SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4wnr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_D_RIMD499_1
(MATRIX PROTEIN 2)		 4wnr LEUCINE-RICH-REPEAT
PROTEIN
(Methanosarcina
barkeri) 		4 / 6 ILE A 458
ARG A 340
LEU A 337
ASP A 463
 None
 0.88A 2rlfA-4wnrA:
undetectable
2rlfD-4wnrA:
undetectable		 2rlfA-4wnrA:
13.14
2rlfD-4wnrA:
13.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UGR_A_IMNA2001_2
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 4wnr LEUCINE-RICH-REPEAT
PROTEIN
(Methanosarcina
barkeri) 		4 / 7 TYR A 411
GLU A 613
PRO A 626
TYR A 616
 None
 1.09A 3ugrA-4wnrA:
undetectable		 3ugrA-4wnrA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JX1_F_CAMF502_0
(CAMPHOR
5-MONOOXYGENASE)		 4wnr LEUCINE-RICH-REPEAT
PROTEIN
(Methanosarcina
barkeri) 		4 / 4 TYR A 597
THR A 559
VAL A 552
ILE A 605
 None
 1.44A 4jx1F-4wnrA:
undetectable		 4jx1F-4wnrA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OR0_B_NPSB603_1
(SERUM ALBUMIN)		 4wnr LEUCINE-RICH-REPEAT
PROTEIN
(Methanosarcina
barkeri) 		5 / 11 LEU A 341
SER A 470
VAL A 372
LEU A 477
LEU A 338
 None
 1.20A 4or0B-4wnrA:
undetectable		 4or0B-4wnrA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_A_DGXA1107_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 4wnr LEUCINE-RICH-REPEAT
PROTEIN
(Methanosarcina
barkeri) 		5 / 12 LEU A 429
LEU A 477
GLY A 454
GLU A 439
LEU A 413
 None
None
None
SO4  A 704 ( 4.4A)
None
 1.09A 4retA-4wnrA:
undetectable		 4retA-4wnrA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_C_DGXC2005_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 4wnr LEUCINE-RICH-REPEAT
PROTEIN
(Methanosarcina
barkeri) 		5 / 12 LEU A 429
LEU A 477
GLY A 454
GLU A 439
LEU A 413
 None
None
None
SO4  A 704 ( 4.4A)
None
 1.09A 4retC-4wnrA:
undetectable		 4retC-4wnrA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X61_A_SAMA701_1
(PROTEIN ARGININE
N-METHYLTRANSFERASE
5)		 4wnr LEUCINE-RICH-REPEAT
PROTEIN
(Methanosarcina
barkeri) 		4 / 5 TYR A 563
TYR A 597
GLU A 381
ASP A 376
 None
None
None
GDP  A 701 ( 4.6A)
 1.44A 4x61A-4wnrA:
1.7		 4x61A-4wnrA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z91_E_4LEE401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 4wnr LEUCINE-RICH-REPEAT
PROTEIN
(Methanosarcina
barkeri) 		5 / 10 LEU A 401
LEU A 440
LEU A 445
LEU A 413
LEU A 399
 None
 1.04A 4z91A-4wnrA:
undetectable
4z91B-4wnrA:
undetectable
4z91C-4wnrA:
undetectable
4z91D-4wnrA:
undetectable
4z91E-4wnrA:
undetectable		 4z91A-4wnrA:
21.01
4z91B-4wnrA:
21.01
4z91C-4wnrA:
21.01
4z91D-4wnrA:
21.01
4z91E-4wnrA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEN_B_VDYB201_1
(CDL2.2)		 4wnr LEUCINE-RICH-REPEAT
PROTEIN
(Methanosarcina
barkeri) 		5 / 10 ILE A 458
LEU A 337
VAL A 324
LEU A 396
LEU A 429
 None
 1.05A 5ienB-4wnrA:
undetectable		 5ienB-4wnrA:
16.57