SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4wk7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTB_A_PZQA901_0
(GLUTATHIONE
S-TRANSFERASE)		 4wk7 A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 4
(Homo
sapiens) 		3 / 3 GLN A 354
TYR A 241
ARG A 240
 None
 0.81A 1gtbA-4wk7A:
undetectable		 1gtbA-4wk7A:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OS2_A_HAEA874_1
(MACROPHAGE
METALLOELASTASE)		 4wk7 A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 4
(Homo
sapiens) 		4 / 5 HIS A 361
GLU A 362
HIS A 365
HIS A 371
 ZN  A 501 ( 3.2A)
3PQ  A 505 (-2.6A)
ZN  A 501 ( 3.3A)
ZN  A 501 ( 3.2A)
 0.29A 1os2A-4wk7A:
10.6		 1os2A-4wk7A:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OS2_D_HAED574_1
(MACROPHAGE
METALLOELASTASE)		 4wk7 A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 4
(Homo
sapiens) 		4 / 4 HIS A 361
GLU A 362
HIS A 365
HIS A 371
 ZN  A 501 ( 3.2A)
3PQ  A 505 (-2.6A)
ZN  A 501 ( 3.3A)
ZN  A 501 ( 3.2A)
 0.25A 1os2D-4wk7A:
10.6		 1os2D-4wk7A:
22.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1R55_A_097A518_1
(ADAM 33)		 4wk7 A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 4
(Homo
sapiens) 		6 / 10 THR A 329
THR A 358
HIS A 361
GLU A 362
HIS A 365
HIS A 371
 3PQ  A 505 ( 4.6A)
3PQ  A 505 ( 4.0A)
ZN  A 501 ( 3.2A)
3PQ  A 505 (-2.6A)
ZN  A 501 ( 3.3A)
ZN  A 501 ( 3.2A)
 0.39A 1r55A-4wk7A:
25.9		 1r55A-4wk7A:
30.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTT_A_HAEA1265_1
(MACROPHAGE
METALLOELASTASE)		 4wk7 A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 4
(Homo
sapiens) 		4 / 4 HIS A 361
GLU A 362
HIS A 365
HIS A 371
 ZN  A 501 ( 3.2A)
3PQ  A 505 (-2.6A)
ZN  A 501 ( 3.3A)
ZN  A 501 ( 3.2A)
 0.19A 1uttA-4wk7A:
10.9		 1uttA-4wk7A:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTZ_A_HAEA1267_1
(MACROPHAGE
METALLOELASTASE)		 4wk7 A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 4
(Homo
sapiens) 		4 / 4 HIS A 361
GLU A 362
HIS A 365
HIS A 371
 ZN  A 501 ( 3.2A)
3PQ  A 505 (-2.6A)
ZN  A 501 ( 3.3A)
ZN  A 501 ( 3.2A)
 0.27A 1utzA-4wk7A:
10.7		 1utzA-4wk7A:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTZ_B_HAEB1266_1
(MACROPHAGE
METALLOELASTASE)		 4wk7 A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 4
(Homo
sapiens) 		4 / 4 HIS A 361
GLU A 362
HIS A 365
HIS A 371
 ZN  A 501 ( 3.2A)
3PQ  A 505 (-2.6A)
ZN  A 501 ( 3.3A)
ZN  A 501 ( 3.2A)
 0.24A 1utzB-4wk7A:
10.8		 1utzB-4wk7A:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_A_CUA517_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I)		 4wk7 A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 4
(Homo
sapiens) 		3 / 3 HIS A 371
HIS A 365
HIS A 361
 ZN  A 501 ( 3.2A)
ZN  A 501 ( 3.3A)
ZN  A 501 ( 3.2A)
 0.76A 1v54A-4wk7A:
undetectable		 1v54A-4wk7A:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_N_CUN517_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I)		 4wk7 A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 4
(Homo
sapiens) 		3 / 3 HIS A 371
HIS A 365
HIS A 361
 ZN  A 501 ( 3.2A)
ZN  A 501 ( 3.3A)
ZN  A 501 ( 3.2A)
 0.76A 1v54N-4wk7A:
undetectable		 1v54N-4wk7A:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_A_CUA517_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I)		 4wk7 A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 4
(Homo
sapiens) 		3 / 3 HIS A 371
HIS A 365
HIS A 361
 ZN  A 501 ( 3.2A)
ZN  A 501 ( 3.3A)
ZN  A 501 ( 3.2A)
 0.74A 1v55A-4wk7A:
undetectable		 1v55A-4wk7A:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_N_CUN517_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I)		 4wk7 A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 4
(Homo
sapiens) 		3 / 3 HIS A 371
HIS A 365
HIS A 361
 ZN  A 501 ( 3.2A)
ZN  A 501 ( 3.3A)
ZN  A 501 ( 3.2A)
 0.75A 1v55N-4wk7A:
undetectable		 1v55N-4wk7A:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y93_A_HAEA301_1
(MACROPHAGE
METALLOELASTASE)		 4wk7 A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 4
(Homo
sapiens) 		4 / 6 HIS A 361
GLU A 362
HIS A 365
HIS A 371
 ZN  A 501 ( 3.2A)
3PQ  A 505 (-2.6A)
ZN  A 501 ( 3.3A)
ZN  A 501 ( 3.2A)
 0.24A 1y93A-4wk7A:
10.9		 1y93A-4wk7A:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4wk7 A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 4
(Homo
sapiens) 		3 / 3 HIS A 371
HIS A 365
HIS A 361
 ZN  A 501 ( 3.2A)
ZN  A 501 ( 3.3A)
ZN  A 501 ( 3.2A)
 0.74A 2dyrA-4wk7A:
undetectable		 2dyrA-4wk7A:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4wk7 A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 4
(Homo
sapiens) 		3 / 3 HIS A 371
HIS A 365
