SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4wk4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXD_A_ACRA733_1
(ALPHA AMYLASE)		 4wk4 INTEGRIN ALPHA-5
(Homo
sapiens) 		4 / 6 THR A 245
ASN A 266
LEU A 273
ASP A 247
 None
NAG  A 519 (-1.6A)
NAG  A 519 (-4.4A)
CA  A 501 (-2.1A)
 1.33A 1mxdA-4wk4A:
undetectable		 1mxdA-4wk4A:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RU9_H_BEZH601_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 4wk4 INTEGRIN ALPHA-5
(Homo
sapiens) 		5 / 9 ALA A 250
GLY A 286
PHE A 285
GLY A 260
TYR A 261
 None
None
None
None
NAG  A 505 (-4.2A)
 1.42A 1ru9H-4wk4A:
undetectable
1ru9L-4wk4A:
undetectable		 1ru9H-4wk4A:
18.67
1ru9L-4wk4A:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RUA_H_BEZH601_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 4wk4 INTEGRIN ALPHA-5
(Homo
sapiens) 		5 / 10 ALA A 250
GLY A 286
PHE A 285
GLY A 260
TYR A 261
 None
None
None
None
NAG  A 505 (-4.2A)
 1.38A 1ruaH-4wk4A:
undetectable
1ruaL-4wk4A:
undetectable		 1ruaH-4wk4A:
18.67
1ruaL-4wk4A:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA6_A_SCKA902_1
(ACETYLCHOLINESTERASE)		 4wk4 INTEGRIN ALPHA-5
(Homo
sapiens) 		5 / 10 ASP A 311
THR A 341
GLU A 279
LEU A 309
TYR A 325
 None
 1.43A 2ha6A-4wk4A:
undetectable		 2ha6A-4wk4A:
24.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA6_B_SCKB952_1
(ACETYLCHOLINESTERASE)		 4wk4 INTEGRIN ALPHA-5
(Homo
sapiens) 		5 / 10 ASP A 311
THR A 341
GLU A 279
LEU A 309
TYR A 325
 None
 1.42A 2ha6B-4wk4A:
undetectable		 2ha6B-4wk4A:
24.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_D_DHID8_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 4wk4 INTEGRIN ALPHA-5
(Homo
sapiens) 		4 / 4 SER A 437
GLY A 439
GLY A 416
GLY A 382
 None
 0.87A 3bogB-4wk4A:
undetectable
3bogD-4wk4A:
undetectable		 3bogB-4wk4A:
undetectable
3bogD-4wk4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_F_SAMF300_0
(PUTATIVE RRNA
METHYLASE)		 4wk4 INTEGRIN ALPHA-5
(Homo
sapiens) 		6 / 12 ASN A 367
ASP A 293
ASN A 295
LEU A 394
THR A 339
THR A 337
 None
CA  A 502 (-3.3A)
CA  A 502 (-3.0A)
None
None
MAN  A 514 ( 4.9A)
 1.48A 3eeyF-4wk4A:
undetectable		 3eeyF-4wk4A:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GYQ_A_SAMA270_0
(RRNA
(ADENOSINE-2'-O-)-ME
THYLTRANSFERASE)		 4wk4 INTEGRIN ALPHA-5
(Homo
sapiens) 		5 / 12 ALA A 370
GLY A 436
ILE A 371
LEU A 355
ARG A 106
 None
 1.34A 3gyqA-4wk4A:
undetectable
3gyqB-4wk4A:
undetectable		 3gyqA-4wk4A:
23.01
3gyqB-4wk4A:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_A_ACTA4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 4wk4 INTEGRIN ALPHA-5
(Homo
sapiens) 		4 / 4 LEU A 180
GLY A 181
GLY A 167
THR A 104
 None
 0.74A 3si7A-4wk4A:
undetectable		 3si7A-4wk4A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7S_D_SAMD300_0
(PUTATIVE
METHYLTRANSFERASE)		 4wk4 INTEGRIN ALPHA-5
(Homo
sapiens) 		5 / 12 GLY A 376
GLY A 377
GLN A 403
PHE A 348
ALA A 373
 None
 1.24A 3t7sD-4wk4A:
undetectable		 3t7sD-4wk4A:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3THR_C_C2FC1410_0
(GLYCINE
N-METHYLTRANSFERASE)		 4wk4 INTEGRIN ALPHA-5
(Homo
sapiens) 		3 / 3 ARG A 420
PRO A 431
PHE A  25
 None
 1.04A 3thrC-4wk4A:
undetectable		 3thrC-4wk4A:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UBO_B_ADNB353_2
(ADENOSINE KINASE)		 4wk4 INTEGRIN ALPHA-5
(Homo
sapiens) 		4 / 5 SER A 229
TYR A 261
GLY A 190
PRO A 183
 None
NAG  A 505 (-4.2A)
None
None
 1.05A 3uboB-4wk4A:
undetectable		 3uboB-4wk4A:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DXU_A_ACAA711_1
(LACTOTRANSFERRIN)		 4wk4 INTEGRIN ALPHA-5
