SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4wl2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JST_A_HLTA101_1
(FOUR-ALPHA-HELIX
BUNDLE)		 4wl2 PUTATIVE EXPORTED
CHOLOYLGLYCINE
HYDROLASE
(Pectobacterium
atrosepticum) 		4 / 5 ALA A 339
TRP A  32
LEU A  31
ALA A 316
 None
 1.14A 2jstA-4wl2A:
undetectable
2jstB-4wl2A:
undetectable		 2jstA-4wl2A:
10.67
2jstB-4wl2A:
10.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RK8_A_PPFA3969_1
(PHOSPHOENOLPYRUVATE
CARBOXYKINASE,
CYTOSOLIC [GTP])		 4wl2 PUTATIVE EXPORTED
CHOLOYLGLYCINE
HYDROLASE
(Pectobacterium
atrosepticum) 		4 / 8 ARG A 278
LYS A   1
ASP A  22
ALA A 293
 None
 1.17A 2rk8A-4wl2A:
undetectable		 2rk8A-4wl2A:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_B_DGXB1_2
(NUCLEAR RECEPTOR
ROR-GAMMA)		 4wl2 PUTATIVE EXPORTED
CHOLOYLGLYCINE
HYDROLASE
(Pectobacterium
atrosepticum) 		3 / 3 LEU A 153
VAL A 281
ARG A   3
 None
 0.86A 3b0wB-4wl2A:
undetectable		 3b0wB-4wl2A:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_E_9PLE1_1
(CYTOCHROME P450 2A13)		 4wl2 PUTATIVE EXPORTED
CHOLOYLGLYCINE
HYDROLASE
(Pectobacterium
atrosepticum) 		4 / 8 PHE A 133
PHE A 344
ALA A 111
THR A  72
 None
 1.07A 3t3sE-4wl2A:
undetectable		 3t3sE-4wl2A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKD_A_CYZA266_2
(GLUTAMATE RECEPTOR 2)		 4wl2 PUTATIVE EXPORTED
CHOLOYLGLYCINE
HYDROLASE
(Pectobacterium
atrosepticum) 		4 / 5 ILE A 134
PRO A  98
SER A 106
GLY A 104
 None
 0.87A 3tkdB-4wl2A:
undetectable		 3tkdB-4wl2A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKD_B_CYZB267_1
(GLUTAMATE RECEPTOR 2)		 4wl2 PUTATIVE EXPORTED
CHOLOYLGLYCINE
HYDROLASE
(Pectobacterium
atrosepticum) 		4 / 5 ILE A 134
PRO A  98
SER A 106
GLY A 104
 None
 0.87A 3tkdA-4wl2A:
undetectable		 3tkdA-4wl2A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_A_FOLA703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4wl2 PUTATIVE EXPORTED
CHOLOYLGLYCINE
HYDROLASE
(Pectobacterium
atrosepticum) 		5 / 11 VAL A 125
ASP A 155
SER A 175
MET A 181
THR A 120
 None
 1.46A 4eilA-4wl2A:
undetectable		 4eilA-4wl2A:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_D_FOLD703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4wl2 PUTATIVE EXPORTED
CHOLOYLGLYCINE
HYDROLASE
(Pectobacterium
atrosepticum) 		5 / 10 VAL A 125
ASP A 155
SER A 175
MET A 181
THR A 120
 None
 1.46A 4eilD-4wl2A:
undetectable		 4eilD-4wl2A:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_E_FOLE703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4wl2 PUTATIVE EXPORTED
CHOLOYLGLYCINE
HYDROLASE
(Pectobacterium
atrosepticum) 		5 / 11 VAL A 125
ASP A 155
SER A 175
MET A 181
THR A 120
 None
 1.46A 4eilE-4wl2A:
undetectable		 4eilE-4wl2A:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_G_FOLG703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4wl2 PUTATIVE EXPORTED
CHOLOYLGLYCINE
HYDROLASE
(Pectobacterium
atrosepticum) 		5 / 10 VAL A 125
ASP A 155
SER A 175
MET A 181
THR A 120
 None
 1.44A 4eilG-4wl2A:
undetectable		 4eilG-4wl2A:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IK7_A_IMNA201_1
(TRANSTHYRETIN)		 4wl2 PUTATIVE EXPORTED
CHOLOYLGLYCINE
HYDROLASE
(Pectobacterium
atrosepticum) 		4 / 7 LEU A  86
THR A  17
THR A 279
VAL A 281
 None
 0.90A 4ik7A-4wl2A:
undetectable		 4ik7A-4wl2A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_B_FOLB703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4wl2 PUTATIVE EXPORTED
CHOLOYLGLYCINE
HYDROLASE
(Pectobacterium
atrosepticum) 		5 / 12 VAL A 125
ASP A 155
SER A 175
MET A 181
THR A 120
 None
 1.40A 4kyaB-4wl2A:
undetectable		 4kyaB-4wl2A:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_C_FOLC703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4wl2 PUTATIVE EXPORTED
CHOLOYLGLYCINE
HYDROLASE
(Pectobacterium
atrosepticum) 		5 / 10 VAL A 125
