SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4wj0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHI_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 4wj0 CRISPR-ASSOCIATED
ENDONUCLEASE CAS1
(Pyrococcus
horikoshii) 		5 / 11 ILE A  61
ILE A  48
LEU A  14
ILE A  56
THR A 199
 None
 1.04A 1dhiB-4wj0A:
undetectable		 1dhiB-4wj0A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRA_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 4wj0 CRISPR-ASSOCIATED
ENDONUCLEASE CAS1
(Pyrococcus
horikoshii) 		5 / 12 ILE A  61
ILE A  48
LEU A  14
ILE A  56
THR A 199
 None
 1.04A 1draB-4wj0A:
undetectable		 1draB-4wj0A:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_A_ACTA1870_0
(FPRA)		 4wj0 CRISPR-ASSOCIATED
ENDONUCLEASE CAS1
(Pyrococcus
horikoshii) 		4 / 4 HIS A 285
PRO A 286
LYS A 287
ILE A 288
 None
 1.15A 1lqtA-4wj0A:
undetectable		 1lqtA-4wj0A:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_A_ACTA1427_0
(FPRA)		 4wj0 CRISPR-ASSOCIATED
ENDONUCLEASE CAS1
(Pyrococcus
horikoshii) 		4 / 4 HIS A 285
PRO A 286
LYS A 287
ILE A 288
 None
 1.14A 1lquA-4wj0A:
0.0		 1lquA-4wj0A:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_B_BEZB503_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 4wj0 CRISPR-ASSOCIATED
ENDONUCLEASE CAS1
(Pyrococcus
horikoshii) 		4 / 6 ARG A 192
ALA A 195
TYR A 275
ILE A 298
 None
 1.14A 1oniB-4wj0A:
undetectable
1oniC-4wj0A:
undetectable		 1oniB-4wj0A:
21.05
1oniC-4wj0A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RA3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 4wj0 CRISPR-ASSOCIATED
ENDONUCLEASE CAS1
(Pyrococcus
horikoshii) 		5 / 12 ILE A  61
ILE A  48
LEU A  14
ILE A  56
THR A 199
 None
 1.01A 1ra3A-4wj0A:
undetectable		 1ra3A-4wj0A:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RB3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 4wj0 CRISPR-ASSOCIATED
ENDONUCLEASE CAS1
(Pyrococcus
horikoshii) 		5 / 10 ALA A 195
LYS A   4
ILE A   8
ILE A  40
THR A 196
 None
 1.25A 1rb3A-4wj0A:
undetectable		 1rb3A-4wj0A:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RD7_B_FOLB361_0
(DIHYDROFOLATE
REDUCTASE)		 4wj0 CRISPR-ASSOCIATED
ENDONUCLEASE CAS1
(Pyrococcus
horikoshii) 		5 / 12 ILE A  61
ILE A  48
LEU A  14
ILE A  56
THR A 199
 None
 1.01A 1rd7B-4wj0A:
undetectable		 1rd7B-4wj0A:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_B_LPRB705_2
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		 4wj0 CRISPR-ASSOCIATED
ENDONUCLEASE CAS1
(Pyrococcus
horikoshii) 		3 / 3 ALA A 302
THR A 204
PHE A 231
 None
 0.71A 2c6nB-4wj0A:
undetectable		 2c6nB-4wj0A:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DRC_B_MTXB161_1
(DIHYDROFOLATE
REDUCTASE)		 4wj0 CRISPR-ASSOCIATED
ENDONUCLEASE CAS1
(Pyrococcus
horikoshii) 		5 / 12 ILE A  61
ILE A  48
LEU A  14
ILE A  56
THR A 199
 None
 1.06A 2drcB-4wj0A:
undetectable		 2drcB-4wj0A:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VN0_A_TDZA501_1
(CYTOCHROME P450 2C8)		 4wj0 CRISPR-ASSOCIATED
ENDONUCLEASE CAS1
(Pyrococcus
horikoshii) 		5 / 12 ASN A 180
VAL A 271
VAL A 244
GLU A 167
ILE A 170
 None
 1.21A 2vn0A-4wj0A:
undetectable		 2vn0A-4wj0A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DRC_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 4wj0 CRISPR-ASSOCIATED
ENDONUCLEASE CAS1
(Pyrococcus
horikoshii) 		5 / 12 ILE A  61
ILE A  48
LEU A  14
ILE A  56
THR A 199
 None
 1.05A 3drcB-4wj0A:
undetectable		 3drcB-4wj0A:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I5U_A_SAMA401_0
(O-METHYLTRANSFERASE)		 4wj0 CRISPR-ASSOCIATED
ENDONUCLEASE CAS1
(Pyrococcus
horikoshii) 		5 / 12 LEU A 136
GLY A 111
GLY A 112
PRO A 233
