SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4wm0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_D_BRLD503_2
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 4wm0 XYLOSIDE
XYLOSYLTRANSFERASE 1
(Mus
musculus) 		4 / 4 ILE A 234
LEU A 347
VAL A 291
ILE A 380
 None
 0.90A 1fm6D-4wm0A:
undetectable		 1fm6D-4wm0A:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RA8_A_FOLA161_1
(DIHYDROFOLATE
REDUCTASE)		 4wm0 XYLOSIDE
XYLOSYLTRANSFERASE 1
(Mus
musculus) 		3 / 3 ASP A 201
LYS A 189
ARG A 324
 None
 1.19A 1ra8A-4wm0A:
undetectable		 1ra8A-4wm0A:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_A_SAMA301_0
(HEMK PROTEIN)		 4wm0 XYLOSIDE
XYLOSYLTRANSFERASE 1
(Mus
musculus) 		5 / 12 PRO A 215
ILE A 169
VAL A  96
GLU A 134
PHE A 130
 None
 1.12A 1sg9A-4wm0A:
undetectable		 1sg9A-4wm0A:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6K_A_ADNA699_1
(CHLORINASE)		 4wm0 XYLOSIDE
XYLOSYLTRANSFERASE 1
(Mus
musculus) 		4 / 7 ASP A 201
PHE A 204
TYR A 198
TYR A 199
 None
 1.50A 2q6kA-4wm0A:
undetectable		 2q6kA-4wm0A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DFR_A_MTXA164_1
(DIHYDROFOLATE
REDUCTASE)		 4wm0 XYLOSIDE
XYLOSYLTRANSFERASE 1
(Mus
musculus) 		5 / 12 LEU A 226
LEU A 125
LEU A 138
HIS A 139
ALA A 117
 None
 1.07A 3dfrA-4wm0A:
undetectable		 3dfrA-4wm0A:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZW_B_KKKB413_1
(FLAVOHEMOGLOBIN)		 4wm0 XYLOSIDE
XYLOSYLTRANSFERASE 1
(Mus
musculus) 		5 / 12 TYR A 230
GLN A 223
LEU A 138
LEU A 125
ILE A 203
 None
 1.02A 3ozwB-4wm0A:
undetectable		 3ozwB-4wm0A:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R24_A_SAMA302_0
(2'-O-METHYL
TRANSFERASE)		 4wm0 XYLOSIDE
XYLOSYLTRANSFERASE 1
(Mus
musculus) 		5 / 12 GLY A 286
PRO A 280
GLY A 283
ASN A 288
ASP A 329
 None
 1.46A 3r24A-4wm0A:
undetectable		 3r24A-4wm0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3THR_C_C2FC1410_0
(GLYCINE
N-METHYLTRANSFERASE)		 4wm0 XYLOSIDE
XYLOSYLTRANSFERASE 1
(Mus
musculus) 		3 / 3 ARG A 254
PRO A 341
PHE A 287
 None
 1.04A 3thrC-4wm0A:
undetectable		 3thrC-4wm0A:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CLA_A_CLMA221_0
(TYPE III
CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4wm0 XYLOSIDE
XYLOSYLTRANSFERASE 1
(Mus
musculus) 		5 / 11 ALA A 128
LEU A 136
PHE A 130
SER A 123
ILE A 380
 None
 1.07A 4claA-4wm0A:
undetectable		 4claA-4wm0A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CLA_A_CLMA221_0
(TYPE III
CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4wm0 XYLOSIDE
XYLOSYLTRANSFERASE 1
(Mus
musculus) 		5 / 11 ALA A 128
LEU A 136
PHE A 130
SER A 123
VAL A 291
 None
 1.18A 4claA-4wm0A:
undetectable		 4claA-4wm0A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_A_ADNA401_2
(ADENOSINE KINASE)		 4wm0 XYLOSIDE
XYLOSYLTRANSFERASE 1
(Mus
musculus) 		4 / 4 LEU A 347
ILE A 222
GLY A 251
PHE A 241
 None
 1.09A 4dc3A-4wm0A:
undetectable		 4dc3A-4wm0A:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_1
(ADENOSINE KINASE)		 4wm0 XYLOSIDE
XYLOSYLTRANSFERASE 1
(Mus
musculus) 		5 / 12 ASN A 386
GLY A 383
ASN A 288
GLY A 290
ASP A 225
 None
 0.86A 4dc3B-4wm0A:
undetectable		 4dc3B-4wm0A:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJG_B_NCTB501_1
(CYTOCHROME P450 2A13)		 4wm0 XYLOSIDE
XYLOSYLTRANSFERASE 1
(Mus
musculus) 		4 / 8 PHE A 140
ALA A 117
LEU A 157
LEU A 154
 None
 0.74A 4ejgB-4wm0A:
undetectable		 4ejgB-4wm0A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JVL_A_ESTA702_1
(ESTROGEN
SULFOTRANSFERASE)		 4wm0 XYLOSIDE
XYLOSYLTRANSFERASE 1
(Mus
musculus) 		4 / 9 TYR A 305
PHE A 332
ILE A 252
MET A 292
 None
 1.01A 4jvlA-4wm0A:
undetectable		 4jvlA-4wm0A:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_B_AERB601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4wm0 XYLOSIDE
XYLOSYLTRANSFERASE 1
(Mus
musculus) 		4 / 5 ARG A 261
ASP A 278
GLU A 255
VAL A 346
 None
 1.50A 4nkvB-4wm0A:
undetectable		 4nkvB-4wm0A:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F7L_B_ACTB505_0
(AMINE OXIDASE LKCE)		 4wm0 XYLOSIDE
XYLOSYLTRANSFERASE 1
(Mus
musculus) 		3 / 3 HIS A  99
ASN A 137
LEU A 136
 None
 0.69A 6f7lB-4wm0A:
undetectable		 6f7lB-4wm0A:
19.86