SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4wlp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P93_A_DEXA1999_1
(GLUCOCORTICOID
RECEPTOR)		 4wlp UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE ISOZYME L5
(Homo
sapiens) 		5 / 12 LEU A  98
ASN A  99
LEU A  97
GLN A 119
ILE A  77
 None
 1.47A 1p93A-4wlpA:
undetectable		 1p93A-4wlpA:
24.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_C_CHDC3271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE III
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 4wlp UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE ISOZYME L5
NUCLEAR FACTOR
RELATED TO
KAPPA-B-BINDING
PROTEIN
(Homo
sapiens;
Homo
sapiens) 		4 / 8 LEU B  70
GLN B  71
PHE A 294
LEU A 298
 None
 0.83A 1v54C-4wlpB:
undetectable
1v54J-4wlpB:
undetectable		 1v54C-4wlpB:
17.50
1v54J-4wlpB:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_P_CHDP4271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE III
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 4wlp UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE ISOZYME L5
NUCLEAR FACTOR
RELATED TO
KAPPA-B-BINDING
PROTEIN
(Homo
sapiens;
Homo
sapiens) 		4 / 8 LEU B  70
GLN B  71
PHE A 294
LEU A 298
 None
 0.82A 1v54P-4wlpB:
undetectable
1v54W-4wlpB:
undetectable		 1v54P-4wlpB:
17.50
1v54W-4wlpB:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VPO_H_TESH1010_1
(ANTI-TESTOSTERONE
(HEAVY CHAIN)
ANTI-TESTOSTERONE
(LIGHT CHAIN))		 4wlp UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE ISOZYME L5
(Homo
sapiens) 		5 / 12 SER A 198
ALA A 190
GLY A 189
LEU A 175
PRO A 202
 None
 1.27A 1vpoH-4wlpA:
undetectable
1vpoL-4wlpA:
undetectable		 1vpoH-4wlpA:
20.38
1vpoL-4wlpA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_F_TFPF211_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 4wlp UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE ISOZYME L5
(Homo
sapiens) 		4 / 7 PHE A  18
PHE A  25
LEU A 130
SER A 167
 None
 0.90A 1wrlE-4wlpA:
undetectable
1wrlF-4wlpA:
undetectable		 1wrlE-4wlpA:
14.29
1wrlF-4wlpA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4wlp UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE ISOZYME L5
NUCLEAR FACTOR
RELATED TO
KAPPA-B-BINDING
PROTEIN
(Homo
sapiens;
Homo
sapiens) 		4 / 8 LEU B  70
GLN B  71
PHE A 294
LEU A 298
 None
 0.84A 2dyrC-4wlpB:
undetectable
2dyrJ-4wlpB:
undetectable		 2dyrC-4wlpB:
17.50
2dyrJ-4wlpB:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4wlp UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE ISOZYME L5
NUCLEAR FACTOR
RELATED TO
KAPPA-B-BINDING
PROTEIN
(Homo
sapiens;
Homo
sapiens) 		4 / 8 LEU B  70
GLN B  71
PHE A 294
LEU A 298
 None
 0.82A 2dyrP-4wlpB:
undetectable
2dyrW-4wlpB:
undetectable		 2dyrP-4wlpB:
17.50
2dyrW-4wlpB:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P16_A_GG2A298_2
(COAGULATION FACTOR X
(EC 3.4.21.6)
(STUART FACTOR)
(STUART-PROWER
FACTOR))		 4wlp UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE ISOZYME L5
(Homo
sapiens) 		3 / 3 ARG A 137
GLU A   7
GLN A 138
 None
 0.93A 2p16A-4wlpA:
undetectable		 2p16A-4wlpA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_L_ASDL1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 4wlp UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE ISOZYME L5
(Homo
sapiens) 		4 / 7 LEU A 130
ALA A  80
PHE A  79
PHE A  78
 None
 0.95A 2vcvL-4wlpA:
undetectable		 2vcvL-4wlpA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9H_A_TOPA1160_1
(DIHYDROFOLATE
REDUCTASE)		 4wlp UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE ISOZYME L5
(Homo