HIS A 361
 ZN  A 501 ( 3.2A)
ZN  A 501 ( 3.3A)
ZN  A 501 ( 3.2A)
 0.76A 2dyrN-4wk7A:
undetectable		 2dyrN-4wk7A:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_A_CUA601_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4wk7 A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 4
(Homo
sapiens) 		3 / 3 HIS A 371
HIS A 365
HIS A 361
 ZN  A 501 ( 3.2A)
ZN  A 501 ( 3.3A)
ZN  A 501 ( 3.2A)
 0.75A 2dysA-4wk7A:
undetectable		 2dysA-4wk7A:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4wk7 A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 4
(Homo
sapiens) 		3 / 3 HIS A 371
HIS A 365
HIS A 361
 ZN  A 501 ( 3.2A)
ZN  A 501 ( 3.3A)
ZN  A 501 ( 3.2A)
 0.72A 2eijA-4wk7A:
undetectable		 2eijA-4wk7A:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4wk7 A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 4
(Homo
sapiens) 		3 / 3 HIS A 371
HIS A 365
HIS A 361
 ZN  A 501 ( 3.2A)
ZN  A 501 ( 3.3A)
ZN  A 501 ( 3.2A)
 0.74A 2eijN-4wk7A:
undetectable		 2eijN-4wk7A:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4wk7 A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 4
(Homo
sapiens) 		3 / 3 HIS A 371
HIS A 365
HIS A 361
 ZN  A 501 ( 3.2A)
ZN  A 501 ( 3.3A)
ZN  A 501 ( 3.2A)
 0.73A 2eikA-4wk7A:
undetectable		 2eikA-4wk7A:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4wk7 A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 4
(Homo
sapiens) 		3 / 3 HIS A 371
HIS A 365
HIS A 361
 ZN  A 501 ( 3.2A)
ZN  A 501 ( 3.3A)
ZN  A 501 ( 3.2A)
 0.76A 2eikN-4wk7A:
undetectable		 2eikN-4wk7A:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4wk7 A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 4
(Homo
sapiens) 		3 / 3 HIS A 371
HIS A 365
HIS A 361
 ZN  A 501 ( 3.2A)
ZN  A 501 ( 3.3A)
ZN  A 501 ( 3.2A)
 0.74A 2eilA-4wk7A:
undetectable		 2eilA-4wk7A:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4wk7 A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 4
(Homo
sapiens) 		3 / 3 HIS A 371
HIS A 365
HIS A 361
 ZN  A 501 ( 3.2A)
ZN  A 501 ( 3.3A)
ZN  A 501 ( 3.2A)
 0.75A 2eilN-4wk7A:
undetectable		 2eilN-4wk7A:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4wk7 A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 4
(Homo
sapiens) 		3 / 3 HIS A 371
HIS A 365
HIS A 361
 ZN  A 501 ( 3.2A)
ZN  A 501 ( 3.3A)
ZN  A 501 ( 3.2A)
 0.74A 2eimA-4wk7A:
undetectable		 2eimA-4wk7A:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4wk7 A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 4
(Homo
sapiens) 		3 / 3 HIS A 371
HIS A 365
HIS A 361
 ZN  A 501 ( 3.2A)
ZN  A 501 ( 3.3A)
ZN  A 501 ( 3.2A)
 0.73A 2eimN-4wk7A:
undetectable		 2eimN-4wk7A:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4wk7 A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 4
(Homo
sapiens) 		3 / 3 HIS A 371
HIS A 365
HIS A 361
 ZN  A 501 ( 3.2A)
ZN  A 501 ( 3.3A)
ZN  A 501 ( 3.2A)
 0.74A 2einA-4wk7A:
undetectable		 2einA-4wk7A:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4wk7 A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 4
(Homo
sapiens) 		3 / 3 HIS A 371
HIS A 365
HIS A 361
 ZN  A 501 ( 3.2A)
ZN  A 501 ( 3.3A)
ZN  A 501 ( 3.2A)
 0.70A 2einN-4wk7A:
undetectable		 2einN-4wk7A:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HU6_A_HAEA269_1
(MACROPHAGE
METALLOELASTASE)		 4wk7 A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 4
(Homo
sapiens) 		4 / 4 HIS A 361
GLU A 362
HIS A 365
HIS A 371
 ZN  A 501 ( 3.2A)
3PQ  A 505 (-2.6A)
ZN  A 501 ( 3.3A)
ZN  A 501 ( 3.2A)
 0.20A 2hu6A-4wk7A:
10.8		 2hu6A-4wk7A:
19.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2JIH_A_097A1001_1
(ADAMTS-1)		 4wk7 A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 4
(Homo
sapiens) 		7 / 9 ASP A 328
LEU A 330
THR A 358
HIS A 361
GLU A 362
HIS A 365
HIS A 371
 None
3PQ  A 505 (-4.5A)
3PQ  A 505 ( 4.0A)
ZN  A 501 ( 3.2A)
3PQ  A 505 (-2.6A)
ZN  A 501 ( 3.3A)
ZN  A 501 ( 3.2A)
 0.37A 2jihA-4wk7A:
36.1		 2jihA-4wk7A:
53.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2JIH_B_097B1001_1
(ADAMTS-1)		 4wk7 A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 4
(Homo
sapiens) 		7 / 8 ASP A 328
LEU A 330
THR A 358
HIS A 361
GLU A 362
HIS A 365
HIS A 371
 None
3PQ  A 505 (-4.5A)
3PQ  A 505 ( 4.0A)
ZN  A 501 ( 3.2A)
3PQ  A 505 (-2.6A)
ZN  A 501 ( 3.3A)
ZN  A 501 ( 3.2A)
 0.51A 2jihB-4wk7A:
35.9		 2jihB-4wk7A:
53.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OW9_A_HAEA502_1
(COLLAGENASE 3)		 4wk7 A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 4
(Homo
sapiens) 		4 / 6 HIS A 361
GLU A 362
HIS A 365
HIS A 371
 ZN  A 501 ( 3.2A)
3PQ  A 505 (-2.6A)