ASP A 155
SER A 175
MET A 181
THR A 120
 None
 1.49A 4kyaC-4wl2A:
undetectable		 4kyaC-4wl2A:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_D_FOLD703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4wl2 PUTATIVE EXPORTED
CHOLOYLGLYCINE
HYDROLASE
(Pectobacterium
atrosepticum) 		5 / 12 VAL A 125
ASP A 155
SER A 175
MET A 181
THR A 120
 None
 1.42A 4kyaD-4wl2A:
undetectable		 4kyaD-4wl2A:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_F_FOLF703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4wl2 PUTATIVE EXPORTED
CHOLOYLGLYCINE
HYDROLASE
(Pectobacterium
atrosepticum) 		5 / 12 VAL A 125
ASP A 155
SER A 175
MET A 181
THR A 120
 None
 1.40A 4kyaF-4wl2A:
undetectable		 4kyaF-4wl2A:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_H_FOLH703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4wl2 PUTATIVE EXPORTED
CHOLOYLGLYCINE
HYDROLASE
(Pectobacterium
atrosepticum) 		5 / 12 VAL A 125
ASP A 155
SER A 175
MET A 181
THR A 120
 None
 1.43A 4kyaH-4wl2A:
undetectable		 4kyaH-4wl2A:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MX0_A_BCZA513_0
(NEURAMINIDASE)		 4wl2 PUTATIVE EXPORTED
CHOLOYLGLYCINE
HYDROLASE
(Pectobacterium
atrosepticum) 		5 / 12 ARG A  40
TRP A  51
SER A  41
ALA A  70
GLU A 343
 None
 1.44A 4mx0A-4wl2A:
undetectable		 4mx0A-4wl2A:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WH5_A_3QBA204_1
(LINCOSAMIDE
RESISTANCE PROTEIN)		 4wl2 PUTATIVE EXPORTED
CHOLOYLGLYCINE
HYDROLASE
(Pectobacterium
atrosepticum) 		5 / 12 ASP A 244
ASP A 282
PHE A 289
ILE A  16
ALA A 251
 None
 1.28A 4wh5A-4wl2A:
undetectable		 4wh5A-4wl2A:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XEY_A_1N1A601_2
(TYROSINE-PROTEIN
KINASE ABL1)		 4wl2 PUTATIVE EXPORTED
CHOLOYLGLYCINE
HYDROLASE
(Pectobacterium
atrosepticum) 		3 / 3 MET A 205
ASP A 214
PHE A 216
 None
 1.04A 4xeyA-4wl2A:
undetectable		 4xeyA-4wl2A:
24.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EU8_B_010B6_0
(N-[(5-METHYLISOXAZOL
-3-YL)CARBONYL]ALANY
L-L-VALYL-N~1~-((1R,
2Z)-4-(BENZYLOXY)-4-
OXO-1-{[(3R)-2-OXOPY
RROLIDIN-3-YL]METHYL
}BUT-2-ENYL)-L-LEUCI
NAMIDE
MAIN PROTEASE)		 4wl2 PUTATIVE EXPORTED
CHOLOYLGLYCINE
HYDROLASE
(Pectobacterium
atrosepticum) 		4 / 5 ASN A  84
LEU A  86
THR A 279
CYH A   1
 None
 1.38A 5eu8A-4wl2A:
undetectable		 5eu8A-4wl2A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LUH_A_SRYA304_1
(STREPTOMYCIN
3''-ADENYLYLTRANSFER
ASE)		 4wl2 PUTATIVE EXPORTED
CHOLOYLGLYCINE
HYDROLASE
(Pectobacterium
atrosepticum) 		5 / 10 ASP A  74
ASP A 282
HIS A 283
ILE A  16
THR A  17
 None
 1.47A 5luhA-4wl2A:
0.0		 5luhA-4wl2A:
11.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LUH_B_SRYB303_1
(STREPTOMYCIN
3''-ADENYLYLTRANSFER
ASE)		 4wl2 PUTATIVE EXPORTED
CHOLOYLGLYCINE
HYDROLASE
(Pectobacterium
atrosepticum) 		5 / 10 ASP A  74
ASP A 282
HIS A 283
ILE A  16
THR A  17
 None
 1.48A 5luhB-4wl2A:
0.0		 5luhB-4wl2A:
11.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKU_A_ZMRA901_2
(SIALIDASE)		 4wl2 PUTATIVE EXPORTED
CHOLOYLGLYCINE
HYDROLASE
(Pectobacterium
atrosepticum) 		4 / 6 ASP A 116
LEU A 128
SER A 127
PHE A 133
 None
 1.16A 6ekuA-4wl2A:
undetectable		 6ekuA-4wl2A:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_A_FJQA501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		 4wl2 PUTATIVE EXPORTED
CHOLOYLGLYCINE
HYDROLASE
(Pectobacterium
atrosepticum) 		5 / 10 ALA A 332
VAL A 301
ILE A  59
ALA A  60
THR A  29
 None
 1.30A 6h1lA-4wl2A:
undetectable		 6h1lA-4wl2A:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_B_FJQB501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		 4wl2 PUTATIVE EXPORTED
CHOLOYLGLYCINE
HYDROLASE
(Pectobacterium
atrosepticum) 		5 / 11 ALA A 332
VAL A 301
ILE A  59
ALA A  60
THR A  29
 None
 1.27A 6h1lB-4wl2A:
undetectable		 6h1lB-4wl2A:
20.71