SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4wjg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HZE_A_RBFA98_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 4wjg HAPTOGLOBIN
(Homo
sapiens) 		5 / 9 LEU C 219
LEU C 193
THR C 195
THR C 216
ILE C 213
 None
 1.45A 1hzeA-4wjgC:
1.1
1hzeB-4wjgC:
1.1		 1hzeA-4wjgC:
14.60
1hzeB-4wjgC:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HZE_B_RBFB99_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 4wjg HAPTOGLOBIN
(Homo
sapiens) 		5 / 9 THR C 216
ILE C 213
LEU C 219
LEU C 193
THR C 195
 None
 1.45A 1hzeA-4wjgC:
1.1
1hzeB-4wjgC:
1.1		 1hzeA-4wjgC:
14.60
1hzeB-4wjgC:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_A_RBFA501_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 4wjg HAPTOGLOBIN
(Homo
sapiens) 		5 / 12 GLY C 184
SER C 353
ILE C 370
ILE C 246
LEU C 194
 None
 1.25A 1kyvA-4wjgC:
undetectable
1kyvE-4wjgC:
undetectable		 1kyvA-4wjgC:
20.69
1kyvE-4wjgC:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_E_RBFE505_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 4wjg HAPTOGLOBIN
(Homo
sapiens) 		5 / 12 ILE C 246
LEU C 194
GLY C 184
SER C 353
ILE C 370
 None
 1.23A 1kyvD-4wjgC:
undetectable
1kyvE-4wjgC:
undetectable		 1kyvD-4wjgC:
20.69
1kyvE-4wjgC:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7X_A_CFFA864_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 4wjg HAPTOGLOBIN
(Homo
sapiens) 		3 / 3 TRP C 280
HIS C 291
LYS C 293
 None
 1.41A 1l7xA-4wjgC:
undetectable		 1l7xA-4wjgC:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_B_9CRB600_1
(RETINOIC ACID
RECEPTOR, BETA)		 4wjg HAPTOGLOBIN
(Homo
sapiens) 		5 / 12 ALA C 173
ILE C 188
SER C 278
LEU C 245
LEU C 248
 None
 1.05A 1xdkB-4wjgC:
undetectable		 1xdkB-4wjgC:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_B_9CRB600_1
(RETINOIC ACID
RECEPTOR, BETA)		 4wjg HAPTOGLOBIN
(Homo
sapiens) 		5 / 12 ALA C 173
LEU C 187
ILE C 188
LEU C 245
LEU C 248
 None
 1.15A 1xdkB-4wjgC:
undetectable		 1xdkB-4wjgC:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_F_9CRF1600_1
(RETINOIC ACID
RECEPTOR, BETA)		 4wjg HAPTOGLOBIN
(Homo
sapiens) 		6 / 12 ALA C 173
LEU C 187
ILE C 188
SER C 278
LEU C 245
LEU C 248
 None
 1.24A 1xdkF-4wjgC:
undetectable		 1xdkF-4wjgC:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_B_SAMB301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4wjg HAPTOGLOBIN
(Homo
sapiens) 		5 / 12 LYS C 158
GLY C 349
TYR C 348
ASP C 350
ALA C 351
 None
 1.02A 2br4B-4wjgC:
undetectable		 2br4B-4wjgC:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EGV_A_SAMA1300_0
(UPF0088 PROTEIN
AQ_165)		 4wjg HAPTOGLOBIN
(Homo
sapiens) 		5 / 12 LEU C 194
GLY C 352
GLY C 184
LEU C 245
THR C 196
 None
 0.82A 2egvA-4wjgC:
undetectable		 2egvA-4wjgC:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EGV_B_SAMB1400_0
(UPF0088 PROTEIN
AQ_165)		 4wjg HAPTOGLOBIN
(Homo
sapiens) 		5 / 12 LEU C 194
GLY C 352
GLY C 184
LEU C 245
THR C 196
 None
 0.82A 2egvB-4wjgC:
undetectable		 2egvB-4wjgC:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_B_SAMB602_0
(HYPOTHETICAL PROTEIN)		 4wjg HAPTOGLOBIN
(Homo
sapiens) 		5 / 12 GLY C 349
GLY C 184
LEU C 371
VAL C 176
ASP C 350
 None
 0.95A 2yvlB-4wjgC:
undetectable		 2yvlB-4wjgC:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOB_C_RFPC2002_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 4wjg HAPTOGLOBIN