ZN  A 501 ( 3.3A)
ZN  A 501 ( 3.2A)
 0.34A 2ow9A-4wk7A:
10.5		 2ow9A-4wk7A:
25.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OW9_B_HAEB502_1
(COLLAGENASE 3)		 4wk7 A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 4
(Homo
sapiens) 		4 / 4 HIS A 361
GLU A 362
HIS A 365
HIS A 371
 ZN  A 501 ( 3.2A)
3PQ  A 505 (-2.6A)
ZN  A 501 ( 3.3A)
ZN  A 501 ( 3.2A)
 0.30A 2ow9B-4wk7A:
10.3		 2ow9B-4wk7A:
25.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZR_C_HAEC3001_1
(COLLAGENASE 3)		 4wk7 A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 4
(Homo
sapiens) 		4 / 4 HIS A 361
GLU A 362
HIS A 365
HIS A 371
 ZN  A 501 ( 3.2A)
3PQ  A 505 (-2.6A)
ZN  A 501 ( 3.3A)
ZN  A 501 ( 3.2A)
 0.34A 2ozrC-4wk7A:
10.2		 2ozrC-4wk7A:
25.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZR_D_HAED3002_1
(COLLAGENASE 3)		 4wk7 A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 4
(Homo
sapiens) 		4 / 4 HIS A 361
GLU A 362
HIS A 365
HIS A 371
 ZN  A 501 ( 3.2A)
3PQ  A 505 (-2.6A)
ZN  A 501 ( 3.3A)
ZN  A 501 ( 3.2A)
 0.37A 2ozrD-4wk7A:
10.2		 2ozrD-4wk7A:
25.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZR_E_HAEE3003_1
(COLLAGENASE 3)		 4wk7 A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 4
(Homo
sapiens) 		4 / 4 HIS A 361
GLU A 362
HIS A 365
HIS A 371
 ZN  A 501 ( 3.2A)
3PQ  A 505 (-2.6A)
ZN  A 501 ( 3.3A)
ZN  A 501 ( 3.2A)
 0.32A 2ozrE-4wk7A:
10.1		 2ozrE-4wk7A:
25.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZR_F_HAEF3004_1
(COLLAGENASE 3)		 4wk7 A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 4
(Homo
sapiens) 		3 / 3 HIS A 361
HIS A 365
HIS A 371
 ZN  A 501 ( 3.2A)
ZN  A 501 ( 3.3A)
ZN  A 501 ( 3.2A)
 0.27A 2ozrF-4wk7A:
10.2		 2ozrF-4wk7A:
25.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD3_B_CHDB504_0
(FERROCHELATASE)		 4wk7 A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 4
(Homo
sapiens) 		4 / 6 MET A 369
ILE A 258
ARG A 259
SER A 374
 None
 1.46A 2qd3B-4wk7A:
3.3		 2qd3B-4wk7A:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y69_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4wk7 A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 4
(Homo
sapiens) 		3 / 3 HIS A 371
HIS A 365
HIS A 361
 ZN  A 501 ( 3.2A)
ZN  A 501 ( 3.3A)
ZN  A 501 ( 3.2A)
 0.77A 2y69N-4wk7A:
undetectable		 2y69N-4wk7A:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4wk7 A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 4
(Homo
sapiens) 		3 / 3 HIS A 371
HIS A 365
HIS A 361
 ZN  A 501 ( 3.2A)
ZN  A 501 ( 3.3A)
ZN  A 501 ( 3.2A)
 0.77A 3ablA-4wk7A:
undetectable		 3ablA-4wk7A:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4wk7 A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 4
(Homo
sapiens) 		3 / 3 HIS A 371
HIS A 365
HIS A 361
 ZN  A 501 ( 3.2A)
ZN  A 501 ( 3.3A)
ZN  A 501 ( 3.2A)
 0.76A 3abmA-4wk7A:
undetectable		 3abmA-4wk7A:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG1_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4wk7 A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 4
(Homo
sapiens) 		3 / 3 HIS A 371
HIS A 365
HIS A 361
 ZN  A 501 ( 3.2A)
ZN  A 501 ( 3.3A)
ZN  A 501 ( 3.2A)
 0.73A 3ag1A-4wk7A:
undetectable		 3ag1A-4wk7A:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG1_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4wk7 A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 4
(Homo
sapiens) 		3 / 3 HIS A 371
HIS A 365
HIS A 361
 ZN  A 501 ( 3.2A)
ZN  A 501 ( 3.3A)
ZN  A 501 ( 3.2A)
 0.75A 3ag1N-4wk7A:
undetectable		 3ag1N-4wk7A:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4wk7 A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 4
(Homo
sapiens) 		3 / 3 HIS A 371
HIS A 365
HIS A 361
 ZN  A 501 ( 3.2A)
ZN  A 501 ( 3.3A)
ZN  A 501 ( 3.2A)
 0.76A 3ag3A-4wk7A:
undetectable		 3ag3A-4wk7A:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4wk7 A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 4
(Homo
sapiens) 		3 / 3 HIS A 371
HIS A 365
HIS A 361
 ZN  A 501 ( 3.2A)
ZN  A 501 ( 3.3A)
ZN  A 501 ( 3.2A)
 0.76A 3ag3N-4wk7A:
undetectable		 3ag3N-4wk7A:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4wk7 A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 4
(Homo
sapiens) 		3 / 3 HIS A 371
HIS A 365
HIS A 361
 ZN  A 501 ( 3.2A)
ZN  A 501 ( 3.3A)
ZN  A 501 ( 3.2A)
 0.76A 3ag4N-4wk7A:
undetectable		 3ag4N-4wk7A:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4wk7 A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 4
(Homo
sapiens) 		3 / 3 HIS A 371
HIS A 365
HIS A 361
 ZN  A 501 ( 3.2A)
ZN  A 501 ( 3.3A)
ZN  A 501 ( 3.2A)
 0.76A 3asnN-4wk7A:
