SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4wnx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DB1_A_VDXA428_2
(VITAMIN D NUCLEAR
RECEPTOR)		 4wnx NETRIN-4
(Mus
musculus) 		4 / 6 LEU A  47
ILE A 221
ARG A 146
VAL A 258
 None
 1.08A 1db1A-4wnxA:
undetectable		 1db1A-4wnxA:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_B_DESB459_1
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 4wnx NETRIN-4
(Mus
musculus) 		5 / 12 LEU A 130
LEU A  43
VAL A 289
ARG A  37
LEU A 119
 None
 1.15A 1s9pB-4wnxA:
undetectable		 1s9pB-4wnxA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRK_A_TFPA204_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 4wnx NETRIN-4
(Mus
musculus) 		5 / 9 VAL A 226
LEU A 144
PHE A 134
SER A 186
LEU A 130
 None
 1.37A 1wrkA-4wnxA:
undetectable
1wrkB-4wnxA:
undetectable		 1wrkA-4wnxA:
10.75
1wrkB-4wnxA:
10.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCJ_A_THHA401_0
(PROBABLE
5'-PHOSPHORIBOSYLGLY
CINAMIDE
FORMYLTRANSFERASE
PURN)		 4wnx NETRIN-4
(Mus
musculus) 		5 / 12 LEU A 119
LEU A 224
THR A 104
VAL A 258
PRO A  91
 None
None
CA  A 507 (-3.6A)
None
None
 1.26A 3dcjA-4wnxA:
undetectable
3dcjB-4wnxA:
undetectable		 3dcjA-4wnxA:
18.98
3dcjB-4wnxA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SOA_A_DB8A445_1
(CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II
SUBUNIT ALPHA WITH A
BETA 7 LINKER)		 4wnx NETRIN-4
(Mus
musculus) 		4 / 6 LEU A 144
VAL A 226
PHE A 256
PHE A 134
 None
 1.15A 3soaA-4wnxA:
undetectable		 3soaA-4wnxA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_A_ADNA401_1
(ADENOSINE KINASE)		 4wnx NETRIN-4
(Mus
musculus) 		5 / 12 LEU A 201
GLY A 266
LEU A 219
GLY A 324
ASP A 320
 None
 1.01A 4dc3A-4wnxA:
undetectable		 4dc3A-4wnxA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_I_HCYI900_2
(GLUCOCORTICOID
RECEPTOR)		 4wnx NETRIN-4
(Mus
musculus) 		3 / 3 MET A  38
MET A 294
TYR A 126
 None
 1.01A 4p6xI-4wnxA:
undetectable		 4p6xI-4wnxA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YO9_B_ACTB401_0
(3C-LIKE PROTEINASE)		 4wnx NETRIN-4
(Mus
musculus) 		3 / 3 ARG A 227
ASP A 145
TYR A 159
 None
 0.93A 4yo9B-4wnxA:
undetectable		 4yo9B-4wnxA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4E_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 4wnx NETRIN-4
(Mus
musculus) 		4 / 7 ARG A 322
ILE A 207
PRO A 210
ASP A 320
 None
 1.09A 4z4eA-4wnxA:
undetectable		 4z4eA-4wnxA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MLM_A_STRA401_1
(-)		 4wnx NETRIN-4
(Mus
musculus) 		5 / 12 MET A  94
PHE A 134
MET A 142
ALA A 109
PRO A  91
 None
None
None
NAG  A 503 ( 4.5A)
None
 1.46A 5mlmA-4wnxA:
undetectable		 5mlmA-4wnxA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVS_A_ADNA401_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 4wnx NETRIN-4
(Mus
musculus) 		4 / 7 GLY A 418
LYS A 393
ALA A 394
ASP A 381
 None
 1.01A 5mvsA-4wnxA:
undetectable		 5mvsA-4wnxA:
22.15