SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4wky'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CQE_A_FLPA1650_1
(PROTEIN
(PROSTAGLANDIN H2
SYNTHASE-1))		 4wky BETA-KETOACYL
SYNTHASE
(Streptomyces
albus) 		5 / 12 LEU A  42
ILE A 377
GLY A 375
ALA A 374
LEU A 367
 None
 1.01A 1cqeA-4wkyA:
undetectable		 1cqeA-4wkyA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CQE_B_FLPB2650_1
(PROTEIN
(PROSTAGLANDIN H2
SYNTHASE-1))		 4wky BETA-KETOACYL
SYNTHASE
(Streptomyces
albus) 		5 / 12 LEU A  42
ILE A 377
GLY A 375
ALA A 374
LEU A 367
 None
 1.01A 1cqeB-4wkyA:
undetectable		 1cqeB-4wkyA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_U_9CRU502_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4wky BETA-KETOACYL
SYNTHASE
(Streptomyces
albus) 		6 / 12 ALA A 200
LEU A 262
ALA A 212
VAL A 427
ILE A 440
HIS A 438
 None
 1.49A 1fm6U-4wkyA:
undetectable		 1fm6U-4wkyA:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK1_A_T44A3003_1
(SERUM ALBUMIN)		 4wky BETA-KETOACYL
SYNTHASE
(Streptomyces
albus) 		4 / 6 HIS A 198
ILE A 197
ALA A 277
VAL A 260
 None
 1.04A 1hk1A-4wkyA:
undetectable		 1hk1A-4wkyA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IEP_B_STIB202_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 4wky BETA-KETOACYL
SYNTHASE
(Streptomyces
albus) 		4 / 7 VAL A 217
VAL A 131
ARG A 105
LEU A 179
 None
 0.93A 1iepB-4wkyA:
undetectable		 1iepB-4wkyA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXD_A_ACRA732_1
(ALPHA AMYLASE)		 4wky BETA-KETOACYL
SYNTHASE
(Streptomyces
albus) 		5 / 9 GLY A 327
PRO A 335
GLY A 333
GLY A 250
GLY A 249
 None
 1.07A 1mxdA-4wkyA:
undetectable		 1mxdA-4wkyA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXG_A_ACRA442_1
(ALPHA AMYLASE)		 4wky BETA-KETOACYL
SYNTHASE
(Streptomyces
albus) 		5 / 11 GLY A 327
PRO A 335
GLY A 333
GLY A 250
GLY A 249
 None
 1.07A 1mxgA-4wkyA:
undetectable		 1mxgA-4wkyA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P33_B_MTXB352_1
(PTERIDINE REDUCTASE
1)		 4wky BETA-KETOACYL
SYNTHASE
(Streptomyces
albus) 		5 / 12 PHE A 573
LEU A 459
TYR A 574
LEU A 549
PRO A 545
 None
 1.50A 1p33B-4wkyA:
undetectable		 1p33B-4wkyA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN0_B_T44B602_1
(TRANSTHYRETIN)		 4wky BETA-KETOACYL
SYNTHASE
(Streptomyces
albus) 		4 / 7 LEU A 477
ALA A 517
LEU A 489
ALA A 492
 None
 0.87A 1sn0B-4wkyA:
undetectable
1sn0D-4wkyA:
undetectable		 1sn0B-4wkyA:
15.50
1sn0D-4wkyA:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZQ9_A_SAMA4000_1
(PROBABLE
DIMETHYLADENOSINE
TRANSFERASE)		 4wky BETA-KETOACYL
SYNTHASE
(Streptomyces
albus) 		3 / 3 GLY A 358
GLU A 324
ASN A 411
 None
 0.71A 1zq9A-4wkyA:
undetectable		 1zq9A-4wkyA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F9W_A_PAUA6001_0
(PANTOTHENATE KINASE)		 4wky BETA-KETOACYL
SYNTHASE
(Streptomyces
albus) 		5 / 11 GLY A 272
ARG A 580
THR A 450
