GLYCOSIDE HYDROLASE
FAMILY 18
(Desulfitobacteri
um
hafniense) 		7 / 11 ASP A 458
GLU A 460
MET A 530
TYR A 532
ASP A 533
TYR A 574
TRP A 666
 CA  A 704 ( 4.4A)
CA  A 704 (-2.8A)
CA  A 704 ( 4.4A)
None
None
None
None
 0.43A 3wqvA-4wiwA:
32.6		 3wqvA-4wiwA:
25.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WQW_A_GCSA501_1
(CHITINASE)		 4wiw GLYCOSIDE HYDROLASE
FAMILY 18
(Desulfitobacteri
um
hafniense) 		7 / 11 ASP A 458
GLU A 460
MET A 530
TYR A 532
ASP A 533
TYR A 574
TRP A 666
 CA  A 704 ( 4.4A)
CA  A 704 (-2.8A)
CA  A 704 ( 4.4A)
None
None
None
None
 0.42A 3wqwA-4wiwA:
32.5		 3wqwA-4wiwA:
25.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_A_MXMA606_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4wiw GLYCOSIDE HYDROLASE
FAMILY 18
(Desulfitobacteri
um
hafniense) 		5 / 12 LEU A 479
ILE A 457
VAL A 497
ALA A 523
LEU A 520
 None
 1.20A 4m11A-4wiwA:
0.1		 4m11A-4wiwA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M51_A_BEZA501_0
(AMIDOHYDROLASE
FAMILY PROTEIN)		 4wiw GLYCOSIDE HYDROLASE
FAMILY 18
(Desulfitobacteri
um
hafniense) 		4 / 6 ILE A 419
ILE A 440
PHE A 459
LEU A 429
 None
 0.95A 4m51A-4wiwA:
6.0		 4m51A-4wiwA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_A_GCSA301_1
(CHITOSANASE)		 4wiw GLYCOSIDE HYDROLASE
FAMILY 18
(Desulfitobacteri
um
hafniense) 		3 / 3 TYR A 372
GLY A 367
PRO A 366
 None
 0.61A 4qwpA-4wiwA:
undetectable		 4qwpA-4wiwA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_B_032B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4wiw GLYCOSIDE HYDROLASE
FAMILY 18
(Desulfitobacteri
um
hafniense) 		4 / 5 ILE A 571
PHE A 596
HIS A 686
ASP A 644
 None
 1.40A 4rzvB-4wiwA:
undetectable		 4rzvB-4wiwA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YOA_A_017A100_1
(HIV-1 PROTEASE)		 4wiw GLYCOSIDE HYDROLASE
FAMILY 18
(Desulfitobacteri
um
hafniense) 		4 / 6 ASP A 533
THR A 625
PRO A 626
THR A 627
 None
 1.12A 4yoaA-4wiwA:
undetectable		 4yoaA-4wiwA:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXA_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 4wiw GLYCOSIDE HYDROLASE
FAMILY 18
(Desulfitobacteri
um
hafniense) 		4 / 5 GLU A 460
THR A 461
HIS A 522
LEU A 527
 CA  A 704 (-2.8A)
None
None
None
 1.17A 5axaA-4wiwA:
undetectable		 5axaA-4wiwA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXA_C_ADNC502_2
(ADENOSYLHOMOCYSTEINA
SE)		 4wiw GLYCOSIDE HYDROLASE
FAMILY 18
(Desulfitobacteri
um
hafniense) 		4 / 5 GLU A 460
THR A 461
HIS A 522
LEU A 527
 CA  A 704 (-2.8A)
None
None
None
 1.15A 5axaC-4wiwA:
undetectable		 5axaC-4wiwA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECL_A_ILEA602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 4wiw GLYCOSIDE HYDROLASE
FAMILY 18
(Desulfitobacteri
um
hafniense) 		4 / 6 ALA A 676
VAL A 671
TYR A 573
VAL A 373
 None
 1.02A 5eclA-4wiwA:
undetectable		 5eclA-4wiwA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GQB_A_GCSA603_1
(CHITINASE)		 4wiw GLYCOSIDE HYDROLASE
FAMILY 18
(Desulfitobacteri
um
hafniense) 		4 / 8 GLU A 460
TYR A 532
ASP A 533
TRP A 666
 CA  A 704 (-2.8A)
None
None
None
 0.47A 5gqbA-4wiwA:
29.0		 5gqbA-4wiwA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXL_B_SAMB401_0
(2-(3-AMINO-3-CARBOXY
PROPYL)HISTIDINE
SYNTHASE)		 4wiw GLYCOSIDE HYDROLASE
FAMILY 18
(Desulfitobacteri
um
hafniense) 		5 / 12 TYR A 348
GLY A 669
SER A 345
GLN A 347
VAL A 663
 None
 1.31A 6bxlB-4wiwA:
undetectable		 6bxlB-4wiwA:
21.84