SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4wk5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RQJ_A_RISA901_1
(GERANYLTRANSTRANSFER
ASE)		 4wk5 GERANYLTRANSTRANSFER
ASE
(Thermotoga
neapolitana) 		6 / 11 LEU A  71
ASP A  80
ARG A  85
THR A 164
GLN A 198
ASP A 201
 None
 0.81A 1rqjA-4wk5A:
31.7		 1rqjA-4wk5A:
34.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RQJ_B_RISB903_1
(GERANYLTRANSTRANSFER
ASE)		 4wk5 GERANYLTRANSTRANSFER
ASE
(Thermotoga
neapolitana) 		6 / 11 LEU A  71
ASP A  80
ARG A  85
THR A 164
GLN A 198
ASP A 201
 None
 0.78A 1rqjB-4wk5A:
31.8		 1rqjB-4wk5A:
34.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_L_TRPL81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4wk5 GERANYLTRANSTRANSFER
ASE
(Thermotoga
neapolitana) 		5 / 12 GLY A  96
HIS A  92
ALA A  25
ILE A  99
SER A  29
 None
 0.97A 1utdL-4wk5A:
undetectable
1utdM-4wk5A:
undetectable		 1utdL-4wk5A:
14.19
1utdM-4wk5A:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YHL_A_RISA1400_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4wk5 GERANYLTRANSTRANSFER
ASE
(Thermotoga
neapolitana) 		6 / 11 LEU A  71
ASP A  80
ARG A  85
THR A 164
GLN A 198
ASP A 201
 None
 0.76A 1yhlA-4wk5A:
24.7		 1yhlA-4wk5A:
25.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YQ7_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHETASE)		 4wk5 GERANYLTRANSTRANSFER
ASE
(Thermotoga
neapolitana) 		5 / 11 LEU A  71
ASP A  74
ASP A  80
THR A 164
GLN A 198
 None
 1.18A 1yq7A-4wk5A:
24.3		 1yq7A-4wk5A:
27.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YQ7_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHETASE)		 4wk5 GERANYLTRANSTRANSFER
ASE
(Thermotoga
neapolitana) 		6 / 11 LEU A  71
ASP A  80
ARG A  85
THR A 164
GLN A 198
ASP A 201
 None
 0.76A 1yq7A-4wk5A:
24.3		 1yq7A-4wk5A:
27.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YV5_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHETASE)		 4wk5 GERANYLTRANSTRANSFER
ASE
(Thermotoga
neapolitana) 		5 / 10 LEU A  71
ASP A  74
ARG A  85
THR A 164
GLN A 198
 None
 0.97A 1yv5A-4wk5A:
24.5		 1yv5A-4wk5A:
27.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YV5_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHETASE)		 4wk5 GERANYLTRANSTRANSFER
ASE
(Thermotoga
neapolitana) 		6 / 10 LEU A  71
ASP A  80
ARG A  85
THR A 164
GLN A 198
ASP A 201
 None
 0.80A 1yv5A-4wk5A:
24.5		 1yv5A-4wk5A:
27.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZW5_A_ZOLA901_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 4wk5 GERANYLTRANSTRANSFER
ASE
(Thermotoga
neapolitana) 		5 / 9 ASP A  74
ASP A  80
ARG A  85
THR A 164
GLN A 198
 None
 1.11A 1zw5A-4wk5A:
24.6		 1zw5A-4wk5A:
26.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZW5_A_ZOLA901_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 4wk5 GERANYLTRANSTRANSFER
ASE
(Thermotoga
neapolitana) 		5 / 9 ASP A  80
ARG A  85
LYS A 163
THR A 164
GLN A 198
 None
 1.28A 1zw5A-4wk5A:
24.6		 1zw5A-4wk5A:
26.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZW5_A_ZOLA901_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 4wk5 GERANYLTRANSTRANSFER
ASE
(Thermotoga
neapolitana) 		5 / 9 ASP A  80