THR A 495
ARG A 581
 None
 1.41A 2f9wA-4wkyA:
undetectable
2f9wB-4wkyA:
undetectable		 2f9wA-4wkyA:
20.61
2f9wB-4wkyA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_A_SALA1302_1
(LYSR-TYPE REGULATORY
PROTEIN)		 4wky BETA-KETOACYL
SYNTHASE
(Streptomyces
albus) 		5 / 11 THR A  50
ILE A  78
GLY A  77
GLY A  48
PRO A  80
 None
 1.37A 2y7kA-4wkyA:
undetectable		 2y7kA-4wkyA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_C_SALC1302_1
(LYSR-TYPE REGULATORY
PROTEIN)		 4wky BETA-KETOACYL
SYNTHASE
(Streptomyces
albus) 		5 / 12 THR A  50
ILE A  78
GLY A  77
GLY A  48
PRO A  80
 None
 1.32A 2y7kC-4wkyA:
undetectable		 2y7kC-4wkyA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7W_B_SALB1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 4wky BETA-KETOACYL
SYNTHASE
(Streptomyces
albus) 		5 / 10 THR A  50
ILE A  78
GLY A  77
GLY A  48
PRO A  80
 None
 1.36A 2y7wB-4wkyA:
undetectable		 2y7wB-4wkyA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_C_SAMC604_0
(HYPOTHETICAL PROTEIN)		 4wky BETA-KETOACYL
SYNTHASE
(Streptomyces
albus) 		5 / 12 GLY A 133
SER A 185
LEU A 199
ALA A 370
VAL A 217
 None
 1.23A 2yvlC-4wkyA:
2.0		 2yvlC-4wkyA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARU_A_PNXA606_1
(CHITINASE A)		 4wky BETA-KETOACYL
SYNTHASE
(Streptomyces
albus) 		4 / 7 GLY A 127
ASP A 178
TYR A 125
ARG A 123
 None
 1.21A 3aruA-4wkyA:
undetectable		 3aruA-4wkyA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Y_A_DIFA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4wky BETA-KETOACYL
SYNTHASE
(Streptomyces
albus) 		5 / 11 LEU A  42
ILE A 377
GLY A 375
ALA A 374
LEU A 367
 None
 1.02A 3n8yA-4wkyA:
undetectable		 3n8yA-4wkyA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Z_B_FLPB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4wky BETA-KETOACYL
SYNTHASE
(Streptomyces
albus) 		5 / 12 LEU A  42
ILE A 377
GLY A 375
ALA A 374
LEU A 367
 None
 1.05A 3n8zB-4wkyA:
undetectable		 3n8zB-4wkyA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q1E_C_T44C128_1
(5-HYDROXYISOURATE
HYDROLASE)		 4wky BETA-KETOACYL
SYNTHASE
(Streptomyces
albus) 		4 / 6 LEU A 460
LEU A 496
LEU A 470
LEU A 473
 None
 1.04A 3q1eA-4wkyA:
undetectable
3q1eC-4wkyA:
undetectable		 3q1eA-4wkyA:
12.27
3q1eC-4wkyA:
12.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TEG_A_DAHA416_1
(PHENYLALANYL-TRNA
SYNTHETASE,
MITOCHONDRIAL)		 4wky BETA-KETOACYL
SYNTHASE
(Streptomyces
albus) 		5 / 12 GLN A 187
PHE A 107
GLY A 215
GLY A 258
ALA A 370
 None
 1.15A 3tegA-4wkyA:
undetectable		 3tegA-4wkyA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9J_C_TYLC1184_1
(BROMODOMAIN
CONTAINING 2)		 4wky BETA-KETOACYL
SYNTHASE
(Streptomyces
albus) 		4 / 5 VAL A 173
LEU A 177
LEU A 179
ILE A 259
 None
 0.92A 4a9jC-4wkyA:
undetectable		 4a9jC-4wkyA:
11.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F93_B_SANB3004_1
(U5 SMALL NUCLEAR
RIBONUCLEOPROTEIN