undetectable		 3asnN-4wk7A:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4wk7 A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 4
(Homo
sapiens) 		3 / 3 HIS A 371
HIS A 365
HIS A 361
 ZN  A 501 ( 3.2A)
ZN  A 501 ( 3.3A)
ZN  A 501 ( 3.2A)
 0.75A 3asoN-4wk7A:
undetectable		 3asoN-4wk7A:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_A_DGXA1_2
(NUCLEAR RECEPTOR
ROR-GAMMA)		 4wk7 A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 4
(Homo
sapiens) 		3 / 3 TRP A 404
VAL A 348
ARG A 318
 None
 0.75A 3b0wA-4wk7A:
undetectable		 3b0wA-4wk7A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BVD_A_CUA803_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4wk7 A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 4
(Homo
sapiens) 		3 / 3 HIS A 371
HIS A 365
HIS A 361
 ZN  A 501 ( 3.2A)
ZN  A 501 ( 3.3A)
ZN  A 501 ( 3.2A)
 0.77A 3bvdA-4wk7A:
undetectable		 3bvdA-4wk7A:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DTU_A_CUA1023_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4wk7 A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 4
(Homo
sapiens) 		3 / 3 HIS A 371
HIS A 365
HIS A 361
 ZN  A 501 ( 3.2A)
ZN  A 501 ( 3.3A)
ZN  A 501 ( 3.2A)
 0.74A 3dtuA-4wk7A:
undetectable		 3dtuA-4wk7A:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DTU_C_CUC569_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4wk7 A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 4
(Homo
sapiens) 		3 / 3 HIS A 371
HIS A 365
HIS A 361
 ZN  A 501 ( 3.2A)
ZN  A 501 ( 3.3A)
ZN  A 501 ( 3.2A)
 0.74A 3dtuC-4wk7A:
undetectable		 3dtuC-4wk7A:
17.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HY7_A_097A801_1
(A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 5)		 4wk7 A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 4
(Homo
sapiens) 		7 / 9 ASP A 328
LEU A 330
THR A 358
HIS A 361
GLU A 362
HIS A 365
HIS A 371
 None
3PQ  A 505 (-4.5A)
3PQ  A 505 ( 4.0A)
ZN  A 501 ( 3.2A)
3PQ  A 505 (-2.6A)
ZN  A 501 ( 3.3A)
ZN  A 501 ( 3.2A)
 0.30A 3hy7A-4wk7A:
34.8		 3hy7A-4wk7A:
47.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HY7_B_097B801_1
(A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 5)		 4wk7 A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 4
(Homo
sapiens) 		7 / 9 ASP A 328
LEU A 330
THR A 358
HIS A 361
GLU A 362
HIS A 365
HIS A 371
 None
3PQ  A 505 (-4.5A)
3PQ  A 505 ( 4.0A)
ZN  A 501 ( 3.2A)
3PQ  A 505 (-2.6A)
ZN  A 501 ( 3.3A)
ZN  A 501 ( 3.2A)
 0.30A 3hy7B-4wk7A:
33.8		 3hy7B-4wk7A:
47.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEC_A_HAEA272_1
(COLLAGENASE 3)		 4wk7 A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 4
(Homo
sapiens) 		4 / 5 HIS A 361
GLU A 362
HIS A 365
HIS A 371
 ZN  A 501 ( 3.2A)
3PQ  A 505 (-2.6A)
ZN  A 501 ( 3.3A)
ZN  A 501 ( 3.2A)
 0.28A 3kecA-4wk7A:
10.5		 3kecA-4wk7A:
24.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEC_B_HAEB271_1
(COLLAGENASE 3)		 4wk7 A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 4
(Homo
sapiens) 		3 / 3 HIS A 361
GLU A 362
HIS A 365
 ZN  A 501 ( 3.2A)
3PQ  A 505 (-2.6A)
ZN  A 501 ( 3.3A)
 0.20A 3kecB-4wk7A:
10.3		 3kecB-4wk7A:
24.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LIK_A_HAEA302_1
(MACROPHAGE
METALLOELASTASE)		 4wk7 A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 4
(Homo
sapiens) 		4 / 5 HIS A 361
GLU A 362
HIS A 365
HIS A 371
 ZN  A 501 ( 3.2A)
3PQ  A 505 (-2.6A)
ZN  A 501 ( 3.3A)
ZN  A 501 ( 3.2A)
 0.24A 3likA-4wk7A:
10.9		 3likA-4wk7A:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LIL_A_HAEA302_1
(MACROPHAGE
METALLOELASTASE)		 4wk7 A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 4
(Homo
sapiens) 		4 / 4 HIS A 361
GLU A 362
HIS A 365
HIS A 371
 ZN  A 501 ( 3.2A)
3PQ  A 505 (-2.6A)
ZN  A 501 ( 3.3A)
ZN  A 501 ( 3.2A)
 0.23A 3lilA-4wk7A:
10.9		 3lilA-4wk7A:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LJG_A_HAEA301_1
(MACROPHAGE
METALLOELASTASE)		 4wk7 A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 4
(Homo
sapiens) 		4 / 5 HIS A 361
GLU A 362
HIS A 365
HIS A 371
 ZN  A 501 ( 3.2A)
3PQ  A 505 (-2.6A)
ZN  A 501 ( 3.3A)
ZN  A 501 ( 3.2A)
 0.22A 3ljgA-4wk7A:
11.0		 3ljgA-4wk7A:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LKA_A_HAEA269_1
(MACROPHAGE
METALLOELASTASE)		 4wk7 A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 4
(Homo
sapiens) 		4 / 5 HIS A 361
GLU A 362
HIS A 365
HIS A 371
 ZN  A 501 ( 3.2A)
3PQ  A 505 (-2.6A)
ZN  A 501 ( 3.3A)
ZN  A 501 ( 3.2A)
 0.25A 3lkaA-4wk7A:
10.8		 3lkaA-4wk7A:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QJ7_A_SPMA264_1
