SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4wjv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_B_DESB459_2
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 4wjv RIBOSOME ASSEMBLY
PROTEIN 4
(Saccharomyces
cerevisiae) 		3 / 3 LEU A 478
HIS A 443
ILE A 426
 None
 0.69A 1s9pB-4wjvA:
undetectable		 1s9pB-4wjvA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UOF_A_PNNA1312_0
(DEACETOXYCEPHALOSPOR
IN C SYNTHETASE)		 4wjv RIBOSOME ASSEMBLY
PROTEIN 4
(Saccharomyces
cerevisiae) 		5 / 11 ASP A 423
HIS A 401
VAL A 418
SER A 461
VAL A 447
 None
 1.45A 1uofA-4wjvA:
undetectable		 1uofA-4wjvA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_C_SAMC300_1
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 4wjv RIBOSOME ASSEMBLY
PROTEIN 4
(Saccharomyces
cerevisiae) 		4 / 4 SER A 144
GLY A 164
HIS A 485
ASP A 465
 None
 1.20A 2oxtC-4wjvA:
undetectable		 2oxtC-4wjvA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N3I_A_ROCA201_2
(PROTEASE)		 4wjv RIBOSOME ASSEMBLY
PROTEIN 4
(Saccharomyces
cerevisiae) 		4 / 6 ILE A 363
PRO A 239
GLY A 287
VAL A 375
 None
 0.87A 3n3iA-4wjvA:
undetectable		 3n3iA-4wjvA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZT_A_ACTA202_0
(RETINOL-BINDING
PROTEIN 2)		 4wjv RIBOSOME ASSEMBLY
PROTEIN 4
(Saccharomyces
cerevisiae) 		4 / 6 TYR A 293
THR A 330
LEU A 328
GLN A 289
 None
 1.45A 4qztA-4wjvA:
undetectable		 4qztA-4wjvA:
14.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UDA_A_DEXA1985_1
(MINERALOCORTICOID
RECEPTOR)		 4wjv RIBOSOME ASSEMBLY
PROTEIN 4
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 468
SER A 495
ARG A 335
MET A 159
LEU A 512
 None
 1.44A 4udaA-4wjvA:
undetectable		 4udaA-4wjvA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_N_EVPN2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 4wjv RIBOSOME ASSEMBLY
PROTEIN 4
(Saccharomyces
cerevisiae) 		4 / 6 GLY A 414
ASP A 413
ARG A 415
GLY A 431
 None
 0.91A 5cdnR-4wjvA:
undetectable
5cdnS-4wjvA:
undetectable		 5cdnR-4wjvA:
21.46
5cdnS-4wjvA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_A_1N1A501_2
(PROTEIN-TYROSINE
KINASE 6)		 4wjv RIBOSOME ASSEMBLY
PROTEIN 4
(Saccharomyces
cerevisiae) 		3 / 3 ILE A 146
MET A 206
ASP A 165
 None
 0.78A 5h2uA-4wjvA:
undetectable		 5h2uA-4wjvA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNX_B_TA1B902_1
(TUBULIN BETA-2B
CHAIN)		 4wjv RIBOSOME ASSEMBLY
PROTEIN 4
(Saccharomyces
cerevisiae) 		5 / 12 HIS A 325
LEU A 326
SER A 234
LEU A 328
THR A 330
 None
 1.31A 5hnxB-4wjvA:
undetectable		 5hnxB-4wjvA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IH0_A_ERYA404_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 4wjv RIBOSOME ASSEMBLY
PROTEIN 4
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 288
GLU A 199
ARG A 250
ALA A 252
SER A 247
 None
 1.19A 5ih0A-4wjvA:
2.1		 5ih0A-4wjvA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_B_EY4B500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 4wjv RIBOSOME ASSEMBLY
PROTEIN 4
(Saccharomyces
cerevisiae) 		4 / 6 VAL A 160
TRP A 171
ALA A 168
THR A 167
 None
 1.05A 6cduB-4wjvA:
undetectable
6cduC-4wjvA:
undetectable		 6cduB-4wjvA:
20.73
6cduC-4wjvA:
20.73