200 KDA HELICASE)		 4wky BETA-KETOACYL
SYNTHASE
(Streptomyces
albus) 		4 / 8 GLU A  40
ASN A 363
GLY A  45
SER A  44
 None
 0.95A 4f93B-4wkyA:
1.8		 4f93B-4wkyA:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6C_A_STRA501_1
(CYTOCHROME P450
MONOOXYGENASE)		 4wky BETA-KETOACYL
SYNTHASE
(Streptomyces
albus) 		5 / 11 ALA A 374
ALA A 371
ALA A 370
VAL A 219
LEU A  79
 None
 1.07A 4j6cA-4wkyA:
undetectable		 4j6cA-4wkyA:
24.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6C_B_STRB503_1
(CYTOCHROME P450
MONOOXYGENASE)		 4wky BETA-KETOACYL
SYNTHASE
(Streptomyces
albus) 		5 / 10 ALA A 374
ALA A 371
ALA A 370
VAL A 219
LEU A  79
 None
 1.08A 4j6cB-4wkyA:
undetectable		 4j6cB-4wkyA:
24.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6D_A_TESA503_1
(CYTOCHROME P450
MONOOXYGENASE)		 4wky BETA-KETOACYL
SYNTHASE
(Streptomyces
albus) 		5 / 12 ALA A 374
ALA A 371
ALA A 370
VAL A 219
LEU A  79
 None
 1.02A 4j6dA-4wkyA:
undetectable		 4j6dA-4wkyA:
24.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JBT_A_ASDA501_1
(CYTOCHROME P450
MONOOXYGENASE)		 4wky BETA-KETOACYL
SYNTHASE
(Streptomyces
albus) 		5 / 12 ALA A 374
ALA A 371
ALA A 370
VAL A 219
LEU A  79
 None
 1.03A 4jbtA-4wkyA:
undetectable		 4jbtA-4wkyA:
24.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JBT_B_ASDB502_1
(CYTOCHROME P450
MONOOXYGENASE)		 4wky BETA-KETOACYL
SYNTHASE
(Streptomyces
albus) 		5 / 11 ALA A 374
ALA A 371
ALA A 370
VAL A 219
LEU A  79
 None
 1.03A 4jbtB-4wkyA:
undetectable		 4jbtB-4wkyA:
24.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_B_ACTB701_0
(RNA (33-MER)
RNA POLYMERASE
3D-POL)		 4wky BETA-KETOACYL
SYNTHASE
(Streptomyces
albus) 		3 / 3 HIS A 310
GLY A 426
ILE A 440
 None
 0.59A 4k50A-4wkyA:
undetectable		 4k50A-4wkyA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_J_ACTJ701_0
(RNA (33-MER)
RNA POLYMERASE
3D-POL)		 4wky BETA-KETOACYL
SYNTHASE
(Streptomyces
albus) 		3 / 3 HIS A 310
GLY A 426
ILE A 440
 None
 0.59A 4k50I-4wkyA:
undetectable		 4k50I-4wkyA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LS7_A_1X9A504_1
(3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2)		 4wky BETA-KETOACYL
SYNTHASE
(Streptomyces
albus) 		6 / 12 ALA A 189
CYH A 190
HIS A 326
THR A 328
HIS A 366
GLY A 431
 None
 0.60A 4ls7A-4wkyA:
48.9		 4ls7A-4wkyA:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LS7_B_1X9B503_1
(3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2)		 4wky BETA-KETOACYL
SYNTHASE
(Streptomyces
albus) 		7 / 12 ILE A 137
ALA A 189
CYH A 190
HIS A 326
THR A 328
HIS A 366
GLY A 431
 None
 0.72A 4ls7A-4wkyA:
48.9
4ls7B-4wkyA:
48.5		 4ls7A-4wkyA:
24.02
4ls7B-4wkyA:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMA_A_CXXA603_1
(TRANSPORTER)		 4wky BETA-KETOACYL
SYNTHASE
(Streptomyces
albus) 		5 / 11 VAL A 195
ALA A 196
SER A 185
GLY A 134
THR A 435
 None
 1.19A 4mmaA-4wkyA:
undetectable		 4mmaA-4wkyA:
