SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4wja'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_A_STRA601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4wja UNCHARACTERIZED
PROTEIN C9ORF142
(Homo
sapiens) 		4 / 6 ARG A  63
ASP A 108
VAL A  85
ALA A  86
 None
 0.90A 4nkxA-4wjaA:
undetectable		 4nkxA-4wjaA:
15.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_A_IPHA101_0
(INSULIN)		 4wja UNCHARACTERIZED
PROTEIN C9ORF142
(Homo
sapiens) 		5 / 10 CYH A  22
LEU A  87
ALA A  94
LEU A  47
LEU A  89
 None
 1.05A 4p65A-4wjaA:
undetectable
4p65B-4wjaA:
undetectable
4p65F-4wjaA:
undetectable
4p65H-4wjaA:
undetectable		 4p65A-4wjaA:
11.46
4p65B-4wjaA:
11.18
4p65F-4wjaA:
11.18
4p65H-4wjaA:
11.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_C_IPHC101_0
(INSULIN)		 4wja UNCHARACTERIZED
PROTEIN C9ORF142
(Homo
sapiens) 		5 / 11 CYH A  22
LEU A  87
ALA A  94
LEU A  89
LEU A  47
 None
 1.04A 4p65C-4wjaA:
undetectable
4p65D-4wjaA:
undetectable
4p65J-4wjaA:
undetectable
4p65L-4wjaA:
undetectable		 4p65C-4wjaA:
11.46
4p65D-4wjaA:
11.18
4p65J-4wjaA:
11.18
4p65L-4wjaA:
11.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_E_IPHE101_0
(INSULIN)		 4wja UNCHARACTERIZED
PROTEIN C9ORF142
(Homo
sapiens) 		5 / 11 CYH A  22
LEU A  87
ALA A  94
LEU A  47
LEU A  89
 None
 1.10A 4p65E-4wjaA:
undetectable
4p65F-4wjaA:
undetectable
4p65J-4wjaA:
undetectable
4p65L-4wjaA:
undetectable		 4p65E-4wjaA:
11.46
4p65F-4wjaA:
11.18
4p65J-4wjaA:
11.18
4p65L-4wjaA:
11.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_G_IPHG101_0
(INSULIN)		 4wja UNCHARACTERIZED
PROTEIN C9ORF142
(Homo
sapiens) 		5 / 11 LEU A  89
LEU A  47
CYH A  22
LEU A  87
ALA A  94
 None
 1.16A 4p65B-4wjaA:
undetectable
4p65D-4wjaA:
undetectable
4p65G-4wjaA:
undetectable
4p65H-4wjaA:
undetectable		 4p65B-4wjaA:
11.18
4p65D-4wjaA:
11.18
4p65G-4wjaA:
11.46
4p65H-4wjaA:
11.18