SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4wjs'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ9_A_CAMA503_0
(CYTOCHROME P450-CAM)		 4wjs RSA4
(Chaetomium
thermophilum) 		4 / 8 LEU A 480
THR A 428
VAL A 449
ASP A 467
 None
 0.96A 1dz9A-4wjsA:
undetectable		 1dz9A-4wjsA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FPQ_A_SAMA1699_0
(ISOLIQUIRITIGENIN
2'-O-METHYLTRANSFERA
SE)		 4wjs RSA4
(Chaetomium
thermophilum) 		5 / 10 GLY A 464
ASN A 408
ASP A 483
ALA A 493
TRP A 515
 None
 1.40A 1fpqA-4wjsA:
undetectable		 1fpqA-4wjsA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSE_A_EAAA224_1
(GLUTATHIONE
TRANSFERASE)		 4wjs RSA4
(Chaetomium
thermophilum) 		5 / 12 PHE A 361
GLY A 289
LEU A 375
PRO A 389
ALA A 365
 None
 1.08A 1gseA-4wjsA:
undetectable		 1gseA-4wjsA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HPV_B_478B200_2
(HIV-1 PROTEASE)		 4wjs RSA4
(Chaetomium
thermophilum) 		5 / 9 ALA A 308
ASP A 307
GLY A 290
VAL A 286
ILE A 294
 None
 1.11A 1hpvB-4wjsA:
undetectable		 1hpvB-4wjsA:
11.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKV_A_EFZA2000_1
(POL POLYPROTEIN)		 4wjs RSA4
(Chaetomium
thermophilum) 		5 / 9 VAL A 283
VAL A 303
TYR A 295
GLY A 297
LEU A 276
 None
 1.37A 1ikvA-4wjsA:
undetectable		 1ikvA-4wjsA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKW_A_EFZA2000_1
(POL POLYPROTEIN)		 4wjs RSA4
(Chaetomium
thermophilum) 		5 / 10 VAL A 283
VAL A 303
TYR A 295
GLY A 297
LEU A 276
 None
 1.40A 1ikwA-4wjsA:
undetectable		 1ikwA-4wjsA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LW0_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 4wjs RSA4
(Chaetomium
thermophilum) 		5 / 10 LEU A 442
VAL A 449
GLY A 423
TRP A 454
LEU A 430
 None
 1.38A 1lw0A-4wjsA:
undetectable		 1lw0A-4wjsA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LWC_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 4wjs RSA4
(Chaetomium
thermophilum) 		5 / 11 LEU A 442
VAL A 449
GLY A 423
TRP A 454
LEU A 430
 None
 1.44A 1lwcA-4wjsA:
undetectable		 1lwcA-4wjsA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_C_SAMC2293_0
(GLYCINE
N-METHYLTRANSFERASE)		 4wjs RSA4
(Chaetomium
thermophilum) 		5 / 12 GLY A 297
THR A 296
ALA A 378
SER A 377
GLY A 281
 None
 1.13A 1nbiC-4wjsA:
undetectable		 1nbiC-4wjsA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_D_SAMD3293_0
(GLYCINE
N-METHYLTRANSFERASE)		 4wjs RSA4
(Chaetomium
thermophilum) 		5 / 12 GLY A 297
THR A 296
ALA A 378
SER A 377
GLY A 281
 None
 1.14A 1nbiD-4wjsA:
undetectable		 1nbiD-4wjsA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TYR_A_9CRA131_1
(TRANSTHYRETIN)		 4wjs RSA4
(Chaetomium
thermophilum) 		4 / 6 LEU A 193
LEU A 236
SER A 257
THR A 211
 None
 1.24A 1tyrA-4wjsA:
undetectable		 1tyrA-4wjsA:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XF1_B_ACTB1108_0
(C5A PEPTIDASE)		 4wjs RSA4
(Chaetomium
thermophilum) 		5 / 6 LEU A 400
GLY A 436
ASN A 432
ILE A 419
PHE A 438
 None
 1.44A 1xf1B-4wjsA:
undetectable		 1xf1B-4wjsA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HND_A_NVPA999_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 4wjs RSA4
(Chaetomium
thermophilum) 		5 / 10 LEU A 442
VAL A 449
GLY A 423
TRP A 454
LEU A 430
 None
 1.36A 2hndA-4wjsA:
undetectable		 2hndA-4wjsA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HNY_A_NVPA999_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 4wjs RSA4
(Chaetomium
thermophilum) 		5 / 10 LEU A 442
VAL A 449
GLY A 423
TRP A 454
LEU A 430
 None
 1.34A 2hnyA-4wjsA:
undetectable		 2hnyA-4wjsA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HAV_A_SRYA403_1
(AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 4wjs RSA4
