SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4wmo'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_B_DVAB8_0
(GRAMICIDIN A)		 4wmo XEEL PROTEIN
(Xenopus
laevis) 		3 / 3 TRP F 190
VAL F 337
TRP F 179
 None
 1.24A 1c4dA-4wmoF:
undetectable
1c4dB-4wmoF:
undetectable		 1c4dA-4wmoF:
6.40
1c4dB-4wmoF:
6.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBC_A_BHAA396_0
(P-HYDROXYBENZOATE
HYDROXYLASE)		 4wmo XEEL PROTEIN
(Xenopus
laevis) 		5 / 10 VAL F 265
TRP F 146
LEU F 176
LEU F 212
TYR F 216
 None
 1.34A 1pbcA-4wmoF:
undetectable		 1pbcA-4wmoF:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_B_DIFB1376_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 4wmo XEEL PROTEIN
(Xenopus
laevis) 		4 / 7 GLY F 310
ALA F 313
LEU F 315
SER F 130
 CA  F 403 ( 4.6A)
None
None
None
 0.88A 2wekB-4wmoF:
undetectable		 2wekB-4wmoF:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_A_SAMA801_0
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)		 4wmo XEEL PROTEIN
(Xenopus
laevis) 		5 / 12 ASN F 139
GLY F 298
GLY F 142
ASP F 143
TYR F 223
 None
 1.07A 2zw9A-4wmoF:
undetectable		 2zw9A-4wmoF:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_Q_TFPQ201_1
(PROTEIN S100-A4)		 4wmo XEEL PROTEIN
(Xenopus
laevis) 		4 / 8 GLY F 203
PHE F 204
ILE F 171
PHE F 267
 None
 0.88A 3ko0O-4wmoF:
undetectable
3ko0Q-4wmoF:
undetectable		 3ko0O-4wmoF:
16.12
3ko0Q-4wmoF:
16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NBQ_A_URFA400_1
(URIDINE
PHOSPHORYLASE 1)		 4wmo XEEL PROTEIN
(Xenopus
laevis) 		5 / 9 THR F 248
GLY F 243
GLU F 246
LEU F 196
ILE F 195
 None
 1.41A 3nbqA-4wmoF:
undetectable		 3nbqA-4wmoF:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1478_0
(MJ0495-LIKE PROTEIN)		 4wmo XEEL PROTEIN
(Xenopus
laevis) 		4 / 7 GLY F 106
THR F 103
THR F  97
PHE F  98
 None
 1.00A 4ac9C-4wmoF:
undetectable		 4ac9C-4wmoF:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_D_SAMD601_1
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 4wmo XEEL PROTEIN
(Xenopus
laevis) 		3 / 3 ASN F 117
ASP F 162
ASP F 143
 None
CA  F 402 (-2.1A)
None
 0.79A 4obwD-4wmoF:
undetectable		 4obwD-4wmoF:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDQ_A_BEZA306_0
(GLYCOSIDE HYDROLASE
FAMILY PROTEIN)		 4wmo XEEL PROTEIN
(Xenopus
laevis) 		3 / 3 ARG F 128
ASP F 162
TRP F 129
 None
CA  F 402 (-2.1A)
None
 1.09A 4xdqA-4wmoF:
undetectable		 4xdqA-4wmoF:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EQB_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4wmo XEEL PROTEIN
(Xenopus
laevis) 		5 / 12 GLY F 107
TYR F 216
PHE F 204
GLY F 233
LEU F 178
 None
 1.03A 5eqbA-4wmoF:
undetectable		 5eqbA-4wmoF:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCY_A_DB8A401_2
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 4wmo XEEL PROTEIN
(Xenopus
laevis) 		4 / 4 VAL F 221
LEU F 277
ASN F 145
ASP F 143
 None
 1.33A 5vcyA-4wmoF:
undetectable		 5vcyA-4wmoF:
22.69