ARG A  85
THR A 164
GLN A 198
ASP A 201
 None
 0.83A 1zw5A-4wk5A:
24.6		 1zw5A-4wk5A:
26.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E91_A_ZOLA901_1
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE)		 4wk5 GERANYLTRANSTRANSFER
ASE
(Thermotoga
neapolitana) 		5 / 9 ASP A  80
ARG A  85
LYS A 163
THR A 164
ASP A 201
 None
 1.27A 2e91A-4wk5A:
20.9		 2e91A-4wk5A:
24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E91_A_ZOLA901_1
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE)		 4wk5 GERANYLTRANSTRANSFER
ASE
(Thermotoga
neapolitana) 		5 / 9 ASP A  80
ARG A  85
THR A 164
GLN A 198
ASP A 201
 None
 0.65A 2e91A-4wk5A:
20.9		 2e91A-4wk5A:
24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E91_B_ZOLB902_1
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE)		 4wk5 GERANYLTRANSTRANSFER
ASE
(Thermotoga
neapolitana) 		5 / 9 ASP A  80
ARG A  85
THR A 164
GLN A 198
ASP A 201
 None
 0.72A 2e91B-4wk5A:
20.0		 2e91B-4wk5A:
24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F89_F_210F9001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 4wk5 GERANYLTRANSTRANSFER
ASE
(Thermotoga
neapolitana) 		5 / 9 ASP A  80
ARG A  85
THR A 164
GLN A 198
ASP A 201
 None
 0.76A 2f89F-4wk5A:
24.7		 2f89F-4wk5A:
25.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8C_F_ZOLF9001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 4wk5 GERANYLTRANSTRANSFER
ASE
(Thermotoga
neapolitana) 		6 / 11 LEU A  71
ASP A  80
ARG A  85
THR A 164
GLN A 198
ASP A 201
 None
 0.80A 2f8cF-4wk5A:
24.7		 2f8cF-4wk5A:
25.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8Z_F_ZOLF5001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 4wk5 GERANYLTRANSTRANSFER
ASE
(Thermotoga
neapolitana) 		5 / 10 LEU A  71
ASP A  74
ARG A  85
THR A 164
GLN A 198
 None
 0.98A 2f8zF-4wk5A:
24.8		 2f8zF-4wk5A:
25.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8Z_F_ZOLF5001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 4wk5 GERANYLTRANSTRANSFER
ASE
(Thermotoga
neapolitana) 		6 / 10 LEU A  71
ASP A  80
ARG A  85
THR A 164
GLN A 198
ASP A 201
 None
 0.79A 2f8zF-4wk5A:
24.8		 2f8zF-4wk5A:
25.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F94_F_BFQF9001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 4wk5 GERANYLTRANSTRANSFER
ASE
(Thermotoga
neapolitana) 		6 / 12 LEU A  71
ASP A  80
ARG A  85
THR A 164
GLN A 198
ASP A 201
 None
 0.77A 2f94F-4wk5A:
24.7		 2f94F-4wk5A:
25.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F9K_F_ZOLF9001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 4wk5 GERANYLTRANSTRANSFER
ASE
(Thermotoga
neapolitana) 		6 / 10 LEU A  71
ASP A  80
ARG A  85
THR A 164
GLN A 198
ASP A 201
 None
 0.81A 2f9kF-4wk5A:
24.5		 2f9kF-4wk5A:
25.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O1O_A_RISA400_1
(PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4wk5 GERANYLTRANSTRANSFER
ASE
(Thermotoga
neapolitana) 		5 / 9 LEU A  71
ASP A  80
ARG A  85
LYS A 163
THR A 164
 None
 1.12A 2o1oA-4wk5A:
22.5		 2o1oA-4wk5A:
26.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O1O_A_RISA400_1
(PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4wk5 GERANYLTRANSTRANSFER