24.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z91_F_4LEF401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 4wky BETA-KETOACYL
SYNTHASE
(Streptomyces
albus) 		4 / 7 THR A 495
LEU A 496
THR A 487
LEU A 481
 None
 0.80A 4z91F-4wkyA:
undetectable
4z91G-4wkyA:
undetectable
4z91H-4wkyA:
undetectable
4z91I-4wkyA:
undetectable
4z91J-4wkyA:
undetectable		 4z91F-4wkyA:
19.10
4z91G-4wkyA:
19.10
4z91H-4wkyA:
19.10
4z91I-4wkyA:
19.10
4z91J-4wkyA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EQB_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4wky BETA-KETOACYL
SYNTHASE
(Streptomyces
albus) 		5 / 12 GLY A 250
ILE A 197
GLY A 215
GLY A 258
LEU A 360
 None
 1.07A 5eqbA-4wkyA:
undetectable		 5eqbA-4wkyA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K9D_A_CE9A402_0
(DIHYDROOROTATE
DEHYDROGENASE
(QUINONE),
MITOCHONDRIAL)		 4wky BETA-KETOACYL
SYNTHASE
(Streptomyces
albus) 		5 / 12 ALA A 439
HIS A 198
ALA A 437
PHE A 430
THR A 435
 None
 1.11A 5k9dA-4wkyA:
undetectable		 5k9dA-4wkyA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_H_RITH602_1
(CYTOCHROME P450 3A5)		 4wky BETA-KETOACYL
SYNTHASE
(Streptomyces
albus) 		5 / 12 LEU A 177
GLY A  27
ILE A 129
ALA A 212
GLY A 258
 None
 1.05A 5veuH-4wkyA:
undetectable		 5veuH-4wkyA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_C_SAMC902_0
(MRNA CAPPING ENZYME
P5)		 4wky BETA-KETOACYL
SYNTHASE
(Streptomyces
albus) 		5 / 12 GLY A 434
PRO A 297
ALA A 296
ASP A 287
THR A 435
 None
 1.22A 5x6yC-4wkyA:
undetectable		 5x6yC-4wkyA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6J_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 4wky BETA-KETOACYL
SYNTHASE
(Streptomyces
albus) 		3 / 3 MET A 211
ASP A 273
ARG A 500
 None
 0.81A 5z6jA-4wkyA:
undetectable		 5z6jA-4wkyA:
13.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6K_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 4wky BETA-KETOACYL
SYNTHASE
(Streptomyces
albus) 		3 / 3 MET A 211
ASP A 273
ARG A 500
 None
 0.87A 5z6kA-4wkyA:
undetectable		 5z6kA-4wkyA:
13.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A4I_A_TRPA403_0
(TRYPTOPHAN
2,3-DIOXYGENASE)		 4wky BETA-KETOACYL
SYNTHASE
(Streptomyces
albus) 		4 / 8 ARG A 240
ARG A  51
THR A  50
ILE A  78
 None
 1.08A 6a4iA-4wkyA:
undetectable		 6a4iA-4wkyA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GTQ_B_ACTB207_0
(DUF1778
DOMAIN-CONTAINING
PROTEIN
N-ACETYLTRANSFERASE)		 4wky BETA-KETOACYL
SYNTHASE
(Streptomyces
albus) 		4 / 6 LEU A 584
THR A 495
GLY A 119
ARG A 500
 None
 1.39A 6gtqB-4wkyA:
undetectable
6gtqD-4wkyA:
undetectable		 6gtqB-4wkyA:
15.94
6gtqD-4wkyA:
6.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN8_A_HFGA603_0
(UNCHARACTERIZED
PROTEIN)		 4wky BETA-KETOACYL
SYNTHASE
(Streptomyces
albus) 		5 / 12 LEU A 341
GLU A 324
VAL A 323
THR A 251
GLY A 250
 None
 1.26A 6mn8A-4wkyA:
undetectable		 6mn8A-4wkyA:
21.30