(Homo
sapiens) 		5 / 12 PHE C 373
THR C 346
ASN C 199
GLY C 184
LEU C 202
 None
 1.20A 3aobC-4wjgC:
undetectable		 3aobC-4wjgC:
14.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APT_B_ACTB311_0
(METHYLENETETRAHYDROF
OLATE REDUCTASE)		 4wjg HAPTOGLOBIN
(Homo
sapiens) 		5 / 9 LEU C 217
PRO C 215
ALA C 214
ILE C 213
HIS C 204
 None
 1.33A 3aptB-4wjgC:
undetectable		 3aptB-4wjgC:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_A_PFLA319_1
(GLR4197 PROTEIN)		 4wjg HAPTOGLOBIN
(Homo
sapiens) 		4 / 7 LEU C 263
THR C 398
ILE C 399
ASN C 189
 None
 0.91A 3p50A-4wjgC:
undetectable		 3p50A-4wjgC:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_B_PFLB319_1
(GLR4197 PROTEIN)		 4wjg HAPTOGLOBIN
(Homo
sapiens) 		4 / 7 LEU C 263
THR C 398
ILE C 399
ASN C 189
 None
 0.90A 3p50B-4wjgC:
undetectable		 3p50B-4wjgC:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_C_PFLC319_1
(GLR4197 PROTEIN)		 4wjg HAPTOGLOBIN
(Homo
sapiens) 		4 / 7 LEU C 263
THR C 398
ILE C 399
ASN C 189
 None
 0.90A 3p50C-4wjgC:
undetectable		 3p50C-4wjgC:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_D_PFLD320_1
(GLR4197 PROTEIN)		 4wjg HAPTOGLOBIN
(Homo
sapiens) 		4 / 7 LEU C 263
THR C 398
ILE C 399
ASN C 189
 None
 0.90A 3p50D-4wjgC:
undetectable		 3p50D-4wjgC:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_E_PFLE319_1
(GLR4197 PROTEIN)		 4wjg HAPTOGLOBIN
(Homo
sapiens) 		4 / 7 LEU C 263
THR C 398
ILE C 399
ASN C 189
 None
 0.89A 3p50E-4wjgC:
undetectable		 3p50E-4wjgC:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P73_A_ACTA275_0
(MHC RFP-Y CLASS I
ALPHA CHAIN)		 4wjg HAPTOGLOBIN-HEMOGLOB
IN RECEPTOR
(Trypanosoma
brucei) 		3 / 3 ILE E  65
VAL E 244
ARG E 248
 None
 0.69A 3p73A-4wjgE:
undetectable		 3p73A-4wjgE:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U52_A_CUA515_0
(PHENOL HYDROXYLASE
COMPONENT PHL
PHENOL HYDROXYLASE
COMPONENT PHN)		 4wjg HAPTOGLOBIN
(Homo
sapiens) 		3 / 3 HIS C 333
HIS C 235
ILE C 391
 NAG  C1005 ( 4.7A)
None
None
 0.83A 3u52A-4wjgC:
undetectable
3u52C-4wjgC:
undetectable		 3u52A-4wjgC:
21.65
3u52C-4wjgC:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V8V_B_SAMB801_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE L)		 4wjg HAPTOGLOBIN
(Homo
sapiens) 		5 / 11 GLY C 281
ASP C 350
ASP C 374
VAL C 295
ASN C 283
 None
 1.23A 3v8vB-4wjgC:
undetectable		 3v8vB-4wjgC:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DUB_A_LDPA501_1
(CYTOCHROME P450 BM3
VARIANT 9D7)		 4wjg HAPTOGLOBIN
(Homo
sapiens) 		4 / 6 PHE C 335
ALA C 269
GLY C 275
VAL C 357
 None
 0.51A 4dubA-4wjgC:
undetectable		 4dubA-4wjgC:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_C_URFC1301_1
(URIDINE
PHOSPHORYLASE)		 4wjg HAPTOGLOBIN
HAPTOGLOBIN-HEMOGLOB
IN RECEPTOR
(Homo
sapiens;
Trypanosoma
brucei) 		5 / 8 THR E  81
GLY C 272
GLN E  75
VAL C 299
PRO C 298
 None
 1.46A 4e1vC-4wjgE:
undetectable		 4e1vC-4wjgE:
24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_G_URFG1301_1
(URIDINE
PHOSPHORYLASE)		 4wjg HAPTOGLOBIN
HAPTOGLOBIN-HEMOGLOB
IN RECEPTOR
(Homo
sapiens;
Trypanosoma
brucei) 		5 / 8 THR E  81
GLY C 272
GLN E  75
VAL C 299
PRO C 298
 None
 1.50A 4e1vG-4wjgE:
undetectable		 4e1vG-4wjgE:
24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F3T_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 4wjg HAPTOGLOBIN
