SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4woe'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_A_FFOA1293_2
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4woe TAUROCYAMINE KINASE
(Schistosoma
mansoni) 		3 / 3 SER A 171
GLU A 172
GLU A 173
 None
 0.68A 1eqbD-4woeA:
undetectable		 1eqbD-4woeA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_C_FFOC3293_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4woe TAUROCYAMINE KINASE
(Schistosoma
mansoni) 		3 / 3 SER A 171
GLU A 172
GLU A 173
 None
 0.68A 1eqbB-4woeA:
undetectable		 1eqbB-4woeA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QW6_A_H4BA901_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4woe TAUROCYAMINE KINASE
(Schistosoma
mansoni) 		3 / 3 ARG A 121
VAL A 217
TRP A 218
 ADP  A 801 (-3.1A)
None
None
 1.01A 1qw6A-4woeA:
undetectable		 1qw6A-4woeA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QW6_A_H4BA901_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4woe TAUROCYAMINE KINASE
(Schistosoma
mansoni) 		3 / 3 ARG A 484
VAL A 580
TRP A 581
 ADP  A 802 (-3.0A)
None
None
 1.08A 1qw6A-4woeA:
undetectable		 1qw6A-4woeA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QWC_A_H4BA901_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4woe TAUROCYAMINE KINASE
(Schistosoma
mansoni) 		3 / 3 ARG A 121
VAL A 217
TRP A 218
 ADP  A 801 (-3.1A)
None
None
 1.00A 1qwcA-4woeA:
undetectable		 1qwcA-4woeA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VAG_A_H4BA901_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4woe TAUROCYAMINE KINASE
(Schistosoma
mansoni) 		3 / 3 ARG A 121
VAL A 217
TRP A 218
 ADP  A 801 (-3.1A)
None
None
 1.06A 1vagA-4woeA:
undetectable		 1vagA-4woeA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZVI_A_H4BA901_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4woe TAUROCYAMINE KINASE
(Schistosoma
mansoni) 		3 / 3 ARG A 121
VAL A 217
TRP A 218
 ADP  A 801 (-3.1A)
None
None
 1.01A 1zviA-4woeA:
undetectable		 1zviA-4woeA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZVI_A_H4BA901_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4woe TAUROCYAMINE KINASE
(Schistosoma
mansoni) 		3 / 3 ARG A 484
VAL A 580
TRP A 581
 ADP  A 802 (-3.0A)
None
None
 1.07A 1zviA-4woeA:
undetectable		 1zviA-4woeA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QE6_A_SAMA400_1
(UNCHARACTERIZED
PROTEIN TFU_2867)		 4woe TAUROCYAMINE KINASE
(Schistosoma
mansoni) 		3 / 3 ASN A 271
ARG A 326
ASP A 320
 NO3  A 807 ( 3.2A)
None
ADP  A 801 (-3.9A)
 0.89A 2qe6A-4woeA:
undetectable		 2qe6A-4woeA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QE6_B_SAMB400_1
(UNCHARACTERIZED
PROTEIN TFU_2867)		 4woe TAUROCYAMINE KINASE
(Schistosoma
mansoni) 		3 / 3 ASN A 271
ARG A 326
ASP A 320
 NO3  A 807 ( 3.2A)
None
ADP  A 801 (-3.9A)
 0.89A 2qe6B-4woeA:
