SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4wlh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_P_CHDP4271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE III
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 4wlh KYNURENINE--OXOGLUTA
RATE TRANSAMINASE 1
(Homo
sapiens) 		4 / 8 LEU A 202
GLN A 204
PHE A 171
LEU A 167
 None
 0.82A 1v54P-4wlhA:
undetectable
1v54W-4wlhA:
undetectable		 1v54P-4wlhA:
20.24
1v54W-4wlhA:
9.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRK_B_TFPB203_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 4wlh KYNURENINE--OXOGLUTA
RATE TRANSAMINASE 1
(Homo
sapiens) 		4 / 5 PHE A 347
LEU A 422
PHE A 366
MET A 370
 None
 1.10A 1wrkB-4wlhA:
undetectable		 1wrkB-4wlhA:
14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_A_TFPA204_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 4wlh KYNURENINE--OXOGLUTA
RATE TRANSAMINASE 1
(Homo
sapiens) 		4 / 7 PHE A 347
LEU A 422
PHE A 366
VAL A 377
 None
 1.03A 1wrlA-4wlhA:
undetectable
1wrlB-4wlhA:
undetectable		 1wrlA-4wlhA:
14.56
1wrlB-4wlhA:
14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZLQ_A_ACTA1507_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 4wlh KYNURENINE--OXOGLUTA
RATE TRANSAMINASE 1
(Homo
sapiens) 		3 / 3 GLN A 409
HIS A 319
ARG A 322
 None
 1.09A 1zlqA-4wlhA:
undetectable		 1zlqA-4wlhA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BYO_A_LNLA1217_1
(LIPOPROTEIN LPPX)		 4wlh KYNURENINE--OXOGLUTA
RATE TRANSAMINASE 1
(Homo
sapiens) 		4 / 4 VAL A 381
LEU A 154
ILE A 321
LEU A 324
 None
 1.00A 2byoA-4wlhA:
undetectable		 2byoA-4wlhA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2N_A_X2NA1480_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 4wlh KYNURENINE--OXOGLUTA
RATE TRANSAMINASE 1
(Homo
sapiens) 		5 / 12 MET A 131
PHE A 108
TYR A 128
ALA A 107
ALA A 103
 None
 0.99A 2x2nA-4wlhA:
undetectable		 2x2nA-4wlhA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2N_B_X2NB1479_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 4wlh KYNURENINE--OXOGLUTA
RATE TRANSAMINASE 1
(Homo
sapiens) 		5 / 12 MET A 131
PHE A 108
TYR A 128
ALA A 107
ALA A 103
 None
 1.02A 2x2nB-4wlhA:
undetectable		 2x2nB-4wlhA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2N_D_X2ND1479_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 4wlh KYNURENINE--OXOGLUTA
RATE TRANSAMINASE 1
(Homo
sapiens) 		5 / 12 MET A 131
PHE A 108
TYR A 128
ALA A 107
ALA A 103
 None
 0.95A 2x2nD-4wlhA:
undetectable		 2x2nD-4wlhA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_C_CHDC271_0
(CYTOCHROME C OXIDASE
SUBUNIT 3)		 4wlh KYNURENINE--OXOGLUTA
RATE TRANSAMINASE 1
(Homo
sapiens) 		4 / 7 LEU A 202
GLN A 204
PHE A 171
LEU A 167
 None
 0.80A 3ag2C-4wlhA:
undetectable		 3ag2C-4wlhA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4wlh KYNURENINE--OXOGLUTA
RATE TRANSAMINASE 1
(Homo
sapiens) 		4 / 8 LEU A 202
GLN A 204
PHE A 171
LEU A 167
 None
 0.80A 3ag4C-4wlhA:
undetectable
3ag4J-4wlhA:
undetectable		 3ag4C-4wlhA:
20.24
3ag4J-4wlhA:
9.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KHM_A_TPFA501_1
(STEROL 14
ALPHA-DEMETHYLASE)		 4wlh KYNURENINE--OXOGLUTA
RATE TRANSAMINASE 1
(Homo
sapiens) 		4 / 8 MET A 131
TYR A 128
ALA A 107
ALA A 103
 None
 0.80A 3khmA-4wlhA:
undetectable		 3khmA-4wlhA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RUK_D_AERD601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4wlh KYNURENINE--OXOGLUTA
RATE TRANSAMINASE 1
(Homo