ASE
(Thermotoga
neapolitana) 		5 / 9 LEU A  71
ASP A  80
ARG A  85
THR A 164
GLN A 198
 None
 0.77A 2o1oA-4wk5A:
22.5		 2o1oA-4wk5A:
26.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O1O_B_RISB400_1
(PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4wk5 GERANYLTRANSTRANSFER
ASE
(Thermotoga
neapolitana) 		5 / 10 LEU A  71
ASP A  80
ARG A  85
THR A 164
GLN A 198
 None
 0.79A 2o1oB-4wk5A:
23.0		 2o1oB-4wk5A:
26.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QIS_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHETASE)		 4wk5 GERANYLTRANSTRANSFER
ASE
(Thermotoga
neapolitana) 		5 / 10 LEU A  71
ASP A  80
ARG A  85
GLN A 198
ASP A 201
 None
 0.76A 2qisA-4wk5A:
24.3		 2qisA-4wk5A:
27.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EZ3_A_ZOLA397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE, PUTATIVE)		 4wk5 GERANYLTRANSTRANSFER
ASE
(Thermotoga
neapolitana) 		5 / 9 ASP A  80
ARG A  85
THR A 164
GLN A 198
ASP A 201
 None
 0.75A 3ez3A-4wk5A:
23.6		 3ez3A-4wk5A:
27.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EZ3_B_ZOLB397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE, PUTATIVE)		 4wk5 GERANYLTRANSTRANSFER
ASE
(Thermotoga
neapolitana) 		5 / 9 ASP A  80
ARG A  85
THR A 164
GLN A 198
ASP A 201
 None
 0.80A 3ez3B-4wk5A:
23.7		 3ez3B-4wk5A:
27.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EZ3_C_ZOLC397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE, PUTATIVE)		 4wk5 GERANYLTRANSTRANSFER
ASE
(Thermotoga
neapolitana) 		5 / 9 ASP A  80
ARG A  85
THR A 164
GLN A 198
ASP A 201
 None
 0.78A 3ez3C-4wk5A:
23.8		 3ez3C-4wk5A:
27.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EZ3_D_ZOLD397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE, PUTATIVE)		 4wk5 GERANYLTRANSTRANSFER
ASE
(Thermotoga
neapolitana) 		6 / 10 LEU A  71
ASP A  80
ARG A  85
THR A 164
GLN A 198
ASP A 201
 None
 0.76A 3ez3D-4wk5A:
23.5		 3ez3D-4wk5A:
27.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IBA_A_ZOLA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4wk5 GERANYLTRANSTRANSFER
ASE
(Thermotoga
neapolitana) 		5 / 10 ASP A  80
ARG A  85
THR A 164
GLN A 198
ASP A 201
 None
 0.70A 3ibaA-4wk5A:
24.6		 3ibaA-4wk5A:
25.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LDW_A_ZOLA397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4wk5 GERANYLTRANSTRANSFER
ASE
(Thermotoga
neapolitana) 		5 / 9 ASP A  80
ARG A  85
THR A 164
GLN A 198
ASP A 201
 None
 0.74A 3ldwA-4wk5A:
23.7		 3ldwA-4wk5A:
27.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LDW_B_ZOLB397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4wk5 GERANYLTRANSTRANSFER
ASE
(Thermotoga
neapolitana) 		5 / 9 ASP A  80
ARG A  85
THR A 164
GLN A 198
ASP A 201
 None
 0.83A 3ldwB-4wk5A:
23.6		 3ldwB-4wk5A:
27.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LDW_C_ZOLC397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4wk5 GERANYLTRANSTRANSFER
ASE
(Thermotoga
neapolitana) 		5 / 9 ASP A  80
ARG A  85
THR A 164
GLN A 198
ASP A 201
 None
 0.75A 3ldwC-4wk5A:
23.6		 3ldwC-4wk5A:
27.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LDW_D_ZOLD397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4wk5 GERANYLTRANSTRANSFER