undetectable		 2qe6B-4woeA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_D_SALD1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 4woe TAUROCYAMINE KINASE
(Schistosoma
mansoni) 		5 / 12 THR A 403
GLY A 428
LEU A 495
PRO A 360
ILE A 499
 None
 1.00A 2y7kD-4woeA:
undetectable		 2y7kD-4woeA:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9M_A_SALA1200_1
(SERUM ALBUMIN)		 4woe TAUROCYAMINE KINASE
(Schistosoma
mansoni) 		4 / 5 ILE A 444
HIS A 448
TYR A 433
GLY A 636
 None
 1.27A 3b9mA-4woeA:
undetectable		 3b9mA-4woeA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D4S_A_TIMA401_2
(BETA-2 ADRENERGIC
RECEPTOR/T4-LYSOZYME
CHIMERA)		 4woe TAUROCYAMINE KINASE
(Schistosoma
mansoni) 		3 / 3 THR A 577
SER A 575
PHE A 571
 None
 0.73A 3d4sA-4woeA:
undetectable		 3d4sA-4woeA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K9F_H_LFXH0_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		 4woe TAUROCYAMINE KINASE
(Schistosoma
mansoni) 		4 / 6 SER A 482
ARG A 589
GLU A 585
GLU A 584
 ADP  A 802 (-2.5A)
NO3  A 808 ( 3.0A)
3S5  A 804 ( 2.7A)
MG  A 805 (-3.6A)
 1.16A 3k9fA-4woeA:
2.4
3k9fB-4woeA:
2.4
3k9fD-4woeA:
undetectable		 3k9fA-4woeA:
20.35
3k9fB-4woeA:
20.35
3k9fD-4woeA:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LTW_A_HLZA302_1
(ARYLAMINE
N-ACETYLTRANSFERASE
NAT)		 4woe TAUROCYAMINE KINASE
(Schistosoma
mansoni) 		4 / 6 LEU A 372
GLU A 367
ARG A 414
HIS A 411
 None
 1.47A 3ltwA-4woeA:
0.9		 3ltwA-4woeA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGY_B_GLYB511_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4woe TAUROCYAMINE KINASE
(Schistosoma
mansoni) 		4 / 5 SER A 289
GLU A 349
LEU A 352
GLN A 353
 None
 1.19A 3pgyB-4woeA:
1.1		 3pgyB-4woeA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9C_A_ECLA451_1
(CYTOCHROME P450
164A2)		 4woe TAUROCYAMINE KINASE
(Schistosoma
mansoni) 		5 / 10 LEU A 372
ILE A 413
ALA A 410
THR A 408
THR A 498
 None
 1.28A 3r9cA-4woeA:
undetectable		 3r9cA-4woeA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_C_SUEC1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 4woe TAUROCYAMINE KINASE
(Schistosoma
mansoni) 		5 / 12 HIS A 311
GLY A 309
ILE A 284
GLY A 306
ALA A 282
 None
 0.96A 3sudC-4woeA:
undetectable		 3sudC-4woeA:
16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 4woe TAUROCYAMINE KINASE
(Schistosoma
mansoni) 		5 / 12 HIS A 311
GLY A 309
ILE A 284
GLY A 306
ALA A 282
 None
 1.00A 3sueA-4woeA:
undetectable		 3sueA-4woeA:
16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_D_SUED1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 4woe TAUROCYAMINE KINASE
(Schistosoma
mansoni) 		5 / 12 HIS A 311
GLY A 309
ILE A 284
GLY A 306
ALA A 282
 None
 0.94A 3sufD-4woeA:
undetectable		 3sufD-4woeA:
16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UWL_B_FOZB316_0
(THYMIDYLATE SYNTHASE)		 4woe TAUROCYAMINE KINASE
(Schistosoma
mansoni) 		5 / 12 LEU A 508
LEU A 516
GLY A 514
