SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4wmj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1F86_A_T44A428_1
(TRANSTHYRETIN
THR119MET VARIANT)		 4wmj GLUCOSE-6-PHOSPHATE
ISOMERASE
(Colias
eurytheme) 		4 / 4 LYS A  77
LEU A  73
ALA A  76
LEU A  72
 None
 1.42A 1f86A-4wmjA:
undetectable		 1f86A-4wmjA:
12.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_B_CHDB2501_0
(FERROCHELATASE)		 4wmj GLUCOSE-6-PHOSPHATE
ISOMERASE
(Colias
eurytheme) 		5 / 12 LEU A 348
PHE A 351
MET A 170
ILE A 480
TRP A 280
 None
 1.37A 1hrkB-4wmjA:
2.6		 1hrkB-4wmjA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ME7_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 4wmj GLUCOSE-6-PHOSPHATE
ISOMERASE
(Colias
eurytheme) 		4 / 8 ASN A 511
ILE A 510
GLY A 505
GLY A 358
 None
 0.75A 1me7A-4wmjA:
undetectable		 1me7A-4wmjA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQF_A_SAMA430_1
(SUN PROTEIN)		 4wmj GLUCOSE-6-PHOSPHATE
ISOMERASE
(Colias
eurytheme) 		3 / 3 PRO A 487
ASP A  52
ASP A 301
 None
 0.73A 1sqfA-4wmjA:
undetectable		 1sqfA-4wmjA:
26.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOU_A_CQAA403_0
(HISTAMINE
N-METHYLTRANSFERASE)		 4wmj GLUCOSE-6-PHOSPHATE
ISOMERASE
(Colias
eurytheme) 		4 / 8 ASP A 238
GLY A 260
PHE A 259
THR A 226
 None
 1.00A 2aouA-4wmjA:
1.6		 2aouA-4wmjA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y00_B_Y00B601_2
(BETA-1 ADRENERGIC
RECEPTOR)		 4wmj GLUCOSE-6-PHOSPHATE
ISOMERASE
(Colias
eurytheme) 		3 / 3 VAL A 102
ASN A 511
TRP A 516
 None
 0.83A 2y00B-4wmjA:
undetectable		 2y00B-4wmjA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_A_CHDA1_0
(FERROCHELATASE)		 4wmj GLUCOSE-6-PHOSPHATE
ISOMERASE
(Colias
eurytheme) 		5 / 11 LEU A 348
PHE A 351
MET A 170
ILE A 480
TRP A 280
 None
 1.43A 3aqiA-4wmjA:
2.5		 3aqiA-4wmjA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZU_A_9CRA7223_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4wmj GLUCOSE-6-PHOSPHATE
ISOMERASE
(Colias
eurytheme) 		5 / 12 ILE A 210
ALA A 212
ILE A 287
LEU A 249
VAL A 140
 None
 1.12A 3dzuA-4wmjA:
undetectable		 3dzuA-4wmjA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P6H_A_IBPA133_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 4wmj GLUCOSE-6-PHOSPHATE
ISOMERASE
(Colias
eurytheme) 		4 / 7 ASP A 509
ILE A  94
VAL A 102
TYR A 277
 None
 1.05A 3p6hA-4wmjA:
undetectable		 3p6hA-4wmjA:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_A_CHDA1502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4wmj GLUCOSE-6-PHOSPHATE
ISOMERASE
(Colias
eurytheme) 		5 / 12 LEU A 348
PHE A 351
MET A 170
ILE A 480
TRP A 280
 None
 1.32A 3w1wA-4wmjA:
2.6		 3w1wA-4wmjA:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_D_VIVD301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 4wmj GLUCOSE-6-PHOSPHATE
ISOMERASE
(Colias
eurytheme) 		5 / 12 VAL A 129
PHE A 296
ILE A 494
VAL A 273
VAL A 126
 None
 1.01A 3w68D-4wmjA:
undetectable		 3w68D-4wmjA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DAN_B_2FAB301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 4wmj GLUCOSE-6-PHOSPHATE
ISOMERASE
(Colias
eurytheme) 		5 / 12 HIS A 104
SER A 362
GLY A 505
SER A 512
VAL A 506
 None
 1.23A 4danA-4wmjA:
undetectable
4danB-4wmjA:
undetectable		 4danA-4wmjA:
18.23
4danB-4wmjA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EB4_A_D16A402_1
(THYMIDYLATE SYNTHASE)		 4wmj GLUCOSE-6-PHOSPHATE
ISOMERASE
(Colias
eurytheme) 		5 / 12 LEU A 175
PHE A 485
TYR A 290
LYS A 298
ALA A 179
 None
 1.28A 4eb4A-4wmjA:
undetectable		 4eb4A-4wmjA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_B_NCTB501_1
(CYTOCHROME P450 2A6)		 4wmj GLUCOSE-6-PHOSPHATE
ISOMERASE
(Colias
eurytheme) 		4 / 7 PHE A 351
VAL A 171
GLY A 491
PHE A 355
 None
 0.82A 4ejjB-4wmjA:
undetectable		 4ejjB-4wmjA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAQ_A_2GMA2001_1
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 1B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 4wmj GLUCOSE-6-PHOSPHATE
ISOMERASE
(Colias
eurytheme) 		5 / 12 ASP A 359
ALA A 324
TRP A 508
MET A  88
PHE A 513
 None
 1.27A 4iaqA-4wmjA:
undetectable		 4iaqA-4wmjA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAR_A_ERMA2001_1
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 1B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 4wmj GLUCOSE-6-PHOSPHATE
ISOMERASE
(Colias
eurytheme) 		5 / 12 ASP A 359
ALA A 324
TRP A 508
MET A  88
PHE A 513
 None
 1.28A 4iarA-4wmjA:
undetectable		 4iarA-4wmjA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_A_DGXA1107_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 4wmj GLUCOSE-6-PHOSPHATE
ISOMERASE
(Colias
eurytheme) 		5 / 12 LEU A 279
GLU A 294
ALA A 303
GLU A 498
LEU A 130
 None
 1.19A 4retA-4wmjA:
undetectable		 4retA-4wmjA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_C_DGXC2005_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 4wmj GLUCOSE-6-PHOSPHATE
ISOMERASE
(Colias
eurytheme) 		5 / 12 LEU A 279
GLU A 294
ALA A 303
GLU A 498
LEU A 130
 None
 1.19A 4retC-4wmjA:
undetectable		 4retC-4wmjA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTR_A_SAMA301_0
(DNA ADENINE
METHYLASE)		 4wmj GLUCOSE-6-PHOSPHATE
ISOMERASE
(Colias
eurytheme) 		5 / 11 TRP A 145
GLY A 147
PHE A 246
ILE A 261
TYR A 148
 None
 1.35A 4rtrA-4wmjA:
undetectable		 4rtrA-4wmjA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTR_A_SAMA301_0
(DNA ADENINE
METHYLASE)		 4wmj GLUCOSE-6-PHOSPHATE
ISOMERASE
(Colias
eurytheme) 		5 / 11 TRP A 145
PHE A 246
ILE A 261
ASN A 265
TYR A 148
 None
 1.36A 4rtrA-4wmjA:
undetectable		 4rtrA-4wmjA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTS_A_SAMA301_0
(DNA ADENINE
METHYLASE)		 4wmj GLUCOSE-6-PHOSPHATE
ISOMERASE
(Colias
eurytheme) 		6 / 12 TRP A 145
GLY A 147
PHE A 246
ILE A 261
ASN A 265
TYR A 148
 None
 1.28A 4rtsA-4wmjA:
undetectable		 4rtsA-4wmjA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U95_B_MIYB1102_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 4wmj GLUCOSE-6-PHOSPHATE
ISOMERASE
(Colias
eurytheme) 		5 / 12 PHE A 502
GLY A 505
ILE A 507
ALA A 324
ARG A  79
 None
 1.15A 4u95B-4wmjA:
undetectable		 4u95B-4wmjA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECK_A_ILEA601_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 4wmj GLUCOSE-6-PHOSPHATE
ISOMERASE
(Colias
eurytheme) 		4 / 6 ALA A 372
THR A 373
VAL A 367
TYR A 366
 None
 0.99A 5eckA-4wmjA:
3.2		 5eckA-4wmjA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECK_D_ILED601_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 4wmj GLUCOSE-6-PHOSPHATE
ISOMERASE
(Colias
eurytheme) 		4 / 6 ALA A 372
THR A 373
VAL A 367
TYR A 366
 None
 0.99A 5eckD-4wmjA:
1.8		 5eckD-4wmjA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECL_A_ILEA602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 4wmj GLUCOSE-6-PHOSPHATE
ISOMERASE
(Colias
eurytheme) 		4 / 6 ALA A 372
THR A 373
VAL A 367
TYR A 366
 None
 0.89A 5eclA-4wmjA:
0.6		 5eclA-4wmjA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECO_A_LEUA602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 4wmj GLUCOSE-6-PHOSPHATE