(Homo
sapiens) 		4 / 6 GLY A 255
PRO A 253
GLY A 232
TYR A 233
 None
 0.87A 4dxuA-4wk4A:
undetectable		 4dxuA-4wk4A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E3A_A_ADNA500_2
(SUGAR KINASE PROTEIN)		 4wk4 INTEGRIN ALPHA-5
(Homo
sapiens) 		4 / 4 SER A 229
TYR A 261
GLY A 190
PRO A 183
 None
NAG  A 505 (-4.2A)
None
None
 0.99A 4e3aA-4wk4A:
undetectable		 4e3aA-4wk4A:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E3A_B_ADNB500_1
(SUGAR KINASE PROTEIN)		 4wk4 INTEGRIN ALPHA-5
(Homo
sapiens) 		6 / 12 GLY A 390
GLY A 389
THR A 292
LEU A 303
GLY A 365
ASP A 364
 None
None
None
None
None
CA  A 503 (-2.8A)
 1.46A 4e3aB-4wk4A:
undetectable		 4e3aB-4wk4A:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB2_B_DM5B601_1
(SERUM ALBUMIN)		 4wk4 INTEGRIN ALPHA-5
(Homo
sapiens) 		5 / 9 LEU A 302
VAL A 326
PRO A 338
TYR A 274
ILE A 264
 None
 1.37A 4lb2B-4wk4A:
undetectable		 4lb2B-4wk4A:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCI_A_SAMA2409_0
(RNA-DIRECTED RNA
POLYMERASE L)		 4wk4 INTEGRIN ALPHA-5
(Homo
sapiens) 		5 / 12 GLY A 184
GLY A 182
GLY A 232
SER A 185
ALA A 158
 None
 0.94A 4uciA-4wk4A:
undetectable		 4uciA-4wk4A:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCI_B_SAMB2409_0
(RNA-DIRECTED RNA
POLYMERASE L)		 4wk4 INTEGRIN ALPHA-5
(Homo
sapiens) 		5 / 12 GLY A 184
GLY A 182
GLY A 232
SER A 185
ALA A 158
 None
 0.95A 4uciB-4wk4A:
undetectable		 4uciB-4wk4A:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCK_A_SAMA2409_0
(RNA-DIRECTED RNA
POLYMERASE L)		 4wk4 INTEGRIN ALPHA-5
(Homo
sapiens) 		5 / 12 GLY A 184
GLY A 182
GLY A 232
SER A 185
ALA A 158
 None
 0.95A 4uckA-4wk4A:
undetectable		 4uckA-4wk4A:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ALB_L_TIQL1210_2
(MEDI2452 LIGHT CHAIN)		 4wk4 INTEGRIN ALPHA-5
(Homo
sapiens) 		4 / 8 SER A 234
GLY A 251
ALA A 282
GLY A 260
 None
 0.87A 5albL-4wk4A:
undetectable		 5albL-4wk4A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BW4_B_SAMB301_0
(16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE)		 4wk4 INTEGRIN ALPHA-5
(Homo
sapiens) 		5 / 12 GLY A 133
GLY A 167
PRO A 150
LEU A 118
ALA A 103
 None
 1.19A 5bw4B-4wk4A:
undetectable		 5bw4B-4wk4A:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0Y_A_FOLA201_0
(CONSERVED
HYPOTHETICAL
MEMBRANE PROTEIN)		 4wk4 INTEGRIN ALPHA-5
(Homo
sapiens) 		5 / 12 GLY A 333
ASP A 243
ASN A 266
THR A 245
VAL A 249
 None
CA  A 501 (-2.7A)
NAG  A 519 (-1.6A)
None
None
 0.93A 5d0yA-4wk4A:
undetectable		 5d0yA-4wk4A:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WYQ_B_SAMB301_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 4wk4 INTEGRIN ALPHA-5
(Homo
sapiens) 		5 / 12 LEU A 394
GLY A 390
SER A 396
GLY A 392
GLY A 393
 None
 1.00A 5wyqB-4wk4A:
undetectable		 5wyqB-4wk4A:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_A_SALA201_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 4wk4 INTEGRIN ALPHA-5
(Homo
sapiens) 		4 / 5 VAL A 252
PRO A 183
GLY A 190
TYR A 230
 None
 1.35A 5x80A-4wk4A:
undetectable
5x80B-4wk4A:
undetectable		 5x80A-4wk4A:
17.38
5x80B-4wk4A:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_A_GMJA301_1
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 4wk4 INTEGRIN ALPHA-5
(Homo
sapiens) 		4 / 6 SER A  77
TYR A 119
GLN A  46
GLU A 147
 None
 1.33A 6djzA-4wk4A:
undetectable		 6djzA-4wk4A:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_2
(-)		 4wk4 INTEGRIN ALPHA-5
(Homo
sapiens) 		5 / 12 GLY A 393
LEU A 394
GLY A 238
ASN A 367
GLU A 246
 None
 0.93A 6gngB-4wk4A:
undetectable		 6gngB-4wk4A:
22.42