ILE A 613
ALA A 612
 None
 0.95A 3uwlB-4woeA:
undetectable		 3uwlB-4woeA:
16.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UWL_D_FOZD316_0
(THYMIDYLATE SYNTHASE)		 4woe TAUROCYAMINE KINASE
(Schistosoma
mansoni) 		5 / 12 LEU A 508
LEU A 516
GLY A 514
ILE A 613
ALA A 612
 None
 0.93A 3uwlD-4woeA:
undetectable		 3uwlD-4woeA:
16.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_G_ACTG306_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 4woe TAUROCYAMINE KINASE
(Schistosoma
mansoni) 		3 / 3 ARG A 562
ARG A 568
ASP A 504
 None
 0.78A 3wipG-4woeA:
undetectable
3wipH-4woeA:
undetectable		 3wipG-4woeA:
15.36
3wipH-4woeA:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DO3_A_0LAA602_1
(FATTY-ACID AMIDE
HYDROLASE 1)		 4woe TAUROCYAMINE KINASE
(Schistosoma
mansoni) 		4 / 5 LEU A 346
LEU A 110
MET A 338
THR A 120
 None
 1.36A 4do3A-4woeA:
2.2		 4do3A-4woeA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DUZ_A_SRYA1601_1
(16S RRNA
RIBOSOMAL PROTEIN
S12)		 4woe TAUROCYAMINE KINASE
(Schistosoma
mansoni) 		3 / 3 LYS A 646
PRO A 648
LYS A 478
 None
 1.45A 4duzL-4woeA:
undetectable		 4duzL-4woeA:
11.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KHP_A_PARA1606_1
(16S RIBOSOMAL RNA
30S RIBOSOMAL
PROTEIN S9
30S RIBOSOMAL
PROTEIN S10)		 4woe TAUROCYAMINE KINASE
(Schistosoma
mansoni) 		3 / 3 TYR A 447
ARG A 690
SER A 633
 None
None
3S5  A 804 ( 4.0A)
 1.08A 4khpI-4woeA:
undetectable
4khpJ-4woeA:
undetectable		 4khpI-4woeA:
11.32
4khpJ-4woeA:
9.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RKU_A_PQNA5001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 4woe TAUROCYAMINE KINASE
(Schistosoma
mansoni) 		4 / 8 PHE A 215
ALA A 244
LEU A 243
PHE A 133
 None
 0.82A 4rkuA-4woeA:
undetectable
4rkuJ-4woeA:
undetectable		 4rkuA-4woeA:
20.60
4rkuJ-4woeA:
5.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBQ_A_DIFA601_1
(SERUM ALBUMIN)		 4woe TAUROCYAMINE KINASE
(Schistosoma
mansoni) 		5 / 11 LEU A 579
VAL A 580
ARG A 484
GLY A 488
LEU A 606
 None
None
ADP  A 802 (-3.0A)
None
None
 0.93A 4zbqA-4woeA:
undetectable		 4zbqA-4woeA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1O_F_DVAF9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 4woe TAUROCYAMINE KINASE
(Schistosoma
mansoni) 		3 / 3 ALA A 152
ASN A 155
LEU A 156
 None
 0.30A 5i1oC-4woeA:
undetectable		 5i1oC-4woeA:
4.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQY_B_017B101_2
(PROTEASE E35D-DRV)		 4woe TAUROCYAMINE KINASE
(Schistosoma
mansoni) 		4 / 7 GLY A 132
ASP A 223
GLY A 197
ILE A 199
 None
 0.69A 5kqyB-4woeA:
undetectable		 5kqyB-4woeA:
8.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LRB_A_ACRA1003_1
(ALPHA-1,4 GLUCAN
PHOSPHORYLASE)		 4woe TAUROCYAMINE KINASE
(Schistosoma
mansoni) 		4 / 6 GLU A 509
PHE A 571
THR A 526
TYR A 527
 None
 1.31A 5lrbA-4woeA:
undetectable		 5lrbA-4woeA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N4T_A_BEZA507_0