sapiens) 		5 / 11 ALA A 287
PHE A  50
GLY A 246
ALA A 245
VAL A  96
 None
None
LLP  A 247 ( 2.4A)
None
None
 1.20A 3rukD-4wlhA:
undetectable		 3rukD-4wlhA:
24.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3X2Q_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4wlh KYNURENINE--OXOGLUTA
RATE TRANSAMINASE 1
(Homo
sapiens) 		4 / 7 LEU A 202
GLN A 204
PHE A 171
LEU A 167
 None
 0.88A 3x2qP-4wlhA:
undetectable
3x2qW-4wlhA:
undetectable		 3x2qP-4wlhA:
20.24
3x2qW-4wlhA:
9.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7A_B_RGZB601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 4wlh KYNURENINE--OXOGLUTA
RATE TRANSAMINASE 1
(Homo
sapiens) 		5 / 12 LEU A 162
LEU A 198
LEU A 202
CYH A 203
ILE A 119
 None
 1.10A 4a7aB-4wlhA:
undetectable		 4a7aB-4wlhA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G1B_A_ECNA403_1
(FLAVOHEMOGLOBIN)		 4wlh KYNURENINE--OXOGLUTA
RATE TRANSAMINASE 1
(Homo
sapiens) 		5 / 12 PHE A  40
PHE A 309
ALA A 251
THR A 252
VAL A 402
 None
None
None
LLP  A 247 ( 4.4A)
None
 1.14A 4g1bA-4wlhA:
undetectable		 4g1bA-4wlhA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAQ_A_2GMA2001_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 1B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 4wlh KYNURENINE--OXOGLUTA
RATE TRANSAMINASE 1
(Homo
sapiens) 		4 / 6 ILE A 229
THR A 239
VAL A 190
SER A 231
 None
 1.04A 4iaqA-4wlhA:
undetectable		 4iaqA-4wlhA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNV_D_QI9D602_0
(CYTOCHROME P450 2D6)		 4wlh KYNURENINE--OXOGLUTA
RATE TRANSAMINASE 1
(Homo
sapiens) 		4 / 7 PHE A  80
LEU A  84
GLU A 214
THR A 248
 None
None
None
LLP  A 247 ( 4.3A)
 1.02A 4wnvD-4wlhA:
undetectable		 4wnvD-4wlhA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A5Z_C_WJZC304_0
(BETA-LACTAMASE NDM-1)		 4wlh KYNURENINE--OXOGLUTA
RATE TRANSAMINASE 1
(Homo
sapiens) 		4 / 7 MET A 266
CYH A 280
GLY A 102
HIS A 273
 None
 1.12A 5a5zC-4wlhA:
undetectable		 5a5zC-4wlhA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4wlh KYNURENINE--OXOGLUTA
RATE TRANSAMINASE 1
(Homo
sapiens) 		4 / 7 LEU A 202
GLN A 204
PHE A 171
LEU A 167
 None
 0.88A 5b1bP-4wlhA:
undetectable
5b1bW-4wlhA:
undetectable		 5b1bP-4wlhA:
20.24
5b1bW-4wlhA:
9.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OGC_B_TA1B601_1
(TUBULIN BETA CHAIN)		 4wlh KYNURENINE--OXOGLUTA
RATE TRANSAMINASE 1
(Homo
sapiens) 		5 / 12 ASP A 222
LEU A 408
ARG A 322
PRO A 334
LEU A 340
 None
 1.27A 5ogcB-4wlhA:
undetectable		 5ogcB-4wlhA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z85_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4wlh KYNURENINE--OXOGLUTA
RATE TRANSAMINASE 1
(Homo
sapiens) 		4 / 7 LEU A 202
GLN A 204
PHE A 171
LEU A 167
 None
 0.89A 5z85C-4wlhA:
undetectable
5z85J-4wlhA:
undetectable		 5z85C-4wlhA:
20.24
5z85J-4wlhA:
9.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZNI_A_YMZA302_0
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4wlh KYNURENINE--OXOGLUTA
RATE TRANSAMINASE 1
(Homo
sapiens) 		5 / 9 VAL A 179
GLY A 243
VAL A 215
GLU A 214
GLY A 257
 None
None
LLP  A 247 ( 3.7A)
None
None
 1.33A 5zniA-4wlhA:
undetectable		 5zniA-4wlhA:
11.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A7P_A_9SCA601_0
(SERUM ALBUMIN)		 4wlh KYNURENINE--OXOGLUTA
RATE TRANSAMINASE 1
(Homo
sapiens) 		5 / 12 ILE A 397
VAL A 179
LEU A 104
GLY A  34
PHE A 124
 None
None
LLP  A 247 ( 4.5A)
None
None
 1.17A 6a7pA-4wlhA:
undetectable		 6a7pA-4wlhA:
21.89