ASE
(Thermotoga
neapolitana) 		5 / 9 ASP A  80
ARG A  85
THR A 164
GLN A 198
ASP A 201
 None
 0.83A 3ldwD-4wk5A:
23.4		 3ldwD-4wk5A:
27.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N23_C_OBNC1_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 4wk5 GERANYLTRANSTRANSFER
ASE
(Thermotoga
neapolitana) 		5 / 11 ASP A  74
LEU A  76
ALA A 103
PHE A 108
PHE A  66
 None
 1.39A 3n23C-4wk5A:
undetectable		 3n23C-4wk5A:
15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N45_F_ZOLF354_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4wk5 GERANYLTRANSTRANSFER
ASE
(Thermotoga
neapolitana) 		6 / 11 LEU A  71
ASP A  80
ARG A  85
THR A 164
GLN A 198
ASP A 201
 None
 0.82A 3n45F-4wk5A:
24.4		 3n45F-4wk5A:
25.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N46_F_ZOLF354_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4wk5 GERANYLTRANSTRANSFER
ASE
(Thermotoga
neapolitana) 		5 / 10 LEU A  71
ASP A  80
ARG A  85
THR A 164
GLN A 198
 None
 0.71A 3n46F-4wk5A:
24.4		 3n46F-4wk5A:
25.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N46_F_ZOLF354_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4wk5 GERANYLTRANSTRANSFER
ASE
(Thermotoga
neapolitana) 		5 / 10 LEU A  71
ASP A  80
THR A 164
GLN A 198
ASP A 201
 None
 0.64A 3n46F-4wk5A:
24.4		 3n46F-4wk5A:
25.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F3T_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 4wk5 GERANYLTRANSTRANSFER
ASE
(Thermotoga
neapolitana) 		4 / 6 LEU A 262
LYS A 266
LEU A 247
TYR A 243
 None
 1.05A 4f3tA-4wk5A:
undetectable		 4f3tA-4wk5A:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KPD_A_RISA405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4wk5 GERANYLTRANSTRANSFER
ASE
(Thermotoga
neapolitana) 		5 / 10 LEU A  71
ASP A  80
ARG A  85
THR A 164
GLN A 198
 None
 0.68A 4kpdA-4wk5A:
24.8		 4kpdA-4wk5A:
28.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KPD_A_RISA405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4wk5 GERANYLTRANSTRANSFER
ASE
(Thermotoga
neapolitana) 		5 / 10 LEU A  71
ASP A  80
THR A 164
GLN A 198
ASP A 201
 None
 0.70A 4kpdA-4wk5A:
24.8		 4kpdA-4wk5A:
28.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KPJ_A_210A901_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4wk5 GERANYLTRANSTRANSFER
ASE
(Thermotoga
neapolitana) 		6 / 9 LEU A  71
ASP A  80
ARG A  85
THR A 164
GLN A 198
ASP A 201
 None
 0.77A 4kpjA-4wk5A:
24.5		 4kpjA-4wk5A:
28.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KQ5_A_ZOLA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4wk5 GERANYLTRANSTRANSFER
ASE
(Thermotoga
neapolitana) 		5 / 10 LEU A  71
ASP A  80
ARG A  85
THR A 164
GLN A 198
 None
 0.66A 4kq5A-4wk5A:
24.6		 4kq5A-4wk5A:
28.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KQ5_A_ZOLA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4wk5 GERANYLTRANSTRANSFER
ASE
(Thermotoga
neapolitana) 		5 / 10 LEU A  71
ASP A  80
THR A 164
GLN A 198
ASP A 201
 None
 0.71A 4kq5A-4wk5A:
24.6		 4kq5A-4wk5A:
28.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KQS_A_RISA405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4wk5 GERANYLTRANSTRANSFER