(THYMIDYLATE SYNTHASE)		 4wk7 A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 4
(Homo
sapiens) 		4 / 8 ARG A 259
LEU A 370
ASP A 372
SER A 405
 None
 0.99A 3qj7A-4wk7A:
undetectable
3qj7D-4wk7A:
undetectable		 3qj7A-4wk7A:
24.01
3qj7D-4wk7A:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4wk7 A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 4
(Homo
sapiens) 		3 / 3 HIS A 371
HIS A 365
HIS A 361
 ZN  A 501 ( 3.2A)
ZN  A 501 ( 3.3A)
ZN  A 501 ( 3.2A)
 0.74A 3wg7A-4wk7A:
undetectable		 3wg7A-4wk7A:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4wk7 A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 4
(Homo
sapiens) 		3 / 3 HIS A 371
HIS A 365
HIS A 361
 ZN  A 501 ( 3.2A)
ZN  A 501 ( 3.3A)
ZN  A 501 ( 3.2A)
 0.76A 3wg7N-4wk7A:
undetectable		 3wg7N-4wk7A:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3X2Q_A_CUA604_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4wk7 A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 4
(Homo
sapiens) 		3 / 3 HIS A 371
HIS A 365
HIS A 361
 ZN  A 501 ( 3.2A)
ZN  A 501 ( 3.3A)
ZN  A 501 ( 3.2A)
 0.75A 3x2qA-4wk7A:
undetectable		 3x2qA-4wk7A:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3X2Q_N_CUN604_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4wk7 A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 4
(Homo
sapiens) 		3 / 3 HIS A 371
HIS A 365
HIS A 361
 ZN  A 501 ( 3.2A)
ZN  A 501 ( 3.3A)
ZN  A 501 ( 3.2A)
 0.71A 3x2qN-4wk7A:
undetectable		 3x2qN-4wk7A:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7B_A_HAEA1273_1
(COLLAGENASE 3)		 4wk7 A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 4
(Homo
sapiens) 		4 / 6 HIS A 361
GLU A 362
HIS A 365
HIS A 371
 ZN  A 501 ( 3.2A)
3PQ  A 505 (-2.6A)
ZN  A 501 ( 3.3A)
ZN  A 501 ( 3.2A)
 0.41A 4a7bA-4wk7A:
10.2		 4a7bA-4wk7A:
24.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IB4_A_ERMA2001_1
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 4wk7 A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 4
(Homo
sapiens) 		5 / 12 MET A 246
ALA A 252
PHE A 253
VAL A 266
VAL A 366
 None
 1.26A 4ib4A-4wk7A:
undetectable		 4ib4A-4wk7A:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_B_GCSB301_1
(CHITOSANASE)		 4wk7 A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 4
(Homo
sapiens) 		3 / 3 GLY A 282
PRO A 283
GLN A 287
 None
 0.48A 4oltB-4wk7A:
undetectable		 4oltB-4wk7A:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4wk7 A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 4
(Homo
sapiens) 		3 / 3 HIS A 371
HIS A 365
HIS A 361
 ZN  A 501 ( 3.2A)
ZN  A 501 ( 3.3A)
ZN  A 501 ( 3.2A)
 0.74A 5b1aA-4wk7A:
undetectable		 5b1aA-4wk7A:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4wk7 A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 4
(Homo
sapiens) 		3 / 3 HIS A 371
HIS A 365
HIS A 361
 ZN  A 501 ( 3.2A)
ZN  A 501 ( 3.3A)
ZN  A 501 ( 3.2A)
 0.77A 5b1aN-4wk7A:
undetectable		 5b1aN-4wk7A:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4wk7 A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 4
(Homo
sapiens) 		3 / 3 HIS A 371
HIS A 365
HIS A 361
 ZN  A 501 ( 3.2A)
ZN  A 501 ( 3.3A)
ZN  A 501 ( 3.2A)
 0.72A 5b1bA-4wk7A:
undetectable		 5b1bA-4wk7A:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4wk7 A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 4
(Homo
sapiens) 		3 / 3 HIS A 371
HIS A 365
HIS A 361
 ZN  A 501 ( 3.2A)
ZN  A 501 ( 3.3A)
ZN  A 501 ( 3.2A)
 0.74A 5b1bN-4wk7A:
undetectable		 5b1bN-4wk7A:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4wk7 A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 4
(Homo
sapiens) 		3 / 3 HIS A 371
HIS A 365
HIS A 361
 ZN  A 501 ( 3.2A)
ZN  A 501 ( 3.3A)
ZN  A 501 ( 3.2A)
 0.74A 5b3sA-4wk7A:
undetectable		 5b3sA-4wk7A:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_A_CUA601_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4wk7 A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 4
(Homo
sapiens) 		3 / 3 HIS A 371
HIS A 365
HIS A 361
 ZN  A 501 ( 3.2A)
ZN  A 501 ( 3.3A)
ZN  A 501 ( 3.2A)
 0.73A 5iy5A-4wk7A:
undetectable		 5iy5A-4wk7A:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_N_CUN602_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4wk7 A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 4
(Homo
sapiens) 		3 / 3 HIS A 371
HIS A 365
HIS A 361
 ZN  A 501 ( 3.2A)
ZN  A 501 ( 3.3A)
ZN  A 501 ( 3.2A)
 0.75A 5iy5N-4wk7A:
undetectable		 5iy5N-4wk7A:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5J_A_HAEA306_1
(MACROPHAGE
METALLOELASTASE)		 4wk7 A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 4
