SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4wn5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2CDQ_A_SAMA1500_0 (ASPARTOKINASE)	4wn5	HYPOXIA-INDUCIBLE FACTOR 3-ALPHA (Homo sapiens)	4 / 8	ILE A 258 SER A 265 ASP A 268 SER A 310	MVC A 402 ( 4.8A) None None None	0.74A	2cdqA-4wn5A: undetectable	2cdqA-4wn5A: 13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2XYT_D_TC9D1206_2 (SOLUBLE ACETYLCHOLINE RECEPTOR)	4wn5	HYPOXIA-INDUCIBLE FACTOR 3-ALPHA (Homo sapiens)	4 / 8	TYR A 275 ARG A 305 ILE A 278 ASP A 284	None	1.00A	2xytE-4wn5A: undetectable	2xytE-4wn5A: 19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2XYT_G_TC9G1206_2 (SOLUBLE ACETYLCHOLINE RECEPTOR)	4wn5	HYPOXIA-INDUCIBLE FACTOR 3-ALPHA (Homo sapiens)	4 / 8	TYR A 275 ARG A 305 ILE A 278 ASP A 284	None	1.00A	2xytH-4wn5A: undetectable	2xytH-4wn5A: 19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6B89_A_NOVA403_2 (LIPOPOLYSACCHARIDE EXPORT SYSTEM ATP-BINDING PROTEIN LPTB)	4wn5	HYPOXIA-INDUCIBLE FACTOR 3-ALPHA (Homo sapiens)	4 / 6	PHE A 306 ARG A 305 LEU A 314 ALA A 262	MVC A 402 (-2.8A) None None None	1.03A	6b89B-4wn5A: undetectable	6b89B-4wn5A: 23.15

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["2CDQ_A_SAMA1500_0","ASPARTOKINASE","4wn5","HYPOXIA-INDUCIBLE FACTOR 3-ALPHA","Homo sapiens",4,"ILE A 258;SER A 265;ASP A 268;SER A 310","MVC A 402 ( 4.8A);None;None;None","0.74A","2cdqA-4wn5A:undetectable","2cdqA-4wn5A:13.71"],["2XYT_D_TC9D1206_2","SOLUBLE ACETYLCHOLINE RECEPTOR;SOLUBLE ACETYLCHOLINE RECEPTOR","4wn5","HYPOXIA-INDUCIBLE FACTOR 3-ALPHA","Homo sapiens",4,"TYR A 275;ARG A 305;ILE A 278;ASP A 284","None","1.00A","2xytE-4wn5A:undetectable","2xytE-4wn5A:19.28"],["2XYT_G_TC9G1206_2","SOLUBLE ACETYLCHOLINE RECEPTOR;SOLUBLE ACETYLCHOLINE RECEPTOR","4wn5","HYPOXIA-INDUCIBLE FACTOR 3-ALPHA","Homo sapiens",4,"TYR A 275;ARG A 305;ILE A 278;ASP A 284","None","1.00A","2xytH-4wn5A:undetectable","2xytH-4wn5A:19.28"],["6B89_A_NOVA403_2","LIPOPOLYSACCHARIDE EXPORT SYSTEM ATP-BINDING PROTEIN LPTB;LIPOPOLYSACCHARIDE EXPORT SYSTEM ATP-BINDING PROTEIN LPTB","4wn5","HYPOXIA-INDUCIBLE FACTOR 3-ALPHA","Homo sapiens",4,"PHE A 306;ARG A 305;LEU A 314;ALA A 262","MVC A 402 (-2.8A);None;None;None","1.03A","6b89B-4wn5A:undetectable","6b89B-4wn5A:23.15"]]