ASP A 226
 None
 1.19A 3i5uA-4wj0A:
undetectable		 3i5uA-4wj0A:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_A_TFPA202_1
(PROTEIN S100-A4)		 4wj0 CRISPR-ASSOCIATED
ENDONUCLEASE CAS1
(Pyrococcus
horikoshii) 		5 / 12 LEU A  14
ILE A   8
LEU A   6
ASP A  39
PHE A  65
 None
 1.16A 3ko0A-4wj0A:
undetectable
3ko0B-4wj0A:
undetectable
3ko0C-4wj0A:
undetectable
3ko0D-4wj0A:
undetectable		 3ko0A-4wj0A:
16.94
3ko0B-4wj0A:
16.94
3ko0C-4wj0A:
16.94
3ko0D-4wj0A:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_J_TFPJ202_1
(PROTEIN S100-A4)		 4wj0 CRISPR-ASSOCIATED
ENDONUCLEASE CAS1
(Pyrococcus
horikoshii) 		5 / 11 PHE A  65
LEU A   6
ASP A  39
LEU A  14
ILE A   8
 None
 1.17A 3ko0A-4wj0A:
undetectable
3ko0B-4wj0A:
undetectable
3ko0I-4wj0A:
undetectable
3ko0J-4wj0A:
undetectable		 3ko0A-4wj0A:
16.94
3ko0B-4wj0A:
16.94
3ko0I-4wj0A:
16.94
3ko0J-4wj0A:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_L_TFPL202_1
(PROTEIN S100-A4)		 4wj0 CRISPR-ASSOCIATED
ENDONUCLEASE CAS1
(Pyrococcus
horikoshii) 		5 / 12 LEU A   6
ASP A  39
LEU A  14
ILE A   8
PHE A  65
 None
 1.09A 3ko0K-4wj0A:
undetectable
3ko0L-4wj0A:
undetectable
3ko0M-4wj0A:
undetectable
3ko0N-4wj0A:
undetectable		 3ko0K-4wj0A:
16.94
3ko0L-4wj0A:
16.94
3ko0M-4wj0A:
16.94
3ko0N-4wj0A:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_M_TFPM202_1
(PROTEIN S100-A4)		 4wj0 CRISPR-ASSOCIATED
ENDONUCLEASE CAS1
(Pyrococcus
horikoshii) 		5 / 12 LEU A  14
ILE A   8
LEU A   6
ASP A  39
PHE A  65
 None
 1.20A 3ko0M-4wj0A:
undetectable
3ko0N-4wj0A:
undetectable
3ko0O-4wj0A:
undetectable
3ko0P-4wj0A:
undetectable		 3ko0M-4wj0A:
16.94
3ko0N-4wj0A:
16.94
3ko0O-4wj0A:
16.94
3ko0P-4wj0A:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TQ9_A_MTXA2001_1
(DIHYDROFOLATE
REDUCTASE)		 4wj0 CRISPR-ASSOCIATED
ENDONUCLEASE CAS1
(Pyrococcus
horikoshii) 		5 / 12 ILE A  61
ILE A  48
LEU A  14
ILE A  56
THR A 199
 None
 1.04A 3tq9A-4wj0A:
undetectable		 3tq9A-4wj0A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DFR_B_MTXB162_1
(DIHYDROFOLATE
REDUCTASE)		 4wj0 CRISPR-ASSOCIATED
ENDONUCLEASE CAS1
(Pyrococcus
horikoshii) 		5 / 12 ILE A  61
ILE A  48
LEU A  14
ILE A  56
THR A 199
 None
 1.05A 4dfrB-4wj0A:
undetectable		 4dfrB-4wj0A:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_I_ACTI504_0
(RNA POLYMERASE
3D-POL)		 4wj0 CRISPR-ASSOCIATED
ENDONUCLEASE CAS1
(Pyrococcus
horikoshii) 		3 / 3 VAL A 244
GLY A 247
LYS A 250
 None
 0.59A 4k50I-4wj0A:
undetectable		 4k50I-4wj0A:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PTH_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4wj0 CRISPR-ASSOCIATED
ENDONUCLEASE CAS1
(Pyrococcus
horikoshii) 		5 / 12 ILE A  61
ILE A  48
LEU A  14
ILE A  56
THR A 199
 None
 1.01A 4pthA-4wj0A:
undetectable		 4pthA-4wj0A:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5G_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 4wj0 CRISPR-ASSOCIATED
ENDONUCLEASE CAS1
(Pyrococcus
horikoshii) 		5 / 12 ILE A  61
ILE A  48
LEU A  14
ILE A  56
THR A 199
 None
 1.01A 4x5gB-4wj0A:
undetectable		 4x5gB-4wj0A:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGY_A_ERYA403_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 4wj0 CRISPR-ASSOCIATED
ENDONUCLEASE CAS1
(Pyrococcus
horikoshii) 		4 / 6 ASP A  39
ILE A  42
TYR A  43
TYR A 275
 None
 1.46A 5igyA-4wj0A:
undetectable		 5igyA-4wj0A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6K_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4wj0 CRISPR-ASSOCIATED
ENDONUCLEASE CAS1
(Pyrococcus
horikoshii) 		5 / 12 ILE A  61
ILE A  48
LEU A  14
ILE A  56
THR A 199
 None
 0.99A 5z6kA-4wj0A:
undetectable		 5z6kA-4wj0A:
18.35