ASE
(Thermotoga
neapolitana) 		6 / 10 LEU A  71
ASP A  80
ARG A  85
THR A 164
GLN A 198
ASP A 201
 None
 0.79A 4kqsA-4wk5A:
24.9		 4kqsA-4wk5A:
28.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N9U_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4wk5 GERANYLTRANSTRANSFER
ASE
(Thermotoga
neapolitana) 		6 / 10 LEU A  71
ASP A  80
ARG A  85
THR A 164
GLN A 198
ASP A 201
 None
 0.78A 4n9uA-4wk5A:
24.3		 4n9uA-4wk5A:
28.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NG6_A_RISA405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4wk5 GERANYLTRANSTRANSFER
ASE
(Thermotoga
neapolitana) 		5 / 12 LEU A  71
ASP A  80
ARG A  85
THR A 164
GLN A 198
 None
 0.62A 4ng6A-4wk5A:
24.7		 4ng6A-4wk5A:
28.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NG6_A_RISA405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4wk5 GERANYLTRANSTRANSFER
ASE
(Thermotoga
neapolitana) 		5 / 12 LEU A  71
ASP A  80
THR A 164
GLN A 198
ASP A 201
 None
 0.68A 4ng6A-4wk5A:
24.7		 4ng6A-4wk5A:
28.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKE_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4wk5 GERANYLTRANSTRANSFER
ASE
(Thermotoga
neapolitana) 		5 / 10 LEU A  71
ASP A  74
ARG A  85
THR A 164
GLN A 198
 None
 0.98A 4nkeA-4wk5A:
24.7		 4nkeA-4wk5A:
27.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKE_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4wk5 GERANYLTRANSTRANSFER
ASE
(Thermotoga
neapolitana) 		6 / 10 LEU A  71
ASP A  80
ARG A  85
THR A 164
GLN A 198
ASP A 201
 None
 0.78A 4nkeA-4wk5A:
24.7		 4nkeA-4wk5A:
27.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKF_A_210A404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4wk5 GERANYLTRANSTRANSFER
ASE
(Thermotoga
neapolitana) 		6 / 9 LEU A  71
ASP A  80
ARG A  85
THR A 164
GLN A 198
ASP A 201
 None
 0.79A 4nkfA-4wk5A:
24.4		 4nkfA-4wk5A:
27.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NUA_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4wk5 GERANYLTRANSTRANSFER
ASE
(Thermotoga
neapolitana) 		6 / 10 LEU A  71
ASP A  80
ARG A  85
THR A 164
GLN A 198
ASP A 201
 None
 0.76A 4nuaA-4wk5A:
24.7		 4nuaA-4wk5A:
27.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGU_A_210A405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4wk5 GERANYLTRANSTRANSFER
ASE
(Thermotoga
neapolitana) 		6 / 9 LEU A  71
ASP A  80
ARG A  85
THR A 164
GLN A 198
ASP A 201
 None
 0.77A 4oguA-4wk5A:
24.3		 4oguA-4wk5A:
27.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P0V_A_ZOLA401_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4wk5 GERANYLTRANSTRANSFER
ASE
(Thermotoga
neapolitana) 		5 / 9 ASP A  80
ARG A  85
THR A 164
GLN A 198
ASP A 201
 None
 0.90A 4p0vA-4wk5A:
24.6		 4p0vA-4wk5A:
25.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P0W_A_ZOLA501_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4wk5 GERANYLTRANSTRANSFER
ASE
(Thermotoga
neapolitana) 		5 / 11 LEU A  71
ASP A  80
ARG A  85
THR A 164
GLN A 198
 None
 0.72A 4p0wA-4wk5A:
24.5		 4p0wA-4wk5A:
25.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P0W_A_ZOLA501_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4wk5 GERANYLTRANSTRANSFER
