SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4wnz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_B_CCSB381_0
(ESTROGEN RECEPTOR)		 4wnz CRISPR SYSTEM CMR
SUBUNIT CMR4
(Pyrococcus
furiosus) 		3 / 3 GLU A 173
ALA A 171
SER A 167
 None
 0.70A 1errB-4wnzA:
undetectable		 1errB-4wnzA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_G_BEZG3385_0
(CES1 PROTEIN)		 4wnz CRISPR SYSTEM CMR
SUBUNIT CMR4
(Pyrococcus
furiosus) 		3 / 3 SER A 238
VAL A 281
LEU A   8
 None
 0.74A 1yajG-4wnzA:
undetectable		 1yajG-4wnzA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F9W_A_PAUA6002_0
(PANTOTHENATE KINASE)		 4wnz CRISPR SYSTEM CMR
SUBUNIT CMR4
(Pyrococcus
furiosus) 		4 / 8 THR A 127
GLY A 163
ASP A 160
ILE A 129
 None
 0.92A 2f9wA-4wnzA:
undetectable
2f9wB-4wnzA:
undetectable		 2f9wA-4wnzA:
22.26
2f9wB-4wnzA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_D_KLND1499_1
(CYTOCHROME P450 3A4)		 4wnz CRISPR SYSTEM CMR
SUBUNIT CMR4
(Pyrococcus
furiosus) 		4 / 5 PHE A 113
SER A 139
PHE A 176
ILE A 142
 None
 1.35A 2v0mD-4wnzA:
undetectable		 2v0mD-4wnzA:
25.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WUZ_A_TPFA1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE
, PUTATIVE)		 4wnz CRISPR SYSTEM CMR
SUBUNIT CMR4
(Pyrococcus
furiosus) 		5 / 10 TYR A 237
PHE A 176
ALA A 175
ALA A 171
LEU A 110
 None
 1.34A 2wuzA-4wnzA:
undetectable		 2wuzA-4wnzA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WUZ_B_TPFB1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE
, PUTATIVE)		 4wnz CRISPR SYSTEM CMR
SUBUNIT CMR4
(Pyrococcus
furiosus) 		5 / 10 TYR A 237
PHE A 176
ALA A 175
ALA A 171
LEU A 110
 None
 1.32A 2wuzB-4wnzA:
undetectable		 2wuzB-4wnzA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB200_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4wnz CRISPR SYSTEM CMR
SUBUNIT CMR4
(Pyrococcus
furiosus) 		4 / 5 PRO A  93
VAL A  94
THR A  35
GLY A  36
 None
 1.21A 3elzB-4wnzA:
undetectable		 3elzB-4wnzA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SOA_A_DB8A445_1
(CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II
SUBUNIT ALPHA WITH A
BETA 7 LINKER)		 4wnz CRISPR SYSTEM CMR
SUBUNIT CMR4
(Pyrococcus
furiosus) 		4 / 6 VAL A 168
PHE A  91
VAL A 109
PHE A 176
 None
 1.03A 3soaA-4wnzA:
undetectable		 3soaA-4wnzA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_C_AERC601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4wnz CRISPR SYSTEM CMR
SUBUNIT CMR4
(Pyrococcus
furiosus) 		4 / 6 LEU A  97
GLU A 151
VAL A 104
ALA A 189
 None
 1.05A 4nkvC-4wnzA:
undetectable		 4nkvC-4wnzA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEN_B_VDYB201_1
(CDL2.2)		 4wnz CRISPR SYSTEM CMR
SUBUNIT CMR4
(Pyrococcus
furiosus) 		5 / 10 ILE A  82
LEU A 258
VAL A 281
LEU A   8
LEU A 241
 None
 1.12A 5ienB-4wnzA:
undetectable		 5ienB-4wnzA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_E_PFLE409_1
(PROTON-GATED ION
CHANNEL)		 4wnz CRISPR SYSTEM CMR
SUBUNIT CMR4
(Pyrococcus
furiosus) 		6 / 10 ILE A 188
LEU A 165
ILE A 157
ALA A 136
ILE A 137
ILE A 191
 None
 1.46A 5mvmD-4wnzA:
undetectable
5mvmE-4wnzA:
undetectable		 5mvmD-4wnzA:
14.13
5mvmE-4wnzA:
14.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0O_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 4wnz CRISPR SYSTEM CMR
SUBUNIT CMR4
(Pyrococcus
furiosus) 		5 / 12 ILE A 142
GLY A 186
VAL A 169
ALA A 138
VAL A 104
 None
 1.05A 5n0oB-4wnzA:
undetectable		 5n0oB-4wnzA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0T_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 4wnz CRISPR SYSTEM CMR
SUBUNIT CMR4
(Pyrococcus
furiosus) 		5 / 12 ILE A 142
GLY A  99
ALA A 102
ILE A 191
ALA A 189
 None
 1.06A 5n0tB-4wnzA:
undetectable		 5n0tB-4wnzA:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0T_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 4wnz CRISPR SYSTEM CMR
SUBUNIT CMR4
(Pyrococcus
furiosus) 		5 / 12 ILE A 142
GLY A 186
VAL A 169
ALA A 138
VAL A 104
 None
 1.04A 5n0tB-4wnzA:
undetectable		 5n0tB-4wnzA:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_B_NOVB403_1
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		 4wnz CRISPR SYSTEM CMR
SUBUNIT CMR4
(Pyrococcus
furiosus) 		4 / 7 PHE A 113
ARG A 115
ALA A 171
GLN A 174
 None
 1.17A 6b89A-4wnzA:
undetectable		 6b89A-4wnzA:
14.23