(Homo
sapiens) 		4 / 4 HIS A 361
GLU A 362
HIS A 365
HIS A 371
 ZN  A 501 ( 3.2A)
3PQ  A 505 (-2.6A)
ZN  A 501 ( 3.3A)
ZN  A 501 ( 3.2A)
 0.23A 5n5jA-4wk7A:
10.9		 5n5jA-4wk7A:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5K_A_HAEA306_1
(MACROPHAGE
METALLOELASTASE)		 4wk7 A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 4
(Homo
sapiens) 		4 / 5 HIS A 361
GLU A 362
HIS A 365
HIS A 371
 ZN  A 501 ( 3.2A)
3PQ  A 505 (-2.6A)
ZN  A 501 ( 3.3A)
ZN  A 501 ( 3.2A)
 0.26A 5n5kA-4wk7A:
10.9		 5n5kA-4wk7A:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGJ_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 4wk7 A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 4
(Homo
sapiens) 		3 / 3 VAL A 270
VAL A 225
GLN A 296
 None
 0.51A 5qgjA-4wk7A:
undetectable		 5qgjA-4wk7A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGM_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 4wk7 A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 4
(Homo
sapiens) 		3 / 3 VAL A 270
VAL A 225
GLN A 296
 None
 0.52A 5qgmA-4wk7A:
undetectable		 5qgmA-4wk7A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGN_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 4wk7 A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 4
(Homo
sapiens) 		3 / 3 VAL A 270
VAL A 225
GLN A 296
 None
 0.55A 5qgnA-4wk7A:
undetectable		 5qgnA-4wk7A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGY_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 4wk7 A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 4
(Homo
sapiens) 		3 / 3 VAL A 270
VAL A 225
GLN A 296
 None
 0.55A 5qgyA-4wk7A:
undetectable		 5qgyA-4wk7A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGZ_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 4wk7 A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 4
(Homo
sapiens) 		3 / 3 VAL A 270
VAL A 225
GLN A 296
 None
 0.54A 5qgzA-4wk7A:
undetectable		 5qgzA-4wk7A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH0_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 4wk7 A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 4
(Homo
sapiens) 		3 / 3 VAL A 270
VAL A 225
GLN A 296
 None
 0.53A 5qh0A-4wk7A:
undetectable		 5qh0A-4wk7A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH2_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 4wk7 A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 4
(Homo
sapiens) 		3 / 3 VAL A 270
VAL A 225
GLN A 296
 None
 0.55A 5qh2A-4wk7A:
undetectable		 5qh2A-4wk7A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH3_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 4wk7 A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 4
(Homo
sapiens) 		3 / 3 VAL A 270
VAL A 225
GLN A 296
 None
 0.55A 5qh3A-4wk7A:
undetectable		 5qh3A-4wk7A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH5_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 4wk7 A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 4
(Homo
sapiens) 		3 / 3 VAL A 270
VAL A 225
GLN A 296
 None
 0.55A 5qh5A-4wk7A:
undetectable		 5qh5A-4wk7A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH6_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 4wk7 A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 4
(Homo
sapiens) 		3 / 3 VAL A 270
VAL A 225
GLN A 296
 None
 0.54A 5qh6A-4wk7A:
undetectable		 5qh6A-4wk7A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH7_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 4wk7 A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 4
(Homo
sapiens) 		3 / 3 VAL A 270
VAL A 225
GLN A 296
 None
 0.54A 5qh7A-4wk7A:
undetectable		 5qh7A-4wk7A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QHA_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 4wk7 A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 4
(Homo
sapiens) 		3 / 3 VAL A 270
VAL A 225
GLN A 296
 None
 0.53A 5qhaA-4wk7A:
undetectable		 5qhaA-4wk7A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QHH_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 4wk7 A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 4
(Homo
sapiens) 		3 / 3 VAL A 270
VAL A 225
GLN A 296
 None
 0.52A 5qhhA-4wk7A:
undetectable		 5qhhA-4wk7A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_D_ERMD1201_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)		 4wk7 A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 4
(Homo
sapiens) 		5 / 12 MET A 246
ALA A 252
PHE A 253
VAL A 266
VAL A 366
 None
 1.19A 5tudD-4wk7A:
undetectable		 5tudD-4wk7A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W97_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4wk7 A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 4