(BETA-LACTAMASE VIM-2)		 4woe TAUROCYAMINE KINASE
(Schistosoma
mansoni) 		3 / 3 THR A 526
HIS A 572
ASN A 573
 None
 0.96A 5n4tA-4woeA:
undetectable		 5n4tA-4woeA:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NOO_C_D16C402_1
(THYMIDYLATE SYNTHASE)		 4woe TAUROCYAMINE KINASE
(Schistosoma
mansoni) 		4 / 6 ASP A  66
LEU A  42
GLY A 132
PHE A 131
 None
 0.91A 5nooC-4woeA:
undetectable		 5nooC-4woeA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OGJ_A_ACTA307_0
(CARBONIC ANHYDRASE
13)		 4woe TAUROCYAMINE KINASE
(Schistosoma
mansoni) 		4 / 6 HIS A 182
HIS A 281
VAL A 118
THR A 307
 ADP  A 801 (-3.6A)
ADP  A 801 (-3.8A)
None
None
 1.19A 5ogjA-4woeA:
undetectable		 5ogjA-4woeA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OGJ_B_ACTB305_0
(CARBONIC ANHYDRASE
13)		 4woe TAUROCYAMINE KINASE
(Schistosoma
mansoni) 		4 / 6 HIS A 182
HIS A 281
VAL A 118
THR A 307
 ADP  A 801 (-3.6A)
ADP  A 801 (-3.8A)
None
None
 1.18A 5ogjB-4woeA:
undetectable		 5ogjB-4woeA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OHH_A_ACTA307_0
(CARBONIC ANHYDRASE
13)		 4woe TAUROCYAMINE KINASE
(Schistosoma
mansoni) 		4 / 5 HIS A 182
HIS A 281
VAL A 118
THR A 307
 ADP  A 801 (-3.6A)
ADP  A 801 (-3.8A)
None
None
 1.18A 5ohhA-4woeA:
undetectable		 5ohhA-4woeA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OHH_B_ACTB311_0
(CARBONIC ANHYDRASE
13)		 4woe TAUROCYAMINE KINASE
(Schistosoma
mansoni) 		4 / 6 HIS A 182
HIS A 281
VAL A 118
THR A 307
 ADP  A 801 (-3.6A)
ADP  A 801 (-3.8A)
None
None
 1.20A 5ohhB-4woeA:
undetectable		 5ohhB-4woeA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_A_SALA201_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 4woe TAUROCYAMINE KINASE
(Schistosoma
mansoni) 		4 / 5 VAL A 487
ARG A 489
GLY A 636
TYR A 627
 None
 1.26A 5x80A-4woeA:
undetectable
5x80B-4woeA:
undetectable		 5x80A-4woeA:
12.67
5x80B-4woeA:
12.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AZ3_1_PAR11802_1
(RRNA ALPHA
RIBOSOMAL PROTEIN
UL4
RIBOSOMAL PROTEIN
UL15
RIBOSOMAL PROTEIN
EL15)		 4woe TAUROCYAMINE KINASE
(Schistosoma
mansoni) 		3 / 3 ARG A 277
LYS A 294
ARG A 123
 ADP  A 801 (-3.8A)
None
ADP  A 801 ( 3.9A)
 1.44A 6az3C-4woeA:
0.1
6az3L-4woeA:
undetectable
6az3M-4woeA:
undetectable		 6az3C-4woeA:
8.01
6az3L-4woeA:
7.72
6az3M-4woeA:
7.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_D_SUED1202_0
(NS3 PROTEASE)		 4woe TAUROCYAMINE KINASE
(Schistosoma
mansoni) 		5 / 12 HIS A 311
GLY A 309
ILE A 284
GLY A 306
ALA A 282
 None
 0.92A 6c2mD-4woeA:
0.0		 6c2mD-4woeA:
8.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HLO_A_GBQA1501_1
(SUBSTANCE-P
RECEPTOR,GLGA
GLYCOGEN
SYNTHASE,SUBSTANCE-P
RECEPTOR)		 4woe TAUROCYAMINE KINASE
(Schistosoma
mansoni) 		5 / 9 ILE A 613
ILE A 610
GLU A 509
VAL A 580
ILE A 590
 None
 1.24A 6hloA-4woeA:
undetectable		 6hloA-4woeA:
21.35