ASE
(Thermotoga
neapolitana) 		5 / 11 LEU A  71
ASP A  80
THR A 164
GLN A 198
ASP A 201
 None
 0.73A 4p0wA-4wk5A:
24.5		 4p0wA-4wk5A:
25.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q23_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4wk5 GERANYLTRANSTRANSFER
ASE
(Thermotoga
neapolitana) 		5 / 10 LEU A  71
ASP A  80
ARG A  85
GLN A 198
ASP A 201
 None
 0.80A 4q23A-4wk5A:
24.2		 4q23A-4wk5A:
28.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RXD_A_RISA1404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4wk5 GERANYLTRANSTRANSFER
ASE
(Thermotoga
neapolitana) 		5 / 10 LEU A  71
ASP A  74
ARG A  85
THR A 164
GLN A 198
 None
 0.95A 4rxdA-4wk5A:
23.7		 4rxdA-4wk5A:
27.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RXD_A_RISA1404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4wk5 GERANYLTRANSTRANSFER
ASE
(Thermotoga
neapolitana) 		6 / 10 LEU A  71
ASP A  80
ARG A  85
THR A 164
GLN A 198
ASP A 201
 None
 0.73A 4rxdA-4wk5A:
23.7		 4rxdA-4wk5A:
27.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RXD_B_RISB1504_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4wk5 GERANYLTRANSTRANSFER
ASE
(Thermotoga
neapolitana) 		5 / 10 LEU A  71
ASP A  74
ARG A  85
THR A 164
GLN A 198
 None
 0.94A 4rxdB-4wk5A:
24.1		 4rxdB-4wk5A:
27.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RXD_B_RISB1504_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4wk5 GERANYLTRANSTRANSFER
ASE
(Thermotoga
neapolitana) 		6 / 10 LEU A  71
ASP A  80
ARG A  85
THR A 164
GLN A 198
ASP A 201
 None
 0.73A 4rxdB-4wk5A:
24.1		 4rxdB-4wk5A:
27.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RXD_C_RISC1600_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4wk5 GERANYLTRANSTRANSFER
ASE
(Thermotoga
neapolitana) 		5 / 10 LEU A  71
ASP A  74
ARG A  85
THR A 164
GLN A 198
 None
 0.95A 4rxdC-4wk5A:
24.1		 4rxdC-4wk5A:
27.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RXD_C_RISC1600_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4wk5 GERANYLTRANSTRANSFER
ASE
(Thermotoga
neapolitana) 		6 / 10 LEU A  71
ASP A  80
ARG A  85
THR A 164
GLN A 198
ASP A 201
 None
 0.73A 4rxdC-4wk5A:
24.1		 4rxdC-4wk5A:
27.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XJE_A_TOYA202_1
(AADB)		 4wk5 GERANYLTRANSTRANSFER
ASE
(Thermotoga
neapolitana) 		4 / 8 ASP A 205
ASP A 201
TYR A 160
ASP A 202
 None
 0.83A 4xjeA-4wk5A:
1.5		 4xjeA-4wk5A:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBQ_A_ACTA605_0
(SERUM ALBUMIN)		 4wk5 GERANYLTRANSTRANSFER
ASE
(Thermotoga
neapolitana) 		4 / 6 HIS A  67
GLY A  34
GLU A  64
ARG A  36
 None
 1.07A 4zbqA-4wk5A:
3.6		 4zbqA-4wk5A:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CFS_A_TOYA203_1
(AAD(2''),GENTAMICIN
2''-NUCLEOTIDYLTRANS
FERASE,GENTAMICIN
RESISTANCE PROTEIN)		 4wk5 GERANYLTRANSTRANSFER
ASE
(Thermotoga
neapolitana) 		4 / 8 ASP A 205
ASP A 201
TYR A 160
ASP A 202
 None
 0.79A 5cfsA-4wk5A:
1.0		 5cfsA-4wk5A:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CG5_A_RISA400_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4wk5 GERANYLTRANSTRANSFER
ASE
(Thermotoga
neapolitana) 		6 / 12 LEU A  71