(Homo
sapiens) 		3 / 3 HIS A 371
HIS A 365
HIS A 361
 ZN  A 501 ( 3.2A)
ZN  A 501 ( 3.3A)
ZN  A 501 ( 3.2A)
 0.71A 5w97a-4wk7A:
undetectable		 5w97a-4wk7A:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WYQ_A_SAMA401_1
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 4wk7 A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 4
(Homo
sapiens) 		4 / 4 ASP A 351
SER A 355
ASP A 350
HIS A 234
 None
 1.28A 5wyqB-4wk7A:
undetectable		 5wyqB-4wk7A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X19_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4wk7 A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 4
(Homo
sapiens) 		3 / 3 HIS A 371
HIS A 365
HIS A 361
 ZN  A 501 ( 3.2A)
ZN  A 501 ( 3.3A)
ZN  A 501 ( 3.2A)
 0.70A 5x19N-4wk7A:
undetectable		 5x19N-4wk7A:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4wk7 A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 4
(Homo
sapiens) 		3 / 3 HIS A 371
HIS A 365
HIS A 361
 ZN  A 501 ( 3.2A)
ZN  A 501 ( 3.3A)
ZN  A 501 ( 3.2A)
 0.71A 5x1bA-4wk7A:
undetectable		 5x1bA-4wk7A:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4wk7 A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 4
(Homo
sapiens) 		3 / 3 HIS A 371
HIS A 365
HIS A 361
 ZN  A 501 ( 3.2A)
ZN  A 501 ( 3.3A)
ZN  A 501 ( 3.2A)
 0.68A 5x1bN-4wk7A:
undetectable		 5x1bN-4wk7A:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4wk7 A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 4
(Homo
sapiens) 		3 / 3 HIS A 371
HIS A 365
HIS A 361
 ZN  A 501 ( 3.2A)
ZN  A 501 ( 3.3A)
ZN  A 501 ( 3.2A)
 0.72A 5x1fA-4wk7A:
undetectable		 5x1fA-4wk7A:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4wk7 A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 4
(Homo
sapiens) 		3 / 3 HIS A 371
HIS A 365
HIS A 361
 ZN  A 501 ( 3.2A)
ZN  A 501 ( 3.3A)
ZN  A 501 ( 3.2A)
 0.65A 5x1fN-4wk7A:
undetectable		 5x1fN-4wk7A:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4wk7 A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 4
(Homo
sapiens) 		3 / 3 HIS A 371
HIS A 365
HIS A 361
 ZN  A 501 ( 3.2A)
ZN  A 501 ( 3.3A)
ZN  A 501 ( 3.2A)
 0.76A 5xdqA-4wk7A:
undetectable		 5xdqA-4wk7A:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4wk7 A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 4
(Homo
sapiens) 		3 / 3 HIS A 371
HIS A 365
HIS A 361
 ZN  A 501 ( 3.2A)
ZN  A 501 ( 3.3A)
ZN  A 501 ( 3.2A)
 0.76A 5xdqN-4wk7A:
undetectable		 5xdqN-4wk7A:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4wk7 A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 4
(Homo
sapiens) 		3 / 3 HIS A 371
HIS A 365
HIS A 361
 ZN  A 501 ( 3.2A)
ZN  A 501 ( 3.3A)
ZN  A 501 ( 3.2A)
 0.73A 5xdxA-4wk7A:
undetectable		 5xdxA-4wk7A:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4wk7 A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 4
(Homo
sapiens) 		3 / 3 HIS A 371
HIS A 365
HIS A 361
 ZN  A 501 ( 3.2A)
ZN  A 501 ( 3.3A)
ZN  A 501 ( 3.2A)
 0.72A 5xdxN-4wk7A:
undetectable		 5xdxN-4wk7A:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_B_8LXB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4wk7 A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 4
(Homo
sapiens) 		4 / 8 HIS A 365
PHE A 367
SER A 344
LEU A 424
 ZN  A 501 ( 3.3A)
None
None
None
 1.11A 5y2tB-4wk7A:
undetectable		 5y2tB-4wk7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_N_CUN604_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4wk7 A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 4
(Homo
sapiens) 		3 / 3 HIS A 371
HIS A 365
HIS A 361
 ZN  A 501 ( 3.2A)
ZN  A 501 ( 3.3A)
ZN  A 501 ( 3.2A)
 0.77A 5z84N-4wk7A:
undetectable		 5z84N-4wk7A:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z85_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4wk7 A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 4
(Homo
sapiens) 		3 / 3 HIS A 371
HIS A 365
HIS A 361
 ZN  A 501 ( 3.2A)
ZN  A 501 ( 3.3A)
ZN  A 501 ( 3.2A)
 0.79A 5z85A-4wk7A:
undetectable		 5z85A-4wk7A:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z85_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4wk7 A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 4
(Homo
sapiens) 		3 / 3 HIS A 371
HIS A 365
HIS A 361
 ZN  A 501 ( 3.2A)
ZN  A 501 ( 3.3A)
ZN  A 501 ( 3.2A)
 0.77A 5z85N-4wk7A:
undetectable		 5z85N-4wk7A:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4wk7 A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 4
(Homo
sapiens) 		3 / 3 HIS A 371
HIS A 365
HIS A 361
 ZN  A 501 ( 3.2A)
