SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4wkw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TBF_A_VIAA501_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 4wkw UNCHARACTERIZED
PROTEIN
(Mycobacterium
leprae) 		5 / 9 LEU A  18
LEU A 106
VAL A  74
ALA A  77
LEU A 136
 None
 0.94A 1tbfA-4wkwA:
undetectable		 1tbfA-4wkwA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NXU_A_RITA600_1
(CYTOCHROME P450 3A4)		 4wkw UNCHARACTERIZED
PROTEIN
(Mycobacterium
leprae) 		5 / 12 LEU A  87
ILE A  76
ALA A  72
ILE A 110
GLU A 122
 None
 1.07A 3nxuA-4wkwA:
undetectable		 3nxuA-4wkwA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZNC_A_BZ1A500_1
(CARBONIC ANHYDRASE
IV)		 4wkw UNCHARACTERIZED
PROTEIN
(Mycobacterium
leprae) 		5 / 10 HIS A 157
PHE A  42
LEU A  13
THR A 155
TRP A  14
 None
 1.45A 3zncA-4wkwA:
undetectable		 3zncA-4wkwA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOP_C_HQEC503_1
(CATALASE)		 4wkw UNCHARACTERIZED
PROTEIN
(Mycobacterium
leprae) 		4 / 8 ILE A  24
PRO A 154
LEU A  13
PHE A  42
 None
 0.80A 4qopC-4wkwA:
undetectable		 4qopC-4wkwA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OGJ_A_ACTA307_0
(CARBONIC ANHYDRASE
13)		 4wkw UNCHARACTERIZED
PROTEIN
(Mycobacterium
leprae) 		4 / 6 HIS A 157
LEU A  13
THR A 155
TRP A  14
 None
 1.18A 5ogjA-4wkwA:
undetectable		 5ogjA-4wkwA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OGJ_B_ACTB305_0
(CARBONIC ANHYDRASE
13)		 4wkw UNCHARACTERIZED
PROTEIN
(Mycobacterium
leprae) 		4 / 6 HIS A 157
LEU A  13
THR A 155
TRP A  14
 None
 1.20A 5ogjB-4wkwA:
undetectable		 5ogjB-4wkwA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OHH_B_ACTB311_0
(CARBONIC ANHYDRASE
13)		 4wkw UNCHARACTERIZED
PROTEIN
(Mycobacterium
leprae) 		4 / 6 HIS A 157
LEU A  13
THR A 155
TRP A  14
 None
 1.20A 5ohhB-4wkwA:
undetectable		 5ohhB-4wkwA:
22.66