(Chaetomium
thermophilum) 		4 / 8 ASP A 177
ASP A 499
ASP A 495
TRP A 197
 None
 0.97A 3havA-4wjsA:
2.8		 3havA-4wjsA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LBD_A_9CRA424_1
(RETINOIC ACID
RECEPTOR GAMMA)		 4wjs RSA4
(Chaetomium
thermophilum) 		5 / 12 ALA A  39
LEU A  69
MET A  49
ILE A  42
ILE A  55
 None
 1.41A 3lbdA-4wjsA:
undetectable		 3lbdA-4wjsA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LP0_A_NVPA701_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 4wjs RSA4
(Chaetomium
thermophilum) 		5 / 9 LEU A 442
VAL A 449
GLY A 423
TRP A 454
LEU A 430
 None
 1.36A 3lp0A-4wjsA:
undetectable		 3lp0A-4wjsA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LP1_A_NVPA701_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 4wjs RSA4
(Chaetomium
thermophilum) 		5 / 10 LEU A 442
VAL A 449
GLY A 423
TRP A 454
LEU A 430
 None
 1.34A 3lp1A-4wjsA:
undetectable		 3lp1A-4wjsA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBG_C_ACTC800_0
(FAD-LINKED
SULFHYDRYL OXIDASE
ALR)		 4wjs RSA4
(Chaetomium
thermophilum) 		3 / 3 ASP A 292
ARG A 252
ALA A 308
 None
 0.71A 3mbgC-4wjsA:
undetectable		 3mbgC-4wjsA:
13.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MED_A_65BA561_0
(P51 REVERSE
TRANSCRIPTASE
P66 REVERSE
TRANSCRIPTASE)		 4wjs RSA4
(Chaetomium
thermophilum) 		5 / 12 VAL A 283
VAL A 303
TYR A 295
GLY A 297
LEU A 276
 None
 1.35A 3medA-4wjsA:
undetectable
3medB-4wjsA:
undetectable		 3medA-4wjsA:
22.56
3medB-4wjsA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_2
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		 4wjs RSA4
(Chaetomium
thermophilum) 		3 / 3 SER A 160
SER A 159
HIS A 140
 None
 0.84A 3mzeA-4wjsA:
undetectable		 3mzeA-4wjsA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QIP_A_NVPA561_1
(REVERSE HIV-1
REVERSE
TRANSCRIPTASE P66)		 4wjs RSA4
(Chaetomium
thermophilum) 		5 / 10 LEU A 442
VAL A 449
GLY A 423
TRP A 454
LEU A 430
 None
 1.36A 3qipA-4wjsA:
undetectable		 3qipA-4wjsA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_C_ACTC4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 4wjs RSA4
(Chaetomium
thermophilum) 		4 / 4 GLY A 165
GLY A 194
THR A 206
LEU A 204
 None
 0.79A 3si7C-4wjsA:
undetectable
3si7D-4wjsA:
undetectable		 3si7C-4wjsA:
22.24
3si7D-4wjsA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_D_ACTD4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 4wjs RSA4
(Chaetomium
thermophilum) 		4 / 5 LEU A 204
GLY A 165
GLY A 194
THR A 206
 None
 0.81A 3si7C-4wjsA:
undetectable
3si7D-4wjsA:
undetectable		 3si7C-4wjsA:
22.24
3si7D-4wjsA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_E_ACTE502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 4wjs RSA4
(Chaetomium
thermophilum) 		3 / 3 LYS A 440
ARG A  84
LEU A 418
 None
 1.38A 3v4tE-4wjsA:
undetectable		 3v4tE-4wjsA:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DUB_A_LDPA501_1
(CYTOCHROME P450 BM3
VARIANT 9D7)		 4wjs RSA4
(Chaetomium
thermophilum) 		4 / 6 PHE A 412
ALA A 433
LEU A 386
VAL A 397
 None
 1.00A 4dubA-4wjsA:
undetectable		 4dubA-4wjsA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_B_ACTB701_0
(RNA (33-MER)
RNA POLYMERASE
3D-POL)		 4wjs RSA4
(Chaetomium
thermophilum) 		3 / 3 HIS A  88
GLY A  46
ILE A  42
 None
 0.59A 4k50A-4wjsA:
undetectable		 4k50A-4wjsA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_J_ACTJ701_0
(RNA (33-MER)
RNA POLYMERASE
3D-POL)		 4wjs RSA4
(Chaetomium
thermophilum) 		3 / 3 HIS A  88
GLY A  46
ILE A  42
 None
 0.59A 4k50I-4wjsA:
undetectable		 4k50I-4wjsA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LL3_A_017A202_2
(PROTEASE)		 4wjs RSA4
(Chaetomium
thermophilum) 		5 / 9 ALA A 308