ZN  A 501 ( 3.3A)
ZN  A 501 ( 3.2A)
 0.78A 5z86N-4wk7A:
undetectable		 5z86N-4wk7A:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4wk7 A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 4
(Homo
sapiens) 		3 / 3 HIS A 371
HIS A 365
HIS A 361
 ZN  A 501 ( 3.2A)
ZN  A 501 ( 3.3A)
ZN  A 501 ( 3.2A)
 0.76A 5zcoA-4wk7A:
undetectable		 5zcoA-4wk7A:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_N_CUN604_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4wk7 A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 4
(Homo
sapiens) 		3 / 3 HIS A 371
HIS A 365
HIS A 361
 ZN  A 501 ( 3.2A)
ZN  A 501 ( 3.3A)
ZN  A 501 ( 3.2A)
 0.73A 5zcoN-4wk7A:
undetectable		 5zcoN-4wk7A:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4wk7 A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 4
(Homo
sapiens) 		3 / 3 HIS A 371
HIS A 365
HIS A 361
 ZN  A 501 ( 3.2A)
ZN  A 501 ( 3.3A)
ZN  A 501 ( 3.2A)
 0.76A 5zcpA-4wk7A:
undetectable		 5zcpA-4wk7A:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_N_CUN604_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4wk7 A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 4
(Homo
sapiens) 		3 / 3 HIS A 371
HIS A 365
HIS A 361
 ZN  A 501 ( 3.2A)
ZN  A 501 ( 3.3A)
ZN  A 501 ( 3.2A)
 0.78A 5zcpN-4wk7A:
undetectable		 5zcpN-4wk7A:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCQ_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4wk7 A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 4
(Homo
sapiens) 		3 / 3 HIS A 371
HIS A 365
HIS A 361
 ZN  A 501 ( 3.2A)
ZN  A 501 ( 3.3A)
ZN  A 501 ( 3.2A)
 0.76A 5zcqA-4wk7A:
undetectable		 5zcqA-4wk7A:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCQ_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4wk7 A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 4
(Homo
sapiens) 		3 / 3 HIS A 371
HIS A 365
HIS A 361
 ZN  A 501 ( 3.2A)
ZN  A 501 ( 3.3A)
ZN  A 501 ( 3.2A)
 0.77A 5zcqN-4wk7A:
undetectable		 5zcqN-4wk7A:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECE_C_DVAC3010_0
(VLM2
DODECADEPSIPEPTIDE)		 4wk7 A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 4
(Homo
sapiens) 		3 / 3 ALA A 248
PHE A 357
GLN A 354
 None
 0.85A 6eceA-4wk7A:
undetectable		 6eceA-4wk7A:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_A_CUA601_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4wk7 A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 4
(Homo
sapiens) 		3 / 3 HIS A 371
HIS A 365
HIS A 361
 ZN  A 501 ( 3.2A)
ZN  A 501 ( 3.3A)
ZN  A 501 ( 3.2A)
 0.74A 6hu9a-4wk7A:
undetectable		 6hu9a-4wk7A:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_M_CUM601_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4wk7 A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 4
(Homo
sapiens) 		3 / 3 HIS A 371
HIS A 365
HIS A 361
 ZN  A 501 ( 3.2A)
ZN  A 501 ( 3.3A)
ZN  A 501 ( 3.2A)
 0.76A 6hu9m-4wk7A:
undetectable		 6hu9m-4wk7A:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_N_CUN602_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4wk7 A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 4
(Homo
sapiens) 		3 / 3 HIS A 371
HIS A 365
HIS A 361
 ZN  A 501 ( 3.2A)
ZN  A 501 ( 3.3A)
ZN  A 501 ( 3.2A)
 0.76A 6nknN-4wk7A:
undetectable		 6nknN-4wk7A:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMF_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4wk7 A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 4
(Homo
sapiens) 		3 / 3 HIS A 371
HIS A 365
HIS A 361
 ZN  A 501 ( 3.2A)
ZN  A 501 ( 3.3A)
ZN  A 501 ( 3.2A)
 0.71A 6nmfA-4wk7A:
undetectable		 6nmfA-4wk7A:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMF_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4wk7 A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 4
(Homo
sapiens) 		3 / 3 HIS A 371
HIS A 365
HIS A 361
 ZN  A 501 ( 3.2A)
ZN  A 501 ( 3.3A)
ZN  A 501 ( 3.2A)
 0.71A 6nmfN-4wk7A:
undetectable		 6nmfN-4wk7A:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_A_CUA601_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4wk7 A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 4
(Homo
sapiens) 		3 / 3 HIS A 371
HIS A 365
HIS A 361
 ZN  A 501 ( 3.2A)
ZN  A 501 ( 3.3A)
ZN  A 501 ( 3.2A)
 0.77A 6nmpA-4wk7A:
undetectable		 6nmpA-4wk7A:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_N_CUN601_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4wk7 A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 4
(Homo
sapiens) 		3 / 3 HIS A 371
HIS A 365
HIS A 361
 ZN  A 501 ( 3.2A)
ZN  A 501 ( 3.3A)
ZN  A 501 ( 3.2A)
 0.75A 6nmpN-4wk7A:
undetectable		 6nmpN-4wk7A:
17.57