SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4wl1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_C_BEZC505_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 4wl1 LIPOPOLYSACCHARIDE
BIOSYNTHESIS PROTEIN
WZZE
(Escherichia
coli) 		4 / 6 TYR A 102
ILE A  61
PHE A 154
ARG A  64
 None
 0.91A 1oniA-4wl1A:
undetectable
1oniC-4wl1A:
undetectable		 1oniA-4wl1A:
18.03
1oniC-4wl1A:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_D_BEZD507_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 4wl1 LIPOPOLYSACCHARIDE
BIOSYNTHESIS PROTEIN
WZZE
(Escherichia
coli) 		4 / 7 PHE A 154
ARG A  64
TYR A 102
ILE A  61
 None
 0.89A 1oniD-4wl1A:
undetectable
1oniF-4wl1A:
undetectable		 1oniD-4wl1A:
18.03
1oniF-4wl1A:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_E_BEZE509_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 4wl1 LIPOPOLYSACCHARIDE
BIOSYNTHESIS PROTEIN
WZZE
(Escherichia
coli) 		4 / 7 TYR A 102
ILE A  61
PHE A 154
ARG A  64
 None
 1.00A 1oniD-4wl1A:
undetectable
1oniE-4wl1A:
undetectable		 1oniD-4wl1A:
18.03
1oniE-4wl1A:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_A_ACHA1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4wl1 LIPOPOLYSACCHARIDE
BIOSYNTHESIS PROTEIN
WZZE
(Escherichia
coli) 		4 / 7 TRP A 119
SER A  58
GLN A 178
ILE A 147
 None
 1.25A 2xz5A-4wl1A:
undetectable
2xz5B-4wl1A:
undetectable		 2xz5A-4wl1A:
20.11
2xz5B-4wl1A:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_B_ACHB1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4wl1 LIPOPOLYSACCHARIDE
BIOSYNTHESIS PROTEIN
WZZE
(Escherichia
coli) 		4 / 8 TYR A 124
SER A  58
GLN A 178
ILE A 147
 None
 1.03A 2xz5B-4wl1A:
undetectable
2xz5E-4wl1A:
undetectable		 2xz5B-4wl1A:
20.11
2xz5E-4wl1A:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_E_ACHE1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4wl1 LIPOPOLYSACCHARIDE
BIOSYNTHESIS PROTEIN
WZZE
(Escherichia
coli) 		4 / 7 GLN A 178
ILE A 147
TYR A 124
TRP A 119
 None
 1.19A 2xz5D-4wl1A:
undetectable
2xz5E-4wl1A:
undetectable		 2xz5D-4wl1A:
20.11
2xz5E-4wl1A:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N58_D_ADND500_1
(ADENOSYLHOMOCYSTEINA
SE)		 4wl1 LIPOPOLYSACCHARIDE
BIOSYNTHESIS PROTEIN
WZZE
(Escherichia
coli) 		5 / 12 LEU A 175
THR A 122
ASP A 171
THR A 168
MET A 143
 None
 1.25A 3n58D-4wl1A:
undetectable		 3n58D-4wl1A:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM4_A_8PRA603_1
(TRANSPORTER)		 4wl1 LIPOPOLYSACCHARIDE
BIOSYNTHESIS PROTEIN
WZZE
(Escherichia
coli) 		5 / 12 VAL A 180
ALA A 181
TYR A 179
PHE A 105
THR A  62
 None
 1.37A 4mm4A-4wl1A:
undetectable		 4mm4A-4wl1A:
23.13