SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4wj7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKN_A_RALA600_2
(ESTROGEN RECEPTOR
BETA)		 4wj7 MALCAVERNIN
(Homo
sapiens) 		3 / 3 ASP A 147
LEU A 152
HIS A  99
 None
 0.68A 1qknA-4wj7A:
undetectable		 1qknA-4wj7A:
24.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_A_1FLA2001_1
(SERUM ALBUMIN)		 4wj7 MALCAVERNIN
(Homo
sapiens) 		5 / 11 LEU A 155
ILE A 139
VAL A 216
GLY A 214
LEU A 115
 None
 1.41A 2bxeA-4wj7A:
undetectable		 2bxeA-4wj7A:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFH_A_CL6A1413_1
(ERYTHROMYCIN B/D
C-12 HYDROXYLASE)		 4wj7 MALCAVERNIN
(Homo
sapiens) 		4 / 6 HIS A 137
ALA A 158
ALA A 140
PHE A 217
 None
 0.96A 2xfhA-4wj7A:
undetectable		 2xfhA-4wj7A:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_D_VD3D2001_1
(VITAMIN D
HYDROXYLASE)		 4wj7 MALCAVERNIN
(Homo
sapiens) 		5 / 12 ILE A  76
LEU A  80
LEU A  89
ILE A  92
ALA A  95
 None
 1.14A 3a50D-4wj7A:
undetectable		 3a50D-4wj7A:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_A_IPHA101_0
(INSULIN)		 4wj7 MALCAVERNIN
(Homo
sapiens) 		5 / 10 LEU A  70
HIS A 151
LEU A 152
ALA A 199
LEU A 105
 None
 1.22A 4p65A-4wj7A:
undetectable
4p65B-4wj7A:
undetectable
4p65F-4wj7A:
undetectable
4p65H-4wj7A:
undetectable		 4p65A-4wj7A:
6.75
4p65B-4wj7A:
14.07
4p65F-4wj7A:
14.07
4p65H-4wj7A:
14.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_C_IPHC101_0
(INSULIN)		 4wj7 MALCAVERNIN
(Homo
sapiens) 		5 / 11 LEU A  70
HIS A 151
LEU A 152
ALA A 199
LEU A 105
 None
 1.16A 4p65C-4wj7A:
undetectable
4p65D-4wj7A:
undetectable
4p65J-4wj7A:
undetectable
4p65L-4wj7A:
undetectable		 4p65C-4wj7A:
6.75
4p65D-4wj7A:
14.07
4p65J-4wj7A:
14.07
4p65L-4wj7A:
14.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEN_B_VDYB201_1
(CDL2.2)		 4wj7 MALCAVERNIN
(Homo
sapiens) 		5 / 10 ILE A  76
LEU A  80
VAL A 145
ILE A 197
LEU A 152
 None
 1.16A 5ienB-4wj7A:
undetectable		 5ienB-4wj7A:
20.50