sapiens) 		5 / 10 LEU A 178
ALA A  80
LEU A 130
LEU A  98
ILE A  93
 None
 1.01A 2w9hA-4wlpA:
undetectable		 2w9hA-4wlpA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_A_TOPA1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 4wlp UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE ISOZYME L5
(Homo
sapiens) 		5 / 11 LEU A  98
LEU A 130
ILE A 136
ILE A  93
PHE A  25
 None
 0.98A 2w9sA-4wlpA:
undetectable		 2w9sA-4wlpA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_B_TOPB1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 4wlp UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE ISOZYME L5
(Homo
sapiens) 		5 / 11 LEU A  98
LEU A 130
ILE A 136
ILE A  93
PHE A  25
 None
 0.94A 2w9sB-4wlpA:
undetectable		 2w9sB-4wlpA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A3Y_A_OBNA6000_1
(NA, K-ATPASE ALPHA
SUBUNIT)		 4wlp UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE ISOZYME L5
(Homo
sapiens) 		5 / 10 GLY A  51
VAL A 224
PHE A  54
LEU A 220
ARG A 207
 None
 1.32A 3a3yA-4wlpA:
undetectable		 3a3yA-4wlpA:
15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_C_CHDC271_0
(CYTOCHROME C OXIDASE
SUBUNIT 3)		 4wlp UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE ISOZYME L5
NUCLEAR FACTOR
RELATED TO
KAPPA-B-BINDING
PROTEIN
(Homo
sapiens;
Homo
sapiens) 		4 / 7 LEU B  70
GLN B  71
PHE A 294
LEU A 298
 None
 0.82A 3ag2C-4wlpB:
undetectable		 3ag2C-4wlpB:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4wlp UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE ISOZYME L5
NUCLEAR FACTOR
RELATED TO
KAPPA-B-BINDING
PROTEIN
(Homo
sapiens;
Homo
sapiens) 		4 / 8 LEU B  70
GLN B  71
PHE A 294
LEU A 298
 None
 0.77A 3ag4C-4wlpB:
undetectable
3ag4J-4wlpB:
undetectable		 3ag4C-4wlpB:
17.50
3ag4J-4wlpB:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4wlp UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE ISOZYME L5
NUCLEAR FACTOR
RELATED TO
KAPPA-B-BINDING
PROTEIN
(Homo
sapiens;
Homo
sapiens) 		4 / 7 LEU B  70
GLN B  71
PHE A 294
LEU A 298
 None
 0.78A 3ag4P-4wlpB:
undetectable
3ag4W-4wlpB:
undetectable		 3ag4P-4wlpB:
17.50
3ag4W-4wlpB:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3X2Q_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4wlp UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE ISOZYME L5
NUCLEAR FACTOR
RELATED TO
KAPPA-B-BINDING
PROTEIN
(Homo
sapiens;
Homo
sapiens) 		4 / 7 LEU B  70
GLN B  71
PHE A 294
LEU A 298
 None
 0.69A 3x2qC-4wlpB:
undetectable
3x2qJ-4wlpB:
undetectable		 3x2qC-4wlpB:
17.50
3x2qJ-4wlpB:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3X2Q_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4wlp UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE ISOZYME L5
NUCLEAR FACTOR
RELATED TO
KAPPA-B-BINDING
PROTEIN
(Homo
sapiens;
Homo
sapiens) 		4 / 7 LEU B  70
GLN B  71
PHE A 294
LEU A 298
 None
 0.66A 3x2qP-4wlpB:
undetectable
3x2qW-4wlpB:
undetectable		 3x2qP-4wlpB:
17.50
3x2qW-4wlpB:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_A_CQAA302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 4wlp UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE ISOZYME L5
(Homo
sapiens) 		4 / 7 GLU A 177
TYR A 176
ARG A  73
GLY A 189
 None
 1.03A 4fgzA-4wlpA:
undetectable		 4fgzA-4wlpA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOP_C_HQEC503_1
(CATALASE)		 4wlp NUCLEAR FACTOR
RELATED TO
KAPPA-B-BINDING
PROTEIN
UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE ISOZYME L5
(Homo
sapiens) 		4 / 8 PHE A  43
LEU A  52
LEU A  38
PHE B 100
 None
 0.84A 4qopC-4wlpA:
undetectable		 4qopC-4wlpA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNU_C_QDNC602_1
(CYTOCHROME P450 2D6)		 4wlp NUCLEAR FACTOR
RELATED TO
KAPPA-B-BINDING
PROTEIN
UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE ISOZYME L5
(Homo
sapiens) 		5 / 11 LEU B 146
PHE A 121
ALA A 123
ASP A 122
PHE A 114
 None
 1.38A 4wnuC-4wlpB:
undetectable		 4wnuC-4wlpB:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZB_C_ACTC401_0
(PROTON-GATED ION
CHANNEL)		 4wlp UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE ISOZYME L5
(Homo
sapiens) 		4 / 7 ILE A 197
PHE A  43
VAL A 200
ILE A 204
 None
 0.97A 4zzbC-4wlpA:
undetectable
4zzbD-4wlpA:
undetectable		 4zzbC-4wlpA:
22.25
4zzbD-4wlpA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4wlp UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE ISOZYME L5
NUCLEAR FACTOR
RELATED TO
KAPPA-B-BINDING
PROTEIN
(Homo
sapiens;
Homo
sapiens) 		4 / 7 LEU B  70
GLN B  71
PHE A 294
LEU A 298
 None
 0.86A 5b1bP-4wlpB:
undetectable
5b1bW-4wlpB:
undetectable		 5b1bP-4wlpB:
17.50
5b1bW-4wlpB:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UAN_B_REAB503_1
(RETINOIC ACID
RECEPTOR BETA)		 4wlp NUCLEAR FACTOR
RELATED TO
KAPPA-B-BINDING
PROTEIN
UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE ISOZYME L5
(Homo
sapiens) 		5 / 12 PHE B  93
LEU A 302
ILE A 295
LEU B  70
VAL B  61
 None
 1.15A 5uanB-4wlpB:
undetectable		 5uanB-4wlpB:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_H_RITH602_2
(CYTOCHROME P450 3A5)		 4wlp UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE ISOZYME L5
(Homo
sapiens) 		4 / 5 PHE A  18
PHE A 143
LEU A  21
LEU A 277
 None
 1.35A 5veuH-4wlpA:
undetectable		 5veuH-4wlpA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z85_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4wlp UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE ISOZYME L5
NUCLEAR FACTOR
RELATED TO
KAPPA-B-BINDING
PROTEIN
(Homo
sapiens;
Homo
sapiens) 		4 / 7 LEU B  70
GLN B  71
PHE A 294
LEU A 298
 None
 0.74A 5z85C-4wlpB:
undetectable
5z85J-4wlpB:
undetectable		 5z85C-4wlpB:
17.50
5z85J-4wlpB:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4wlp UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE ISOZYME L5
NUCLEAR FACTOR
RELATED TO
KAPPA-B-BINDING
PROTEIN
(Homo
sapiens;
Homo
sapiens) 		4 / 7 LEU B  70
GLN B  71
PHE A 294
LEU A 298
 None
 0.67A 5zcoC-4wlpB:
undetectable
5zcoJ-4wlpB:
undetectable		 5zcoC-4wlpB:
17.50
5zcoJ-4wlpB:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCQ_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4wlp UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE ISOZYME L5
NUCLEAR FACTOR
RELATED TO
KAPPA-B-BINDING
PROTEIN
(Homo
sapiens;
Homo
sapiens) 		4 / 7 LEU B  70
GLN B  71
PHE A 294
LEU A 298
 None
 0.71A 5zcqC-4wlpB:
undetectable
5zcqJ-4wlpB:
undetectable		 5zcqC-4wlpB:
17.50
5zcqJ-4wlpB:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCQ_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4wlp UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE ISOZYME L5
NUCLEAR FACTOR
RELATED TO
KAPPA-B-BINDING
PROTEIN
(Homo
sapiens;
Homo
sapiens) 		4 / 7 LEU B  70
GLN B  71
PHE A 294
LEU A 298
 None
 0.74A 5zcqP-4wlpB:
undetectable
5zcqW-4wlpB:
undetectable		 5zcqP-4wlpB:
17.50
5zcqW-4wlpB:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6J_D_ACTD404_0
(L-LYSINE
3-HYDROXYLASE)		 4wlp UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE ISOZYME L5
(Homo
sapiens) 		4 / 6 GLN A  82
TRP A   8
HIS A 140
GLN A  91
 None
 1.42A 6f6jC-4wlpA:
undetectable
6f6jD-4wlpA:
undetectable		 6f6jC-4wlpA:
22.75
6f6jD-4wlpA:
22.75