ASP A  80
ARG A  85
THR A 164
GLN A 198
ASP A 201
 None
 0.74A 5cg5A-4wk5A:
23.9		 5cg5A-4wk5A:
25.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CG6_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4wk5 GERANYLTRANSTRANSFER
ASE
(Thermotoga
neapolitana) 		6 / 12 LEU A  71
ASP A  80
ARG A  85
THR A 164
GLN A 198
ASP A 201
 None
 0.76A 5cg6A-4wk5A:
24.5		 5cg6A-4wk5A:
25.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERO_A_210A804_1
(FUSICOCCADIENE
SYNTHASE)		 4wk5 GERANYLTRANSTRANSFER
ASE
(Thermotoga
neapolitana) 		5 / 9 LEU A  71
ASP A  80
ARG A  85
GLN A 198
ASP A 201
 None
 0.83A 5eroA-4wk5A:
23.7		 5eroA-4wk5A:
26.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERO_C_210C804_1
(FUSICOCCADIENE
SYNTHASE)		 4wk5 GERANYLTRANSTRANSFER
ASE
(Thermotoga
neapolitana) 		6 / 10 ASP A  75
ASP A  80
ARG A  85
LYS A 163
GLN A 198
ASP A 201
 None
 1.20A 5eroC-4wk5A:
23.8		 5eroC-4wk5A:
26.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HV1_A_RFPA902_1
(PHOSPHOENOLPYRUVATE
SYNTHASE)		 4wk5 GERANYLTRANSTRANSFER
ASE
(Thermotoga
neapolitana) 		5 / 12 PRO A 175
ALA A 174
LEU A 134
SER A  70
LEU A  43
 None
 1.15A 5hv1A-4wk5A:
undetectable		 5hv1A-4wk5A:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KI6_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 4wk5 GERANYLTRANSTRANSFER
ASE
(Thermotoga
neapolitana) 		4 / 5 LEU A 262
LYS A 266
LEU A 247
TYR A 243
 None
 1.12A 5ki6A-4wk5A:
undetectable		 5ki6A-4wk5A:
16.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T7B_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 4wk5 GERANYLTRANSTRANSFER
ASE
(Thermotoga
neapolitana) 		4 / 7 LEU A 262
LYS A 266
LEU A 247
TYR A 243
 None
 1.07A 5t7bA-4wk5A:
undetectable		 5t7bA-4wk5A:
16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_D_ZOLD401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 4wk5 GERANYLTRANSTRANSFER
ASE
(Thermotoga
neapolitana) 		4 / 7 LEU A  71
ASP A  80
ARG A  85
GLN A 198
 None
 0.51A 6g31D-4wk5A:
23.6		 6g31D-4wk5A:
12.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_J_ZOLJ401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 4wk5 GERANYLTRANSTRANSFER
ASE
(Thermotoga
neapolitana) 		4 / 6 LEU A  71
ASP A  80
ARG A  85
GLN A 198
 None
 0.80A 6g31J-4wk5A:
24.2		 6g31J-4wk5A:
12.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IBL_A_H98A501_0
(THIOREDOXIN 1,BETA-1
ADRENERGIC RECEPTOR)		 4wk5 GERANYLTRANSTRANSFER
ASE
(Thermotoga
neapolitana) 		5 / 12 THR A  44
ASP A 260
PHE A 261
PHE A 193
PHE A 197
 None
 1.49A 6iblA-4wk5A:
undetectable		 6iblA-4wk5A:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IBL_B_H98B501_0
(THIOREDOXIN 1,BETA-1
ADRENERGIC RECEPTOR)		 4wk5 GERANYLTRANSTRANSFER
ASE
(Thermotoga
neapolitana) 		5 / 12 THR A  44
ASP A 260
PHE A 261
PHE A 193
PHE A 168
 None
 1.48A 6iblB-4wk5A:
undetectable		 6iblB-4wk5A:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IBL_B_H98B501_0
(THIOREDOXIN 1,BETA-1
ADRENERGIC RECEPTOR)		 4wk5 GERANYLTRANSTRANSFER
ASE
(Thermotoga
neapolitana) 		5 / 12 THR A  44
ASP A 260
PHE A 261
PHE A 193
PHE A 197
 None
 1.48A 6iblB-4wk5A:
undetectable		 6iblB-4wk5A:
22.30