ASP A 307
GLY A 290
VAL A 286
ILE A 294
 None
 1.18A 4ll3B-4wjsA:
undetectable		 4ll3B-4wjsA:
11.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWU_B_BEZB1401_0
(MAGNESIUM-CHELATASE
SUBUNIT CHLH,
CHLOROPLASTIC)		 4wjs RSA4
(Chaetomium
thermophilum) 		4 / 6 GLY A 464
THR A 463
VAL A 449
HIS A 409
 None
 1.02A 5ewuB-4wjsA:
undetectable		 5ewuB-4wjsA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_A_1N1A501_2
(PROTEIN-TYROSINE
KINASE 6)		 4wjs RSA4
(Chaetomium
thermophilum) 		3 / 3 ILE A 149
MET A 209
ASP A 168
 None
 0.77A 5h2uA-4wjsA:
undetectable		 5h2uA-4wjsA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HBM_A_NVPA601_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 4wjs RSA4
(Chaetomium
thermophilum) 		5 / 11 LEU A 442
VAL A 449
GLY A 423
TRP A 454
LEU A 430
 None
 1.38A 5hbmA-4wjsA:
undetectable		 5hbmA-4wjsA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_C_IPHC101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 4wjs RSA4
(Chaetomium
thermophilum) 		4 / 5 CYH A 152
ILE A 149
LEU A 162
HIS A 145
 None
 1.50A 5hrqC-4wjsA:
undetectable
5hrqD-4wjsA:
undetectable
5hrqL-4wjsA:
undetectable		 5hrqC-4wjsA:
3.73
5hrqD-4wjsA:
5.67
5hrqL-4wjsA:
5.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQY_B_017B101_1
(PROTEASE E35D-DRV)		 4wjs RSA4
(Chaetomium
thermophilum) 		5 / 12 ALA A 308
ASP A 307
GLY A 290
VAL A 286
ILE A 294
 None
 1.13A 5kqyA-4wjsA:
undetectable		 5kqyA-4wjsA:
10.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4E_D_EDPD402_1
(PROTON-GATED ION
CHANNEL)		 4wjs RSA4
(Chaetomium
thermophilum) 		4 / 8 THR A 272
SER A 255
THR A 261
SER A 257
 None
 1.00A 5l4eA-4wjsA:
undetectable
5l4eB-4wjsA:
undetectable
5l4eC-4wjsA:
undetectable
5l4eD-4wjsA:
undetectable
5l4eE-4wjsA:
undetectable		 5l4eA-4wjsA:
20.12
5l4eB-4wjsA:
20.12
5l4eC-4wjsA:
20.12
5l4eD-4wjsA:
20.12
5l4eE-4wjsA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MFX_A_ACTA701_0
(GENOME POLYPROTEIN)		 4wjs RSA4
(Chaetomium
thermophilum) 		4 / 5 ARG A 263
THR A 211
HIS A 231
ALA A 232
 None
 1.42A 5mfxA-4wjsA:
undetectable		 5mfxA-4wjsA:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YBB_A_SAMA601_1
(TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT)		 4wjs RSA4
(Chaetomium
thermophilum) 		4 / 5 PHE A 228
THR A 206
ASP A 210
GLU A 227
 None
 1.42A 5ybbA-4wjsA:
undetectable		 5ybbA-4wjsA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSG_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 4wjs RSA4
(Chaetomium
thermophilum) 		5 / 10 LEU A 442
VAL A 449
GLY A 423
TRP A 454
LEU A 430
 None
 1.37A 6bsgA-4wjsA:
undetectable		 6bsgA-4wjsA:
12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSI_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 4wjs RSA4
(Chaetomium
thermophilum) 		5 / 10 LEU A 442
VAL A 449
GLY A 423
TRP A 454
LEU A 430
 None
 1.41A 6bsiA-4wjsA:
undetectable		 6bsiA-4wjsA:
12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSJ_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 4wjs RSA4
(Chaetomium
thermophilum) 		5 / 10 LEU A 442
VAL A 449
GLY A 423
TRP A 454
LEU A 430
 None
 1.37A 6bsjA-4wjsA:
undetectable		 6bsjA-4wjsA:
12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXN_A_SAMA901_0
(DIPHTHAMIDE
BIOSYNTHESIS ENZYME
DPH2)		 4wjs RSA4
(Chaetomium
thermophilum) 		5 / 12 SER A 421
LYS A 429
VAL A 407
ARG A 399
ASP A 381
 None
 1.08A 6bxnA-4wjsA:
undetectable		 6bxnA-4wjsA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXN_B_SAMB901_0
(DIPHTHAMIDE
BIOSYNTHESIS ENZYME
DPH2)		 4wjs RSA4
(Chaetomium
thermophilum) 		5 / 12 SER A 421
LYS A 429
VAL A 407
ARG A 399
ASP A 381
 None
 1.10A 6bxnB-4wjsA:
undetectable		 6bxnB-4wjsA:
22.27