(Homo
sapiens) 		4 / 4 PHE C 355
VAL C 277
ALA C 356
PHE C 169
 None
 1.47A 4f3tA-4wjgC:
undetectable		 4f3tA-4wjgC:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FIA_A_0U9A601_1
(CHOLESTEROL
24-HYDROXYLASE)		 4wjg HAPTOGLOBIN-HEMOGLOB
IN RECEPTOR
(Trypanosoma
brucei) 		5 / 12 LEU E  97
VAL E 100
ALA E 278
GLU E 130
ALA E 128
 None
 1.02A 4fiaA-4wjgE:
undetectable		 4fiaA-4wjgE:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FIA_A_198A602_1
(CHOLESTEROL
24-HYDROXYLASE)		 4wjg HAPTOGLOBIN-HEMOGLOB
IN RECEPTOR
(Trypanosoma
brucei) 		5 / 12 LEU E  97
VAL E 100
ALA E 278
GLU E 130
ALA E 128
 None
 1.02A 4fiaA-4wjgE:
undetectable		 4fiaA-4wjgE:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5Q_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 4wjg HAPTOGLOBIN
(Homo
sapiens) 		4 / 4 PHE C 355
VAL C 277
ALA C 356
PHE C 169
 None
 1.41A 4w5qA-4wjgC:
undetectable		 4w5qA-4wjgC:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5R_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 4wjg HAPTOGLOBIN
(Homo
sapiens) 		4 / 4 PHE C 355
VAL C 277
ALA C 356
PHE C 169
 None
 1.47A 4w5rA-4wjgC:
undetectable		 4w5rA-4wjgC:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5T_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 4wjg HAPTOGLOBIN
(Homo
sapiens) 		4 / 4 PHE C 355
VAL C 277
ALA C 356
PHE C 169
 None
 1.48A 4w5tA-4wjgC:
undetectable		 4w5tA-4wjgC:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4G_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 4wjg HAPTOGLOBIN
(Homo
sapiens) 		4 / 4 PHE C 355
VAL C 277
ALA C 356
PHE C 169
 None
 1.44A 4z4gA-4wjgC:
undetectable		 4z4gA-4wjgC:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_D_SORD1343_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 4wjg HAPTOGLOBIN-HEMOGLOB
IN RECEPTOR
(Trypanosoma
brucei) 		4 / 5 ALA E  52
ARG E 199
ALA E 170
GLU E 172
 None
 1.13A 5a06C-4wjgE:
undetectable
5a06D-4wjgE:
undetectable		 5a06C-4wjgE:
21.84
5a06D-4wjgE:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IFU_B_GBMB801_1
(PROLINE--TRNA LIGASE)		 4wjg HAPTOGLOBIN
(Homo
sapiens) 		5 / 9 TYR C 385
LEU C 297
THR C 346
ILE C 158
GLY C 279
 None
 1.33A 5ifuB-4wjgC:
undetectable		 5ifuB-4wjgC:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KI6_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 4wjg HAPTOGLOBIN
(Homo
sapiens) 		4 / 4 PHE C 355
VAL C 277
ALA C 356
PHE C 169
 None
 1.45A 5ki6A-4wjgC:
undetectable		 5ki6A-4wjgC:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWU_A_ACAA18_1
(WTFP-TAG,GP41)		 4wjg HAPTOGLOBIN-HEMOGLOB
IN RECEPTOR
(Trypanosoma
brucei) 		5 / 12 ALA E 169
GLY E 167
GLN E  54
LEU E 210
GLU E 209
 None
 1.15A 5nwuA-4wjgE:
undetectable		 5nwuA-4wjgE:
7.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_G_SAMG501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 4wjg HAPTOGLOBIN
(Homo
sapiens) 		5 / 11 LEU C 194
GLY C 352
GLY C 184
LEU C 245
THR C 196
 None
 1.01A 5o96G-4wjgC:
undetectable		 5o96G-4wjgC:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_H_SAMH501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 4wjg HAPTOGLOBIN
(Homo
sapiens) 		5 / 10 LEU C 194
GLY C 352
GLY C 184
LEU C 245
THR C 196
 None
 1.01A 5o96G-4wjgC:
undetectable
5o96H-4wjgC:
undetectable		 5o96G-4wjgC:
21.74
5o96H-4wjgC:
21.74