ISOMERASE
(Colias
eurytheme) 		4 / 6 ALA A 372
THR A 373
VAL A 367
TYR A 366
 None
 0.99A 5ecoA-4wmjA:
undetectable		 5ecoA-4wmjA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I71_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 4wmj GLUCOSE-6-PHOSPHATE
ISOMERASE
(Colias
eurytheme) 		5 / 12 ILE A 494
ALA A 495
GLY A 302
GLY A 167
VAL A 171
 None
 1.18A 5i71A-4wmjA:
undetectable		 5i71A-4wmjA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I75_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 4wmj GLUCOSE-6-PHOSPHATE
ISOMERASE
(Colias
eurytheme) 		5 / 12 ILE A 494
ALA A 495
GLY A 302
GLY A 167
VAL A 171
 None
 1.21A 5i75A-4wmjA:
undetectable		 5i75A-4wmjA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IMS_A_ACTA708_0
(ACETOLACTATE
SYNTHASE CATALYTIC
SUBUNIT,
MITOCHONDRIAL)		 4wmj GLUCOSE-6-PHOSPHATE
ISOMERASE
(Colias
eurytheme) 		3 / 3 GLY A 274
GLY A 275
GLN A 515
 None
 0.38A 5imsA-4wmjA:
2.9		 5imsA-4wmjA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IWU_A_ERYA404_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 4wmj GLUCOSE-6-PHOSPHATE
ISOMERASE
(Colias
eurytheme) 		5 / 12 THR A 172
PHE A 209
ALA A 228
SER A 164
ILE A 161
 None
 1.34A 5iwuA-4wmjA:
undetectable		 5iwuA-4wmjA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JW1_B_CELB602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4wmj GLUCOSE-6-PHOSPHATE
ISOMERASE
(Colias
eurytheme) 		5 / 12 ARG A 108
LEU A 493
ALA A 174
GLY A 302
ALA A 303
 None
 0.98A 5jw1B-4wmjA:
undetectable		 5jw1B-4wmjA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOC_A_SAMA401_0
(PAVINE
N-METHYLTRANSFERASE)		 4wmj GLUCOSE-6-PHOSPHATE
ISOMERASE
(Colias
eurytheme) 		5 / 12 ASP A 121
VAL A 122
THR A 123
VAL A 102
LEU A 103
 None
 0.92A 5kocA-4wmjA:
undetectable		 5kocA-4wmjA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 4wmj GLUCOSE-6-PHOSPHATE
ISOMERASE
(Colias
eurytheme) 		3 / 3 LYS A 500
LEU A  57
ASP A 408
 None
 0.75A 5zv2A-4wmjA:
undetectable		 5zv2A-4wmjA:
9.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BOC_A_EU7A102_0
(MATRIX PROTEIN 2)		 4wmj GLUCOSE-6-PHOSPHATE
ISOMERASE
(Colias
eurytheme) 		4 / 6 SER A 164
ALA A 282
SER A 281
ALA A 212
 None
 0.83A 6bocA-4wmjA:
undetectable
6bocB-4wmjA:
undetectable
6bocC-4wmjA:
undetectable
6bocD-4wmjA:
undetectable		 6bocA-4wmjA:
4.28
6bocB-4wmjA:
4.28
6bocC-4wmjA:
4.28
6bocD-4wmjA:
4.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_B_SUEB1202_0
(NS3 PROTEASE)		 4wmj GLUCOSE-6-PHOSPHATE
ISOMERASE
(Colias
eurytheme) 		5 / 12 ARG A 108
ILE A  47
GLY A  53
PHE A 488
ALA A 492
 None
 1.21A 6c2mB-4wmjA:
undetectable		 6c2mB-4wmjA:
8.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ESM_A_PZEA307_1
(MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9)		 4wmj GLUCOSE-6-PHOSPHATE
ISOMERASE
(Colias
eurytheme) 		3 / 3 TYR A 148
HIS A 245
PHE A 232
 None
 1.04A 6esmA-4wmjA:
undetectable		 6esmA-4wmjA:
8.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBV_D_FI8D1904_0
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		 4wmj GLUCOSE-6-PHOSPHATE
ISOMERASE
(Colias
eurytheme) 		4 / 8 ILE A 157
THR A 172
VAL A 171
SER A 288
 None
 1.16A 6fbvC-4wmjA:
undetectable		 6fbvC-4wmjA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_B_ADNB501_2
(-)		 4wmj GLUCOSE-6-PHOSPHATE
ISOMERASE
(Colias
eurytheme) 		4 / 5 GLN A 435
THR A 436
HIS A 339
LEU A 342
 None
 1.20A 6gbnB-4wmjA:
undetectable		 6gbnB-4wmjA:
21.61