SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4wmh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E3V_A_DXCA801_0
(STEROID
DELTA-ISOMERASE)		 4wmh HEME OXYGENASE 2
(Homo
sapiens) 		5 / 12 PHE A 186
TYR A 187
PHE A  53
VAL A  54
ALA A  70
 None
 1.46A 1e3vA-4wmhA:
undetectable		 1e3vA-4wmhA:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NHZ_A_486A800_1
(GLUCOCORTICOID
RECEPTOR)		 4wmh HEME OXYGENASE 2
(Homo
sapiens) 		5 / 12 MET A 158
LEU A 161
GLY A 164
GLN A 165
VAL A 166
 None
 1.07A 1nhzA-4wmhA:
undetectable		 1nhzA-4wmhA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P93_B_DEXB2999_1
(GLUCOCORTICOID
RECEPTOR)		 4wmh HEME OXYGENASE 2
(Homo
sapiens) 		5 / 12 MET A 158
LEU A  97
MET A 206
THR A  41
PHE A 227
 None
 1.45A 1p93B-4wmhA:
undetectable		 1p93B-4wmhA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PO7_A_ZONA601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 4wmh HEME OXYGENASE 2
(Homo
sapiens) 		4 / 8 TYR A  98
LEU A  81
TYR A 157
TYR A 202
 None
 1.28A 3po7A-4wmhA:
undetectable		 3po7A-4wmhA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_I_HCYI900_1
(GLUCOCORTICOID
RECEPTOR)		 4wmh HEME OXYGENASE 2
(Homo
sapiens) 		5 / 12 MET A 158
LEU A  97
MET A 206
THR A  41
PHE A 227
 None
 1.39A 4p6xI-4wmhA:
undetectable		 4p6xI-4wmhA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXE_B_ESTB1000_1
(ESTROGEN RECEPTOR)		 4wmh HEME OXYGENASE 2
(Homo
sapiens) 		5 / 10 ALA A  93
LEU A 209
LEU A  33
HIS A 152
LEU A 149
 None
 1.43A 5dxeB-4wmhA:
undetectable		 5dxeB-4wmhA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXE_B_ESTB1000_1
(ESTROGEN RECEPTOR)		 4wmh HEME OXYGENASE 2
(Homo
sapiens) 		5 / 10 ALA A  93
LEU A 209
MET A 206
HIS A 152
LEU A 149
 None
 1.49A 5dxeB-4wmhA:
undetectable		 5dxeB-4wmhA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC3_B_486B801_1
(GLUCOCORTICOID
RECEPTOR)		 4wmh HEME OXYGENASE 2
(Homo
sapiens) 		5 / 12 MET A 158
LEU A 161
GLY A 164
GLN A 165
VAL A 166
 None
 1.17A 5uc3B-4wmhA:
undetectable		 5uc3B-4wmhA:
15.92